[go: up one dir, main page]

AR002251A1 - Derivados de sulfonamidas, procedimiento para su obtencion, composiciones farmaceuticas y utilizacion de los compuestos para preparacion de medicamentos para enfermedades asociadas con la endotelina. - Google Patents

Derivados de sulfonamidas, procedimiento para su obtencion, composiciones farmaceuticas y utilizacion de los compuestos para preparacion de medicamentos para enfermedades asociadas con la endotelina.

Info

Publication number
AR002251A1
AR002251A1 ARP950100297A AR10029795A AR002251A1 AR 002251 A1 AR002251 A1 AR 002251A1 AR P950100297 A ARP950100297 A AR P950100297A AR 10029795 A AR10029795 A AR 10029795A AR 002251 A1 AR002251 A1 AR 002251A1
Authority
AR
Argentina
Prior art keywords
lower alkyl
phenyl
alkoxy
alkyl
lower alkoxy
Prior art date
Application number
ARP950100297A
Other languages
English (en)
Original Assignee
Speedel Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Speedel Pharma Ag filed Critical Speedel Pharma Ag
Publication of AR002251A1 publication Critical patent/AR002251A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)

Abstract

Los compuestos de fórmula (I) en donde R1 es heterocíclilo;R2 eshidrógeno, alquilo inferior, alcoxilo inferior, alquiltio inferior, alcoxiloinferior-alquilo inferior, alquilsulfonilo inferior-alcoxilo inferior, fenilo, alquilo inferior- fenilo,alcoxilo inferior-fenilo, alquileno inferior-dioxifenilo, fenilo alquilo inferior, alquilo inferior-fenilo,alquilo inferior, alcoxilo inferior fenilo-alquilo inferior, alquileno inferior dioxifeniloalquilo inferior, heterociclilo o heterocicl o-alquilo inferior; R3 es alquilo inferior alcoxilo inferior, formilo, haloalquilo inferior, hidroxilo-alquiloinferior amino-alquilo inferior o un radical -CH2O-A-alquilo inferior,-(CH2)m-O -(CD G)nCH,-(CH2)m-O-(CD G)n OR9,-(CH2)m-O-(CD G)n NH2 ó -(CH2)m-O-(CD G)n-B-R9;R4 y R8 son hidrógeno,alcoxilo inferior o halógeno;R9 significa heterociclilo; fenilo o fenilo sustituido con alquilo inferior, alcoxilo inferior y/ohalógeno, ó alquilo inferior;D y G significan hidrógeno o alquiloinferior ; A significa un grupo 1,2 dihidroxi-etileno cetalizado; B significa -OC(O)O,O(C(O)NH, -NH(C(O)NH- e -NHC(O)O-, n es 2, 3 ó 4; y m es 0 ó 1, son sustancias que inhiben los receptores de la endotelia. Pueden utilizarse, por lo tanto,parael trata miento de enfermedades que están asociadas a las actividades de la endotelina, en particular, las enfermedades circulatorias como la hipertensión,isquemia, espasmos vasculares y angina pectoris.
ARP950100297A 1994-11-25 1995-11-23 Derivados de sulfonamidas, procedimiento para su obtencion, composiciones farmaceuticas y utilizacion de los compuestos para preparacion de medicamentos para enfermedades asociadas con la endotelina. AR002251A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH355994 1994-11-25

Publications (1)

Publication Number Publication Date
AR002251A1 true AR002251A1 (es) 1998-03-11

Family

ID=4258608

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP950100297A AR002251A1 (es) 1994-11-25 1995-11-23 Derivados de sulfonamidas, procedimiento para su obtencion, composiciones farmaceuticas y utilizacion de los compuestos para preparacion de medicamentos para enfermedades asociadas con la endotelina.
ARP970105148A AR010549A2 (es) 1994-11-25 1997-11-04 DERIVADOS DE SULFONAMIDAS uTILES COMO INTERMEDIARIOS DE SíNTESIS.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP970105148A AR010549A2 (es) 1994-11-25 1997-11-04 DERIVADOS DE SULFONAMIDAS uTILES COMO INTERMEDIARIOS DE SíNTESIS.

Country Status (9)

Country Link
AR (2) AR002251A1 (es)
BR (1) BR9505528A (es)
CO (1) CO4650181A1 (es)
PE (1) PE52496A1 (es)
PL (1) PL185692B1 (es)
TR (1) TR199501486A2 (es)
UY (1) UY24100A1 (es)
WO (1) WO1996016963A1 (es)
ZA (1) ZA959808B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI284642B (en) * 1999-01-18 2007-08-01 Hoffmann La Roche Novel heterocyclic sulfonamides
ATE323079T1 (de) * 2000-12-18 2006-04-15 Actelion Pharmaceuticals Ltd Neue sulfamiden und deren verwendung als endothelin-antagonisten
PL1725540T3 (pl) 2004-03-05 2013-02-28 Hoffmann La Roche Diaminopirymidyny jako antagoniści p2x3 i p2x2/3
AR062501A1 (es) 2006-08-29 2008-11-12 Actelion Pharmaceuticals Ltd Composiciones terapeuticas
MX2010001837A (es) 2007-08-17 2010-03-10 Actelion Pharmaceuticals Ltd Derivados de 4-pirimidinasulfamida.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2086544C1 (ru) * 1991-06-13 1997-08-10 Хоффманн-Ля Рош АГ Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина

Also Published As

Publication number Publication date
BR9505528A (pt) 1997-11-04
TR199501486A2 (tr) 1996-07-21
CO4650181A1 (es) 1998-09-03
PL185692B1 (pl) 2003-07-31
PL311487A1 (en) 1996-05-27
ZA959808B (en) 1996-05-27
UY24100A1 (es) 2000-12-29
WO1996016963A1 (de) 1996-06-06
AR010549A2 (es) 2000-06-28
PE52496A1 (es) 1996-12-12

Similar Documents

Publication Publication Date Title
ECSP045095A (es) COMPUESTOS HETEROCÍCLICOS PARA EL USO EN EL TRATAMIENTO DE LOS TRASTORNOS DE LAS VíAS URINARIAS
AR050530A1 (es) Derivados de heteroaril sulfamida benzo-fusionada utiles como agentes anticonvulsivos
CO5031253A1 (es) Antagonistas receptores y5 de neuropeptidos composiciones farmaceuticas que las contienen
CL2004000788A1 (es) Compuestos derivados de n-[2-oxo-6-(aril o heteroaril)azepan-3-il]-4-(2-oxo-2,3-dihidro-1h-imidazo[4,5-b]piridin-1-il)piperidina-1-carboxamida, antagonistas de los receptores cgrp; composicion farmaceutica; y uso del compuesto en el tratamiento del d
MX9300842A (es) Antagonistas de endotelina de sulfonamida.
PE52499A1 (es) Ftalazinas
AR013184A1 (es) Aminas heterociclicas espiroazobiciclicas, composicion farmaceutica, uso de dichas aminas para preparar medicamentos y metodo de tratamiento o profilaxis
AR045260A1 (es) Compuestos que contienen imidazo-oxima sustituidos
AR029301A1 (es) Compuestos derivados de biarilo, metodos para su preparacion composiciones que los contienen, su uso como agonistas en receptores beta-adreno-receptores atipicos
ES2193921T3 (es) Compuestos de sulfamoilheteroaril-pirazol como agentes antinflamatorios/analgesicos.
AR037193A1 (es) Derivados de quinazolina, composicion farmaceutica, su uso en la fabricacion de un medicamento y procesopara preparar dicho derivado de quinazolina
AR054799A1 (es) Derivados de oxindol
ECSP045253A (es) Derivados de 5-feniltiazol y uso como inhibidores de pi3 cinasa
ECSP066313A (es) Derivados de la piridazina y su uso como agentes terapéuticos
ECSP066315A (es) Derivados de la piridazina y su uso como agentes terapéuticos
AR048641A1 (es) Compuestos de aril- o heteroarilamida ortosustituidos utiles como antago-nistas del receptor de prostaglandinas e2; composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicame
TR199801594A2 (xx) CCR-3 resept�r antagonistleri.
PE20021089A1 (es) Compuestos de triazol como inhibidores de las citoquinas
PE20020566A1 (es) DERIVADOS DE FENILACETAMIDO-PIRAZOLES COMO INHIBIDORES DE LA cdk/CICLINA QUINASA
AR007961A1 (es) Derivados de cicloalquilo como inhibidores de la resorcion osea y antagonistas de receptores de vitronectina, procedimiento para su preparacion y preparado farmaceutico.
AR033379A1 (es) Compuestos de difenilurea, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
UY24482A1 (es) Quinoxalinadionas
DE60121461D1 (de) Kondensierte pyridoindolderivate
AR037681A1 (es) Antagonistas receptores de adenosina a2a de 5-amino-[1,2,4]-triazol biciclico, composiciones farmaceuticas que los comprenden, el uso de las mismas, solo o en combinacion de los compuestos y otros agentes para la preparacion de medicamentos utiles en el tratamiento de la enfermedad de parkinson y un
TR200002481T2 (tr) Muskarinik Reseptör antegonistleri olarak 2-ariletil-(piperidin-4-ilmetil) amin türevleri

Legal Events

Date Code Title Description
FG Grant, registration