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AR003451A1 - Derivados de piperazina, una composicion farmaceutica que los comprende, el uso de los mismos y un metodo para su preparacion. - Google Patents

Derivados de piperazina, una composicion farmaceutica que los comprende, el uso de los mismos y un metodo para su preparacion.

Info

Publication number
AR003451A1
AR003451A1 ARP960103516A AR10351696A AR003451A1 AR 003451 A1 AR003451 A1 AR 003451A1 AR P960103516 A ARP960103516 A AR P960103516A AR 10351696 A AR10351696 A AR 10351696A AR 003451 A1 AR003451 A1 AR 003451A1
Authority
AR
Argentina
Prior art keywords
preparation
pharmaceutical composition
piperazine
derivatives
understands
Prior art date
Application number
ARP960103516A
Other languages
English (en)
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of AR003451A1 publication Critical patent/AR003451A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se describen derivados de piperazina de la fórmula general (A), junto con sus sales de adición ácida farmacéuticamente aceptables. El compuesto es unantagonista 5-HT(1A) que es útil en el tratamiento de los desórdenes CNS en los mamíferos. Sed escribe además una composición farmacéutica que loscomprende, el uso de los mismos y un método para su preparación.
ARP960103516A 1995-07-20 1996-07-10 Derivados de piperazina, una composicion farmaceutica que los comprende, el uso de los mismos y un metodo para su preparacion. AR003451A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9514901.9A GB9514901D0 (en) 1995-07-20 1995-07-20 Piperazine derivatives

Publications (1)

Publication Number Publication Date
AR003451A1 true AR003451A1 (es) 1998-08-05

Family

ID=10778004

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960103516A AR003451A1 (es) 1995-07-20 1996-07-10 Derivados de piperazina, una composicion farmaceutica que los comprende, el uso de los mismos y un metodo para su preparacion.

Country Status (21)

Country Link
EP (1) EP0839146B1 (es)
JP (1) JP4166824B2 (es)
KR (1) KR100447002B1 (es)
CN (2) CN1077889C (es)
AR (1) AR003451A1 (es)
AT (1) ATE196294T1 (es)
AU (1) AU700546B2 (es)
BR (1) BR9609694A (es)
CA (1) CA2227386C (es)
DE (1) DE69610316T2 (es)
DK (1) DK0839146T3 (es)
ES (1) ES2150684T3 (es)
GB (1) GB9514901D0 (es)
GR (1) GR3034408T3 (es)
HU (1) HUP9802447A3 (es)
IL (1) IL122981A (es)
MX (1) MX9800483A (es)
NZ (1) NZ313231A (es)
PT (1) PT839146E (es)
WO (1) WO1997003982A1 (es)
ZA (1) ZA966048B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19730989A1 (de) * 1997-07-18 1999-01-21 Merck Patent Gmbh Piperazin-Derivate
US6271234B1 (en) * 1997-08-01 2001-08-07 Recordati S.A., Chemical And Pharmaceutical Company 1,4-disubstituted piperazines
IT1293804B1 (it) 1997-08-01 1999-03-10 Recordati Chem Pharm Diarilalchilpiperazine attive sulle basse vie urinarie
US6399614B1 (en) 1997-08-01 2002-06-04 Recordati S.A. Chemical And Pharmaceutical Company 1-(N-phenylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring
US6469007B2 (en) * 2000-11-28 2002-10-22 Wyeth Serotonergic agents
US20060287335A1 (en) 2000-11-28 2006-12-21 Wyeth Serotonergic agents for treating sexual dysfunction
US20060223824A1 (en) 2000-11-28 2006-10-05 Wyeth Serotonergic agents
JP5080716B2 (ja) 2001-07-20 2012-11-21 サイコジェニックス・インコーポレーテッド 注意欠陥・多動性障害の治療
JP4391241B2 (ja) * 2002-03-12 2009-12-24 ワイス キラルｎ−アリールピペラジンの合成方法
US7361773B2 (en) 2002-03-12 2008-04-22 Wyeth Preparation of N1-(2'-pyridyl)-1,2-propanediamine sulfamic acid and its use in the synthesis of biologically active piperazines
CN100451014C (zh) 2002-03-12 2009-01-14 惠氏公司 制备手性1,4-二取代哌嗪的方法
US7091349B2 (en) 2002-03-12 2006-08-15 Wyeth Process for synthesizing N-aryl piperazines with chiral N′-1-[benzoyl(2-pyridyl)amino]-2-propane substitution
ES2334836T3 (es) * 2002-03-12 2010-03-16 Wyeth Preparacion de 2-((2,3-dihidro-benzo(1,4)dioxin-5-il)-(2-hidroxietil)-amino)-etanol y productos intermedios correspondientes.
PA8626301A1 (es) * 2004-03-19 2006-12-07 Wyeth Wyeth Proceso para preparar derivados de n-aril-piperazina
TW200800959A (en) 2005-06-10 2008-01-01 Wyeth Corp Piperazine-piperidine antagonists and agonists of the 5-HT1a receptor
EP1893617A1 (en) 2005-06-17 2008-03-05 Wyeth a Corporation of the State of Delaware Tricyclic compounds useful as serotonin inhibitors and 5-ht1a agonists and antagonists
TW200808741A (en) * 2006-06-09 2008-02-16 Wyeth Corp 6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline hydrochloric acid salts
CL2008000119A1 (es) 2007-01-16 2008-05-16 Wyeth Corp Compuestos derivados de pirazol, antagonistas del receptor nicotinico de acetilcolina; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como demencia senil, alzheimer y esquizofrenia.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9201991A (es) * 1991-05-02 1992-11-01 Jonh Wyeth & Brother Limited Derivados de piperazina y procedimiento para su preparacion.
ATE222238T1 (de) * 1994-06-03 2002-08-15 Wyeth John & Brother Ltd Verfahren und zwischenprodukte zur herstellung von piperazinderivaten

Also Published As

Publication number Publication date
DE69610316D1 (de) 2000-10-19
CN1131861C (zh) 2003-12-24
IL122981A (en) 2001-01-28
KR100447002B1 (ko) 2004-12-04
GB9514901D0 (en) 1995-09-20
JP4166824B2 (ja) 2008-10-15
NZ313231A (en) 2001-03-30
ZA966048B (en) 1998-01-16
EP0839146A1 (en) 1998-05-06
CA2227386C (en) 2006-05-16
EP0839146B1 (en) 2000-09-13
ES2150684T3 (es) 2000-12-01
ATE196294T1 (de) 2000-09-15
AU700546B2 (en) 1999-01-07
BR9609694A (pt) 1999-03-23
MX9800483A (es) 1998-04-30
CN1190968A (zh) 1998-08-19
PT839146E (pt) 2000-12-29
AU6524996A (en) 1997-02-18
IL122981A0 (en) 1998-08-16
HUP9802447A3 (en) 1999-11-29
GR3034408T3 (en) 2000-12-29
HUP9802447A2 (hu) 1999-08-30
DK0839146T3 (da) 2000-11-20
DE69610316T2 (de) 2001-03-29
CN1309127A (zh) 2001-08-22
KR19990029067A (ko) 1999-04-15
JPH11509544A (ja) 1999-08-24
WO1997003982A1 (en) 1997-02-06
CN1077889C (zh) 2002-01-16
CA2227386A1 (en) 1997-02-06

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