AR003974A1 - Una nueva proteina mp52 arg humana, un proceso para la produccion y aislacion de la misma y composiciones farmaceuticas que la contienen - Google Patents
Una nueva proteina mp52 arg humana, un proceso para la produccion y aislacion de la misma y composiciones farmaceuticas que la contienenInfo
- Publication number
- AR003974A1 AR003974A1 ARP960103838A AR10383896A AR003974A1 AR 003974 A1 AR003974 A1 AR 003974A1 AR P960103838 A ARP960103838 A AR P960103838A AR 10383896 A AR10383896 A AR 10383896A AR 003974 A1 AR003974 A1 AR 003974A1
- Authority
- AR
- Argentina
- Prior art keywords
- bone
- isolation
- production
- arg
- contain
- Prior art date
Links
- 101100472152 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) REL1 gene Proteins 0.000 title abstract 3
- 238000002955 isolation Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 208000010392 Bone Fractures Diseases 0.000 abstract 1
- 208000020084 Bone disease Diseases 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 230000004097 bone metabolism Effects 0.000 abstract 1
- 230000034127 bone morphogenesis Effects 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000000399 orthopedic effect Effects 0.000 abstract 1
- 238000001356 surgical procedure Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000002054 transplantation Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Compuesto de MP52 Arg humana y composición medicinal farmacéutica que lo comprende para promover entre otros la morfogenésis cartilaginosa y ósea,composición farmacéutica que comprende MP52 Arg humano. En particular, la composiciónmedicinal es útil para tratar enfermedades óseas causadas pormetabolismo óseo anormal, tales como osteoporosis, para tratar fracturas óseas y para el propósito de reconstrucción ortopédica, transplante óseo,cirugía cosmética y terapéuticadental. Asimi smo, es útil para tratar desórdenes cartilaginosos. La invención también se refiere a un proceso parala producción y aislación de una proteína biológicamente activa, en el cual al menos una parte de la secuencia de DNA de lainvención es i ntroducida dentro deuna célula huesped adecuada bajo condiciones adecuadas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP95112241 | 1995-08-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR003974A1 true AR003974A1 (es) | 1998-09-30 |
Family
ID=8219499
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960103838A AR003974A1 (es) | 1995-08-03 | 1996-08-01 | Una nueva proteina mp52 arg humana, un proceso para la produccion y aislacion de la misma y composiciones farmaceuticas que la contienen |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0842274A1 (es) |
| JP (1) | JP2000511155A (es) |
| KR (1) | KR19990036081A (es) |
| CN (1) | CN1192237A (es) |
| AR (1) | AR003974A1 (es) |
| AU (1) | AU699708B2 (es) |
| BR (1) | BR9609983A (es) |
| CA (1) | CA2227204A1 (es) |
| HU (1) | HUP9900362A2 (es) |
| IL (1) | IL122817A0 (es) |
| MX (1) | MX9800801A (es) |
| NO (1) | NO980375D0 (es) |
| PL (1) | PL324822A1 (es) |
| WO (1) | WO1997006254A1 (es) |
| ZA (1) | ZA966489B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6586388B2 (en) | 1988-04-08 | 2003-07-01 | Stryker Corporation | Method of using recombinant osteogenic protein to repair bone or cartilage defects |
| GB9610281D0 (en) * | 1996-05-16 | 1996-07-24 | Ralston Stuart H | Diagnostic method and apparatus |
| DE19906096A1 (de) | 1999-02-13 | 2000-08-17 | Walter Sebald | Protein mit einem Heparin-bindenden Epitop |
| US20130122066A1 (en) | 2010-07-30 | 2013-05-16 | Biopham Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Drug delivery devices and growth factor formulations for accelerated wound healing |
| EP2537538A1 (en) | 2011-06-22 | 2012-12-26 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH | Bioresorbable Wound Dressing |
| EP2602264A1 (en) | 2011-12-05 | 2013-06-12 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH | GDF-5 mutant for inducing cartilage formation |
| KR101213355B1 (ko) * | 2011-12-27 | 2012-12-18 | 오스템임플란트 주식회사 | 초기 안정성이 증진된 치과용 임플란트 및 그 제조 방법 |
| WO2021122545A1 (en) | 2019-12-18 | 2021-06-24 | Merck Patent Gmbh | Use of the gdf-5 mutant for the treatment of pain and cartilage destruction |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE188996T1 (de) * | 1992-02-12 | 2000-02-15 | Bioph Biotech Entw Pharm Gmbh | Dna-sequenzen kodierend für neuartige wachstums- /differentierungsfaktoren |
| DE4420157B4 (de) * | 1993-08-10 | 2013-04-25 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Neuer Wachstums/Differenzierungsfaktor der TGF-β-Familie |
| IL110589A0 (en) * | 1993-08-10 | 1994-11-11 | Bioph Biotech Entw Pharm Gmbh | Growth/differentiation factor of the TGF- beta family |
| DE69434651T2 (de) * | 1993-12-07 | 2007-03-08 | Genetics Institute, Inc., Cambridge | Bmp-12, bmp-13 und diese enthaltende sehne-induzierende zusammensetzungen |
-
1996
- 1996-07-31 ZA ZA9606489A patent/ZA966489B/xx unknown
- 1996-08-01 AR ARP960103838A patent/AR003974A1/es not_active Application Discontinuation
- 1996-08-02 PL PL96324822A patent/PL324822A1/xx unknown
- 1996-08-02 AU AU67891/96A patent/AU699708B2/en not_active Ceased
- 1996-08-02 KR KR1019980700747A patent/KR19990036081A/ko not_active Withdrawn
- 1996-08-02 CN CN96195841A patent/CN1192237A/zh active Pending
- 1996-08-02 JP JP09508115A patent/JP2000511155A/ja active Pending
- 1996-08-02 EP EP96928406A patent/EP0842274A1/en not_active Withdrawn
- 1996-08-02 HU HU9900362A patent/HUP9900362A2/hu unknown
- 1996-08-02 BR BR9609983A patent/BR9609983A/pt not_active Application Discontinuation
- 1996-08-02 CA CA002227204A patent/CA2227204A1/en not_active Abandoned
- 1996-08-02 IL IL12281796A patent/IL122817A0/xx unknown
- 1996-08-02 WO PCT/EP1996/003427 patent/WO1997006254A1/en not_active Ceased
-
1998
- 1998-01-28 MX MX9800801A patent/MX9800801A/es unknown
- 1998-01-28 NO NO980375A patent/NO980375D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2000511155A (ja) | 2000-08-29 |
| ZA966489B (en) | 1997-02-26 |
| NO980375L (no) | 1998-01-28 |
| CA2227204A1 (en) | 1997-02-20 |
| AU6789196A (en) | 1997-03-05 |
| MX9800801A (es) | 1998-11-29 |
| NO980375D0 (no) | 1998-01-28 |
| AU699708B2 (en) | 1998-12-10 |
| IL122817A0 (en) | 1998-08-16 |
| WO1997006254A1 (en) | 1997-02-20 |
| BR9609983A (pt) | 1999-01-12 |
| KR19990036081A (ko) | 1999-05-25 |
| EP0842274A1 (en) | 1998-05-20 |
| CN1192237A (zh) | 1998-09-02 |
| PL324822A1 (en) | 1998-06-22 |
| HUP9900362A2 (hu) | 1999-05-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |