AR007060A1 - Inhibidores de la formacion de la cd23 humana soluble, el uso de los mismos una composicion farmaceutica que los comprende, un metodo para preparar dichosinhibidores y compuestos intermediarios - Google Patents
Inhibidores de la formacion de la cd23 humana soluble, el uso de los mismos una composicion farmaceutica que los comprende, un metodo para preparar dichosinhibidores y compuestos intermediariosInfo
- Publication number
- AR007060A1 AR007060A1 ARP970101926A ARP970101926A AR007060A1 AR 007060 A1 AR007060 A1 AR 007060A1 AR P970101926 A ARP970101926 A AR P970101926A AR P970101926 A ARP970101926 A AR P970101926A AR 007060 A1 AR007060 A1 AR 007060A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- inhibitors
- aryl
- alkenyl
- alkoxy
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 101000878605 Homo sapiens Low affinity immunoglobulin epsilon Fc receptor Proteins 0.000 title abstract 2
- 102100038007 Low affinity immunoglobulin epsilon Fc receptor Human genes 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- -1 hydroxy, nitro, amino Chemical group 0.000 abstract 3
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000005115 alkyl carbamoyl group Chemical group 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004415 heterocyclylalkyl group Chemical group 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000004923 naphthylmethyl group Chemical group C1(=CC=CC2=CC=CC=C12)C* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Quinoline Compounds (AREA)
- Furan Compounds (AREA)
Abstract
Inhibidores de la formación de CD23 humana soluble de la fórmula (I) en la que : R es hidroxi, hidrógeno, alquilo, alquenilo, alquinilo o arilo; R1 esarilmetilo o heterociclilmetilo; R2 es alquilo, alquenilo, arilo cicloalquilo o cicloalquenilo; yR 3 es hidrógeno, alquilo, alquenilo, alquinilo o arilo con lacondición de que: si R1 es fenilmetilo o naftilmetilo, en que el grupo fenilo o naftilo está sin sustituir o sustituido hasta con cinco sustituyentesseleccionados del grupo que consisteen halógeno, alquilo (C1-6) aril-alquilo (C1-6), alcoxi (C1-6)m alcoxi (C1-6)-alquilo (C1-6), halo-alquilo (C1-6),hidroxi, nitro, amino, mono- y di-N-alquil (C1-6)-amino, acilamino, aciloxi carboxi, sales de carboxi, ésteres de carboxi,carbamoíl o, mono y di-N-alquil(C1-6)-carbamoílo, alcoxi (C1-6)-carbonilo, ariloxi-carbonilo, ureído, guanidino, sulfonilamino, aminosulfonilo, alquil(C1-6)-tio, alquil(C1-6)-sulfinilo, alquilo (C1-6)-sulfonilo, heterociclilo,heterociclilalquilo (C1- 6), y una cadena alquileno (C3-5) que enlaza a dos átomos de carbono de anillosadyacentes para formar un anillo carbocíclico; entonces R es hidróxi; son útiles en el tratamiento de trastornos mediados por s-CD23. Sedescribe ademásel uso de los mismos, una compocisión farmacéutica que los contiene, un método para la preparación de dichos inhibidores, un compuesto de fórmula (II) y uncompuesto de fórmula (IV).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9609794.4A GB9609794D0 (en) | 1996-05-10 | 1996-05-10 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR007060A1 true AR007060A1 (es) | 1999-10-13 |
Family
ID=10793494
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970101926A AR007060A1 (es) | 1996-05-10 | 1997-05-08 | Inhibidores de la formacion de la cd23 humana soluble, el uso de los mismos una composicion farmaceutica que los comprende, un metodo para preparar dichosinhibidores y compuestos intermediarios |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6235753B1 (es) |
| EP (1) | EP0918747B1 (es) |
| JP (1) | JP2000510473A (es) |
| KR (1) | KR20000010892A (es) |
| AR (1) | AR007060A1 (es) |
| AT (1) | ATE246673T1 (es) |
| AU (1) | AU2897397A (es) |
| BR (1) | BR9709450A (es) |
| CA (1) | CA2253590A1 (es) |
| CO (1) | CO4990945A1 (es) |
| CZ (1) | CZ363198A3 (es) |
| DE (1) | DE69723984T2 (es) |
| ES (1) | ES2205218T3 (es) |
| GB (1) | GB9609794D0 (es) |
| IL (1) | IL126860A0 (es) |
| NO (1) | NO985214L (es) |
| NZ (1) | NZ332628A (es) |
| PL (1) | PL329855A1 (es) |
| TR (1) | TR199802271T2 (es) |
| WO (1) | WO1997043249A1 (es) |
| ZA (1) | ZA973964B (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020082200A1 (en) * | 1994-07-13 | 2002-06-27 | Smithkline Beecham P.1.C. | Use of inhibitors of human S-CD23 |
| US6548084B2 (en) | 1995-07-20 | 2003-04-15 | Smithkline Beecham Plc | Controlled release compositions |
| AUPO721997A0 (en) * | 1997-06-06 | 1997-07-03 | Queensland Institute Of Medical Research, The | Anticancer compounds |
| DE69828638T2 (de) | 1997-11-12 | 2005-12-01 | Darwin Discovery Ltd., Slough | Hydroxam- und carbonsäurederivate mit mmp- und tnf-hemmender aktivität |
| GB9813451D0 (en) * | 1998-06-22 | 1998-08-19 | Smithkline Beecham Plc | Novel compounds |
| GB9922825D0 (en) * | 1999-09-25 | 1999-11-24 | Smithkline Beecham Biolog | Medical use |
| KR20070053362A (ko) | 1999-11-23 | 2007-05-23 | 메틸진, 인크. | 히스톤 디아세틸라제의 억제제 |
| GB9930754D0 (en) * | 1999-12-29 | 2000-02-16 | Smithkline Beecham Plc | Novel compounds |
| CA2516842A1 (en) | 2003-02-25 | 2004-09-10 | Topotarget Uk Limited | Hydroxamic acid compounds comprising a bicylic heteroaryl group as hdac inhibitors |
| GB0818907D0 (en) * | 2008-10-15 | 2008-11-19 | Isis Innovation | Histone lysine demethylase inhibitors |
| JP5420761B2 (ja) | 2009-05-28 | 2014-02-19 | ノバルティス アーゲー | ネプリリシン阻害剤としての置換アミノプロピオン酸誘導体 |
| MX2011012627A (es) | 2009-05-28 | 2011-12-14 | Novartis Ag | Derivados aminobutiricos sustituidos como inhibidores de nepralisina. |
| EP2507266B1 (en) | 2009-12-01 | 2015-02-18 | Boston Medical Center Corporation | TREATMENT OF IgE-MEDIATED DISEASE |
| KR20150119107A (ko) | 2013-02-14 | 2015-10-23 | 노파르티스 아게 | 개선된 생체내 효능을 갖는 nep 억제제로서의 치환된 비스페닐 부탄산 유도체 |
| PE20151666A1 (es) | 2013-02-14 | 2015-11-19 | Novartis Ag | Derivados sustituidos del acido bisfenil butanoico fosfonico como inhibidores de la nep |
| BR112017010474A2 (pt) * | 2014-11-19 | 2017-12-26 | Actelion Pharmaceuticals Ltd | derivados antibacterianos de benzotiazol |
| BR112021006407A8 (pt) | 2018-10-04 | 2022-12-06 | Inst Nat Sante Rech Med | uso de inibidores do egfr para ceratodermas |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9215665D0 (en) * | 1992-07-23 | 1992-09-09 | British Bio Technology | Compounds |
| EP0740652B1 (en) * | 1994-01-20 | 1998-05-06 | British Biotech Pharmaceuticals Limited | Metalloproteinase inhibitors |
| GB9414157D0 (en) * | 1994-07-13 | 1994-08-31 | Smithkline Beecham Plc | Medical use |
| US5562917A (en) | 1994-12-23 | 1996-10-08 | Pentech Pharmaceuticals, Inc. | Transdermal administration of apomorphine |
| DE19506492C2 (de) | 1995-02-24 | 2003-05-08 | Focke & Co | Einrichtung zum Speichern von Zigaretten oder dergleichen |
| US5570079A (en) | 1995-04-24 | 1996-10-29 | Dockery; Devan | Home security system for detecting an intrusion into a monitored area by an infrared detector |
-
1996
- 1996-05-10 GB GBGB9609794.4A patent/GB9609794D0/en active Pending
-
1997
- 1997-05-06 WO PCT/EP1997/002433 patent/WO1997043249A1/en not_active Ceased
- 1997-05-06 KR KR1019980709039A patent/KR20000010892A/ko not_active Withdrawn
- 1997-05-06 BR BR9709450A patent/BR9709450A/pt not_active Application Discontinuation
- 1997-05-06 JP JP09540514A patent/JP2000510473A/ja not_active Ceased
- 1997-05-06 EP EP97923064A patent/EP0918747B1/en not_active Expired - Lifetime
- 1997-05-06 AT AT97923064T patent/ATE246673T1/de not_active IP Right Cessation
- 1997-05-06 TR TR1998/02271T patent/TR199802271T2/xx unknown
- 1997-05-06 US US09/180,547 patent/US6235753B1/en not_active Expired - Fee Related
- 1997-05-06 DE DE69723984T patent/DE69723984T2/de not_active Expired - Fee Related
- 1997-05-06 ES ES97923064T patent/ES2205218T3/es not_active Expired - Lifetime
- 1997-05-06 CA CA002253590A patent/CA2253590A1/en not_active Abandoned
- 1997-05-06 IL IL12686097A patent/IL126860A0/xx unknown
- 1997-05-06 NZ NZ332628A patent/NZ332628A/en unknown
- 1997-05-06 PL PL97329855A patent/PL329855A1/xx unknown
- 1997-05-06 AU AU28973/97A patent/AU2897397A/en not_active Abandoned
- 1997-05-06 CZ CZ983631A patent/CZ363198A3/cs unknown
- 1997-05-08 AR ARP970101926A patent/AR007060A1/es not_active Application Discontinuation
- 1997-05-08 ZA ZA973964A patent/ZA973964B/xx unknown
- 1997-05-09 CO CO97025078A patent/CO4990945A1/es unknown
-
1998
- 1998-11-09 NO NO985214A patent/NO985214L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| GB9609794D0 (en) | 1996-07-17 |
| EP0918747A1 (en) | 1999-06-02 |
| KR20000010892A (ko) | 2000-02-25 |
| NO985214L (no) | 1998-12-01 |
| AU2897397A (en) | 1997-12-05 |
| DE69723984D1 (de) | 2003-09-11 |
| EP0918747B1 (en) | 2003-08-06 |
| JP2000510473A (ja) | 2000-08-15 |
| ES2205218T3 (es) | 2004-05-01 |
| WO1997043249A1 (en) | 1997-11-20 |
| BR9709450A (pt) | 1999-08-10 |
| DE69723984T2 (de) | 2004-06-09 |
| ATE246673T1 (de) | 2003-08-15 |
| CO4990945A1 (es) | 2000-12-26 |
| IL126860A0 (en) | 1999-09-22 |
| NO985214D0 (no) | 1998-11-09 |
| CZ363198A3 (cs) | 1999-06-16 |
| ZA973964B (en) | 1998-11-09 |
| US6235753B1 (en) | 2001-05-22 |
| NZ332628A (en) | 2000-06-23 |
| PL329855A1 (en) | 1999-04-12 |
| TR199802271T2 (xx) | 2000-08-21 |
| CA2253590A1 (en) | 1997-11-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |