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AR001014A1 - Una molecula de dna aislada que codifica daunorubicina 14-hidroxilasa, dicha daunorubicina 14-hidroxilasa, procedimiento para producir dicho dna,vector que comprende dicho dna, celula huesped que contiene dicho vector, procedimiento para producir doxorubicina mediante dicha celula - Google Patents

Una molecula de dna aislada que codifica daunorubicina 14-hidroxilasa, dicha daunorubicina 14-hidroxilasa, procedimiento para producir dicho dna,vector que comprende dicho dna, celula huesped que contiene dicho vector, procedimiento para producir doxorubicina mediante dicha celula

Info

Publication number
AR001014A1
AR001014A1 ARP960101492A AR10149296A AR001014A1 AR 001014 A1 AR001014 A1 AR 001014A1 AR P960101492 A ARP960101492 A AR P960101492A AR 10149296 A AR10149296 A AR 10149296A AR 001014 A1 AR001014 A1 AR 001014A1
Authority
AR
Argentina
Prior art keywords
vector
daunorubicin
hydroxylase
dna
didiar
Prior art date
Application number
ARP960101492A
Other languages
English (en)
Original Assignee
Pharmacia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Spa filed Critical Pharmacia Spa
Publication of AR001014A1 publication Critical patent/AR001014A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La capacidad de convertir daunorubicina puede ser otorgada a una célula huésped por transformación con un vector recombinante que comprende DNA quecodifica la daunorubicina 14-hidroxilasa. La célula huésped puede ser usada luego paraproducir doxorubicina.
ARP960101492A 1995-02-27 1996-02-23 Una molecula de dna aislada que codifica daunorubicina 14-hidroxilasa, dicha daunorubicina 14-hidroxilasa, procedimiento para producir dicho dna,vector que comprende dicho dna, celula huesped que contiene dicho vector, procedimiento para producir doxorubicina mediante dicha celula AR001014A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/396,218 US5695966A (en) 1995-02-27 1995-02-27 DNA encoding daunorubicin 14-hyroxylase and method for preparing doxorubicin

Publications (1)

Publication Number Publication Date
AR001014A1 true AR001014A1 (es) 1997-08-27

Family

ID=23566340

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960101492A AR001014A1 (es) 1995-02-27 1996-02-23 Una molecula de dna aislada que codifica daunorubicina 14-hidroxilasa, dicha daunorubicina 14-hidroxilasa, procedimiento para producir dicho dna,vector que comprende dicho dna, celula huesped que contiene dicho vector, procedimiento para producir doxorubicina mediante dicha celula

Country Status (19)

Country Link
US (2) US5695966A (es)
EP (1) EP0763112B1 (es)
JP (1) JPH10505506A (es)
KR (1) KR100414999B1 (es)
CN (1) CN1118574C (es)
AR (1) AR001014A1 (es)
AT (1) ATE178653T1 (es)
AU (1) AU711706B2 (es)
CA (1) CA2188571A1 (es)
DE (1) DE69601993T2 (es)
ES (1) ES2132891T3 (es)
FI (1) FI112251B (es)
HU (1) HU220530B1 (es)
IL (1) IL117246A0 (es)
NO (1) NO964482L (es)
RU (1) RU2205222C2 (es)
TW (1) TW419521B (es)
WO (1) WO1996027014A1 (es)
ZA (1) ZA961555B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5695966A (en) * 1995-02-27 1997-12-09 Pharmacia & Upjohn S.P.A. DNA encoding daunorubicin 14-hyroxylase and method for preparing doxorubicin
US5976830A (en) * 1996-05-24 1999-11-02 The Ohio State University Research Foundation Methods of producing doxorubicin
GB2330144B (en) * 1997-03-06 2001-05-02 Pharmacia & Upjohn Spa Process for preparing doxorubicin
EP1071746A4 (en) * 1998-04-24 2003-04-23 Pharmacia Italia Spa METHOD FOR PRODUCING DOXORUBICIN
AU2004235346A1 (en) * 2003-04-25 2004-11-11 North Carolina State University Lactobacillus acidophilus nucleic acid sequences encoding cell surface protein homologues and uses therefore
WO2006111561A1 (en) * 2005-04-21 2006-10-26 Dsm Ip Assets B.V. Improved microbial production of anthracyclins
KR100629896B1 (ko) * 2005-04-28 2006-09-29 인하대학교 산학협력단 방선균 독소루비신 고생산 균주 및 독소루비신 생합성유전자군의 발현양상 분석을 위한 마이크로어레이칩
CN101016533B (zh) * 2005-11-09 2010-05-19 上海医药工业研究院 一种蒽环类抗生素产生工程菌及其应用
CN103087124B (zh) * 2012-11-21 2016-01-13 浙江海正药业股份有限公司 一种制备阿霉素的方法
CN104059892A (zh) * 2013-03-18 2014-09-24 江苏禾昌生物科技有限公司 柔红霉素c-14羟化酶突变体及其基因工程菌的生产方法
CN105861455B (zh) * 2016-05-16 2018-10-26 浙江海正药业股份有限公司 DoxA蛋白突变体及其编码基因与应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57159496A (en) * 1981-03-28 1982-10-01 Sanraku Inc Preparation of adriamycin
US5695966A (en) * 1995-02-27 1997-12-09 Pharmacia & Upjohn S.P.A. DNA encoding daunorubicin 14-hyroxylase and method for preparing doxorubicin
US5976830A (en) * 1996-05-24 1999-11-02 The Ohio State University Research Foundation Methods of producing doxorubicin

Also Published As

Publication number Publication date
ZA961555B (en) 1996-08-19
DE69601993D1 (de) 1999-05-12
KR970702922A (ko) 1997-06-10
CN1118574C (zh) 2003-08-20
HUP9603259A2 (en) 1997-05-28
IL117246A0 (en) 1996-06-18
AU4878496A (en) 1996-09-18
FI964229L (fi) 1996-10-21
HUP9603259A3 (en) 2000-04-28
EP0763112B1 (en) 1999-04-07
TW419521B (en) 2001-01-21
FI964229A0 (fi) 1996-10-21
AU711706B2 (en) 1999-10-21
ES2132891T3 (es) 1999-08-16
WO1996027014A1 (en) 1996-09-06
HU220530B1 (hu) 2002-03-28
DE69601993T2 (de) 1999-11-04
FI112251B (fi) 2003-11-14
CN1147835A (zh) 1997-04-16
RU2205222C2 (ru) 2003-05-27
CA2188571A1 (en) 1996-09-06
NO964482L (no) 1996-12-23
MX9605018A (es) 1998-05-31
US5695966A (en) 1997-12-09
KR100414999B1 (ko) 2004-04-28
NO964482D0 (no) 1996-10-22
EP0763112A1 (en) 1997-03-19
US5786190A (en) 1998-07-28
JPH10505506A (ja) 1998-06-02
ATE178653T1 (de) 1999-04-15

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