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AR016314A1 - Derivados de piridina, su uso como medicamentos y composiciones farmaceuticas que los contienen - Google Patents

Derivados de piridina, su uso como medicamentos y composiciones farmaceuticas que los contienen

Info

Publication number
AR016314A1
AR016314A1 ARP980103330A ARP980103330A AR016314A1 AR 016314 A1 AR016314 A1 AR 016314A1 AR P980103330 A ARP980103330 A AR P980103330A AR P980103330 A ARP980103330 A AR P980103330A AR 016314 A1 AR016314 A1 AR 016314A1
Authority
AR
Argentina
Prior art keywords
carboxy
alkyl
hydroxy
lower alkyl
aminoalkoxy
Prior art date
Application number
ARP980103330A
Other languages
English (en)
Original Assignee
Novartis Ag
Sibia Neurosciences
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27128958&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR016314(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag, Sibia Neurosciences filed Critical Novartis Ag
Publication of AR016314A1 publication Critical patent/AR016314A1/es

Links

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
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    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
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    • A61P25/08—Antiepileptics; Anticonvulsants
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    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
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    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53—Nitrogen atoms
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Abstract

Se refiere al uso de 2-arilalquenil-, 2-heteroarilalquenil-, 2-arilalquinil-2-heteroarilalquinil-2-arilazo, y 2-heteroarilazo-piridinas, o una salfarmacéuticamente aceptable de las mismas que son utiles en el tratamiento de desordenes asociados con irregularidades de la transmision de la senalglutamatérgica y de desordenes del sistema nervioso mediados total o parcialmente por mGluR5. Compuestos de la formula (I) en donde R1 denota hidrogeno,alquilo inferior, hidroxialquilo inferior, alquilo inferior-amino, piperidino, carboxi, carboxi esterificado, carboxi amidado, N-alquilo inferior-N-fenilcarbamoílo insustituido o sustituido por alquilo inferior, alcoxi inferior, halogeno, y/o trifluorometilo; alcoxi inferior, haloalquilo inferior, ohaloalcoxi inferior, R2 denota hidrogeno, alquilo inferior, carboxi, carboxi esterificado, carboxi amidado, hidroxialquilo inferior, hidroxi, alcoxi inferior,o alcanoiloxi inferior, 4-(4-fluoro-benzoil)-piperidin-1-il-carboxi, 4-butiloxi terciario-carbonil-piperazin-1-il-carboxi, 4-(4-azido 2-hidroxibenzoil)-piperazin-1-il-carboxi o 4-(4-azido-2-hidroxi-3-yodo-benzoil)-piperazin-1-il-carboxi, R3 representa hidrogeno, alquilo inferior, carboxi, alcoxi inferiorcarbonilo, alquilo inferior-carbamoílo, hidroxialquilo inferior, dialquilo inferior-aminometilo, morfolinocarbonilo, o 4-(4-fluoro-benzoil)-piperidin-1-il-carboxi, R4 representa hidrogeno, alquilo inferior, hidroxi, hidroxialquilo inferior, aminalquilo inferior, alquilo inferior-aminoalquilo inferior, dialquiloinferior-aminoalquilo inferior, alquileno inferior-aminoalquilo inferior insustituido o sustituido por hidroxi, alcoxi inferior, alcanoiloxi inferior,aminoalcoxi inferior, alquilo inferior-aminoalcoxi inferior, dialquilo inferior-aminoalcoxi inferio, ftalimidoalcoxi inferior, alquileno inferior-aminoalcoxiinferior insustituido o sustituido por hidroxi o por 2-oxo-imidazolidin-1-ilo: carboxi, carboxi esterificado o amidado, carboxialcoxi inferior o carboxialcoxiesterificado;X representa un grupo alquenileno o alquinileno inferior opcionalmente sustituido por halogeno enlazado por medio de átomos de carbono insaturado
ARP980103330A 1997-07-11 1998-07-08 Derivados de piridina, su uso como medicamentos y composiciones farmaceuticas que los contienen AR016314A1 (es)

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