AR009274A1 - A PHARMACEUTICAL COMPOSITION THAT INCLUDES TROPNILPIPERAZINES AS DOPAMINE D4 RECEPTOR LINKS, COMPOUNDS, USES FOR THE PREPARATION OF MEDICINES AND PREPARATION PROCEDURE OF THE COMPOUNDS. - Google Patents
A PHARMACEUTICAL COMPOSITION THAT INCLUDES TROPNILPIPERAZINES AS DOPAMINE D4 RECEPTOR LINKS, COMPOUNDS, USES FOR THE PREPARATION OF MEDICINES AND PREPARATION PROCEDURE OF THE COMPOUNDS.Info
- Publication number
- AR009274A1 AR009274A1 ARP970103771A ARP970103771A AR009274A1 AR 009274 A1 AR009274 A1 AR 009274A1 AR P970103771 A ARP970103771 A AR P970103771A AR P970103771 A ARP970103771 A AR P970103771A AR 009274 A1 AR009274 A1 AR 009274A1
- Authority
- AR
- Argentina
- Prior art keywords
- compounds
- preparation
- phenyl
- 4alkoxy
- halo
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 239000003814 drug Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 102000003962 Dopamine D4 receptors Human genes 0.000 title 1
- 108090000357 Dopamine D4 receptors Proteins 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 5
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 3
- 125000001475 halogen functional group Chemical group 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- -1 C1-alkyl -4 Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000003762 3,4-dimethoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 125000000332 coumarinyl group Chemical group O1C(=O)C(=CC2=CC=CC=C12)* 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/38—[b, e]- or [b, f]-condensed with six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/66—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Abstract
Se describen aquí composiciones farmacéuticas que incluyen compuestos de la formula general (II), un estereoisomero, solvato o sal farmacéuticamenteaceptable del mismo, donde: R1 es H, halo, arilo o arilo sustituido con uno o dos grupos independientemente seleccionados entre halo, alquilo C1-4, alcoxiC1-4, nitro, trifluorometilo, trifluorometoxi o ciano; R5 es alquilo C4-9, fenilo o fenilo substituido con uno o dos grupos seleccionadosindependientemente entre OH, ciano, halo, alcoxi C1-4, alquilo C1-4, trifluorometilo, trifluorometoxi, nitro o fenilo, naftilo, fenilo fusionadoa un heterociclo de 5 o 6 miembros, el resto de cumarina (formula(III), donde R3 y R4 son independientemente seleccionados entre H, alquilo C1-4y alcoxiC1-4, o 1,2-metilendioxifenilo. Incluye nuevos compuestos con la condicion de que R5 no sea fenilo o 3,4-dimetoxifenilo cuando R1 es H. También se describesu uso para la preparacion de productos farmacéuticos para tratar indicaciones en la cuales está implicado el receptor D4, tales como la esquizofrenia y laansiedad y el procedimiento de preparacion de los nuevos compuestos.Pharmaceutical compositions are described herein including compounds of the general formula (II), a stereoisomer, solvate or pharmaceutically acceptable salt thereof, wherein: R1 is H, halo, aryl or aryl substituted with one or two groups independently selected from halo, C1-alkyl -4, C1-4alkoxy, nitro, trifluoromethyl, trifluoromethoxy or cyano; R5 is C4-9alkyl, phenyl or phenyl substituted with one or two groups selected independently from OH, cyano, halo, C1-4alkoxy, C1-4alkyl, trifluoromethyl, trifluoromethoxy, nitro or phenyl, naphthyl, phenyl fused to a heterocycle of 5 or 6-membered, the coumarin residue (formula (III), where R3 and R4 are independently selected from H, C1-4alkyl, and C1-4alkoxy, or 1,2-methylenedioxyphenyl. Includes new compounds provided that R5 is not phenyl or 3,4-dimethoxyphenyl when R1 is H. Its use for the preparation of pharmaceuticals to treat indications in which the D4 receptor is involved, such as schizophrenia and anxiety and the method of preparing the new compounds, is also described.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70137096A | 1996-08-22 | 1996-08-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR009274A1 true AR009274A1 (en) | 2000-04-12 |
Family
ID=24817086
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970103771A AR009274A1 (en) | 1996-08-22 | 1997-08-20 | A PHARMACEUTICAL COMPOSITION THAT INCLUDES TROPNILPIPERAZINES AS DOPAMINE D4 RECEPTOR LINKS, COMPOUNDS, USES FOR THE PREPARATION OF MEDICINES AND PREPARATION PROCEDURE OF THE COMPOUNDS. |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0929537A1 (en) |
| JP (1) | JP2000516629A (en) |
| KR (1) | KR20000068255A (en) |
| CN (1) | CN1227550A (en) |
| AR (1) | AR009274A1 (en) |
| AU (1) | AU3817197A (en) |
| BR (1) | BR9711965A (en) |
| CA (1) | CA2259515A1 (en) |
| HU (1) | HUP9903913A3 (en) |
| IL (1) | IL128629A0 (en) |
| NO (1) | NO990796L (en) |
| NZ (1) | NZ333519A (en) |
| WO (1) | WO1998007711A1 (en) |
| ZA (1) | ZA977445B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100394083B1 (en) * | 2000-12-04 | 2003-08-06 | 학교법인 성신학원 | Novel 4,5-dihydroisoxazolylalkylpiperazine derivatives having selective biological activity at dopamine D3 and D4 receptors, and preparation thereof |
| KR100394086B1 (en) * | 2000-12-04 | 2003-08-06 | 한국과학기술연구원 | Novel isoxazolylalkylpiperazine derivatives having selective biological activity at dopamine D3 and D4 receptors, and preparation thereof |
| US6890919B2 (en) | 2001-06-26 | 2005-05-10 | Shitij Kapur | Atypical antipsychotic agents having low affinity for the D2 receptor |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1153764A (en) * | 1980-02-25 | 1983-09-13 | Jehan F. Bagli | 2-(1-piperazinyl)-2,4,6-cycloheptatrien-1-one derivatives |
| EP0546102B1 (en) * | 1990-08-29 | 1997-10-15 | PHARMACIA & UPJOHN COMPANY | Tropolone derivatives and pharmaceutical composition thereof for preventing and treating ischemic diseases |
| EP0558245A1 (en) * | 1992-02-25 | 1993-09-01 | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY | Heterobicyclic compounds as antagogists of alpha-1 adrenergic and SHT1A receptors |
| US5541179A (en) * | 1995-05-02 | 1996-07-30 | American Home Products Corporation | Tropon-2-one piperazine carboxamides as serotonergic agents |
-
1997
- 1997-07-30 HU HU9903913A patent/HUP9903913A3/en unknown
- 1997-07-30 IL IL12862997A patent/IL128629A0/en unknown
- 1997-07-30 KR KR1019997001390A patent/KR20000068255A/en not_active Withdrawn
- 1997-07-30 NZ NZ333519A patent/NZ333519A/en unknown
- 1997-07-30 EP EP97935166A patent/EP0929537A1/en not_active Withdrawn
- 1997-07-30 CN CN97197238A patent/CN1227550A/en active Pending
- 1997-07-30 BR BR9711965A patent/BR9711965A/en not_active Application Discontinuation
- 1997-07-30 AU AU38171/97A patent/AU3817197A/en not_active Abandoned
- 1997-07-30 CA CA002259515A patent/CA2259515A1/en not_active Abandoned
- 1997-07-30 WO PCT/US1997/013264 patent/WO1998007711A1/en not_active Ceased
- 1997-07-30 JP JP10510754A patent/JP2000516629A/en active Pending
- 1997-08-19 ZA ZA9707445A patent/ZA977445B/en unknown
- 1997-08-20 AR ARP970103771A patent/AR009274A1/en unknown
-
1999
- 1999-02-19 NO NO990796A patent/NO990796L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO990796D0 (en) | 1999-02-19 |
| AU3817197A (en) | 1998-03-06 |
| ZA977445B (en) | 1998-02-23 |
| IL128629A0 (en) | 2000-01-31 |
| HUP9903913A3 (en) | 2000-11-28 |
| EP0929537A1 (en) | 1999-07-21 |
| NO990796L (en) | 1999-02-19 |
| CN1227550A (en) | 1999-09-01 |
| JP2000516629A (en) | 2000-12-12 |
| NZ333519A (en) | 1999-10-28 |
| CA2259515A1 (en) | 1998-02-26 |
| KR20000068255A (en) | 2000-11-25 |
| HUP9903913A2 (en) | 2000-09-28 |
| BR9711965A (en) | 1999-08-24 |
| WO1998007711A1 (en) | 1998-02-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUP9700779A1 (en) | Estrogenic agents, process for producing them, pharmaceutical compositions containing them and their use | |
| ES2064310T3 (en) | PROCEDURE FOR PREPARING IMIDAZOPYRIDINE COMPOUNDS. | |
| ES2094721T3 (en) | ANALOGS OF THE CAMPTOTECINE SOLUBLE IN WATER. | |
| ES2100151T3 (en) | NEW BENZOPYRAN DERIVATIVES, PROCEDURES FOR THEIR PREPARATION AND USE AND COMPOSITIONS CONTAINING THE COMPOUNDS. | |
| MX9300498A (en) | DERIVATIVES OF N-SULFONIL-2-OXO-INDOL, PROCEDURE FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM. | |
| ES8103744A1 (en) | A METHOD FOR THE PREPARATION OF PHTHALIMIDINE DERIVATIVES | |
| ES2169248T3 (en) | AROMATIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM. | |
| MX9201356A (en) | DERIVATIVES OF PIPERIDINE, PROCEDURE FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITION THAT CONTAINS THEM. | |
| AR008291A1 (en) | TETRAHYDROISOQUINOLINE DERIVATIVES, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE FOR THE PREPARATION OF A MEDICINAL PRODUCT. | |
| AR002711A1 (en) | A COMPOUND OF 2-CARBOXINDOL-3-SUBSTITUTED, A PROCESS FOR ITS PREPARATION, A NEW INTERMEDIATE COMPOUND FOR SUCH PROCESS, THE USE OF THE COMPOUND FOR THE MANUFACTURE OF A THERAPEUTIC AGENT AND A PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH A COMPOUND. | |
| ES2038630T3 (en) | A PROCEDURE FOR PREPARING A PHENOXYACETIC ACID COMPOUND. | |
| ES2188743T3 (en) | PIRROLIDINYL HYDROXAMIC ACID COMPOUNDS AND PRODUCTION PROCEDURE OF THE SAME. | |
| PE20021018A1 (en) | DERIVATIVES OF ß - CARBOLINE | |
| ES2106936T3 (en) | CARBAZOLONE DERIVATIVES AND PROCEDURES FOR ITS PREPARATION. | |
| AR012157A1 (en) | DERIVATIVES OF PIRIDINE, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND PROCEDURE FOR THE PREPARATION OF SUCH DERIVATIVES. | |
| DK441180A (en) | 2-HYDROXYALKYL-3,4,5-TRIHYDROXYPIPERIDINES THEIR PREPARATION AND USE | |
| FI844333A0 (en) | 11-SUBSTITUERADE 5H, 11H-PYRROLO / 2,1-C / / 1,4 / BENZOXAZEPINER, FOERFARANDE FOER DERAS FRAMSTAELLNING OCH DERAS ANVAENDNING SOM LAEKEMEDEL. | |
| ES2090024T3 (en) | CEFEMO COMPOUNDS AND PROCEDURES FOR ITS PREPARATION. | |
| ES2063117T3 (en) | DERIVATIVES OF TIENO (2,3-D) ACCEPT, PROCEDURE FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM. | |
| ES2133686T3 (en) | NEW BENZOPYRAN DERIVATIVES, THEIR PREPARATION PROCEDURE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. | |
| AR009274A1 (en) | A PHARMACEUTICAL COMPOSITION THAT INCLUDES TROPNILPIPERAZINES AS DOPAMINE D4 RECEPTOR LINKS, COMPOUNDS, USES FOR THE PREPARATION OF MEDICINES AND PREPARATION PROCEDURE OF THE COMPOUNDS. | |
| DK420682A (en) | PROCEDURE FOR THE PREPARATION OF TRIAZOLOQUINAZOLONS OR SALTS THEREOF | |
| ES2183492T3 (en) | NEW NITRON DERIVATIVES, THEIR PREPARATION PROCEDURE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. | |
| ECSP045489A (en) | AMIDES OF 2-HETEROARILCARBOXILIC ACIDS | |
| ES2063771T3 (en) | NEW AMIDA DERIVATIVES OF THE ACID 4-OXO-4H-PIRIDO (1,2-A) PIRIMIDIN-3-CARBOXILICOS, THEIR PREPARATION AND ELABORATION OF MEDICINES CONTAINING THESE COMPOUNDS, AS WELL AS THE PREPARATION OF THE SAME. |