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MX9605018A - Proceso para la preparacion de doxorrubicina. - Google Patents

Proceso para la preparacion de doxorrubicina.

Info

Publication number
MX9605018A
MX9605018A MX9605018A MX9605018A MX9605018A MX 9605018 A MX9605018 A MX 9605018A MX 9605018 A MX9605018 A MX 9605018A MX 9605018 A MX9605018 A MX 9605018A MX 9605018 A MX9605018 A MX 9605018A
Authority
MX
Mexico
Prior art keywords
doxorubicin
host cell
daunorubicin
preparing doxorubicin
preparing
Prior art date
Application number
MX9605018A
Other languages
English (en)
Other versions
MXPA96005018A (es
Inventor
Augusto Solari Inventi
Umberto Breme
Anna Luisa Colombo
Charles Richard Hutchinson
Sharee Otten
Claudio Scotti
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Publication of MX9605018A publication Critical patent/MX9605018A/es
Publication of MXPA96005018A publication Critical patent/MXPA96005018A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La habilidad para convertir la daunorrubicina a doxorrubicina puede ser conferida a una célula huésped mediante transformacion con un vector recombinante que comprende ADN que codifica para la daunorrubicina -14-hidroxilasa. La célula huésped puede ser luego usada para producir doxorrubicina.
MXPA/A/1996/005018A 1995-02-27 1996-10-22 Proceso para la preparacion de doxorrubicina MXPA96005018A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08396218 1995-02-27
US08/396,218 US5695966A (en) 1995-02-27 1995-02-27 DNA encoding daunorubicin 14-hyroxylase and method for preparing doxorubicin
PCT/EP1996/000692 WO1996027014A1 (en) 1995-02-27 1996-02-20 Process for preparing doxorubicin

Publications (2)

Publication Number Publication Date
MX9605018A true MX9605018A (es) 1998-05-31
MXPA96005018A MXPA96005018A (es) 1998-10-23

Family

ID=

Also Published As

Publication number Publication date
TW419521B (en) 2001-01-21
HUP9603259A2 (en) 1997-05-28
KR100414999B1 (ko) 2004-04-28
EP0763112A1 (en) 1997-03-19
DE69601993D1 (de) 1999-05-12
CN1118574C (zh) 2003-08-20
CN1147835A (zh) 1997-04-16
WO1996027014A1 (en) 1996-09-06
EP0763112B1 (en) 1999-04-07
ATE178653T1 (de) 1999-04-15
IL117246A0 (en) 1996-06-18
KR970702922A (ko) 1997-06-10
RU2205222C2 (ru) 2003-05-27
AU711706B2 (en) 1999-10-21
AR001014A1 (es) 1997-08-27
FI964229A0 (fi) 1996-10-21
NO964482L (no) 1996-12-23
DE69601993T2 (de) 1999-11-04
FI964229L (fi) 1996-10-21
US5695966A (en) 1997-12-09
FI112251B (fi) 2003-11-14
JPH10505506A (ja) 1998-06-02
ZA961555B (en) 1996-08-19
NO964482D0 (no) 1996-10-22
HU220530B1 (hu) 2002-03-28
ES2132891T3 (es) 1999-08-16
CA2188571A1 (en) 1996-09-06
US5786190A (en) 1998-07-28
AU4878496A (en) 1996-09-18
HUP9603259A3 (en) 2000-04-28

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Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees