AR006108A1 - Pirimido[5,4-d]pirimidinas, sus sales fisiologicamente compatibles, un procedimiento para su preparacion, su empleo para la preparacion de composiciones farmaceuticas, y las composiciones farmaceuticas que las contienen - Google Patents
Pirimido[5,4-d]pirimidinas, sus sales fisiologicamente compatibles, un procedimiento para su preparacion, su empleo para la preparacion de composiciones farmaceuticas, y las composiciones farmaceuticas que las contienenInfo
- Publication number
- AR006108A1 AR006108A1 ARP970100873A ARP970100873A AR006108A1 AR 006108 A1 AR006108 A1 AR 006108A1 AR P970100873 A ARP970100873 A AR P970100873A AR P970100873 A ARP970100873 A AR P970100873A AR 006108 A1 AR006108 A1 AR 006108A1
- Authority
- AR
- Argentina
- Prior art keywords
- preparation
- pharmaceutical compositions
- pyrimidines
- formula
- physiologically compatible
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 150000003230 pyrimidines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- JOZPEVMCAKXSEY-UHFFFAOYSA-N pyrimido[5,4-d]pyrimidine Chemical class N1=CN=CC2=NC=NC=C21 JOZPEVMCAKXSEY-UHFFFAOYSA-N 0.000 abstract 1
- 230000019491 signal transduction Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Pirimido[5,4-d]pirimidinas de la fórmula general (I). A sus tautómeros, sus esteroisómeros y sus sales, en particular sus sales fisiológicamentecompatibles con ácidos o bases inorgánicos u orgánicos, que presente valiosas propiedadesfarmacológ icas, en particular un efecto inhibidor sobre latransducción de senales inducida por tirosinquinasas, a su empleo para el tratamiento de enfermedades, en particular, enfermedades tumorales. Seformula también un procedimiento para lapreparación de estos compuestos, que comprende un compuesto de la fórmula (II). Se hace reaccionar con una aminade la fórmula H-RaHRb; composiciones farmacéuticas que contienen estos compuestos y un procedimiento para preparar estascomposiciones, do nde uncompuesto de la fórmula (I) se incorpora en una o varias sustancias de soporte y/o agentes diluyentes inertes por vía no química.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19608588A DE19608588A1 (de) | 1996-03-06 | 1996-03-06 | Pyrimido [5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR006108A1 true AR006108A1 (es) | 1999-08-11 |
Family
ID=7787345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970100873A AR006108A1 (es) | 1996-03-06 | 1997-03-05 | Pirimido[5,4-d]pirimidinas, sus sales fisiologicamente compatibles, un procedimiento para su preparacion, su empleo para la preparacion de composiciones farmaceuticas, y las composiciones farmaceuticas que las contienen |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US5821240A (es) |
| EP (1) | EP0888351B1 (es) |
| JP (1) | JP2000506151A (es) |
| KR (1) | KR19990087504A (es) |
| CN (1) | CN1064362C (es) |
| AR (1) | AR006108A1 (es) |
| AT (1) | ATE252101T1 (es) |
| AU (1) | AU730376B2 (es) |
| BG (1) | BG63163B1 (es) |
| BR (1) | BR9707839A (es) |
| CA (1) | CA2248720A1 (es) |
| CO (1) | CO4650043A1 (es) |
| CZ (1) | CZ281598A3 (es) |
| DE (2) | DE19608588A1 (es) |
| EE (1) | EE9800278A (es) |
| HU (1) | HUP9902049A3 (es) |
| IL (1) | IL125342A0 (es) |
| MX (1) | MX9807073A (es) |
| NO (1) | NO311522B1 (es) |
| NZ (1) | NZ331545A (es) |
| PL (1) | PL328719A1 (es) |
| RU (1) | RU2195461C2 (es) |
| SK (1) | SK120898A3 (es) |
| TR (1) | TR199801755T2 (es) |
| TW (1) | TW454008B (es) |
| UA (1) | UA54421C2 (es) |
| UY (1) | UY24474A1 (es) |
| WO (1) | WO1997032880A1 (es) |
| ZA (1) | ZA971887B (es) |
Families Citing this family (116)
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| AU719327B2 (en) | 1996-03-05 | 2000-05-04 | Astrazeneca Ab | 4-anilinoquinazoline derivatives |
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| JP3270834B2 (ja) * | 1999-01-27 | 2002-04-02 | ファイザー・プロダクツ・インク | 抗がん剤として有用なヘテロ芳香族二環式誘導体 |
| PL203782B1 (pl) | 1999-11-05 | 2009-11-30 | Astrazeneca Ab | Pochodne chinazoliny,sposoby ich wytwarzania,ich kompozycje farmaceutyczne oraz ich zastosowania |
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| DE10115921A1 (de) | 2001-03-30 | 2002-10-02 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung von 4,6-Diaminopyrimido[5,4-d]pyrimidinen |
| EP1300146A1 (en) * | 2001-10-03 | 2003-04-09 | Boehringer Ingelheim International GmbH | Pharmaceutical composition for the treatment of animal mammary tumors |
| EP1460061A4 (en) * | 2001-12-27 | 2006-05-31 | Toray Finechemicals Co Ltd | PROCESS FOR PRODUCING 1-ALCOXYCARBONYL SATURATED NITROGENIC HETEROCYCLIC DERIVATIVE |
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| BRPI0415395A (pt) * | 2003-10-15 | 2006-12-12 | Osi Pharm Inc | composto, métodos para inibir a atividade da proteìna quinase e para tratar um paciente que tenha uma condição que seja mediada pela atividade da proteìna quinase, e, composição |
| WO2005058913A1 (en) * | 2003-12-18 | 2005-06-30 | Janssen Pharmaceutica N.V. | Pyrido- and pyrimidopyrimidine derivatives as anti- proliferative agents |
| JO3088B1 (ar) * | 2004-12-08 | 2017-03-15 | Janssen Pharmaceutica Nv | مشتقات كوينازولين كبيرة الحلقات و استعمالها بصفتها موانع كينيز متعددة الاهداف |
| NI200700147A (es) | 2004-12-08 | 2019-05-10 | Janssen Pharmaceutica Nv | Derivados de quinazolina inhibidores de cinasas dirigidos a multip |
| KR101139038B1 (ko) | 2005-06-28 | 2012-05-02 | 삼성전자주식회사 | 피리미도피리미딘 유도체 및 이를 이용한 유기 박막 트랜지스터 |
| ES2569428T3 (es) | 2006-07-13 | 2016-05-10 | Janssen Pharmaceutica Nv | Derivados de quinazolina como MTKI |
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Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3049207A1 (de) * | 1980-12-27 | 1982-07-29 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue trisubstituierte pyrimido (5,4-d) pyrimidine, ihre herstellung und ihre verwendung als arzneimittel |
| DE4325900A1 (de) * | 1993-08-02 | 1995-02-09 | Thomae Gmbh Dr K | Trisubstituierte Pyrimido [5,4-d] pyrimidine zur Modulation der Multidrugresistenz, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| TW414798B (en) * | 1994-09-07 | 2000-12-11 | Thomae Gmbh Dr K | Pyrimido (5,4-d) pyrimidines, medicaments comprising these compounds, their use and processes for their preparation |
| DE4431867A1 (de) * | 1994-09-07 | 1996-03-14 | Thomae Gmbh Dr K | Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
-
1996
- 1996-03-06 DE DE19608588A patent/DE19608588A1/de not_active Ceased
-
1997
- 1997-02-28 UY UY24474A patent/UY24474A1/es not_active Application Discontinuation
- 1997-03-03 AU AU20945/97A patent/AU730376B2/en not_active Ceased
- 1997-03-03 BR BR9707839A patent/BR9707839A/pt not_active Application Discontinuation
- 1997-03-03 TR TR1998/01755T patent/TR199801755T2/xx unknown
- 1997-03-03 UA UA98105276A patent/UA54421C2/uk unknown
- 1997-03-03 RU RU98118380/04A patent/RU2195461C2/ru not_active IP Right Cessation
- 1997-03-03 NZ NZ331545A patent/NZ331545A/xx unknown
- 1997-03-03 CN CN97192784A patent/CN1064362C/zh not_active Expired - Fee Related
- 1997-03-03 SK SK1208-98A patent/SK120898A3/sk unknown
- 1997-03-03 DE DE59710864T patent/DE59710864D1/de not_active Expired - Fee Related
- 1997-03-03 CA CA002248720A patent/CA2248720A1/en not_active Abandoned
- 1997-03-03 HU HU9902049A patent/HUP9902049A3/hu not_active Application Discontinuation
- 1997-03-03 PL PL97328719A patent/PL328719A1/xx unknown
- 1997-03-03 EE EE9800278A patent/EE9800278A/xx unknown
- 1997-03-03 IL IL12534297A patent/IL125342A0/xx unknown
- 1997-03-03 AT AT97906152T patent/ATE252101T1/de not_active IP Right Cessation
- 1997-03-03 CZ CZ982815A patent/CZ281598A3/cs unknown
- 1997-03-03 KR KR1019980706935A patent/KR19990087504A/ko not_active Ceased
- 1997-03-03 WO PCT/EP1997/001047 patent/WO1997032880A1/de not_active Ceased
- 1997-03-03 EP EP97906152A patent/EP0888351B1/de not_active Expired - Lifetime
- 1997-03-03 JP JP9531440A patent/JP2000506151A/ja not_active Ceased
- 1997-03-05 US US08/811,907 patent/US5821240A/en not_active Expired - Lifetime
- 1997-03-05 AR ARP970100873A patent/AR006108A1/es unknown
- 1997-03-05 ZA ZA971887A patent/ZA971887B/xx unknown
- 1997-03-06 CO CO97012277A patent/CO4650043A1/es unknown
- 1997-03-06 TW TW086102755A patent/TW454008B/zh not_active IP Right Cessation
-
1998
- 1998-08-31 MX MX9807073A patent/MX9807073A/es not_active IP Right Cessation
- 1998-09-04 NO NO19984082A patent/NO311522B1/no not_active IP Right Cessation
- 1998-09-24 BG BG102789A patent/BG63163B1/bg unknown
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