AR005342A1 - Metodo para la manufactura de felodipina - Google Patents
Metodo para la manufactura de felodipinaInfo
- Publication number
- AR005342A1 AR005342A1 ARP970100008A ARP970100008A AR005342A1 AR 005342 A1 AR005342 A1 AR 005342A1 AR P970100008 A ARP970100008 A AR P970100008A AR P970100008 A ARP970100008 A AR P970100008A AR 005342 A1 AR005342 A1 AR 005342A1
- Authority
- AR
- Argentina
- Prior art keywords
- felodipine
- manufacture
- dichlorobenzylidene
- aminocrotonate
- ethyl
- Prior art date
Links
- 229960003580 felodipine Drugs 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- RZTAMFZIAATZDJ-UHFFFAOYSA-N felodipine Chemical compound CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC(Cl)=C1Cl RZTAMFZIAATZDJ-UHFFFAOYSA-N 0.000 title 1
- RZTAMFZIAATZDJ-HNNXBMFYSA-N 5-o-ethyl 3-o-methyl (4s)-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)[C@@H]1C1=CC=CC(Cl)=C1Cl RZTAMFZIAATZDJ-HNNXBMFYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- -1 dichlorobenzylidene Chemical group 0.000 abstract 1
- YPMPTULBFPFSEQ-PLNGDYQASA-N ethyl (z)-3-aminobut-2-enoate Chemical compound CCOC(=O)\C=C(\C)N YPMPTULBFPFSEQ-PLNGDYQASA-N 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Catalysts (AREA)
- General Factory Administration (AREA)
- Pyridine Compounds (AREA)
Abstract
Un método para la manufactura de felodipina mediante la reacción de dicloro bencilideno y 3-aminocrotonato de etilo usando un alcohol como solvente.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9600086A SE9600086D0 (sv) | 1996-01-10 | 1996-01-10 | New manufacturing process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR005342A1 true AR005342A1 (es) | 1999-04-28 |
Family
ID=20400982
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970100008A AR005342A1 (es) | 1996-01-10 | 1997-01-02 | Metodo para la manufactura de felodipina |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US5942624A (es) |
| EP (1) | EP0874822B1 (es) |
| JP (1) | JP4587497B2 (es) |
| KR (1) | KR100488384B1 (es) |
| CN (1) | CN1105104C (es) |
| AR (1) | AR005342A1 (es) |
| AT (1) | ATE249436T1 (es) |
| AU (1) | AU706989B2 (es) |
| BR (1) | BR9612457A (es) |
| CA (1) | CA2240201C (es) |
| CZ (1) | CZ291063B6 (es) |
| DE (1) | DE69629942T2 (es) |
| DK (1) | DK0874822T3 (es) |
| EE (1) | EE03438B1 (es) |
| EG (1) | EG24197A (es) |
| ES (1) | ES2206617T3 (es) |
| HU (1) | HU227384B1 (es) |
| IL (1) | IL125194A (es) |
| IS (1) | IS1826B (es) |
| MY (1) | MY116842A (es) |
| NO (1) | NO310233B1 (es) |
| NZ (1) | NZ325967A (es) |
| PL (1) | PL188308B1 (es) |
| PT (1) | PT874822E (es) |
| RU (1) | RU2171251C2 (es) |
| SE (1) | SE9600086D0 (es) |
| SI (1) | SI0874822T1 (es) |
| SK (1) | SK281989B6 (es) |
| TR (1) | TR199801283T2 (es) |
| TW (1) | TW343194B (es) |
| UA (1) | UA44914C2 (es) |
| WO (1) | WO1997025313A1 (es) |
| ZA (1) | ZA9610937B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2161156C1 (ru) * | 1999-06-01 | 2000-12-27 | Джи.Б.Кемикалс Энд Фармасьютикалс Лтд | Способ получения 3-этил-5-метиловый эфир 2-[2-(n-фталимидо)-этоксиметил]-4-(2-хлорфенил)-1,4-дигидро-6-метил-3,5- пиридиндикарбоновой кислоты |
| US6555139B2 (en) | 1999-06-28 | 2003-04-29 | Wockhardt Europe Limited | Preparation of micron-size pharmaceutical particles by microfluidization |
| KR101369207B1 (ko) | 2007-04-11 | 2014-03-04 | 한국과학기술원 | (ｓ)-(-)-펠로디핀의 제조방법 |
| WO2010027113A2 (en) * | 2008-09-04 | 2010-03-11 | Ahn-Gook Pharmaceutical Co., Ltd | Process for preparing (s)-(-)-felodipine |
| CN101613280B (zh) * | 2009-05-13 | 2012-10-17 | 合肥立方制药股份有限公司 | 非洛地平合成中间体2,3-二氯亚苄基乙酰乙酸甲酯的制备方法 |
| CN101735042B (zh) * | 2009-12-15 | 2013-10-09 | 浙江大学 | 2-烷基-4,4-二芳基反-2-丁烯酸乙酯的合成方法 |
| WO2012123966A1 (en) | 2011-03-04 | 2012-09-20 | Arch Pharmalabs Limited | Process for the preparation of 4 -substituted -1, 4-dihydropyridines |
| CN102304079B (zh) * | 2011-09-29 | 2013-09-25 | 合肥立方制药股份有限公司 | 一种非洛地平环合反应液直接水析纯化方法 |
| CN103373956B (zh) * | 2012-04-23 | 2015-07-01 | 黑龙江省格润药业有限责任公司 | 一种制备丁酸氯维地平的方法 |
| CN104557679A (zh) * | 2013-10-23 | 2015-04-29 | 丹阳恒安化学科技研究所有限公司 | 一种西尼地平的合成方法 |
| CN108840819B (zh) * | 2018-04-02 | 2021-07-30 | 常州瑞明药业有限公司 | 一种非洛地平的制备方法 |
| CN115201379B (zh) * | 2022-07-26 | 2023-10-20 | 常州瑞明药业有限公司 | 非洛地平中基因毒性杂质的检测方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2508181A1 (de) * | 1975-02-26 | 1976-09-09 | Bayer Ag | 1,4-dihydropyridincarbonsaeurearal- kylester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| SE429652B (sv) * | 1978-06-30 | 1983-09-19 | Haessle Ab | 2.6-dimetyl-4-(2.3-diklorfenyl)-1.4-dihydropyridin-3.5-dikarboxylsyra-3-metylester-5-etylester |
| US5310917A (en) * | 1991-09-13 | 1994-05-10 | Merck & Co., Inc. | Process for the preparation of 4-substituted-1,4-dihydropydrines |
-
1996
- 1996-01-10 SE SE9600086A patent/SE9600086D0/xx unknown
- 1996-12-13 EP EP96944714A patent/EP0874822B1/en not_active Expired - Lifetime
- 1996-12-13 PT PT96944714T patent/PT874822E/pt unknown
- 1996-12-13 HU HU9901392A patent/HU227384B1/hu unknown
- 1996-12-13 KR KR1019980705100A patent/KR100488384B1/ko not_active Expired - Lifetime
- 1996-12-13 IL IL12519496A patent/IL125194A/en not_active IP Right Cessation
- 1996-12-13 TR TR1998/01283T patent/TR199801283T2/xx unknown
- 1996-12-13 CZ CZ19982180A patent/CZ291063B6/cs not_active IP Right Cessation
- 1996-12-13 AT AT96944714T patent/ATE249436T1/de active
- 1996-12-13 RU RU98112386/04A patent/RU2171251C2/ru active
- 1996-12-13 ES ES96944714T patent/ES2206617T3/es not_active Expired - Lifetime
- 1996-12-13 UA UA98063019A patent/UA44914C2/uk unknown
- 1996-12-13 JP JP52512297A patent/JP4587497B2/ja not_active Expired - Lifetime
- 1996-12-13 CN CN96199573A patent/CN1105104C/zh not_active Expired - Lifetime
- 1996-12-13 DK DK96944714T patent/DK0874822T3/da active
- 1996-12-13 NZ NZ325967A patent/NZ325967A/xx not_active IP Right Cessation
- 1996-12-13 BR BR9612457A patent/BR9612457A/pt not_active Application Discontinuation
- 1996-12-13 SI SI9630642T patent/SI0874822T1/xx unknown
- 1996-12-13 US US08/750,933 patent/US5942624A/en not_active Expired - Lifetime
- 1996-12-13 DE DE69629942T patent/DE69629942T2/de not_active Expired - Lifetime
- 1996-12-13 SK SK878-98A patent/SK281989B6/sk not_active IP Right Cessation
- 1996-12-13 WO PCT/SE1996/001649 patent/WO1997025313A1/en not_active Ceased
- 1996-12-13 PL PL96327946A patent/PL188308B1/pl unknown
- 1996-12-13 AU AU13230/97A patent/AU706989B2/en not_active Expired
- 1996-12-13 CA CA002240201A patent/CA2240201C/en not_active Expired - Lifetime
- 1996-12-13 EE EE9800201A patent/EE03438B1/xx unknown
- 1996-12-30 TW TW085116296A patent/TW343194B/zh not_active IP Right Cessation
- 1996-12-30 ZA ZA9610937A patent/ZA9610937B/xx unknown
-
1997
- 1997-01-02 AR ARP970100008A patent/AR005342A1/es active IP Right Grant
- 1997-01-07 EG EG1797A patent/EG24197A/xx active
- 1997-01-09 MY MYPI97000093A patent/MY116842A/en unknown
-
1998
- 1998-06-19 IS IS4779A patent/IS1826B/is unknown
- 1998-07-09 NO NO19983166A patent/NO310233B1/no not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |