AR002984A1 - Derivados de 1,3-dihidro-2h-imidazol-2-ona, procedimiento para su preparacion, composicion que los comprende, procedimiento para preparar dicha composicion y el uso de dichos derivados para fabricar medicamentos. - Google Patents
Derivados de 1,3-dihidro-2h-imidazol-2-ona, procedimiento para su preparacion, composicion que los comprende, procedimiento para preparar dicha composicion y el uso de dichos derivados para fabricar medicamentos.Info
- Publication number
- AR002984A1 AR002984A1 ARP960102075A AR10207596A AR002984A1 AR 002984 A1 AR002984 A1 AR 002984A1 AR P960102075 A ARP960102075 A AR P960102075A AR 10207596 A AR10207596 A AR 10207596A AR 002984 A1 AR002984 A1 AR 002984A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- alkyl
- piperidinyl
- derivatives
- procedure
- Prior art date
Links
- 238000000034 method Methods 0.000 title 2
- 239000003814 drug Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 10
- -1 bicyclo [2.2.1] -2-heptenyl Chemical group 0.000 abstract 6
- 125000003386 piperidinyl group Chemical group 0.000 abstract 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 2
- 125000002541 furyl group Chemical group 0.000 abstract 2
- 125000002883 imidazolyl group Chemical group 0.000 abstract 2
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 abstract 2
- 125000002757 morpholinyl group Chemical group 0.000 abstract 2
- 125000002971 oxazolyl group Chemical group 0.000 abstract 2
- 125000004193 piperazinyl group Chemical group 0.000 abstract 2
- 125000004076 pyridyl group Chemical group 0.000 abstract 2
- 125000000335 thiazolyl group Chemical group 0.000 abstract 2
- 125000001544 thienyl group Chemical group 0.000 abstract 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 1
- AICIYIDUYNFPRY-UHFFFAOYSA-N 1,3-dihydro-2H-imidazol-2-one Chemical class O=C1NC=CN1 AICIYIDUYNFPRY-UHFFFAOYSA-N 0.000 abstract 1
- 125000000815 N-oxide group Chemical group 0.000 abstract 1
- PFRUBEOIWWEFOL-UHFFFAOYSA-N [N].[S] Chemical group [N].[S] PFRUBEOIWWEFOL-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- BVCRERJDOOBZOH-UHFFFAOYSA-N bicyclo[2.2.1]heptanyl Chemical group C1C[C+]2CC[C-]1C2 BVCRERJDOOBZOH-UHFFFAOYSA-N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención se relaciona con derivados de 1,3-dihidro-2H-imidazol -2-ona de la fórmula (I), las formas de N-óxido, las sales de adición de ácidoo base farmacéuticamente aceptables y las formas estereoquímicamente isoméricas de las mismas,e n las cuales:R1 y R2 consisten independientemente en hidrógeno,alquilo C1-6, difluorometilo, trifluorometilo, cicloalquilo C2-6,un heterociclo saturado de 5-, 6- ó 7- elementos que contiene uno o dos heteroátomosseleccionados entre oxígeno, azufreo nitrógeno; indanilo, biciclo [2.2.1]-2- heptenilo; biciclo [2.2.1] heptanilo; alquilsulfonilo C1-6; arilsulfonilo; óalquilo C1-10 sustituido;R3 es H, halo o alquiloxi C1-16;donde X es O; alquilo; >C = NOR5; un anillo de metilenos; Alc esalcanodiil o C1-4;-A-B- es un radicalbivalente de la fórmula: -CR6=CR7-; ó -CHR6-CHR7-; L es H, alquilo C1-6; optativamente sustituido alquilcarbonilo C1-6;alquiloxicarbonilo C1-6,alqueniloC3-6; optativamente sustituido; piperidinilooptativamente sustit uido; alquilsulfonilo C1-6 o arilsulfonilo; arilo es fenilo optativamente sustituido.Het 1 es piridinilo, piridinilo sustituido con alquilo C1-4; furanilo, furanilo sustituido con alquilo C1-4;tienilo, tienilosustituido con alquilcarbonilam inoC1-4; hidroxipiridinilo, hidroxipiridinilo sustituido con alquilo C1-4 ó C1-4 alcoxi C1-4 alquilo, imidazolilo, imidazolilo sustituido con alquilo C1-4;tiazolilo,tiazolilo sustituido con alquilo C1-4;oxazolilo;oxazolilo sustituido con alquilo C 1-4; isoquinolinilo; isoquinolinilo sustituido con alquilo C1-4;quinolinonilo; quinolinonilo sustituido con alquilo C1-4; morfolinilo; piperidinilo; piperidinilo sustituido con alquilo C1-4,alquiloxicarbonilo C1-4ó aril C1-4alquilo;y Het2 e s morfolinilo;piperidinilo, piperidinilo sustituido con alquilo C1-4; o aril C1-4alquilo; piperazinilo; piperazinilo sustituido con
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP95200870 | 1995-04-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR002984A1 true AR002984A1 (es) | 1998-05-27 |
Family
ID=8220175
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960102075A AR002984A1 (es) | 1995-04-06 | 1996-04-03 | Derivados de 1,3-dihidro-2h-imidazol-2-ona, procedimiento para su preparacion, composicion que los comprende, procedimiento para preparar dicha composicion y el uso de dichos derivados para fabricar medicamentos. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5869515A (es) |
| EP (1) | EP0832071B1 (es) |
| JP (1) | JP4115519B2 (es) |
| KR (1) | KR100400159B1 (es) |
| CN (1) | CN1103760C (es) |
| AR (1) | AR002984A1 (es) |
| AT (1) | ATE305455T1 (es) |
| CA (1) | CA2216542C (es) |
| DE (1) | DE69635224T2 (es) |
| ES (1) | ES2250988T3 (es) |
| IL (1) | IL117806A (es) |
| MY (1) | MY117936A (es) |
| TW (1) | TW375612B (es) |
| WO (1) | WO1996031487A1 (es) |
| ZA (1) | ZA962753B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5922751A (en) * | 1994-06-24 | 1999-07-13 | Euro-Celtique, S.A. | Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same |
| TR199900732T2 (xx) * | 1996-10-02 | 1999-08-23 | Janssen Pharmaceutica N.V. | PDE IV inhibe eden 2-siyanoiminoimidazol t�revleri. |
| IL138745A0 (en) * | 1998-04-01 | 2001-10-31 | Janssen Pharmaceutica Nv | Pde iv inhibiting pyridine derivatives |
| SK287231B6 (sk) | 1999-08-21 | 2010-04-07 | Nycomed Gmbh | Liečivo zahŕňajúce PDE inhibítor a agonistu beta2 adrenoreceptora |
| US20030175314A1 (en) * | 2001-11-19 | 2003-09-18 | Didriksen Erik Johannes | Pharmaceutical composition for dermal application |
| WO2004087211A2 (en) | 2003-04-01 | 2004-10-14 | Applied Research Systems Ars Holding N.V. | Inhibitors of phosphodiesterases in infertility |
| FR2860514A1 (fr) * | 2003-10-03 | 2005-04-08 | Sanofi Synthelabo | Derives d'arylalkylcarbamates, leur preparation et leur application en therapeutique |
| BRPI0510453A (pt) | 2004-04-30 | 2007-10-30 | Warner Lambert Co | composto substituìdos com morfolina para o tratamento de distúrbios do sistema nervoso central |
| WO2006078698A1 (en) * | 2005-01-19 | 2006-07-27 | Cengent Therapeutics, Inc. | 2-imidazolone and 2-imidazolidinone heterocyclic inhibitors of tyrosine phosphatases |
| WO2007085357A1 (en) * | 2006-01-30 | 2007-08-02 | Euro-Celtique S.A. | Cyclourea compounds as calcium channel blockers |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4636516A (en) * | 1981-02-19 | 1987-01-13 | Yamanouchi Pharmaceutical Co., Ltd. | 3,5-di-tert-butyl-4-hydroxyphenyl-substituted heterocyclic compounds |
| CA1309096C (en) * | 1985-08-13 | 1992-10-20 | Sumitomo Chemical Co., Ltd. | Butenoic acid derivatives, and their production and use |
| US4845233A (en) * | 1987-09-11 | 1989-07-04 | Iprx, Inc. | Imidazolin-2-ones |
| US5401851A (en) * | 1992-06-03 | 1995-03-28 | Eli Lilly And Company | Angiotensin II antagonists |
| PL307265A1 (en) * | 1992-07-28 | 1995-05-15 | Rhone Poulenc Rorer Ltd | Compounds containing a phenyl group bonded with aryl or heteroaryl group through their bonding aliphatic group or that containing heteroatom |
| DE69430747T2 (de) * | 1993-07-28 | 2003-03-06 | Aventis Pharma Ltd., West Malling | Verbindungen als pde iv und tnf inhibitoren |
| GB9401460D0 (en) * | 1994-01-26 | 1994-03-23 | Rhone Poulenc Rorer Ltd | Compositions of matter |
| GB9412672D0 (en) * | 1994-06-23 | 1994-08-10 | Celltech Ltd | Chemical compounds |
| WO1996000218A1 (en) * | 1994-06-24 | 1996-01-04 | Euro-Celtique, S.A. | Compounds for and method of inhibiting phosphodiesterase iv |
-
1996
- 1996-03-22 TW TW085103445A patent/TW375612B/zh not_active IP Right Cessation
- 1996-03-28 CN CN96193104A patent/CN1103760C/zh not_active Expired - Lifetime
- 1996-03-28 KR KR1019970706852A patent/KR100400159B1/ko not_active Expired - Lifetime
- 1996-03-28 WO PCT/EP1996/001393 patent/WO1996031487A1/en not_active Ceased
- 1996-03-28 DE DE69635224T patent/DE69635224T2/de not_active Expired - Lifetime
- 1996-03-28 US US08/930,478 patent/US5869515A/en not_active Expired - Lifetime
- 1996-03-28 JP JP52995896A patent/JP4115519B2/ja not_active Expired - Lifetime
- 1996-03-28 AT AT96911969T patent/ATE305455T1/de active
- 1996-03-28 CA CA002216542A patent/CA2216542C/en not_active Expired - Lifetime
- 1996-03-28 ES ES96911969T patent/ES2250988T3/es not_active Expired - Lifetime
- 1996-03-28 EP EP96911969A patent/EP0832071B1/en not_active Expired - Lifetime
- 1996-04-03 IL IL11780696A patent/IL117806A/xx not_active IP Right Cessation
- 1996-04-03 AR ARP960102075A patent/AR002984A1/es active IP Right Grant
- 1996-04-04 ZA ZA9602753A patent/ZA962753B/xx unknown
- 1996-04-05 MY MYPI96001299A patent/MY117936A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MY117936A (en) | 2004-08-30 |
| ES2250988T3 (es) | 2006-04-16 |
| IL117806A (en) | 2000-02-17 |
| IL117806A0 (en) | 1996-08-04 |
| EP0832071B1 (en) | 2005-09-28 |
| DE69635224D1 (de) | 2006-02-09 |
| AU697390B2 (en) | 1998-10-01 |
| DE69635224T2 (de) | 2006-06-22 |
| AU5497996A (en) | 1996-10-23 |
| CN1103760C (zh) | 2003-03-26 |
| ATE305455T1 (de) | 2005-10-15 |
| JPH11504003A (ja) | 1999-04-06 |
| CN1181073A (zh) | 1998-05-06 |
| KR19980703448A (ko) | 1998-11-05 |
| CA2216542A1 (en) | 1996-10-10 |
| ZA962753B (en) | 1997-10-06 |
| US5869515A (en) | 1999-02-09 |
| TW375612B (en) | 1999-12-01 |
| WO1996031487A1 (en) | 1996-10-10 |
| EP0832071A1 (en) | 1998-04-01 |
| JP4115519B2 (ja) | 2008-07-09 |
| CA2216542C (en) | 2009-01-13 |
| KR100400159B1 (ko) | 2003-12-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FG | Grant, registration |