AR008371A1 - Una sal de adicion con acido de una 10-aminoalifatil-dibenz[b,f],oxepina, su empleo; procedimiento para su elaboracion, una 10-aminoalifatil-dibenz[b,f]oxepina, una preparacion farmaceutica que contiene dicha sal o dicha oxepina y un procedimiento para el tratamiento de enfermedades neurodegenerativ - Google Patents
Una sal de adicion con acido de una 10-aminoalifatil-dibenz[b,f],oxepina, su empleo; procedimiento para su elaboracion, una 10-aminoalifatil-dibenz[b,f]oxepina, una preparacion farmaceutica que contiene dicha sal o dicha oxepina y un procedimiento para el tratamiento de enfermedades neurodegenerativInfo
- Publication number
- AR008371A1 AR008371A1 ARP970102247A ARP970102247A AR008371A1 AR 008371 A1 AR008371 A1 AR 008371A1 AR P970102247 A ARP970102247 A AR P970102247A AR P970102247 A ARP970102247 A AR P970102247A AR 008371 A1 AR008371 A1 AR 008371A1
- Authority
- AR
- Argentina
- Prior art keywords
- oxepine
- dibenz
- procedure
- aminoalifatil
- salts
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 7
- 238000000034 method Methods 0.000 title abstract 4
- 208000015122 neurodegenerative disease Diseases 0.000 title abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 title abstract 2
- ATYBXHSAIOKLMG-UHFFFAOYSA-N oxepin Chemical compound O1C=CC=CC=C1 ATYBXHSAIOKLMG-UHFFFAOYSA-N 0.000 title 3
- 239000002253 acid Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000013543 active substance Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000002555 anti-neurodegenerative effect Effects 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 150000002920 oxepines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D313/14—[b,f]-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Se refiere a sales de adicion con ácidos de 10-aminoalifatil-dibenz[b,f] oxepina de la formula (I), en la que alk es un radical alifático bivalente, Res un grupo amino insubstituido, monosubstituido o disubstituido por radicales alifáticos y/o aralifáticos monovalentes o bien disubstituido por radicalesalifáticos o aralifáticos bivalentes y R1, R2, R3 y R4 independientemente entre ellos denotan hidrogeno, alquilo inferior, alcoxi inferior, halogeno otrifluorometilo, con ácidos carboxílicos orgánicos. Dichas sales pueden ser utilizadas como substancias activas para medicinas antineurodegenerativas.También se refiere a los nuevos compuestos de la formula (I) en su forma libre, al empleo de dichas sales, a un procedimiento para elaborarlas, apreparaciones farmacéuticas que contienen dichas sales o compuestos de formula (I) en su forma libre y a un procedimiento para el tratamiento deenfermedades neurodegenerativas mediante dichas sales o compuestos de formula (I) en suforma libre.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH135296 | 1996-05-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR008371A1 true AR008371A1 (es) | 2000-01-19 |
Family
ID=4208469
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970102247A AR008371A1 (es) | 1996-05-30 | 1997-05-27 | Una sal de adicion con acido de una 10-aminoalifatil-dibenz[b,f],oxepina, su empleo; procedimiento para su elaboracion, una 10-aminoalifatil-dibenz[b,f]oxepina, una preparacion farmaceutica que contiene dicha sal o dicha oxepina y un procedimiento para el tratamiento de enfermedades neurodegenerativ |
Country Status (10)
| Country | Link |
|---|---|
| AR (1) | AR008371A1 (es) |
| AU (1) | AU3030397A (es) |
| CO (1) | CO5080765A1 (es) |
| CZ (1) | CZ296134B6 (es) |
| ID (1) | ID18178A (es) |
| PE (1) | PE70398A1 (es) |
| PL (1) | PL191728B1 (es) |
| TR (1) | TR199802482T2 (es) |
| WO (1) | WO1997045422A1 (es) |
| ZA (1) | ZA974802B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20020016812A (ko) * | 1999-06-03 | 2002-03-06 | 구니이 야스오 | 트리시클릭 융합 헤테로사이클 화합물, 상기물의 제조방법 및 그의 용도 |
| US7355042B2 (en) | 2001-10-16 | 2008-04-08 | Hypnion, Inc. | Treatment of CNS disorders using CNS target modulators |
| WO2003057204A2 (en) * | 2002-01-08 | 2003-07-17 | Nordic Bioscience A/S | Modulation of iamt (pimt or pcmt) in immune system |
| WO2004066993A1 (en) * | 2003-01-29 | 2004-08-12 | Novartis Ag | Use of 10-aminoaliphatyl-dibenz[b,f]oxepines for the treatment of degenerative ocular disorders |
| AR046320A1 (es) * | 2003-11-06 | 2005-11-30 | Novartis Ag | Composiciones farmaceuticas estabilizadas de dibenzo-oxepina. |
| US20060063755A1 (en) | 2004-09-21 | 2006-03-23 | Edgar Dale M | Loxapine analogs and methods of use thereof |
| US7563785B2 (en) | 2004-10-29 | 2009-07-21 | Hypnion, Inc. | Quetiapine analogs and methods of use thereof |
| EP1757284A1 (en) | 2005-08-25 | 2007-02-28 | Santhera Pharmaceuticals (Schweiz) AG | Use of N-(dibenz(b,f)oxepin-10ylmethyl)-N-methyl-N-prop-2-ynylamine (omigapil) for the prophylaxis and/or treatment of muscular dystrophy |
| EP1842539A1 (en) | 2006-04-05 | 2007-10-10 | Santhera Pharmaceuticals (Schweiz) AG | Use of N- (dibenz(b,f)oxepin-10-ylmethyl)N-methyl-N-prop-2-ynylamine (omigapil) for the prophylaxis and/or treatment of congenital muscular dystrophy or myopathy resulting from collagen VI deficiency |
| WO2014120885A1 (en) | 2013-01-30 | 2014-08-07 | The Johns Hopkins University | Treatment of drug abuse by preventing gapdh nitrosylation |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3100207A (en) * | 1959-07-08 | 1963-08-06 | Smith Kline French Lab | 10-aminoalkylbenzo[b,f]thiepin and -dibenz[b,f]oxepin derivatives |
| DE1493782B1 (de) * | 1964-06-29 | 1969-12-11 | Geigy Ag J R | Basisch substituierte Dibenzo[b,f]-oxepine und deren nicht-toxische Salze |
| CH585746A5 (es) * | 1973-06-08 | 1977-03-15 | Hoffmann La Roche | |
| DE59607332D1 (de) * | 1995-02-08 | 2001-08-30 | Novartis Ag | Antineurodegenerativ wirksame 10-Aminoaliphatyl-dibenz- b,f oxepine |
-
1997
- 1997-05-27 AR ARP970102247A patent/AR008371A1/es unknown
- 1997-05-28 PE PE1997000433A patent/PE70398A1/es not_active IP Right Cessation
- 1997-05-28 TR TR1998/02482T patent/TR199802482T2/xx unknown
- 1997-05-28 AU AU30303/97A patent/AU3030397A/en not_active Abandoned
- 1997-05-28 WO PCT/EP1997/002794 patent/WO1997045422A1/en not_active Ceased
- 1997-05-28 CZ CZ0387898A patent/CZ296134B6/cs not_active IP Right Cessation
- 1997-05-28 PL PL330238A patent/PL191728B1/pl unknown
- 1997-05-29 CO CO97029926A patent/CO5080765A1/es unknown
- 1997-05-30 ID IDP971845A patent/ID18178A/id unknown
- 1997-05-30 ZA ZA974802A patent/ZA974802B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997045422A1 (en) | 1997-12-04 |
| CO5080765A1 (es) | 2001-09-25 |
| AU3030397A (en) | 1998-01-05 |
| PE70398A1 (es) | 1998-11-09 |
| CZ387898A3 (cs) | 1999-02-17 |
| ID18178A (id) | 1998-03-12 |
| CZ296134B6 (cs) | 2006-01-11 |
| PL330238A1 (en) | 1999-05-10 |
| PL191728B1 (pl) | 2006-06-30 |
| TR199802482T2 (xx) | 1999-02-22 |
| ZA974802B (en) | 1998-11-30 |
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