AR015037A1 - Derivados de indolilo, composicion farmaceutica que los contiene y su uso para la manufactura de un medicamento - Google Patents
Derivados de indolilo, composicion farmaceutica que los contiene y su uso para la manufactura de un medicamentoInfo
- Publication number
- AR015037A1 AR015037A1 ARP990101976A ARP990101976A AR015037A1 AR 015037 A1 AR015037 A1 AR 015037A1 AR P990101976 A ARP990101976 A AR P990101976A AR P990101976 A ARP990101976 A AR P990101976A AR 015037 A1 AR015037 A1 AR 015037A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkoxy
- manufacture
- derivatives
- indolilo
- pharmaceutical composition
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 229940126601 medicinal product Drugs 0.000 title 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 abstract 1
- 101100097467 Arabidopsis thaliana SYD gene Proteins 0.000 abstract 1
- 101150065749 Churc1 gene Proteins 0.000 abstract 1
- 208000030814 Eating disease Diseases 0.000 abstract 1
- 208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
- 102100038239 Protein Churchill Human genes 0.000 abstract 1
- 101100495925 Schizosaccharomyces pombe (strain 972 / ATCC 24843) chr3 gene Proteins 0.000 abstract 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000001041 indolyl group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- -1 phenyloxy Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000003772 serotonin uptake inhibitor Substances 0.000 abstract 1
- 208000012201 sexual and gender identity disease Diseases 0.000 abstract 1
- 208000015891 sexual disease Diseases 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Derivados de indolilo de la formula (I) en donde: R1 y R2 cada uno independientemente representa hidrogeno, hidroxi, F, Cl, Br, I, CN, alquilo C1-6, alcoxiC1-6, nitro, CF3, y feniloxi o benciloxi, en donde el anillo aromático puede estar optativamente sustituido por entre 1 a 3 grupos seleccionados entre alcoxiC1-6, F, Cl, Br, I, y CF3; R3 y R4 cada uno independientemente representa un hidrogeno, un alquilo C1-6 o un CH2Ph en donde el anillo fenilo puede estaroptativamente sustituido por entre 1a 3 grupos seleccionados entre alcoxi C1-6 (preferentemente OMe), F, Cl, Br, I, y CF3; Y se selecciona entre CH2 o CH y, Xse selecciona entre un grupo representado por N, CR3, CHR3 y CHCH; o su sal farmacéuticamente aceptable, como así también su uso para la manufactura de unmedicamento y composiciones farmacéuticas que utilizan los compuestos para el tratamiento de trastornos en el sistema nervioso central, como ser la depresion,ensiedad, retiro de la droga, trastornos alimenticios y sexualesy otras condiciones para las cuales se utilizan inhibidores de la reabsorcion de serotonina.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6904598A | 1998-04-29 | 1998-04-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR015037A1 true AR015037A1 (es) | 2001-04-11 |
Family
ID=22086373
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990101976A AR015037A1 (es) | 1998-04-29 | 1999-04-28 | Derivados de indolilo, composicion farmaceutica que los contiene y su uso para la manufactura de un medicamento |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1075471B1 (es) |
| JP (1) | JP2002513015A (es) |
| CN (1) | CN1144800C (es) |
| AR (1) | AR015037A1 (es) |
| AT (1) | ATE282606T1 (es) |
| AU (1) | AU3667699A (es) |
| CA (1) | CA2330436A1 (es) |
| DE (1) | DE69921983T2 (es) |
| DK (1) | DK1075471T3 (es) |
| ES (1) | ES2232132T3 (es) |
| PT (1) | PT1075471E (es) |
| TW (1) | TW528754B (es) |
| WO (1) | WO1999055694A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7291646B2 (en) | 1999-11-24 | 2007-11-06 | Wyeth | Ethers of O-desmethyl venlafaxine |
| EP1409476B1 (en) * | 2001-07-11 | 2004-12-15 | Eli Lilly And Company | Pharmaceutical compounds with serotonin receptor activity |
| US7517899B2 (en) | 2004-03-30 | 2009-04-14 | Wyeth | Phenylaminopropanol derivatives and methods of their use |
| US7414052B2 (en) | 2004-03-30 | 2008-08-19 | Wyeth | Phenylaminopropanol derivatives and methods of their use |
| CN101309904A (zh) * | 2005-09-29 | 2008-11-19 | 惠氏公司 | 作为单胺再摄取调节剂用于治疗血管舒缩症状(vasomotorsymptoms，vms)的1－(1h－吲哚－1－基)－3－(甲基氨基)－1－苯基丙－2－醇衍生物和相关化合物 |
| US9232959B2 (en) | 2007-01-02 | 2016-01-12 | Aquabeam, Llc | Multi fluid tissue resection methods and devices |
| US12290277B2 (en) | 2007-01-02 | 2025-05-06 | Aquabeam, Llc | Tissue resection with pressure sensing |
| EP2259742B1 (en) | 2008-03-06 | 2020-01-01 | AquaBeam LLC | Tissue ablation and cautery with optical energy carried in fluid stream |
| US9848904B2 (en) | 2009-03-06 | 2017-12-26 | Procept Biorobotics Corporation | Tissue resection and treatment with shedding pulses |
| WO2014127242A2 (en) | 2013-02-14 | 2014-08-21 | Procept Biorobotics Corporation | Aquablation aquabeam eye surgery methods and apparatus |
| BR112014021482B1 (pt) | 2012-02-29 | 2021-12-21 | Procept Biorobotics Corporation | Aparelho de ressecção de próstata |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA954689B (en) * | 1994-06-08 | 1996-01-29 | Lundbeck & Co As H | 4-Aryl-1-(indanmethyl dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl) piperidines tetrahydropyridines or piperazines |
| TW421649B (en) * | 1995-01-31 | 2001-02-11 | Janssen Pharmaceutica Nv | 4-(1H-indol-1yl)-1-piperidinyl derivatives |
| ZA9711376B (en) * | 1996-12-20 | 1998-07-21 | Lundbeck & Co As H | Indole or dihydroindole derivatives |
-
1999
- 1999-04-27 TW TW088106734A patent/TW528754B/zh active
- 1999-04-28 PT PT99918860T patent/PT1075471E/pt unknown
- 1999-04-28 DK DK99918860T patent/DK1075471T3/da active
- 1999-04-28 CN CNB998078212A patent/CN1144800C/zh not_active Expired - Fee Related
- 1999-04-28 AU AU36676/99A patent/AU3667699A/en not_active Abandoned
- 1999-04-28 DE DE69921983T patent/DE69921983T2/de not_active Expired - Fee Related
- 1999-04-28 AT AT99918860T patent/ATE282606T1/de not_active IP Right Cessation
- 1999-04-28 CA CA002330436A patent/CA2330436A1/en not_active Abandoned
- 1999-04-28 ES ES99918860T patent/ES2232132T3/es not_active Expired - Lifetime
- 1999-04-28 AR ARP990101976A patent/AR015037A1/es unknown
- 1999-04-28 JP JP2000545854A patent/JP2002513015A/ja active Pending
- 1999-04-28 EP EP99918860A patent/EP1075471B1/en not_active Expired - Lifetime
- 1999-04-28 WO PCT/US1999/009129 patent/WO1999055694A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1075471A1 (en) | 2001-02-14 |
| TW528754B (en) | 2003-04-21 |
| DE69921983T2 (de) | 2005-04-07 |
| AU3667699A (en) | 1999-11-16 |
| WO1999055694A1 (en) | 1999-11-04 |
| CN1307574A (zh) | 2001-08-08 |
| JP2002513015A (ja) | 2002-05-08 |
| DK1075471T3 (da) | 2005-01-17 |
| ATE282606T1 (de) | 2004-12-15 |
| EP1075471B1 (en) | 2004-11-17 |
| CA2330436A1 (en) | 1999-11-04 |
| CN1144800C (zh) | 2004-04-07 |
| ES2232132T3 (es) | 2005-05-16 |
| PT1075471E (pt) | 2005-02-28 |
| DE69921983D1 (de) | 2004-12-23 |
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