[go: up one dir, main page]

AR017230A1 - Acidos 2, 3, 4, 5-tetrahidro.1h.[1,4]-benzodiazepina-3-hidroxamicos y composicion farmaceutica que los contiene y uso de dichos compuestos para prepararun medicamento. - Google Patents

Acidos 2, 3, 4, 5-tetrahidro.1h.[1,4]-benzodiazepina-3-hidroxamicos y composicion farmaceutica que los contiene y uso de dichos compuestos para prepararun medicamento.

Info

Publication number
AR017230A1
AR017230A1 ARP990100299A ARP990100299A AR017230A1 AR 017230 A1 AR017230 A1 AR 017230A1 AR P990100299 A ARP990100299 A AR P990100299A AR P990100299 A ARP990100299 A AR P990100299A AR 017230 A1 AR017230 A1 AR 017230A1
Authority
AR
Argentina
Prior art keywords
alkyl
hydrogen
heteroaryl
aryl
tetrahydro
Prior art date
Application number
ARP990100299A
Other languages
English (en)
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of AR017230A1 publication Critical patent/AR017230A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/56—Amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Acidos 2,3,4,5-tetrahidro.1H.[1,4]-benzodiazepina-3-hidroxámicos que comprenden la formula I en la cual R está seleccionado de hidrogeno, alquilo (C1-3)--CN, OR, -SR, -CF3, OCF3, Cl, F, NH2, NH alquilo C1-3, -N(R)CO alquilo C1-3, -N(R)(R), NO2, -CONH2, -SO2NH2- -SO2N(R)(R), o -N(R)COCH2O-alquilo C1-3,donde R es alquilo C1-3 o hidrogeno, R4 es alquilo C1-6-o-, alquilo C1-6-S- II, en la cual R es hidrogeno, ciano, metilo o -OCH3, R1 y R2 son cada unoindependientemente hidrogeno o CH3, R3 es alquilo C1-8, NH2CH2CO-, alquilo C1-6 NHCH2CO-, HO(CH2)mCO-, HCO-, aril(CH2)nCO-, heteroaril(CH2)nCO-, alquilo C1-3-O-(CH2)nCO-, alquilo C1-3 CO-, alquilo C1-3 CO-NHCH2CO-, cicloalquilo C3-7 CO-, alquilo C1-3 SO2-, aril(CH2)n SO2-, heteroaril(CH2)n SO2-, alquilo C1-3-O-(CH2)m-SO2-, alquilo C1-3-O-(CH2)m, alquilo C1-3)-O-(alquilo C1-3)-O-(alquilo C1-3), HO-alquilo C1-3-O-alquilo C1-3, aril-O-CH2CO- heteroaril-O-CH2-CO-,arilCH=CHCO, heteroarilCH=CHCO, alquilo C1-3 CH=CHCO, III; Aril alquilo C1-3, heteroaril alquilo C1-3, arilCH=CHCH2-, heteroarilCH=CHCH2-, alquilo C1-6 CH=CHCH2-, IV; ROCH2CH(OR)CO-, (ROCH2)2C(R)CO- V; [alquilo C1-6]2-N-alquilo C1-6 CO-, o alquilo C1-6-NH-alquilo C1-6 CO-; donde m= 1 a 3; n = 0 a 3; arilo esVI y heteroarilo es VIIdonde X eas hidrogeno, halogeno, alquilo C1-3 o -OCH3 y R y R son tal como se han definido precedentemente; L es hidrogeno, alquiloC1-3, -CN, -OR, -SR, -CF3, -OCF3, Cl, F, NH2, -NH-, alquilo C1-3, -N(R)CO alquilo C1-3, N(R)(R), -NO2, -CONH2, -SO2NH2,-SO2N(R)(R), -N(R)COCH2O-alquilo C1-3, VIII, M es IX o N(R)(R) donde R es tal como se ha definido más arriba; W es O, S, NH o N alquilo C1-3; Y es hidrogeno, F, Cl, CF3 o OCH3 yX es halogneo, hidrogeno, alquilo C1-3, O-alquilo C1-3 o -CH2OH; y sussales farmacéuticamente aceptables, composicion farmacéutica que los contiene y uso dedichos compuestos para preparar un medicamento uitilpara el tratamiento de condiciones de desordenes mediadas mediante la matriz de metaloproteinasa.
ARP990100299A 1998-01-27 1999-01-26 Acidos 2, 3, 4, 5-tetrahidro.1h.[1,4]-benzodiazepina-3-hidroxamicos y composicion farmaceutica que los contiene y uso de dichos compuestos para prepararun medicamento. AR017230A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1437498A 1998-01-27 1998-01-27

Publications (1)

Publication Number Publication Date
AR017230A1 true AR017230A1 (es) 2001-08-22

Family

ID=21765097

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990100299A AR017230A1 (es) 1998-01-27 1999-01-26 Acidos 2, 3, 4, 5-tetrahidro.1h.[1,4]-benzodiazepina-3-hidroxamicos y composicion farmaceutica que los contiene y uso de dichos compuestos para prepararun medicamento.

Country Status (14)

Country Link
EP (1) EP1051407A1 (es)
JP (1) JP2002501056A (es)
KR (1) KR20010034406A (es)
CN (1) CN1293663A (es)
AR (1) AR017230A1 (es)
AU (1) AU2240299A (es)
BR (1) BR9907746A (es)
CA (1) CA2317546A1 (es)
HU (1) HUP0100277A3 (es)
IL (1) IL137162A0 (es)
NO (1) NO20003828L (es)
PL (1) PL342045A1 (es)
WO (1) WO1999037625A1 (es)
ZA (1) ZA99569B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458783B1 (en) * 1997-09-29 2002-10-01 Bristol-Myers Squibb Company Non-imidazole benzodiazepine inhibitors of farnesyl protein transferase
US6544984B1 (en) 1999-01-27 2003-04-08 American Cyanamid Company 2,3,4,5-tetrahydro-1H-(1,4)benzodiazepine-3-hydroxamic acids
AR022423A1 (es) * 1999-01-27 2002-09-04 American Cyanamid Co Compuestos derivados de acidos 2,3,4,5-tetrahidro-1h-[1,4]benzodiazepina-3-hidroxamicos, composicion farmaceutica que los comprenden, y el uso de losmismos para la manufactura de un medicamento
US6808902B1 (en) 1999-11-12 2004-10-26 Amgen Inc. Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules
US7090830B2 (en) 2001-05-24 2006-08-15 Alexza Pharmaceuticals, Inc. Drug condensation aerosols and kits
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US7766013B2 (en) 2001-06-05 2010-08-03 Alexza Pharmaceuticals, Inc. Aerosol generating method and device
US7585493B2 (en) 2001-05-24 2009-09-08 Alexza Pharmaceuticals, Inc. Thin-film drug delivery article and method of use
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
CN103232539B (zh) 2001-06-26 2015-06-03 安姆根弗里蒙特公司 抗opgl抗体
PE20030701A1 (es) 2001-12-20 2003-08-21 Schering Corp Compuestos para el tratamiento de trastornos inflamatorios
US7540286B2 (en) 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
EP2246086A3 (en) 2004-08-12 2012-11-21 Alexza Pharmaceuticals, Inc. Aerosol drug delivery device incorporating percussively activated heating unit
ES2594867T3 (es) 2007-03-09 2016-12-23 Alexza Pharmaceuticals, Inc. Unidad de calentamiento para usar en un dispositivo de administración de fármaco
FR2950057B1 (fr) 2009-09-17 2011-08-26 Galderma Res & Dev Nouveaux composes benzene-carboxylamides, leur procede de synthese et leur utilisation en medecine ainsi qu'en cosmetique
FR2950056B1 (fr) 2009-09-17 2011-08-26 Galderma Res & Dev Nouveaux composes benzene-carboxylamides, leur procede de synthese et leur utilisation en medecine ainsi qu'en cosmetique
KR102852740B1 (ko) 2018-02-02 2025-08-29 알렉스자 파마스티칼즈, 인크. 전기적 응축 에어로졸 디바이스
EP3860608A1 (en) 2018-10-04 2021-08-11 INSERM (Institut National de la Santé et de la Recherche Médicale) Egfr inhibitors for treating keratodermas

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0861236B2 (de) * 1995-11-13 2006-08-16 Sanofi-Aventis Deutschland GmbH Cyclische und heterocyclische n-substituierte alpha-iminohydroxam- und carbonsäuren
IL124559A (en) * 1995-12-08 2004-07-25 Agouron Pharma Inhibitors of metalloproteinases, pharmaceutical preparations containing them and their use

Also Published As

Publication number Publication date
JP2002501056A (ja) 2002-01-15
PL342045A1 (en) 2001-05-21
NO20003828D0 (no) 2000-07-26
CN1293663A (zh) 2001-05-02
NO20003828L (no) 2000-09-26
HUP0100277A3 (en) 2002-03-28
EP1051407A1 (en) 2000-11-15
BR9907746A (pt) 2000-10-17
HUP0100277A2 (hu) 2002-02-28
AU2240299A (en) 1999-08-09
IL137162A0 (en) 2001-07-24
ZA99569B (en) 2000-07-26
WO1999037625A1 (en) 1999-07-29
CA2317546A1 (en) 1999-07-29
KR20010034406A (ko) 2001-04-25

Similar Documents

Publication Publication Date Title
AR017230A1 (es) Acidos 2, 3, 4, 5-tetrahidro.1h.[1,4]-benzodiazepina-3-hidroxamicos y composicion farmaceutica que los contiene y uso de dichos compuestos para prepararun medicamento.
AR007077A1 (es) Derivados tetrahidroisoquinolina, un procedimiento para su preparacion, una composicion farmaceutica que los contiene, el uso de los mismos parala fabricacion de un medicamento
YU8703A (sh) Derivati 4-fenil-piridina kao antagonisti receptora neurokinina-1
AR029821A1 (es) Decahidro-isoquinolinas, un proceso para su preparacion, composiciones farmaceuticas que las comprenden y el uso de las mismas para la fabricacion de un medicamento
BR0112475A (pt) N-óxidos como pró-drogas antagonistas de receptor de nk1 de derivados 4-fenil-piridina
WO2002089800A3 (en) N-aroyl cyclic amine derivatives as orexin receptor antagonists
AR035518A1 (es) Derivados de carboxamida, un procedimiento para su preparacion, un medicamento que los contiene, el u so de los mismos para preparar un medicamento, y un conjunto (kit) que los incluye
BR0307409A (pt) Compostos de hidrazida de ácido 2-furanocarboxìlico, composições farmacêuticas contendo os mesmos e uso dos mesmos para preparação de um agente preventivo ou terapêutico
AR038044A1 (es) Compuesto derivado de pirazina, composicion farmaceutica, su uso en la fabricacion de un medicamento, proceso para su preparacion y compuesto intermediario en dicho proceso.
AR034307A1 (es) Derivados de acido 6-oxo-octahidro-pirido[2,1a][2]benzoazepina-4-carboxilico, procedimiento para su preparacion y la preparacion de un intermediario, composicion farmaceutica, un metodo para su preparacion y el uso de los mismos para la preparacion de un medicamento
NO20071660L (no) Nye pyridinonderivater og deres anvendelse som positive allosteriske modulatorer av MGLUR2-reseptorer
WO2004014902A3 (en) Compounds having an activity at metabotropic glutamate receptors
CA2523261A1 (en) Fused pyrimidine derivatives with crf activity
AR042667A1 (es) Derivados de pirrolopirimidina y pirrolopiridina sustituidos con un grupo amino ciclico
SE0302760D0 (sv) New compounds
AR031526A1 (es) Nuevas fenilpiperazinas, composiciones farmaceuticas que las contienen, metodos para preparar los compuestos y las composiciones y uso de los compuestos en la preparacion de un medicamento.
AR017325A1 (es) Derivados tetraciclicos de tetrahidrofurano halogeno sustituidos, un proceso para su preparacion, composicion farmaceutica que los comprende y el uso de los mismos para la fabricacion de un medicamento
ATE469157T1 (de) Tetrahydrofuroä3,4-düdioxolverbindungen und zusammensetzungen und verfahren zur inhibierung der trombozytenaggregation
MY146599A (en) New azetidine compounds
MX2009005507A (es) Derivados de espiro-piperidina.
DE602004015277D1 (de) Substituierte-1-phthalazinamine als vr-1-antagonisten
CY1112218T1 (el) Νεα παραγωγα ανταγωνιστες υποδοχεα βιτρονεκτινης, μεθοδος παρασκευης τους, η εφαρμογη τους ως φαρμακα και φαρμακευτικες συνθεσεις που τα περιεχουν
NO20060428L (no) 2-amino-bicyklo[3.1.0]heksan-2,6-dikarboksylesterderivat
AR002025A1 (es) Derivados de 4-(1h-indol-1-il)-1-piperidinilo, su uso y un procedimiento para su preparacion, una composicion farmaceutica que los contiene, unprocedimiento para la preparacion de dicha composicion farmaceutica.
HUP9904210A2 (hu) Kamptotecin-analógok, alkalmazásuk gyógyszerként és ilyen vegyületeket tartalmazó gyógyászati készítmények