AR015044A1 - Proceso para la fabricacion de ureas 1,3-disustituidas-4-oxociclicas - Google Patents
Proceso para la fabricacion de ureas 1,3-disustituidas-4-oxociclicasInfo
- Publication number
- AR015044A1 AR015044A1 ARP990101996A ARP990101996A AR015044A1 AR 015044 A1 AR015044 A1 AR 015044A1 AR P990101996 A ARP990101996 A AR P990101996A AR P990101996 A ARP990101996 A AR P990101996A AR 015044 A1 AR015044 A1 AR 015044A1
- Authority
- AR
- Argentina
- Prior art keywords
- oxocyclic
- disubstituted
- substituted
- group
- urea
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 150000003672 ureas Chemical class 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 235000013877 carbamide Nutrition 0.000 abstract 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 4
- 239000004202 carbamide Substances 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 239000003416 antiarrhythmic agent Substances 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 229910006069 SO3H Inorganic materials 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000003440 anti-fibrillation Effects 0.000 abstract 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004404 heteroalkyl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Furan Compounds (AREA)
- Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Un proceso para la realizacion de ureas 1,3-disustituidas-4-oxocíclicas de la formula general (I) donde: R1, R2 y R3 se seleccionan independientemente delgrupo que consiste de H, Cl, F, Br, NH2, NO2, COOH, CH3SO2NH, SO3H, OH, alcoxi, alquilo, alcoxicarbonilo, hidroxialquilo, carboxialquilo, y aciloxi. R4 seselecciona del grupo que consiste de un alquilo sustituido o no sustituido, alquenilo, alquinilo, alquilacilo, y heteroalquilo; y A es un grupo alquilo oalquenilo sustituido o no sustituido, saturado o insaturado, de cadena recta o ramificada que comprende C1-7; o A es un heterociclo sustituido o no sustituido,saturado o insaturado que tiene 5, 6 o 7 miembrosque contienen al mnos un nitrogeno, y R4 se une a dicho nitrogeno; donde dicha urea 1,3-disustituida-4-oxocíclica se realiza sin aislacion de intermedio y comprende los pasos de: (Ia) reaccionar una urea 1-sustituida-4-oxocíclica con una cadena de carbono quecontiene al menos dos grupos leaving en presencia de una base suave y unsolvente para formar un aducto que contiene al menos un grupo leaving, y (Ib)condensar el aducto con una amina para formar una urea 1,3-disustituida-4-oxocíclica, y (II) recuperar dicha urea 1,3-disustituida-4-oxocíclica, se revelan.Este método es particularmente preferido para la realizacion de 1[[[5-(4-clorofenil)-2-furanil]metileno]amino]-3-[4-(4-metil-1-piperazanil)butil]-2,4-imidazolidinediona. Dichos compuestos tienen propiedades como agentes antifibrilatorios y antiarrítmicos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8349398P | 1998-04-29 | 1998-04-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR015044A1 true AR015044A1 (es) | 2001-04-11 |
Family
ID=22178700
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990101996A AR015044A1 (es) | 1998-04-29 | 1999-04-29 | Proceso para la fabricacion de ureas 1,3-disustituidas-4-oxociclicas |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6414151B1 (es) |
| EP (1) | EP1075473B1 (es) |
| JP (1) | JP4549531B2 (es) |
| KR (1) | KR100400050B1 (es) |
| CN (1) | CN1298403A (es) |
| AR (1) | AR015044A1 (es) |
| AT (1) | ATE366251T1 (es) |
| AU (1) | AU751681B2 (es) |
| BR (1) | BR9910074A (es) |
| CA (1) | CA2330686C (es) |
| CO (1) | CO5070625A1 (es) |
| CZ (1) | CZ299163B6 (es) |
| DE (1) | DE69936449T2 (es) |
| DK (1) | DK1075473T3 (es) |
| ES (1) | ES2288020T3 (es) |
| HU (1) | HUP0102666A3 (es) |
| ID (1) | ID27452A (es) |
| IL (1) | IL138404A (es) |
| MY (1) | MY133753A (es) |
| NO (1) | NO20005424L (es) |
| PE (1) | PE20000925A1 (es) |
| PL (1) | PL197776B1 (es) |
| RU (1) | RU2194706C2 (es) |
| SG (1) | SG120901A1 (es) |
| SK (1) | SK15842000A3 (es) |
| TR (1) | TR200003137T2 (es) |
| WO (1) | WO1999055700A1 (es) |
| ZA (1) | ZA200004712B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL198951B1 (pl) * | 1998-04-29 | 2008-08-29 | Procter & Gamble | Sposób wytwarzania 1,3-dipodstawionych-4-oksocyklicznych moczników |
| CN100443473C (zh) * | 2005-04-30 | 2008-12-17 | 中国药科大学 | 1-氨基-3-(氮杂环基烷基)-2,4-咪唑二酮的合成方法 |
| TW200840578A (en) * | 2006-12-15 | 2008-10-16 | Procter & Gamble | Compositions of azimilide dihydrochloride |
| US20120178762A1 (en) | 2006-12-15 | 2012-07-12 | Warner Chilcott Company, Llc | Compositions of azimilide dihydrochloride |
| CN101735203B (zh) * | 2009-12-17 | 2012-05-23 | 天津药物研究院 | 盐酸阿齐利特的晶型ⅱ及其制备方法和用途 |
| CN101735205B (zh) * | 2009-12-17 | 2013-05-15 | 天津药物研究院 | 盐酸阿齐利特的晶型ⅴ及其制备方法和用途 |
| CN101735202B (zh) * | 2009-12-17 | 2012-05-30 | 天津药物研究院 | 盐酸阿齐利特的晶型ⅰ及其制备方法和用途 |
| US10028858B2 (en) | 2011-07-11 | 2018-07-24 | Medicines360 | Intrauterine systems, IUD insertion devices, and related methods and kits therefor |
| USD718435S1 (en) | 2012-05-30 | 2014-11-25 | Medicines360 | Intrauterine insertion device |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3919231A (en) | 1974-06-17 | 1975-11-11 | Morton Norwich Products Inc | Series of 5-aryl-2-furamidines |
| US3906010A (en) | 1974-06-17 | 1975-09-16 | Morton Norwich Products Inc | Series of 5-aryl-2-furamidines |
| US3946049A (en) | 1975-04-03 | 1976-03-23 | Morton-Norwich Products, Inc. | 5-phenyl-2-furamidoximes |
| US4001222A (en) * | 1975-10-14 | 1977-01-04 | Morton-Norwich Products, Inc. | 3-(Aminoacyl)-1-{[5-(substituted phenyl)furfurylidene]amino}hydantoins and process for their preparation thereof |
| JPS5726653A (en) | 1980-05-09 | 1982-02-12 | Ciba Geigy Ag | Substituted phenyl ether |
| US4720580A (en) * | 1984-09-21 | 1988-01-19 | American Home Products Corporation | N-(aminoalkylene)benzenesulfonamides |
| IL82856A0 (en) | 1986-06-26 | 1987-12-20 | Norwich Eaton Pharma | Pharmaceutical compositions containing 2-(5-phenyl-2-furanyl)imidazoles and certain such novel compounds |
| US4882354A (en) * | 1987-12-16 | 1989-11-21 | Norwich Eaton Pharmaceuticals, Inc. | N-hydroxy-5-phenyl-2-furancarboximidamides useful as cardiotonic agents |
| US5019651A (en) | 1990-06-20 | 1991-05-28 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof |
| JP3031973B2 (ja) * | 1990-08-16 | 2000-04-10 | 富士レビオ株式会社 | フェニトイン誘導体 |
| EP0598061B1 (en) | 1991-08-14 | 2002-07-17 | Procter & Gamble Pharmaceuticals | Novel 4-oxocyclic ureas useful as antiarrhythmic and antifibrillatory agents |
| DK0599968T3 (da) | 1991-08-14 | 2000-04-17 | Procter & Gamble Pharma | Oxazolidinonderivater, der er egnede som antiarytmi- og antifibrilleringsmidler |
| CA2163667C (en) * | 1993-06-14 | 1998-12-15 | Rodney W. Stevens | Imidazole lipoxygenase inhibitors |
| PL198951B1 (pl) * | 1998-04-29 | 2008-08-29 | Procter & Gamble | Sposób wytwarzania 1,3-dipodstawionych-4-oksocyklicznych moczników |
-
1999
- 1999-04-27 RU RU2000129803/04A patent/RU2194706C2/ru not_active IP Right Cessation
- 1999-04-27 DE DE69936449T patent/DE69936449T2/de not_active Expired - Lifetime
- 1999-04-27 SK SK1584-2000A patent/SK15842000A3/sk unknown
- 1999-04-27 AU AU35735/99A patent/AU751681B2/en not_active Ceased
- 1999-04-27 JP JP2000545860A patent/JP4549531B2/ja not_active Expired - Fee Related
- 1999-04-27 ES ES99917668T patent/ES2288020T3/es not_active Expired - Lifetime
- 1999-04-27 SG SG200207219A patent/SG120901A1/en unknown
- 1999-04-27 WO PCT/US1999/009092 patent/WO1999055700A1/en not_active Ceased
- 1999-04-27 US US09/674,231 patent/US6414151B1/en not_active Expired - Lifetime
- 1999-04-27 EP EP99917668A patent/EP1075473B1/en not_active Expired - Lifetime
- 1999-04-27 TR TR2000/03137T patent/TR200003137T2/xx unknown
- 1999-04-27 PL PL343734A patent/PL197776B1/pl not_active IP Right Cessation
- 1999-04-27 AT AT99917668T patent/ATE366251T1/de active
- 1999-04-27 KR KR10-2000-7011921A patent/KR100400050B1/ko not_active Expired - Fee Related
- 1999-04-27 HU HU0102666A patent/HUP0102666A3/hu unknown
- 1999-04-27 CA CA002330686A patent/CA2330686C/en not_active Expired - Fee Related
- 1999-04-27 CN CN99805366A patent/CN1298403A/zh active Pending
- 1999-04-27 DK DK99917668T patent/DK1075473T3/da active
- 1999-04-27 IL IL13840499A patent/IL138404A/en not_active IP Right Cessation
- 1999-04-27 ID IDW20002481A patent/ID27452A/id unknown
- 1999-04-27 CZ CZ20003951A patent/CZ299163B6/cs not_active IP Right Cessation
- 1999-04-27 BR BR9910074-6A patent/BR9910074A/pt not_active IP Right Cessation
- 1999-04-29 AR ARP990101996A patent/AR015044A1/es not_active Application Discontinuation
- 1999-04-29 CO CO99025954A patent/CO5070625A1/es unknown
- 1999-04-29 PE PE1999000353A patent/PE20000925A1/es not_active Application Discontinuation
- 1999-04-29 MY MYPI99001687A patent/MY133753A/en unknown
-
2000
- 2000-09-07 ZA ZA200004712A patent/ZA200004712B/en unknown
- 2000-10-27 NO NO20005424A patent/NO20005424L/no not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |