AR003132A1 - Derivados de n-hetero aril piridinsulfonamidas; composiciones farmaceuticas que los contienen; proceso para su preparacion y el uso de los mismos en la produccion de un medicamento - Google Patents
Derivados de n-hetero aril piridinsulfonamidas; composiciones farmaceuticas que los contienen; proceso para su preparacion y el uso de los mismos en la produccion de un medicamentoInfo
- Publication number
- AR003132A1 AR003132A1 ARP960102899A AR10289996A AR003132A1 AR 003132 A1 AR003132 A1 AR 003132A1 AR P960102899 A ARP960102899 A AR P960102899A AR 10289996 A AR10289996 A AR 10289996A AR 003132 A1 AR003132 A1 AR 003132A1
- Authority
- AR
- Argentina
- Prior art keywords
- nitrogen
- substituted
- alkoxy
- alkyl
- ring
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 9
- 229910052757 nitrogen Inorganic materials 0.000 abstract 7
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 5
- -1 amino, hydroxy, carboxy Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical group 0.000 abstract 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 229910003827 NRaRb Inorganic materials 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Chemical group 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical group [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 abstract 1
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
- 229910052717 sulfur Chemical group 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
- 125000005505 thiomorpholino group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
La presente invención se relaciona con compuestos farmacéuticamente útiles de la fórmula (I), en los que A, A2, A3, A4, B1 m, A, W, X, Y, Z y R1 adoptancualquiera de los siguientes significados. Uno entre A1, A2, A3 y A4 es nitrógeno y elre sto son CH, un grupo fenilo no sustituido o sustituido con 1,2 ó 3 sustituyentes seleccionados independientemente entre alquilo (C1-C6) no sustituido o sustituido con amino, hidroxi, carboxi, alcoxicarbonilo,alquilcarboniloxi, carbamoilo,carbamoil oxi, halógeno, alcoxi, sulfinilo, sulfonilo, cicloalquilo (C3-C8), fenilo; alcoxi, alquiltio; alquenilo (C2-C6);alquinilo (C2-C6); cicloalquilo todos sin sustituir o sustituidos; fenilo; fenoxi; mercapto; ciano; nitro; carbonilosustituido o no; benzoilo; sulfamoilosolo o sustituido, ureido, un grupo heterocíclico de 6 miembros que contiene 1, 2 ó 3 heteroátomos independientemente seleccionados entre nitrógeno, oxígeno yazufre y un grupo -NRaRb en el cual Ra y Rb estánseleccionados e ntre hidrógeno alquilo (C1-C6) solo o sustituido o en conjunto el grupo -NRaRb completa unanillo 1-pirrolidinilo, 2-oxo-1-pirrolidinilo, 1-piperidinilo, 2-oxo-1- piperidinilo, morfolino o tiomorfolino; B1 es un sustituyenteoptativo en unátom o de carbono de A1, A2, A3 ó A4 seleccionado entre alquilo (C1-C4), halógeno y alcoxi (C1-C4); m es cero, 1, 2, ó 3; el anillo que contiene W, X,Yy Z y que contiene sustituyente R1 está seleccionado entre: (a) un anillo enel que W es nitróge no; X es CH; Y es nitrógeno; y Z es CRy, donde Ry es hidrógeno,halógeno, alquilo (C1-C4),alcoxi (C1-C4) o trifluorometoxi, (b) anillo donde W es CRz en el cual Rz es hidrógeno, halógeno, alquilo (C1-C4), alcoxi (C1-C4)otrifluorometoxi; X es nitróge no; Y es nitrógeno; y Z es CH; (c)un anillo en el cual W y X son ambos nitrógeno; y Y es CH; y Z es CRx, en el cual Rx es
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9511507.7A GB9511507D0 (en) | 1995-06-07 | 1995-06-07 | Heterocyclic compounds |
| GBGB9519666.3A GB9519666D0 (en) | 1995-09-27 | 1995-09-27 | Heterocyclic derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR003132A1 true AR003132A1 (es) | 1998-07-08 |
Family
ID=26307176
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960102899A AR003132A1 (es) | 1995-06-07 | 1996-06-04 | Derivados de n-hetero aril piridinsulfonamidas; composiciones farmaceuticas que los contienen; proceso para su preparacion y el uso de los mismos en la produccion de un medicamento |
Country Status (31)
| Country | Link |
|---|---|
| US (3) | US5866568A (es) |
| EP (1) | EP0832082B1 (es) |
| JP (1) | JP3193058B2 (es) |
| KR (1) | KR100451523B1 (es) |
| CN (1) | CN1097051C (es) |
| AR (1) | AR003132A1 (es) |
| AT (1) | ATE209200T1 (es) |
| AU (1) | AU715041B2 (es) |
| BR (1) | BR9608611A (es) |
| CA (1) | CA2219742C (es) |
| CZ (1) | CZ289387B6 (es) |
| DE (1) | DE69617236T2 (es) |
| DK (1) | DK0832082T3 (es) |
| EG (1) | EG25227A (es) |
| ES (1) | ES2168487T3 (es) |
| GE (1) | GEP20053470B (es) |
| HR (1) | HRP960272B1 (es) |
| HU (1) | HUP9802300A3 (es) |
| IL (1) | IL122464A (es) |
| MX (1) | MX9709521A (es) |
| MY (1) | MY114926A (es) |
| NO (1) | NO314503B1 (es) |
| NZ (1) | NZ308619A (es) |
| PL (1) | PL187897B1 (es) |
| PT (1) | PT832082E (es) |
| RU (1) | RU2172738C2 (es) |
| SK (1) | SK282338B6 (es) |
| TR (1) | TR199701502T1 (es) |
| TW (1) | TW340845B (es) |
| UA (1) | UA58494C2 (es) |
| WO (1) | WO1996040681A1 (es) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5962490A (en) | 1987-09-25 | 1999-10-05 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
| US6613804B2 (en) | 1993-05-20 | 2003-09-02 | Encysive Pharmaceuticals, Inc. | Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin |
| US6342610B2 (en) | 1993-05-20 | 2002-01-29 | Texas Biotechnology Corp. | N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
| US6541498B2 (en) | 1993-05-20 | 2003-04-01 | Texas Biotechnology | Benzenesulfonamides and the use thereof to modulate the activity of endothelin |
| US6376523B1 (en) | 1994-05-20 | 2002-04-23 | Texas Biotechnology Corporation | Benzenesulfonamides and the use thereof to modulate the activity of endothelin |
| US5612359A (en) * | 1994-08-26 | 1997-03-18 | Bristol-Myers Squibb Company | Substituted biphenyl isoxazole sulfonamides |
| US5760038A (en) * | 1995-02-06 | 1998-06-02 | Bristol-Myers Squibb Company | Substituted biphenyl sulfonamide endothelin antagonists |
| US5780473A (en) * | 1995-02-06 | 1998-07-14 | Bristol-Myers Squibb Company | Substituted biphenyl sulfonamide endothelin antagonists |
| US5846990A (en) * | 1995-07-24 | 1998-12-08 | Bristol-Myers Squibb Co. | Substituted biphenyl isoxazole sulfonamides |
| JPH09124620A (ja) * | 1995-10-11 | 1997-05-13 | Bristol Myers Squibb Co | 置換ビフェニルスルホンアミドエンドセリン拮抗剤 |
| US5977117A (en) | 1996-01-05 | 1999-11-02 | Texas Biotechnology Corporation | Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin |
| US5856507A (en) * | 1997-01-21 | 1999-01-05 | Bristol-Myers Squibb Co. | Methods for the preparation of biphenyl isoxazole sulfonamides |
| AU717230B2 (en) | 1996-02-20 | 2000-03-23 | Bristol-Myers Squibb Company | Methods for the preparation of biphenyl isoxazole sulfonamides |
| US5939446A (en) * | 1996-04-09 | 1999-08-17 | Bristol-Myers Squibb Co. | Heteroaryl substituted phenyl isoxazole sulfonamide endothelin antagonists |
| US5804585A (en) | 1996-04-15 | 1998-09-08 | Texas Biotechnology Corporation | Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin |
| GB9614804D0 (en) * | 1996-07-15 | 1996-09-04 | Chiroscience Ltd | Resolution process |
| WO1998033781A1 (en) * | 1997-01-30 | 1998-08-06 | Bristol-Myers Squibb Company | Method for preventing or treating low renin hypertension by administering an endothelin antagonist |
| TW536540B (en) * | 1997-01-30 | 2003-06-11 | Bristol Myers Squibb Co | Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe |
| GB9704762D0 (en) * | 1997-03-07 | 1997-04-23 | Zeneca Ltd | Chemical process |
| TR200101905T2 (tr) | 1997-04-28 | 2002-06-21 | Texas Biotechnology Corporation | Endotelin ile ilgili hastalıkların tedavisinde kullanılan sülfanoamidler. |
| US5783705A (en) | 1997-04-28 | 1998-07-21 | Texas Biotechnology Corporation | Process of preparing alkali metal salys of hydrophobic sulfonamides |
| WO2000056685A1 (en) | 1999-03-19 | 2000-09-28 | Bristol-Myers Squibb Company | Methods for the preparation of biphenyl isoxazole sulfonamides |
| US6448239B1 (en) * | 1999-06-03 | 2002-09-10 | Trustees Of Princeton University | Peroxynitrite decomposition catalysts and methods of use thereof |
| BR0016821A (pt) | 1999-12-31 | 2002-12-10 | Texas Biotechnology Corp | Sulfonamidas e derivados da mesma que modulam a atividade de endotelina |
| US6639082B2 (en) | 2000-10-17 | 2003-10-28 | Bristol-Myers Squibb Company | Methods for the preparation of biphenyl isoxazole sulfonamides |
| US7041280B2 (en) | 2001-06-29 | 2006-05-09 | Genzyme Corporation | Aryl boronate functionalized polymers for treating obesity |
| US6858592B2 (en) | 2001-06-29 | 2005-02-22 | Genzyme Corporation | Aryl boronic acids for treating obesity |
| GB0219660D0 (en) | 2002-08-23 | 2002-10-02 | Astrazeneca Ab | Therapeutic use |
| GB0223854D0 (en) * | 2002-10-12 | 2002-11-20 | Astrazeneca Ab | Therapeutic treatment |
| RU2234331C1 (ru) * | 2002-12-30 | 2004-08-20 | Смирнов Алексей Владимирович | Лекарственное средство |
| US7169805B2 (en) * | 2003-05-28 | 2007-01-30 | Nicox S.A. | Captopril derivatives |
| GB0320806D0 (en) * | 2003-09-05 | 2003-10-08 | Astrazeneca Ab | Therapeutic treatment |
| GB0403744D0 (en) | 2004-02-20 | 2004-03-24 | Astrazeneca Ab | Chemical process |
| KR100839512B1 (ko) * | 2004-07-02 | 2008-06-19 | 주식회사 코오롱 | 설파제를 디아조화체로 하는 산성 항균 염료 및 그를이용한 항균 섬유 |
| WO2006033446A1 (en) * | 2004-09-21 | 2006-03-30 | Astellas Pharma Inc. | Aminoalcohol derivatives |
| US20090209492A1 (en) | 2004-11-12 | 2009-08-20 | Trustees Of Tufts College | Lipase Inhibitors |
| US20070054325A1 (en) * | 2005-04-14 | 2007-03-08 | Reglia | Materials and methods for screening modulators of neural regeneration |
| GB0514743D0 (en) * | 2005-07-19 | 2005-08-24 | Astrazeneca Ab | Salt |
| HRP20120421T1 (hr) | 2005-12-13 | 2012-07-31 | Medimmune@Limited | Vezni proteini specifični za inzulinu slične čimbenike rasta i njihova upotreba |
| CA2644578A1 (en) * | 2006-03-03 | 2007-09-07 | Torrent Pharmaceuticals Ltd | Novel dual action receptors antagonists (dara) at the ati and eta receptors |
| MX2008013034A (es) * | 2006-04-13 | 2008-10-17 | Actelion Pharmaceuticals Ltd | Antagonistas del receptor de endotelina para etapas tempranas de fibrosis pulmonar idiopatica. |
| RU2460729C2 (ru) * | 2006-09-21 | 2012-09-10 | Пирамал Лайф Сайнсиз Лимитед | Производные 3-амино-пиридина для лечения метаболических нарушений |
| CL2008000191A1 (es) | 2007-01-25 | 2008-08-22 | Astrazeneca Ab | Compuestos derivados de 4-amino-cinnotina-3-carboxamida; inhibidores de csf-1r quinasa; su proceso de preparacion; y su uso para tratar el cancer. |
| CL2008001274A1 (es) | 2007-05-03 | 2008-11-03 | Intermune Inc Y Array Biopharma Inc | Compuestos macrolidos derivados de 5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahidrociclopropan[e]pirrolo[1,2-a][1,4]diazaciclopentadecinilo, inhibidores de la actividad de la proteasa ns3-ns4; su procedimiento de preparacion; composicion farmaceutica; compuestos intermediarios y procedimiento de preparacion; y uso en el tratamiento de..... |
| EA201000545A1 (ru) | 2007-10-12 | 2010-10-29 | Астразенека Аб | Композиция зиботентана, содержащая маннит и/или микрокристаллическую целлюлозу |
| EP2297114B1 (en) | 2008-06-19 | 2018-06-06 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
| AU2010211672B2 (en) * | 2009-02-06 | 2016-08-04 | Nippon Shinyaku Co., Ltd. | Aminopyrazine derivative and medicine |
| CN102491973A (zh) * | 2011-12-15 | 2012-06-13 | 南京友杰医药科技有限公司 | Zd-4054的合成方法 |
| WO2020165226A1 (en) * | 2019-02-12 | 2020-08-20 | The University Court Of The University Of Glasgow | Microvascular angina |
| US20230227477A1 (en) * | 2020-06-25 | 2023-07-20 | Wake Forest University Health Sciences | Compounds for sensing reactive oxygen species and methods for using the same |
| US11730735B2 (en) | 2020-07-10 | 2023-08-22 | Astrazeneca Ab | Combination of zibotentan and dapagliflozin for the treatment of endothelin related diseases |
| AR126178A1 (es) | 2021-06-22 | 2023-09-27 | Alchemedicine Inc | Compuesto, antagonista del receptor de endotelina a y composición farmacéutica |
| CA3264757A1 (en) | 2022-08-12 | 2024-02-15 | Astrazeneca Ab | Polytherapy for the treatment of cirrhosis with portal hypertension |
| TW202446375A (zh) | 2023-02-08 | 2024-12-01 | 瑞典商阿斯特捷利康公司 | 用於治療高蛋白尿慢性腎病的齊泊騰坦和達格列淨之組合 |
| WO2025133907A1 (en) | 2023-12-18 | 2025-06-26 | Astrazeneca Ab | Combination of zibotentan and dapagliflozin for the treatment of microvascular angina |
| WO2025163559A1 (en) | 2024-02-01 | 2025-08-07 | Astrazeneca Ab | Combination of zibotentan and dapagliflozin for use for the treatment of hypertension |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0655708B2 (ja) * | 1985-05-13 | 1994-07-27 | 三井東圧化学株式会社 | スルホンアミド系化合物及び農業用殺菌剤 |
| UA13316A (uk) * | 1986-01-31 | 1997-02-28 | Ісіхара Сангіо Кайся Лтд | Спосіб боротьби з hебажаhим ростом рослиh |
| US5571821A (en) * | 1993-05-20 | 1996-11-05 | Texas Biotechnology Corporation | Sulfonamides and derivatives thereof that modulate the activity of endothelin |
| US5594021A (en) * | 1993-05-20 | 1997-01-14 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives thereof that modulate the activity of endothelin |
| US5591761A (en) * | 1993-05-20 | 1997-01-07 | Texas Biotechnology Corporation | Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
| US5464853A (en) * | 1993-05-20 | 1995-11-07 | Immunopharmaceutics, Inc. | N-(5-isoxazolyl)biphenylsulfonamides, N-(3-isoxazolyl)biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin |
| US5514691A (en) * | 1993-05-20 | 1996-05-07 | Immunopharmaceutics, Inc. | N-(4-halo-isoxazolyl)-sulfonamides and derivatives thereof that modulate the activity of endothelin |
| JPH04503672A (ja) * | 1989-02-27 | 1992-07-02 | イー・アイ・デュポン・ドゥ・ヌムール・アンド・カンパニー | 放射線増感剤としての新規なナフタレンスルホンアミド |
| TW270116B (es) * | 1991-04-25 | 1996-02-11 | Hoffmann La Roche | |
| AU1929292A (en) * | 1991-05-14 | 1992-12-30 | Hybritech Incorporated | Polymeric compositions having bound antibodies |
| RU2086544C1 (ru) * | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина |
| TW224462B (es) * | 1992-02-24 | 1994-06-01 | Squibb & Sons Inc | |
| AU678357B2 (en) * | 1992-04-22 | 1997-05-29 | Warner-Lambert Company | Endothelin antagonists II |
| NZ247440A (en) * | 1992-05-06 | 1995-04-27 | Squibb & Sons Inc | Phenyl sulphonamide derivatives, preparation and pharmaceutical compositions thereof |
| WO1994002474A1 (en) * | 1992-07-17 | 1994-02-03 | Smithkline Beecham Corporation | Endothelin receptor antagonists |
| TW287160B (es) * | 1992-12-10 | 1996-10-01 | Hoffmann La Roche | |
| EP0626174A3 (en) * | 1993-04-21 | 1996-01-03 | Takeda Chemical Industries Ltd | Method and composition for the prophylaxis and / or treatment of underactive organs. |
| US5965732A (en) * | 1993-08-30 | 1999-10-12 | Bristol-Myers Squibb Co. | Sulfonamide endothelin antagonists |
| GB9504854D0 (en) * | 1994-03-31 | 1995-04-26 | Zeneca Ltd | Nitrogen derivatives |
| GB9409618D0 (en) * | 1994-05-13 | 1994-07-06 | Zeneca Ltd | Pyridine derivatives |
| DE4426346A1 (de) * | 1994-07-25 | 1996-02-01 | Basf Ag | Herbizide Pyrazinderivate |
| US5612359A (en) * | 1994-08-26 | 1997-03-18 | Bristol-Myers Squibb Company | Substituted biphenyl isoxazole sulfonamides |
| GB2295616A (en) * | 1994-12-01 | 1996-06-05 | Zeneca Ltd | N-Diazine-benzenesulphonamide derivatives as endothelin receptor antagonists |
| EA007107B1 (ru) * | 1995-04-04 | 2006-06-30 | Инсизив Фармасьютикэлз Инк. | Тиенил- и дифенилсульфонамиды и их производные, модулирующие активность эндотелина |
-
1996
- 1996-03-06 UA UA98010043A patent/UA58494C2/uk unknown
- 1996-06-03 CA CA002219742A patent/CA2219742C/en not_active Expired - Fee Related
- 1996-06-03 DK DK96919941T patent/DK0832082T3/da active
- 1996-06-03 KR KR1019970708807A patent/KR100451523B1/ko not_active Expired - Fee Related
- 1996-06-03 PL PL96324660A patent/PL187897B1/pl not_active IP Right Cessation
- 1996-06-03 BR BR9608611A patent/BR9608611A/pt not_active IP Right Cessation
- 1996-06-03 CN CN96196149A patent/CN1097051C/zh not_active Expired - Fee Related
- 1996-06-03 PT PT96919941T patent/PT832082E/pt unknown
- 1996-06-03 WO PCT/GB1996/001295 patent/WO1996040681A1/en not_active Ceased
- 1996-06-03 AU AU58403/96A patent/AU715041B2/en not_active Ceased
- 1996-06-03 HU HU9802300A patent/HUP9802300A3/hu unknown
- 1996-06-03 NZ NZ308619A patent/NZ308619A/xx not_active IP Right Cessation
- 1996-06-03 ES ES96919941T patent/ES2168487T3/es not_active Expired - Lifetime
- 1996-06-03 DE DE69617236T patent/DE69617236T2/de not_active Expired - Lifetime
- 1996-06-03 MX MX9709521A patent/MX9709521A/es unknown
- 1996-06-03 JP JP50020997A patent/JP3193058B2/ja not_active Expired - Fee Related
- 1996-06-03 EP EP96919941A patent/EP0832082B1/en not_active Expired - Lifetime
- 1996-06-03 TR TR97/01502T patent/TR199701502T1/xx unknown
- 1996-06-03 SK SK1680-97A patent/SK282338B6/sk not_active IP Right Cessation
- 1996-06-03 CZ CZ19973887A patent/CZ289387B6/cs not_active IP Right Cessation
- 1996-06-03 RU RU98100054/04A patent/RU2172738C2/ru not_active IP Right Cessation
- 1996-06-03 AT AT96919941T patent/ATE209200T1/de active
- 1996-06-03 IL IL12246496A patent/IL122464A/en not_active IP Right Cessation
- 1996-06-04 MY MYPI96002166A patent/MY114926A/en unknown
- 1996-06-04 AR ARP960102899A patent/AR003132A1/es active IP Right Grant
- 1996-06-04 TW TW085106632A patent/TW340845B/zh not_active IP Right Cessation
- 1996-06-04 US US08/658,969 patent/US5866568A/en not_active Expired - Lifetime
- 1996-06-06 EG EG50996A patent/EG25227A/xx active
- 1996-06-06 HR HR960272A patent/HRP960272B1/xx not_active IP Right Cessation
-
1997
- 1997-12-05 NO NO19975700A patent/NO314503B1/no not_active IP Right Cessation
-
1998
- 1998-12-14 US US09/211,483 patent/US6060475A/en not_active Expired - Lifetime
-
2000
- 2000-02-15 US US09/504,364 patent/US6258817B1/en not_active Expired - Lifetime
-
2004
- 2004-07-19 GE GE5624A patent/GEP20053470B/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR003132A1 (es) | Derivados de n-hetero aril piridinsulfonamidas; composiciones farmaceuticas que los contienen; proceso para su preparacion y el uso de los mismos en la produccion de un medicamento | |
| AR041009A1 (es) | Compuestos heterociclicos nitrogenados que presentan actividad inhibitoria contra la integrasa del vih | |
| HUP0301953A2 (hu) | 1,5-Benzotiazepinek, eljárás előállításukra és felhasználásuk hiperlipidémia-ellenes szerekként | |
| TW200745117A (en) | Macrocylic inhibitors of hepatitis C virus | |
| IL143806A0 (en) | Pyrimidine compounds | |
| HUP0103404A2 (hu) | Oxazolidinonszármazékok, eljárás előállításukra, és az azokat tartalmazó gyógyászati készítmények | |
| AU572405B2 (en) | Heterocyclic-substituted indole | |
| TW200716528A (en) | Cyclopropanecarboxamide derivatives | |
| HUP0401982A2 (hu) | Indolizinszármazékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyászati készítmények | |
| GEP20084357B (en) | Pyrimidine derivatives for the treatment of abnormal cell growth | |
| YU73300A (sh) | Biciklični pirimidini i biciklični 3,4-dihidropirimidini kao inhibitori ćelijske proliferacije | |
| AU1010692A (en) | Novel phenylimidazolidines, process for their preparation, their use as medicaments and pharmaceutical compositions containing them | |
| AU2003285584A8 (en) | 3-(2-hydroxy-phenyl)-1h-pyrazole-4-carboxylic acid amide derivatives as hsp90 inhibitors for the treatment of cancer | |
| HUP9802865A2 (hu) | N-(szubsztituált fenil-)-pirazol-származékok, előállításuk és alkalmazásuk, a vegyületeket hatóanyagként tartalmazó parazitaellenes készítmények | |
| ES8202334A1 (es) | Un procedimiento para la preparacion de derivados de 2,4-diaminoquinazolina | |
| IL161559A0 (en) | Dibenzylamine derivatives and pharmaceutical compositions containing the same | |
| HUT71482A (en) | 4,1-benzoxazepine derivatives, process for preparing them and pharmaceutical compositions containing them | |
| HUP0001294A2 (hu) | Proteáz inhibitor hatású (heterociklil-karbonil)-hidrazid-származékok, eljárás előállításukra és alkalmazásuk | |
| EP0366304A3 (en) | Heterocyclic derivatives, process for their preparation and pharmaceutical compositions containing them | |
| JO1255B1 (en) | Various compounds loops | |
| AU8997898A (en) | Epoxysuccinamide derivatives | |
| AU2003249484A1 (en) | Novel bio-active molecules | |
| AU6894896A (en) | Indazolecarboxamides | |
| MY140653A (en) | Substituted diketopiperazines and their use as oxytocyn antagonists | |
| HUP0500164A2 (hu) | Heterociklussal szubsztituált benzolszulfonamidok mint HIV proteáz inhibitorok és az ezeket tartalmazó gyógyszerkészítmények |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |