AP3307A - Heteroaryl compounds as 5-HT4 receptor ligands - Google Patents
Heteroaryl compounds as 5-HT4 receptor ligandsInfo
- Publication number
- AP3307A AP3307A AP2013007301A AP2013007301A AP3307A AP 3307 A AP3307 A AP 3307A AP 2013007301 A AP2013007301 A AP 2013007301A AP 2013007301 A AP2013007301 A AP 2013007301A AP 3307 A AP3307 A AP 3307A
- Authority
- AP
- ARIPO
- Prior art keywords
- receptor ligands
- heteroaryl compounds
- heteroaryl
- compounds
- ligands
- Prior art date
Links
- 108091005482 5-HT4 receptors Proteins 0.000 title 1
- 125000001072 heteroaryl group Chemical group 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Semiconductor Integrated Circuits (AREA)
- Structures Or Materials For Encapsulating Or Coating Semiconductor Devices Or Solid State Devices (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN3203CH2011 | 2011-09-19 | ||
| PCT/IN2012/000011 WO2013042135A1 (en) | 2011-09-19 | 2012-01-05 | Heteroaryl compounds as 5-ht4 receptor ligands |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AP2013007301A0 AP2013007301A0 (en) | 2013-12-31 |
| AP3307A true AP3307A (en) | 2015-06-30 |
Family
ID=46001349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AP2013007301A AP3307A (en) | 2011-09-19 | 2012-01-05 | Heteroaryl compounds as 5-HT4 receptor ligands |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US9079894B2 (xx) |
| EP (1) | EP2758394B1 (xx) |
| JP (1) | JP5714729B2 (xx) |
| KR (1) | KR101551481B1 (xx) |
| CN (1) | CN103380131B (xx) |
| AP (1) | AP3307A (xx) |
| AU (1) | AU2012311057B2 (xx) |
| BR (1) | BR112014001083B8 (xx) |
| CA (1) | CA2823548C (xx) |
| CY (1) | CY1116173T1 (xx) |
| DK (1) | DK2758394T3 (xx) |
| EA (1) | EA022374B1 (xx) |
| ES (1) | ES2531885T3 (xx) |
| HR (1) | HRP20150229T1 (xx) |
| IL (1) | IL231305A0 (xx) |
| ME (1) | ME02107B (xx) |
| MX (1) | MX337721B (xx) |
| PL (1) | PL2758394T3 (xx) |
| PT (1) | PT2758394E (xx) |
| RS (1) | RS53940B1 (xx) |
| SG (1) | SG2014003560A (xx) |
| SI (1) | SI2758394T1 (xx) |
| SM (1) | SMT201500087B (xx) |
| WO (1) | WO2013042135A1 (xx) |
| ZA (1) | ZA201309100B (xx) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20140041519A (ko) * | 2011-06-07 | 2014-04-04 | 다이닛본 스미토모 세이야꾸 가부시끼가이샤 | 인다졸-유도체 및 피롤로피리딘-유도체 및 그의 약제학적 용도 |
| US20160039796A1 (en) * | 2013-04-05 | 2016-02-11 | Abc Bioscience As | Barettin and derivatives thereof for medical use, in particular for the treatment of diseases related to oxidative stress or inflammation, and for preserving or washing organs |
| KR101824154B1 (ko) * | 2013-12-16 | 2018-03-14 | 수벤 라이프 사이언시스 리미티드 | 5-ht4 수용체 작용제로서 인다졸 화합물 |
| LT3180333T (lt) * | 2014-08-16 | 2020-10-12 | Suven Life Sciences Limited | Gamybos procesas, skirtas 1-izopropil-3-{5-[1-(3-metoksipropil)piperidin-4-il]-[1,3,4] oksadiazol-2-il}-1h-indazolo oksalato didelės apimties gamybai |
| DK3265459T3 (da) | 2015-02-13 | 2019-07-15 | Suven Life Sciences Ltd | Amidforbindelser som 5-ht4-receptoragonister |
| CN107540568A (zh) * | 2017-08-25 | 2018-01-05 | 许昌恒生制药有限公司 | 一种乙氧酰胺苯甲酯的制备方法 |
| CN113164465A (zh) * | 2018-10-18 | 2021-07-23 | 苏文生命科学有限公司 | 5-ht4受体激动剂的新用途 |
| EP3976192A1 (en) | 2019-05-31 | 2022-04-06 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
| CN110746450A (zh) * | 2019-09-17 | 2020-02-04 | 济南康和医药科技有限公司 | 一种贝前列素钠关键中间体的合成方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997017345A1 (fr) * | 1995-11-09 | 1997-05-15 | Synthelabo | Derives de 5-phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol-2(3h)-one, utiles comme ligands des recepteurs 5-ht4 ou h¿3? |
| US20060194842A1 (en) * | 2005-02-22 | 2006-08-31 | Chikara Uchida | Oxyindole derivatives |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0596933A1 (en) * | 1991-08-03 | 1994-05-18 | Smithkline Beecham Plc | 5-ht4 receptor antagonists |
| TW360653B (en) * | 1995-03-01 | 1999-06-11 | Janssen Pharmaceutica Nv | A oxadiazole compound having colon motility stimulating properties, its preparation process and its pharmaceutical composition |
| GB0115862D0 (en) * | 2001-06-28 | 2001-08-22 | Smithkline Beecham Plc | Compounds |
| CA2545092C (en) | 2003-11-24 | 2010-08-17 | Pfizer Inc. | Quinolonecarboxylic acid compounds having 5-ht4 receptor agonistic activity |
| CA2598516C (en) | 2005-02-25 | 2010-05-11 | Pfizer Inc. | Benzisoxazole derivatives |
| EP1910340B1 (en) | 2005-07-22 | 2009-11-18 | Pfizer, Inc. | Indazolecarboxamide derivatives as 5ht4 receptor agonists |
| KR101121240B1 (ko) * | 2005-12-23 | 2012-06-12 | 에프. 호프만-라 로슈 아게 | 아릴-아이속사졸-4-일-옥사다이아졸 유도체 |
| US20080167286A1 (en) * | 2006-12-12 | 2008-07-10 | Abbott Laboratories | Pharmaceutical compositions and their methods of use |
| US20080255203A1 (en) * | 2007-04-12 | 2008-10-16 | Abbott Laboratories | Heterocyclic compounds and their methods of use |
| EP2406255B1 (en) * | 2009-03-09 | 2015-04-29 | Glaxo Group Limited | 4-oxadiazol-2-yl-indazoles as inhibitors of pi3 kinases |
-
2012
- 2012-01-05 AU AU2012311057A patent/AU2012311057B2/en active Active
- 2012-01-05 US US13/982,486 patent/US9079894B2/en active Active
- 2012-01-05 WO PCT/IN2012/000011 patent/WO2013042135A1/en not_active Ceased
- 2012-01-05 CA CA2823548A patent/CA2823548C/en active Active
- 2012-01-05 EA EA201391056A patent/EA022374B1/ru unknown
- 2012-01-05 EP EP12716662.7A patent/EP2758394B1/en active Active
- 2012-01-05 JP JP2013554062A patent/JP5714729B2/ja active Active
- 2012-01-05 BR BR112014001083A patent/BR112014001083B8/pt not_active IP Right Cessation
- 2012-01-05 AP AP2013007301A patent/AP3307A/xx active
- 2012-01-05 ME MEP-2015-47A patent/ME02107B/me unknown
- 2012-01-05 KR KR1020137020582A patent/KR101551481B1/ko active Active
- 2012-01-05 PT PT127166627T patent/PT2758394E/pt unknown
- 2012-01-05 SG SG2014003560A patent/SG2014003560A/en unknown
- 2012-01-05 PL PL12716662T patent/PL2758394T3/pl unknown
- 2012-01-05 MX MX2013014577A patent/MX337721B/es active IP Right Grant
- 2012-01-05 RS RS20150234A patent/RS53940B1/sr unknown
- 2012-01-05 SI SI201230163T patent/SI2758394T1/sl unknown
- 2012-01-05 CN CN201280009072.1A patent/CN103380131B/zh active Active
- 2012-01-05 HR HRP20150229AT patent/HRP20150229T1/hr unknown
- 2012-01-05 ES ES12716662.7T patent/ES2531885T3/es active Active
- 2012-01-05 DK DK12716662.7T patent/DK2758394T3/en active
-
2013
- 2013-12-04 ZA ZA2013/09100A patent/ZA201309100B/en unknown
-
2014
- 2014-03-04 IL IL231305A patent/IL231305A0/en active IP Right Grant
-
2015
- 2015-03-30 CY CY20151100308T patent/CY1116173T1/el unknown
- 2015-04-09 SM SM201500087T patent/SMT201500087B/xx unknown
- 2015-06-10 US US14/735,237 patent/US9636335B2/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997017345A1 (fr) * | 1995-11-09 | 1997-05-15 | Synthelabo | Derives de 5-phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol-2(3h)-one, utiles comme ligands des recepteurs 5-ht4 ou h¿3? |
| US20060194842A1 (en) * | 2005-02-22 | 2006-08-31 | Chikara Uchida | Oxyindole derivatives |
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