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AR016969A1 - VARIANTE DE PROTEASA, ADN, VECTOR DE EXPRESIoN, MICROORGANISMO HUESPED, COMPOSICIoN DE LIMPIEZA, ALIMENTO PARA ANIMALES Y COMPOSICIoN PARA TRATAR UN TEXTIL - Google Patents

VARIANTE DE PROTEASA, ADN, VECTOR DE EXPRESIoN, MICROORGANISMO HUESPED, COMPOSICIoN DE LIMPIEZA, ALIMENTO PARA ANIMALES Y COMPOSICIoN PARA TRATAR UN TEXTIL

Info

Publication number
AR016969A1
AR016969A1 ARP980105280A ARP980105280A AR016969A1 AR 016969 A1 AR016969 A1 AR 016969A1 AR P980105280 A ARP980105280 A AR P980105280A AR P980105280 A ARP980105280 A AR P980105280A AR 016969 A1 AR016969 A1 AR 016969A1
Authority
AR
Argentina
Prior art keywords
protease
positions
composition
amino acid
residue
Prior art date
Application number
ARP980105280A
Other languages
English (en)
Original Assignee
Procter & Gamble
Genencor Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27420734&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR016969(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Procter & Gamble, Genencor Int filed Critical Procter & Gamble
Publication of AR016969A1 publication Critical patent/AR016969A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38681—Chemically modified or immobilised enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G4/00—Chewing gum
    • A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
    • A23G4/12—Chewing gum characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
    • A23G4/123—Chewing gum characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins containing microorganisms, enzymes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/189—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/66—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38609—Protease or amylase in solid compositions only
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38618—Protease or amylase in liquid compositions only
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/39—Organic or inorganic per-compounds
    • C11D3/3902—Organic or inorganic per-compounds combined with specific additives
    • C11D3/3905—Bleach activators or bleach catalysts
    • C11D3/3907—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/39—Organic or inorganic per-compounds
    • C11D3/3945—Organic per-compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21062—Subtilisin (3.4.21.62)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/86—Products or compounds obtained by genetic engineering
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D2111/00—Cleaning compositions characterised by the objects to be cleaned; Cleaning compositions characterised by non-standard cleaning or washing processes
    • C11D2111/10—Objects to be cleaned
    • C11D2111/12—Soft surfaces, e.g. textile
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D2111/00—Cleaning compositions characterised by the objects to be cleaned; Cleaning compositions characterised by non-standard cleaning or washing processes
    • C11D2111/10—Objects to be cleaned
    • C11D2111/14—Hard surfaces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Animal Husbandry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Biotechnology (AREA)
  • Nutrition Science (AREA)
  • Detergent Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Fodder In General (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Slot Machines And Peripheral Devices (AREA)
  • Exhaust Gas After Treatment (AREA)
  • Finish Polishing, Edge Sharpening, And Grinding By Specific Grinding Devices (AREA)

Abstract

Se describen nuevas variantes de proteasas derivadas de las secuencias de ADN de proteasas naturales o no humanas recombinantes. Las proteasas variantes engeneral, se obtienen mediante modificacion in vitro de una secuencia de ADN precursora quecodi fica la proteasa natural o recombinante para generar lassustituciones de una pluralidad de residuos aminoácidos en la secuencia de aminoácido de una proteasa precursora. Dichas proteasas variantes tienen propiedadesque son diferentes de las dela pro teasa precursora tal como una actividad proteolítica alterada como una estabilidad alterada, etc. Los residuos aminoácidossustituidos que corresponden a la posicion 103 en combinacion con una o más de las siguientes sustituciones en lasposiciones de l residuo que corresponden alas posiciones: 1, 3, 4, 8, 10, 12, 13, 15, 16, 17, 18, 19, 20, 21, 22, 24, 27, 33, 37, 38, 42, 43, 48, 55, 57, 58, 61, 62, 68, 72, 75, 76, 77, 78, 79, 86, 87,89, 97, 98, 99, 101, 102, 104, 106, 107, 109,111, 114, 116, 11 7, 119, 121, 123, 126, 128, 130, 131, 133, 134, 137, 140, 141, 142, 146, 147, 158, 159, 160,166,167, 170, 173, 174, 177, 181, 182, 183, 184, 185, 188, 192, 194, 198, 203, 204, 205, 206, 209, 210, 211, 212, 213, 214, 215, 216, 217,218, 222, 224, 227, 228,230, 232, 236, 237, 238, 240, 242, 243, 244, 245, 246, 247, 248, 249, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 265,268,269,270,271,272,274 y 275 de subtilisina de Bacillus amyloliquefaciens, en la cualcuando una sustenta cion en una posicion que corresponde a la posicion 103 del residuo secombina una sustitucion en una posicion que corresponde a la posicion 76 del residuo, existe también una sustitucion en una o más posiciones delresiduodistintas de las posiciones 2 7, 99, 101, 104, 107, 109, 123, 128, 166, 204, 206, 210, 216,217, 218, 222, 260, 265 o 274, de la subtilisina de Bacillusamyloliquefaciens. También se describen aquí sustituciones específicas que corresponden a62, 212, 230, 232, 252 y 257 de la subt ilisina de Bacillusamyloliquefaciens.
ARP980105280A 1997-10-23 1998-10-22 VARIANTE DE PROTEASA, ADN, VECTOR DE EXPRESIoN, MICROORGANISMO HUESPED, COMPOSICIoN DE LIMPIEZA, ALIMENTO PARA ANIMALES Y COMPOSICIoN PARA TRATAR UN TEXTIL AR016969A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US95632497A 1997-10-23 1997-10-23
US95656497A 1997-10-23 1997-10-23
US95632397A 1997-10-23 1997-10-23

Publications (1)

Publication Number Publication Date
AR016969A1 true AR016969A1 (es) 2001-08-01

Family

ID=27420734

Family Applications (10)

Application Number Title Priority Date Filing Date
ARP980105280A AR016969A1 (es) 1997-10-23 1998-10-22 VARIANTE DE PROTEASA, ADN, VECTOR DE EXPRESIoN, MICROORGANISMO HUESPED, COMPOSICIoN DE LIMPIEZA, ALIMENTO PARA ANIMALES Y COMPOSICIoN PARA TRATAR UN TEXTIL
ARP980105279A AR015977A1 (es) 1997-10-23 1998-10-22 Variantes de proteasa multiplemente substituida con carga neta alterada para su empleo en detergentes
ARP980105303A AR013718A1 (es) 1997-10-23 1998-10-23 Composiciones blanqueadoras que contienen variantes de proteasa sustituidas en forma multiple.
ARP980105305A AR013719A1 (es) 1997-10-23 1998-10-23 Composiciones limpiadoras que contienen variantes de proteasa sustituida en forma multiple
ARP060100108A AR052353A2 (es) 1997-10-23 2006-01-11 Variante de proteasa, adn, vector de expresion, celula huesped, composicion de limpieza, alimento para animales y composicion para tratar textiles
ARP060100112A AR052355A2 (es) 1997-10-23 2006-01-11 Variante de proteasa, alimento para animales, adn, vector de expresion, celula huesped, composicion de limpieza, alimento para animales y composicion para tratar textiles
ARP060100107A AR052281A2 (es) 1997-10-23 2006-01-11 Composicion blanqueadora, metodo para la limpieza de telas, metodo para limpiar vajilla, metodo para la limpieza personal, metodo para pretratar una tela que necesita ser limpiada, composicion para limpieza, composicion para limpieza personal y metodo para pretratar una tela que necesita ser limpiad
ARP060100110A AR052453A2 (es) 1997-10-23 2006-01-11 Composicion para limpieza de telas y/o de vajilla y/o de superficies duras, metodo para la limpieza de telas, metodo para limpiar vajilla, composicion para limpieza personal, metodo para la limpieza personal y metodo pretratar una tela que necesita ser limpiada
ARP060100111A AR052354A2 (es) 1997-10-23 2006-01-11 Metodos para mejorar el desempeno de una subtilisina en sistemas de baja y alta concentracion de detergente, y metodo para producir una composicion detergente
ARP060100109A AR052282A2 (es) 1997-10-23 2006-01-11 Composicion para limpieza de telas y/o de vajilla y/o de superficies duras, metodo para la limpieza de telas, metodo para limpiar vajilla, composicion para limpieza personal, metodo para la limpieza personal, composicion para limpieza de telas y/o de vajilla y/o de superficies duras, composicion par

Family Applications After (9)

Application Number Title Priority Date Filing Date
ARP980105279A AR015977A1 (es) 1997-10-23 1998-10-22 Variantes de proteasa multiplemente substituida con carga neta alterada para su empleo en detergentes
ARP980105303A AR013718A1 (es) 1997-10-23 1998-10-23 Composiciones blanqueadoras que contienen variantes de proteasa sustituidas en forma multiple.
ARP980105305A AR013719A1 (es) 1997-10-23 1998-10-23 Composiciones limpiadoras que contienen variantes de proteasa sustituida en forma multiple
ARP060100108A AR052353A2 (es) 1997-10-23 2006-01-11 Variante de proteasa, adn, vector de expresion, celula huesped, composicion de limpieza, alimento para animales y composicion para tratar textiles
ARP060100112A AR052355A2 (es) 1997-10-23 2006-01-11 Variante de proteasa, alimento para animales, adn, vector de expresion, celula huesped, composicion de limpieza, alimento para animales y composicion para tratar textiles
ARP060100107A AR052281A2 (es) 1997-10-23 2006-01-11 Composicion blanqueadora, metodo para la limpieza de telas, metodo para limpiar vajilla, metodo para la limpieza personal, metodo para pretratar una tela que necesita ser limpiada, composicion para limpieza, composicion para limpieza personal y metodo para pretratar una tela que necesita ser limpiad
ARP060100110A AR052453A2 (es) 1997-10-23 2006-01-11 Composicion para limpieza de telas y/o de vajilla y/o de superficies duras, metodo para la limpieza de telas, metodo para limpiar vajilla, composicion para limpieza personal, metodo para la limpieza personal y metodo pretratar una tela que necesita ser limpiada
ARP060100111A AR052354A2 (es) 1997-10-23 2006-01-11 Metodos para mejorar el desempeno de una subtilisina en sistemas de baja y alta concentracion de detergente, y metodo para producir una composicion detergente
ARP060100109A AR052282A2 (es) 1997-10-23 2006-01-11 Composicion para limpieza de telas y/o de vajilla y/o de superficies duras, metodo para la limpieza de telas, metodo para limpiar vajilla, composicion para limpieza personal, metodo para la limpieza personal, composicion para limpieza de telas y/o de vajilla y/o de superficies duras, composicion par

Country Status (26)

Country Link
US (5) US6482628B1 (es)
EP (10) EP1025194B2 (es)
JP (7) JP2001520308A (es)
KR (6) KR100616143B1 (es)
CN (9) CN100342016C (es)
AR (10) AR016969A1 (es)
AT (9) ATE416624T1 (es)
AU (7) AU742694B2 (es)
BR (6) BRPI9813266B1 (es)
CA (9) CA2307640C (es)
CZ (6) CZ20001479A3 (es)
DE (7) DE69839057T2 (es)
DK (9) DK1624050T3 (es)
EG (2) EG21711A (es)
ES (7) ES2319470T5 (es)
HK (1) HK1039159B (es)
HU (3) HUP0100859A2 (es)
ID (4) ID25637A (es)
MA (2) MA25044A1 (es)
NO (3) NO20001901L (es)
NZ (3) NZ520770A (es)
PL (1) PL191529B1 (es)
PT (8) PT1571199E (es)
TR (8) TR200002013T2 (es)
TW (2) TW585912B (es)
WO (5) WO1999020769A2 (es)

Families Citing this family (622)

* Cited by examiner, † Cited by third party
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MA23346A1 (fr) * 1993-10-14 1995-04-01 Genencor Int Variantes de la subtilisine
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AR016969A1 (es) * 1997-10-23 2001-08-01 Procter & Gamble VARIANTE DE PROTEASA, ADN, VECTOR DE EXPRESIoN, MICROORGANISMO HUESPED, COMPOSICIoN DE LIMPIEZA, ALIMENTO PARA ANIMALES Y COMPOSICIoN PARA TRATAR UN TEXTIL
CA2331783C (en) 1998-07-02 2009-12-29 Genencor International, Inc. Chemically modified proteins with a carbohydrate moiety
WO2000024924A2 (en) * 1998-10-23 2000-05-04 The Procter & Gamble Company Methods for screening protease variants for use in detergent compositions
EP1129180B1 (en) 1998-11-10 2009-06-10 The Governing Council Of The University Of Toronto Chemically modified mutant serine hydrolases
KR20020057797A (ko) * 1999-04-28 2002-07-12 더 거버닝 카운실 오브 더 유니버시티 오브 토론토 특이적으로 표적화된 촉매적 안타고니스트 및 그 용도
US6627744B2 (en) 1999-07-02 2003-09-30 Genencor International, Inc. Synthesis of glycodendrimer reagents
CN1377406A (zh) * 1999-07-22 2002-10-30 宝洁公司 具有空间保护的切割位点的蛋白酶缀合物
CA2376045A1 (en) * 1999-07-22 2001-02-01 The Procter & Gamble Company Subtilisin protease variants having amino acid substitutions in defined epitope regions
WO2001018165A1 (en) * 1999-09-09 2001-03-15 The Procter & Gamble Company A detergent composition containing a protease
KR100387166B1 (ko) * 1999-12-15 2003-06-12 닛뽄덴끼 가부시끼가이샤 유기 일렉트로 루미네선스 소자
US7067049B1 (en) * 2000-02-04 2006-06-27 Exxonmobil Oil Corporation Formulated lubricant oils containing high-performance base oils derived from highly paraffinic hydrocarbons
DE10007608A1 (de) * 2000-02-18 2001-08-30 Henkel Kgaa Protease und Percarbonat enthaltende Wasch- und Reinigungsmittel
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DE69840346D1 (de) 2009-01-22
DE69841226D1 (de) 2009-11-19
JP2001520045A (ja) 2001-10-30
EP1025241B2 (en) 2009-10-21
HUP0104539A2 (hu) 2002-04-29
EP1571199B1 (en) 2011-06-22
JP2001520044A (ja) 2001-10-30
ID25897A (id) 2000-11-09
JP2001520046A (ja) 2001-10-30
CA2306894C (en) 2009-10-06
HUP0104539A3 (en) 2002-12-28
AR052353A2 (es) 2007-03-14
WO1999020723A3 (en) 2001-01-04
KR20010031377A (ko) 2001-04-16
CA2308113A1 (en) 1999-04-29
EP1025194B2 (en) 2012-01-04
NO20001901L (no) 2000-06-19
CN1191347C (zh) 2005-03-02
EP1025194A1 (en) 2000-08-09
PT1025239E (pt) 2008-04-30
CN1198912C (zh) 2005-04-27
PT1624050E (pt) 2010-01-13
DE69839677D1 (de) 2008-08-14
DK1624050T3 (da) 2010-02-15
CN1286723A (zh) 2001-03-07
NO20001900L (no) 2000-06-15
EG22075A (en) 2002-07-31
AU758371B2 (en) 2003-03-20
HUP0103080A2 (hu) 2001-12-28
EP1571199A3 (en) 2006-01-11
TR200002014T2 (tr) 2000-12-21
TR200101199T2 (tr) 2002-05-21
DK1027418T3 (da) 2008-11-10
ID26501A (id) 2001-01-11
EP1027418B2 (en) 2011-01-19
KR20010031374A (ko) 2001-04-16
EP1612271B1 (en) 2011-06-01
EP1025194B1 (en) 2008-12-10
CA2307640A1 (en) 1999-04-29
KR100612981B1 (ko) 2006-08-14
EP1025241A2 (en) 2000-08-09
WO1999020770A2 (en) 1999-04-29
DK1025194T3 (da) 2009-04-06
EP1571199A2 (en) 2005-09-07
EP1612271A3 (en) 2009-02-25
AR013719A1 (es) 2001-01-10
CN102021159A (zh) 2011-04-20
ES2319470T3 (es) 2009-05-07
EP1027418B1 (en) 2008-07-02
AR052355A2 (es) 2007-03-14
AU8733701A (en) 2002-01-03
NO326992B1 (no) 2009-03-30
CZ302287B6 (cs) 2011-02-09
CZ20001503A3 (cs) 2000-12-13
KR100616143B1 (ko) 2006-08-25
AU1199499A (en) 1999-05-10
ID28256A (id) 2001-05-10
NO327607B1 (no) 2009-08-31
AR015977A1 (es) 2001-05-30
BR9814097A (pt) 2000-10-03
PL340600A1 (en) 2001-02-12
HK1039159B (zh) 2008-05-09
TW562859B (en) 2003-11-21
DK1027418T4 (da) 2011-05-16
EP1025240B1 (en) 2005-12-28
AU1118199A (en) 1999-05-10
ATE417099T1 (de) 2008-12-15
TW585912B (en) 2004-05-01
WO1999020723A8 (en) 2001-03-08
US20030073222A1 (en) 2003-04-17
JP2001520308A (ja) 2001-10-30
MA24811A1 (fr) 1999-12-31
CA2618389C (en) 2012-12-11
DE69839057D1 (de) 2008-03-13
PT1025194E (pt) 2009-03-17
AR052281A2 (es) 2007-03-07
CA2307638A1 (en) 1999-04-29
CN1286724A (zh) 2001-03-07
CA2618389A1 (en) 1999-04-29
ATE511540T1 (de) 2011-06-15
CZ301469B6 (cs) 2010-03-17
CN100558871C (zh) 2009-11-11
KR20010031380A (ko) 2001-04-16
TR200001111T2 (tr) 2002-12-23
WO1999020723A2 (en) 1999-04-29
BR9815230A (pt) 2001-10-02
DK1571199T3 (da) 2011-09-26
MA25044A1 (fr) 2000-10-01
BR9813266A (pt) 2001-11-20
DK1025240T3 (da) 2006-05-22
AU742573B2 (en) 2002-01-10
AU742632B2 (en) 2002-01-10
ATE445002T1 (de) 2009-10-15
BRPI9813266B1 (pt) 2015-10-13
JP5612026B2 (ja) 2014-10-22
CZ20001493A3 (cs) 2001-11-14
WO1999020769A2 (en) 1999-04-29
BR9813115A (pt) 2000-08-15
ES2241180T3 (es) 2005-10-16
PT1398367E (pt) 2009-03-12
CA2307638C (en) 2012-01-03
ES2255189T3 (es) 2006-06-16
NZ520770A (en) 2004-05-28
PL191529B1 (pl) 2006-06-30
CN1279720A (zh) 2001-01-10
US6312936B1 (en) 2001-11-06

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