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MX9806171A - Derivados 2,3-benzodiazepina y sus usos como inhibidores del receptor-ampa. - Google Patents

Derivados 2,3-benzodiazepina y sus usos como inhibidores del receptor-ampa.

Info

Publication number
MX9806171A
MX9806171A MX9806171A MX9806171A MX9806171A MX 9806171 A MX9806171 A MX 9806171A MX 9806171 A MX9806171 A MX 9806171A MX 9806171 A MX9806171 A MX 9806171A MX 9806171 A MX9806171 A MX 9806171A
Authority
MX
Mexico
Prior art keywords
designates
ampa
hydrogen
receptor inhibitors
benzodiazepine derivatives
Prior art date
Application number
MX9806171A
Other languages
English (en)
Inventor
Istvan Ling
Gizella Abraham
Sandor Solyom
Tamas Hamori
Istvan Tarnawa
Pal Berzsenyi
Ferenc Andrasi
Emese Csuzdi
Marta Szoellosy
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of MX9806171A publication Critical patent/MX9806171A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La invencion se relaciona con compuestos de la formula (I), en la cual; X indica hidrogeno o halogeno; Y indica -NR3- o N=; R1, R2 y R3 indican hidrogeno o diferentes sustituyentes; R4 designa un radical alquilo C1-C6 opcionalmente sustituido; R5 indica hidrogeno; o R4 y R5 juntos indican oxígeno; R6 indica alquilo de C1-C4; y (a) indica un doble enlace o enlaces sencillos. Debido a sus inhibidores no competitivos de los receptores-AMPA, estos compuestos pueden utilizarse como medicamentos para tratar enfermedades del sistema nervioso central.
MX9806171A 1996-02-01 1998-07-31 Derivados 2,3-benzodiazepina y sus usos como inhibidores del receptor-ampa. MX9806171A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19604920A DE19604920A1 (de) 1996-02-01 1996-02-01 Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
MX9806171A true MX9806171A (es) 1998-10-31

Family

ID=7785065

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9806171A MX9806171A (es) 1996-02-01 1998-07-31 Derivados 2,3-benzodiazepina y sus usos como inhibidores del receptor-ampa.

Country Status (14)

Country Link
US (1) US6200970B1 (es)
EP (1) EP0888313B1 (es)
JP (1) JP2000505793A (es)
AT (1) ATE216373T1 (es)
AU (1) AU2285997A (es)
CA (1) CA2244777C (es)
DE (2) DE19604920A1 (es)
DK (1) DK0888313T3 (es)
ES (1) ES2175386T3 (es)
HU (1) HUP9901473A3 (es)
MX (1) MX9806171A (es)
PT (1) PT888313E (es)
WO (1) WO1997028135A1 (es)
ZA (1) ZA97850B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5891871A (en) * 1996-03-21 1999-04-06 Cocensys, Inc. Substituted 2,3-benzodiazepin-4-ones and the use thereof
CN1245386C (zh) 2000-06-12 2006-03-15 卫材株式会社 1,2－二氢吡啶化合物及其制备方法和用途
WO2001098280A2 (en) * 2000-06-16 2001-12-27 Annovis, Inc. 5h-2,3-benzodiazepine antagonists of excitatory amino acid receptors
US6432944B1 (en) 2000-07-06 2002-08-13 Bristol-Myers Squibb Company Benzodiazepinone β-amyloid inhibitors: arylacetamidoalanyl derivatives
HU225100B1 (hu) * 2000-12-21 2006-06-28 Egyt Gyogyszervegyeszeti Gyar 2,3-Benzodiazepinszármazékok, ilyen hatóanyagot tartalmazó gyógyászati készítmények és alkalmazásuk
IL159105A0 (en) * 2001-06-07 2004-05-12 Neuro3D Cyclic nucleotide phosphodiesterase inhibitors, preparation and uses thereof
GB0129260D0 (en) 2001-12-06 2002-01-23 Eisai London Res Lab Ltd Pharmaceutical compositions and their uses
DK1545546T3 (da) * 2002-09-13 2007-08-06 Motac Neuroscience Ltd Behandling af dyskinesi med 2,3-benzodiazepiner
DE60313474T2 (de) * 2002-09-17 2008-01-03 Motac Neuroscience Ltd. Behandlung von dyskinesie
US20040141152A1 (en) * 2002-09-27 2004-07-22 Marino Joseph A. Apparatus and method for conducting vision screening
US6858605B2 (en) 2003-02-04 2005-02-22 Ivax Drug Research Institute, Ltd. Substituted 2,3-benzodiazepine derivatives
HUP0302449A3 (en) * 2003-08-04 2005-06-28 Egis Gyogyszergyar Nyilvanosan 8-chloro-2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for producing them
MY148809A (en) 2004-07-06 2013-05-31 Eisai R&D Man Co Ltd Crystals of 1,2-dihydropyridine compound and their production process
EA016087B1 (ru) * 2005-12-30 2012-02-28 Эгиш Дьёдьсердьяр Ньильваношан Мюкёдё Ресвеньтаршашаг Оптические изомеры дигидро-2,3-бензодиазепинов и их стереоселективный синтез
TW200902024A (en) * 2007-04-02 2009-01-16 Teva Pharma Novel 2,3-benzodiazepine derivatives and their use as antipsychotic agents
ES2628005T3 (es) * 2012-08-16 2017-08-01 Bayer Pharma Aktiengesellschaft 2,3-Benzodiazepinas
AP2015008673A0 (en) 2013-02-19 2015-08-31 Bayer Pharma Aktiengesellchaft Bicyclo 2,3-benzodiazepines and spirocyclically substituted 2,3-benzodiazepines
WO2015121268A1 (de) * 2014-02-14 2015-08-20 Bayer Pharma Aktiengesellschaft 1-phenyl-3h-2,3-benzodiazepine und ihre verwendung als bromodomänen-inhibitoren
KR102912861B1 (ko) 2018-12-14 2026-01-15 에자이 알앤드디 매니지먼트 가부시키가이샤 1,2-디하이드로피리딘 화합물의 수성 기반 약학적 제형

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU179018B (en) * 1978-10-19 1982-08-28 Gyogyszerkutato Intezet Process for producing new 5h-2,3-benzodiazepine derivatives
HU186760B (en) * 1981-03-12 1985-09-30 Gyogyszerkutato Intezet Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives
HU191698B (en) * 1984-07-27 1987-03-30 Gyogyszerkutato Intezet Process for producing new 1-aryl-5h-2beta-benzodiazepines
HU208429B (en) 1991-05-03 1993-10-28 Gyogyszerkutato Intezet Process for producing 1-/3-chloro-phenyl/-4-methyl-7,8-dimethoxy-5h-2,3-benzodiazepine of high purity
US5891871A (en) * 1996-03-21 1999-04-06 Cocensys, Inc. Substituted 2,3-benzodiazepin-4-ones and the use thereof

Also Published As

Publication number Publication date
DE59707062D1 (de) 2002-05-23
EP0888313A1 (de) 1999-01-07
DE19604920A1 (de) 1997-08-07
DK0888313T3 (da) 2002-07-15
PT888313E (pt) 2002-09-30
EP0888313B1 (de) 2002-04-17
JP2000505793A (ja) 2000-05-16
HUP9901473A2 (hu) 1999-09-28
CA2244777C (en) 2006-11-07
CA2244777A1 (en) 1997-08-07
ZA97850B (en) 1997-08-04
ATE216373T1 (de) 2002-05-15
AU2285997A (en) 1997-08-22
WO1997028135A1 (de) 1997-08-07
US6200970B1 (en) 2001-03-13
HUP9901473A3 (en) 2001-07-30
ES2175386T3 (es) 2002-11-16

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Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees