AR014411A1 - El uso de derivados de fenil-ciclohexano sustituidos para la manufactura de un medicamento para el tratamiento profilactico de un mamifero en situacionde riesgo de desarrollar copd. - Google Patents
El uso de derivados de fenil-ciclohexano sustituidos para la manufactura de un medicamento para el tratamiento profilactico de un mamifero en situacionde riesgo de desarrollar copd.Info
- Publication number
- AR014411A1 AR014411A1 ARP990100057A ARP990100057A AR014411A1 AR 014411 A1 AR014411 A1 AR 014411A1 AR P990100057 A ARP990100057 A AR P990100057A AR P990100057 A ARP990100057 A AR P990100057A AR 014411 A1 AR014411 A1 AR 014411A1
- Authority
- AR
- Argentina
- Prior art keywords
- cr4r5
- substituted
- hydrogen
- alkyl
- risk
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 229940126601 medicinal product Drugs 0.000 title 1
- -1 2-tetrahydrothiopyranyl Chemical group 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- YBYIRNPNPLQARY-UHFFFAOYSA-N 1H-indene Chemical group C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- IGARGHRYKHJQSM-UHFFFAOYSA-N cyclohexylbenzene Chemical class C1CCCCC1C1=CC=CC=C1 IGARGHRYKHJQSM-UHFFFAOYSA-N 0.000 abstract 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 abstract 1
- 125000003454 indenyl group Chemical group C1(C=CC2=CC=CC=C12)* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000005592 polycycloalkyl group Polymers 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 125000004309 pyranyl group Chemical group O1C(C=CC=C1)* 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 abstract 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 abstract 1
- 125000005958 tetrahydrothienyl group Chemical group 0.000 abstract 1
- 125000004632 tetrahydrothiopyranyl group Chemical group S1C(CCCC1)* 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Indole Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
El uso de derivados de fenil-ciclohexano sustituidos para la manufactura de un medicamento para el tratamiento profiláctico de un mamífero en situacion deriesgo de desarrollar COPD, que comprende un compuesto de Formula (I) en el que la Formula (I) comprende: R1 es -(CR4R5)nC(O)O(CR4R5)mR6, -(CR4R5)nC(O)NR4(CR4R5)mR6, -(CR4R5)nO(CR4R5)mR6, o -(CR4R5)rR6, en los que restos alquilo pueden estar opcionalmente sustituidos con uno o más halogenos; m es de 0 a 2; nes de 1 a 4; r es de 0 a 6; R4 y R5 se seleccionan independientemente entre hidrogeno o un alquilo C1-2; R6 es hidrogeno, metilo, hidroxilo, arilo, arilosustituido con halo, ariloxi-alquilo C1-3, ariloxi-alquilo C1-3 sustituido con halo, indanilo, indenilo, policicloalquilo C7-11, tetrahidrofuranilo,furanilo, tetrahidropiranilo, piranilo, tetrahidrotienilo, tienilo, tetrahidrotiopiranilo, tiopiranilo, cicloalquilo C3-6, o un cicloalquilo C4-6 quecontiene uno o dos enlaces insaturados, en que los restos cicloalquilo y heterociclilopueden estar opcionalmente sustituidos con OH, de 1 a 3 grupos metilo oun grupo etilo; siempre que: a) cuando R6 es hidroxilo, entonces m sea 2; o b) cuando R6 es hidroxilo, entonces r sea de 2 a 6; o c) cuando R6 es2-tetrapiranilo, 2-tetrahidrotiopiranilo, 2-tetrahidrofuranilo o 2-tetrahidrotienilo, entones m sea 1 o 2; o d) cuando R6 es 2-tetrahidrpiranilo, 2-tetrahidrotiopiranilo, 2-tetrahidrofuranilo o 2-tetrahidrotienilo, entonces r sea de 1 a 6; e) cuando n es 1 y m es 0, entonces R6 sea distinto de H en-(CR4R5)nO(CR4R5)mR6; X es YR2, halogeno, nitro, NR4R5, o formilamina; Y es O o S(O)m; m es 0, 1 o 2; X2 es O o NR8; X3 es hidrogeno o X; X4 esformula (a) o (b); X5 Es H, R9, OR8, CN, C(O)R8, C(O)OR8, C(O)NR8R8 o NR8R8; R2 se selecciona independientemente del grupo formado por -CH3 y -CH2CH3opcionalmente sustituido con 1 o más halogenos; s es 0 a 4; R3 es hidrogeno, halogeno, alquilo C1-4, CH2NHC(O)C(O)NH2, alquilo C1-4 sustituido con halo, -CH=CR8, R8, R8,ciclopropilo opcionalmente sustituido con R8, CN, OR8, CH2OR8, NR8R10, CH2NR8R10, C(Z)H, C(O)OR8, C(O)NR8R10, o C:::CR8; Z es O, NR9
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7071898P | 1998-01-07 | 1998-01-07 | |
| US10690898P | 1998-10-28 | 1998-10-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR014411A1 true AR014411A1 (es) | 2001-02-28 |
Family
ID=26751429
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990100057A AR014411A1 (es) | 1998-01-07 | 1999-01-08 | El uso de derivados de fenil-ciclohexano sustituidos para la manufactura de un medicamento para el tratamiento profilactico de un mamifero en situacionde riesgo de desarrollar copd. |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US6369108B1 (es) |
| EP (1) | EP1051172B1 (es) |
| JP (1) | JP2003522095A (es) |
| KR (1) | KR100555824B1 (es) |
| CN (1) | CN1291891A (es) |
| AP (1) | AP2000001859A0 (es) |
| AR (1) | AR014411A1 (es) |
| AT (1) | ATE285234T1 (es) |
| AU (1) | AU752497B2 (es) |
| BG (1) | BG104654A (es) |
| BR (1) | BR9906803A (es) |
| CA (1) | CA2317720A1 (es) |
| DE (1) | DE69922786T2 (es) |
| DZ (1) | DZ2703A1 (es) |
| EA (1) | EA006382B1 (es) |
| EG (1) | EG23945A (es) |
| ES (1) | ES2234234T3 (es) |
| HU (1) | HUP0100888A3 (es) |
| ID (1) | ID26164A (es) |
| IL (1) | IL137104A0 (es) |
| MA (1) | MA26592A1 (es) |
| MY (1) | MY133014A (es) |
| NO (1) | NO20003481L (es) |
| NZ (1) | NZ505521A (es) |
| OA (1) | OA11443A (es) |
| PE (1) | PE20000231A1 (es) |
| PL (1) | PL341667A1 (es) |
| PT (1) | PT1051172E (es) |
| SI (1) | SI1051172T1 (es) |
| SK (1) | SK285149B6 (es) |
| TR (1) | TR200001819T2 (es) |
| UY (1) | UY25338A1 (es) |
| WO (1) | WO1999034798A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DZ3019A1 (fr) | 1999-03-01 | 2005-05-20 | Smithkline Beecham Corp | Utilisation d'un inhibiteur de pde4 dans la préparation d'un médicament contre la copd. |
| AR024076A1 (es) * | 1999-05-25 | 2002-09-04 | Smithkline Beecham Corp | Sales de cis-[4-ciano-4-(3-ciclopentiloxi-4-metoxifenil) ciclohexan-1-carboxilato] |
| CO5190716A1 (es) * | 1999-08-10 | 2002-08-29 | Smithkline Beecham Corp | 4,4-diaril-ciclohexanos 1,4-sustituidos |
| EP1237851A4 (en) * | 1999-12-15 | 2004-06-23 | Smithkline Beecham | SALES OF I CIS / I-4-CYANO-4-3- (CYCLOPENTYLOXY) -4-METHOXYPHENYL] CYCLHEXAN-1-CARBONIC ACID |
| WO2001068600A2 (en) | 2000-03-16 | 2001-09-20 | Inflazyme Pharmaceuticals Limited | Benzylated pde4 inhibitors |
| DE10245153A1 (de) * | 2002-09-27 | 2004-04-15 | Infineon Technologies Ag | Integrierter Feldeffekttransistor mit zwei Steuerbereichen, Verwendung dieses Feldeffekttranistors und Herstellungsverfahren |
| ES2382876T3 (es) | 2005-05-31 | 2012-06-14 | Pfizer, Inc. | Compuestos de ariloxi-N-biciclometil-acetamida sustituidos como antagonistas de VR1 |
| CN101679191B (zh) | 2007-06-05 | 2014-03-12 | 塞诺菲-安万特股份有限公司 | 二杂芳基环己烷衍生物、其制备方法、用途及含有它们的药用组合物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0633776B1 (en) * | 1992-04-02 | 2001-05-09 | Smithkline Beecham Corporation | Compounds useful for treating allergic and inflammatory diseases |
| EP0633771A4 (en) * | 1992-04-02 | 1995-02-22 | Smithkline Beecham Corporation | Compounds. |
| GB9525262D0 (en) * | 1995-12-11 | 1996-02-07 | Bayer Ag | Heterocyclylcarbonyl substituted benzofuranyl-ureas |
-
1998
- 1998-12-31 UY UY25338A patent/UY25338A1/es not_active Application Discontinuation
-
1999
- 1999-01-04 MA MA25416A patent/MA26592A1/fr unknown
- 1999-01-05 MY MYPI99000027A patent/MY133014A/en unknown
- 1999-01-06 EG EG1499A patent/EG23945A/xx active
- 1999-01-06 EP EP99901337A patent/EP1051172B1/en not_active Expired - Lifetime
- 1999-01-06 CA CA002317720A patent/CA2317720A1/en not_active Abandoned
- 1999-01-06 US US09/582,739 patent/US6369108B1/en not_active Expired - Fee Related
- 1999-01-06 SK SK1023-2000A patent/SK285149B6/sk not_active IP Right Cessation
- 1999-01-06 PE PE1999000011A patent/PE20000231A1/es not_active Application Discontinuation
- 1999-01-06 AU AU21060/99A patent/AU752497B2/en not_active Ceased
- 1999-01-06 ID IDW20001314A patent/ID26164A/id unknown
- 1999-01-06 DE DE69922786T patent/DE69922786T2/de not_active Expired - Fee Related
- 1999-01-06 PL PL99341667A patent/PL341667A1/xx not_active IP Right Cessation
- 1999-01-06 BR BR9906803-6A patent/BR9906803A/pt not_active Application Discontinuation
- 1999-01-06 JP JP2000527247A patent/JP2003522095A/ja active Pending
- 1999-01-06 EA EA200000740A patent/EA006382B1/ru not_active IP Right Cessation
- 1999-01-06 SI SI9930757T patent/SI1051172T1/xx unknown
- 1999-01-06 AP APAP/P/2000/001859A patent/AP2000001859A0/en unknown
- 1999-01-06 KR KR1020007007487A patent/KR100555824B1/ko not_active Expired - Fee Related
- 1999-01-06 CN CN99803407A patent/CN1291891A/zh active Pending
- 1999-01-06 WO PCT/US1999/000214 patent/WO1999034798A1/en not_active Ceased
- 1999-01-06 PT PT99901337T patent/PT1051172E/pt unknown
- 1999-01-06 HU HU0100888A patent/HUP0100888A3/hu unknown
- 1999-01-06 IL IL13710499A patent/IL137104A0/xx not_active IP Right Cessation
- 1999-01-06 ES ES99901337T patent/ES2234234T3/es not_active Expired - Lifetime
- 1999-01-06 NZ NZ505521A patent/NZ505521A/xx unknown
- 1999-01-06 TR TR2000/01819T patent/TR200001819T2/xx unknown
- 1999-01-06 DZ DZ990004A patent/DZ2703A1/xx active
- 1999-01-06 AT AT99901337T patent/ATE285234T1/de not_active IP Right Cessation
- 1999-01-08 AR ARP990100057A patent/AR014411A1/es unknown
-
2000
- 2000-07-06 NO NO20003481A patent/NO20003481L/no not_active Application Discontinuation
- 2000-07-07 OA OA1200000199A patent/OA11443A/en unknown
- 2000-08-01 BG BG104654A patent/BG104654A/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |