AR014211A1 - Derivados de tiazol, procedimiento para su preparacion, preparaciones farmaceuticas que los contienen, compuestos intermediarios y su uso para lamanufactura de un medicamento - Google Patents
Derivados de tiazol, procedimiento para su preparacion, preparaciones farmaceuticas que los contienen, compuestos intermediarios y su uso para lamanufactura de un medicamentoInfo
- Publication number
- AR014211A1 AR014211A1 ARP980106722A ARP980106722A AR014211A1 AR 014211 A1 AR014211 A1 AR 014211A1 AR P980106722 A ARP980106722 A AR P980106722A AR P980106722 A ARP980106722 A AR P980106722A AR 014211 A1 AR014211 A1 AR 014211A1
- Authority
- AR
- Argentina
- Prior art keywords
- zero
- alkyl
- formula
- pharmaceutical preparations
- cycloalkyl
- Prior art date
Links
- 239000000825 pharmaceutical preparation Substances 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 229940126601 medicinal product Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000004429 atom Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000005330 8 membered heterocyclic group Chemical group 0.000 abstract 1
- 206010012689 Diabetic retinopathy Diseases 0.000 abstract 1
- 206010027476 Metastases Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000010191 Osteitis Deformans Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 208000027868 Paget disease Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 239000000853 adhesive Substances 0.000 abstract 1
- 230000001070 adhesive effect Effects 0.000 abstract 1
- 150000001370 alpha-amino acid derivatives Chemical group 0.000 abstract 1
- 235000008206 alpha-amino acids Nutrition 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000008619 cell matrix interaction Effects 0.000 abstract 1
- 150000002170 ethers Chemical class 0.000 abstract 1
- 230000008611 intercellular interaction Effects 0.000 abstract 1
- 208000002780 macular degeneration Diseases 0.000 abstract 1
- 208000027202 mammary Paget disease Diseases 0.000 abstract 1
- 230000009401 metastasis Effects 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 235000018102 proteins Nutrition 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 208000037803 restenosis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 150000007979 thiazole derivatives Chemical class 0.000 abstract 1
- 230000002792 vascular Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Nutrition Science (AREA)
- Ophthalmology & Optometry (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Virology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
Derivados de tiazol de formula (I), en los que R1 es formula (II); R2 es formula (III), en los que Het es un sistema de anillo heterocíclico de 5 a 8miembros, que está sustituido con R9 y en el que puede estar presente un átomo adicional deN, O o S en el anillo, además del átomo de nitrogeno; R3es hidrogeno, alquilo, cicloalquilo, arilo, aralquilo o heteroarilo; R4 es hidrogeno, alquilo, cicloalquilo, arilo o heteroarilo; R5, R6, R7 y R8 soncada uno independientemente hidrogeno,alquilo o cicloalquilo, o R7 y R8 junto con los átomos de nitrogeno a los que están unidos forman un anilloheterocíclico de 5 a 8 miembros que puede estar sustituido con alquilo; R9 es formula (IV); R10 es arilo, aralquilo, heterociclilo o un alfa-aminoácido unidoa través del grupo amino, deaa ison 0 o numeros positivos enteros,de modo que a y b son cada uno independientemente de cero a 4, d escero o 1, siendo f igual a cero cuando d es igual a cero, la suma de c, d y e es >/= 1 y </== 4, f y h son cada unoindependientemente cero o 1, siendo i diferente de cero cuando h = 1, la suma de g, h e i es >/= 2 y </=5; así como sales y éteresde los mismos farmacéuticamente utilizables, que inhiben la union de proteínas adhesivas sobre la superficie de diferentes tipos de células y deeste modo influyen en las interacciones célula-célula y célula-matriz, procedimiento para su preparacion, preparaciones farmacéuticas que loscontienen, compuestos intermediarios ysu uso en forma de preparaciones farmacéuticas para el control o prevencion de neoplasmas, metástasis detumores, osteoporosis, enfermedad de Paget, retinopatía diabética, degeneracion macular, restenosis tras la intervencion vascular, psoriasis,
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98100007 | 1998-01-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR014211A1 true AR014211A1 (es) | 2001-02-07 |
Family
ID=8231230
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980106722A AR014211A1 (es) | 1998-01-02 | 1998-12-29 | Derivados de tiazol, procedimiento para su preparacion, preparaciones farmaceuticas que los contienen, compuestos intermediarios y su uso para lamanufactura de un medicamento |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6001855A (es) |
| JP (1) | JP3154982B2 (es) |
| KR (1) | KR100312900B1 (es) |
| CN (1) | CN1098849C (es) |
| AR (1) | AR014211A1 (es) |
| AT (1) | ATE217621T1 (es) |
| AU (1) | AU718659B2 (es) |
| BR (1) | BR9805750A (es) |
| CA (1) | CA2257322C (es) |
| CO (1) | CO4990935A1 (es) |
| DE (1) | DE69805392T2 (es) |
| DK (1) | DK0928793T3 (es) |
| ES (1) | ES2176895T3 (es) |
| HR (1) | HRP980644B1 (es) |
| HU (1) | HUP9803041A3 (es) |
| ID (1) | ID21878A (es) |
| IL (1) | IL127784A (es) |
| MA (1) | MA26590A1 (es) |
| NO (1) | NO312134B1 (es) |
| PE (1) | PE20000116A1 (es) |
| PL (1) | PL330620A1 (es) |
| PT (1) | PT928793E (es) |
| RU (1) | RU2166503C2 (es) |
| SG (1) | SG72911A1 (es) |
| TR (1) | TR199802766A2 (es) |
| UY (1) | UY25335A1 (es) |
| YU (1) | YU60998A (es) |
| ZA (1) | ZA9811923B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3530137B2 (ja) | 1998-10-22 | 2004-05-24 | エフ．ホフマン−ラ ロシュ アーゲー | チアゾール誘導体 |
| JP4517454B2 (ja) * | 2000-06-01 | 2010-08-04 | 宇部興産株式会社 | ４−（１−フルオロエチル）チアゾール−５−カルボン酸アミド誘導体及び農園芸用の有害生物防除剤 |
| US6451821B1 (en) * | 2000-06-09 | 2002-09-17 | Aventis Pharma S.A. | Use of 2-aminothiazoline derivatives as inhibitors of inducible no-synthase |
| US6420566B2 (en) * | 2000-06-09 | 2002-07-16 | Aventis Pharma S.A. | Pharmaceutical compositions containing a 4, 5-dihydro-1, 3-thiazol-2-ylamine derivative, novel derivatives and preparation thereof |
| SG11201803781XA (en) * | 2015-12-04 | 2018-06-28 | Janssen Biotech Inc | Treatment of retinal degeneration using progenitor cells |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2138803B (en) * | 1983-04-26 | 1986-06-18 | Shionogi & Co | 2-guanidino-4-hydroxymethylthiazole and derivatives thereof |
| GB8714920D0 (en) * | 1987-06-25 | 1987-07-29 | Shell Int Research | Thiazole derivatives |
| IL95548A0 (en) * | 1989-09-15 | 1991-06-30 | Fujisawa Pharmaceutical Co | Thiazole derivatives,processes for the preparation thereof and pharmaceutical composition containing the same |
| TW201303B (es) * | 1990-07-05 | 1993-03-01 | Hoffmann La Roche | |
| JPH0867676A (ja) * | 1994-03-30 | 1996-03-12 | Eisai Kagaku Kk | 保護アミノチアゾリル酢酸誘導体 |
| CZ293323B6 (cs) * | 1995-08-30 | 2004-04-14 | G. D. Searle & Co. | Meta-guanidinové, močovinové, thiomočovinové nebo azacyklické deriváty aminobenzoové kyseliny jako antagonisty integrinů |
| WO1997026250A1 (en) * | 1996-01-16 | 1997-07-24 | Merck & Co., Inc. | Integrin receptor antagonists |
| EP0859002B1 (en) * | 1997-02-13 | 2003-07-02 | Tokuyama Corporation | Process for producing chloroacetylaminothiazoleacetic acid derivatives |
| ATE334975T1 (de) * | 1997-05-30 | 2006-08-15 | Takeda Pharmaceutical | Sulfonamidderivate, ihre herstellung und verwendung |
-
1998
- 1998-12-22 US US09/218,200 patent/US6001855A/en not_active Expired - Fee Related
- 1998-12-28 NO NO19986160A patent/NO312134B1/no unknown
- 1998-12-29 YU YU60998A patent/YU60998A/sh unknown
- 1998-12-29 IL IL12778498A patent/IL127784A/en not_active IP Right Cessation
- 1998-12-29 PE PE1998001292A patent/PE20000116A1/es not_active Application Discontinuation
- 1998-12-29 ZA ZA9811923A patent/ZA9811923B/xx unknown
- 1998-12-29 AR ARP980106722A patent/AR014211A1/es not_active Application Discontinuation
- 1998-12-29 HR HR980644A patent/HRP980644B1/xx not_active IP Right Cessation
- 1998-12-30 ES ES98124819T patent/ES2176895T3/es not_active Expired - Lifetime
- 1998-12-30 KR KR1019980061644A patent/KR100312900B1/ko not_active Expired - Fee Related
- 1998-12-30 MA MA25410A patent/MA26590A1/fr unknown
- 1998-12-30 PT PT98124819T patent/PT928793E/pt unknown
- 1998-12-30 DK DK98124819T patent/DK0928793T3/da active
- 1998-12-30 TR TR1998/02766A patent/TR199802766A2/xx unknown
- 1998-12-30 DE DE69805392T patent/DE69805392T2/de not_active Expired - Fee Related
- 1998-12-30 AU AU96145/98A patent/AU718659B2/en not_active Ceased
- 1998-12-30 HU HU9803041A patent/HUP9803041A3/hu unknown
- 1998-12-30 AT AT98124819T patent/ATE217621T1/de not_active IP Right Cessation
- 1998-12-30 PL PL98330620A patent/PL330620A1/xx not_active Application Discontinuation
- 1998-12-30 CA CA002257322A patent/CA2257322C/en not_active Expired - Fee Related
- 1998-12-30 CO CO98077474A patent/CO4990935A1/es unknown
- 1998-12-30 SG SG1998005979A patent/SG72911A1/en unknown
- 1998-12-31 BR BR9805750-2A patent/BR9805750A/pt not_active Application Discontinuation
- 1998-12-31 UY UY25335A patent/UY25335A1/es not_active IP Right Cessation
- 1998-12-31 CN CN98125981A patent/CN1098849C/zh not_active Expired - Fee Related
-
1999
- 1999-01-04 JP JP00020699A patent/JP3154982B2/ja not_active Expired - Fee Related
- 1999-01-04 ID IDP990002A patent/ID21878A/id unknown
- 1999-01-05 RU RU99100205/04A patent/RU2166503C2/ru not_active IP Right Cessation
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