[go: up one dir, main page]

AP3283A - N1-pyrazolospiroketone acetyl-coa carboxylase inhibitors - Google Patents

N1-pyrazolospiroketone acetyl-coa carboxylase inhibitors

Info

Publication number
AP3283A
AP3283A AP2012006269A AP2012006269A AP3283A AP 3283 A AP3283 A AP 3283A AP 2012006269 A AP2012006269 A AP 2012006269A AP 2012006269 A AP2012006269 A AP 2012006269A AP 3283 A AP3283 A AP 3283A
Authority
AP
ARIPO
Prior art keywords
coa carboxylase
carboxylase inhibitors
pyrazolospiroketone
acetyl
pyrazolospiroketone acetyl
Prior art date
Application number
AP2012006269A
Other languages
English (en)
Other versions
AP2012006269A0 (en
Inventor
Scott William Bagley
David Andrew Griffith
Daniel Wei-Shung Kung
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of AP2012006269A0 publication Critical patent/AP2012006269A0/xx
Application granted granted Critical
Publication of AP3283A publication Critical patent/AP3283A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AP2012006269A 2009-11-10 2010-10-29 N1-pyrazolospiroketone acetyl-coa carboxylase inhibitors AP3283A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25982309P 2009-11-10 2009-11-10
PCT/IB2010/054908 WO2011058474A1 (fr) 2009-11-10 2010-10-29 Inhibiteurs de n1-pyrazolospirocétone acétyl-coa carboxylase

Publications (2)

Publication Number Publication Date
AP2012006269A0 AP2012006269A0 (en) 2012-06-30
AP3283A true AP3283A (en) 2015-05-31

Family

ID=43357094

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2012006269A AP3283A (en) 2009-11-10 2010-10-29 N1-pyrazolospiroketone acetyl-coa carboxylase inhibitors

Country Status (39)

Country Link
US (4) US8288405B2 (fr)
EP (3) EP2947082A1 (fr)
JP (1) JP5114610B1 (fr)
KR (2) KR101478517B1 (fr)
CN (1) CN102695708B (fr)
AP (1) AP3283A (fr)
AR (1) AR078944A1 (fr)
AU (1) AU2010317501B2 (fr)
BR (1) BR112012011072A2 (fr)
CA (1) CA2778886C (fr)
CL (1) CL2012000999A1 (fr)
CO (1) CO6541569A2 (fr)
CR (1) CR20120190A (fr)
CU (1) CU24077B1 (fr)
DK (1) DK2499139T3 (fr)
DO (1) DOP2012000128A (fr)
EA (1) EA020153B1 (fr)
EC (1) ECSP12011880A (fr)
ES (1) ES2444543T3 (fr)
GE (1) GEP20146169B (fr)
HN (1) HN2012000973A (fr)
HR (1) HRP20140025T1 (fr)
IL (1) IL219373A (fr)
MA (1) MA33734B1 (fr)
MX (1) MX2012005429A (fr)
NI (1) NI201200089A (fr)
NZ (1) NZ599815A (fr)
PE (1) PE20121469A1 (fr)
PH (1) PH12012500903A1 (fr)
PL (1) PL2499139T3 (fr)
PT (1) PT2499139E (fr)
RS (1) RS53156B (fr)
SI (1) SI2499139T1 (fr)
TN (1) TN2012000192A1 (fr)
TW (1) TWI394756B (fr)
UA (1) UA102336C2 (fr)
UY (1) UY33020A (fr)
WO (1) WO2011058474A1 (fr)
ZA (1) ZA201204231B (fr)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2724774C (fr) 2008-05-28 2013-06-25 Pfizer Inc. Inhibiteurs de la pyrazolospirocetone acetl-coa carboxylase
CA2766100C (fr) 2009-06-29 2018-05-22 Incyte Corporation Pyrimidinones comme inhibiteurs de pi3k
NZ599815A (en) 2009-11-10 2013-04-26 Pfizer N1-pyrazolospiroketone acetyl-coa carboxylase inhibitors
WO2011075643A1 (fr) 2009-12-18 2011-06-23 Incyte Corporation Dérivés condensés d'hétéroaryles substitués à titre d'inhibiteurs de pi3k
EP2345643A1 (fr) * 2009-12-29 2011-07-20 Polichem S.A. Nouveaux dérivés de 8-hydroxyquinoline-7-carboxamide et leurs utilisations
WO2011130342A1 (fr) 2010-04-14 2011-10-20 Incyte Corporation Dérivés condensés en tant qu'inhibiteurs de ρi3κδ
WO2011163195A1 (fr) 2010-06-21 2011-12-29 Incyte Corporation Dérivés condensés de pyrrole en tant qu'inhibiteurs de pi3k
JP5824055B2 (ja) 2010-09-30 2015-11-25 ファイザー・インク Ｎ１−ピラゾロスピロケトンアセチル−ＣｏＡカルボキシラーゼ阻害剤
HUE025078T2 (en) 2010-10-29 2016-01-28 Pfizer N1 / N2-lactam-acetyl-CoA carboxylase inhibitors
ES2764848T3 (es) 2010-12-20 2020-06-04 Incyte Holdings Corp N-(1-(fenilo sustituido)etilo)-9H-purina-6-aminas como inhibidores de PI3K
WO2012125629A1 (fr) 2011-03-14 2012-09-20 Incyte Corporation Dérivés diamino-pyrimidines et diamino-pyridines substituées en tant qu'inhibiteurs de pi3k
US9126948B2 (en) 2011-03-25 2015-09-08 Incyte Holdings Corporation Pyrimidine-4,6-diamine derivatives as PI3K inhibitors
MX348860B (es) * 2011-04-22 2017-06-30 Pfizer Derivados de pirazoloespirocetona para usarse como inhibidores de acetil-coa carboxilasa.
KR102131612B1 (ko) 2011-09-02 2020-07-08 인사이트 홀딩스 코포레이션 Ｐｉ３ｋ 억제제로서 헤테로시클릴아민
AR090548A1 (es) 2012-04-02 2014-11-19 Incyte Corp Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
AR094929A1 (es) 2013-02-28 2015-09-09 Bristol Myers Squibb Co Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2
EP2961746B1 (fr) 2013-02-28 2018-01-03 Bristol-Myers Squibb Company Dérivés de phénylpyrazole en tant que puissants inhibiteurs de rock1 et rock2
ES2731773T3 (es) 2013-03-14 2019-11-19 Celgene Quanticel Res Inc Inhibidores de la histona desmetilasa
WO2015036892A1 (fr) 2013-09-12 2015-03-19 Pfizer Inc. Utilisation d'inhibiteurs de l'acétyl-coa carboxylase pour traiter l'acné vulgaire
WO2015056782A1 (fr) 2013-10-17 2015-04-23 塩野義製薬株式会社 Nouveau dérivé d'alkylène
WO2015191677A1 (fr) 2014-06-11 2015-12-17 Incyte Corporation Dérivés d'hétéroarylaminoalkylphényle bicycliques à titre d'inhibiteurs de pi3k
US9896436B2 (en) 2014-09-16 2018-02-20 Celgene Quanticel Research, Inc. Histone demethylase inhibitors
US9676770B2 (en) 2014-09-16 2017-06-13 Celgene Quanticel Research, Inc. Histone demethylase inhibitors
CA2961580A1 (fr) * 2014-09-17 2016-03-24 Celgene Quanticel Research, Inc. Inhibiteurs de l'histone demethylase
JP6539285B2 (ja) 2014-11-10 2019-07-03 国立大学法人横浜国立大学 酸素発生用アノード
SI3831833T1 (sl) 2015-02-27 2023-03-31 Incyte Holdings Corporation Postopki za pripravo inhibitorja PI3K
WO2016183060A1 (fr) 2015-05-11 2016-11-17 Incyte Corporation Procédé de synthèse d'un inhibiteur de phospho-inositide 3-kinases
WO2016183063A1 (fr) 2015-05-11 2016-11-17 Incyte Corporation Formes cristallines d'un inhibiteur de pi3k
AU2018291163B2 (en) 2017-06-30 2024-07-18 Quixgen, Inc. Novel spirolactone compounds
ES2942463T3 (es) 2017-11-21 2023-06-01 Pfizer Sal cristalina 2-amino-2-(hidroximetil)propano-1,3-diol del ácido 4-(4-(1-isopropil-7-oxo-1,4,6,7-tetrahidroespiro[indazol-5,4'-piperidina]-1'-carbonil)-6-metoxipiridin-2-il)benzoico
WO2019178480A1 (fr) 2018-03-15 2019-09-19 Yale University Inhibiteurs du facteur inhibiteur de migration des macrophages contenant du pyrazole
IL278889B2 (en) 2018-06-01 2025-11-01 Incyte Corp Dosing regimen for the treatment of pi3k related disorders
CA3182134A1 (fr) 2020-05-21 2021-11-25 Shionogi & Co., Ltd. Composition pharmaceutique destinee au traitement des steatoses hepatiques
US10989621B1 (en) 2020-08-20 2021-04-27 Trinity Bay Equipment Holdings, LLC Online pipe integrity testing system and method
CN112028834B (zh) * 2020-09-11 2022-03-29 济南悟通生物科技有限公司 一种阿贝西利的中间体的合成方法
JPWO2023090411A1 (fr) 2021-11-19 2023-05-25
CN115124542A (zh) * 2022-07-08 2022-09-30 河南师范大学 羟基苯取代吡唑酮并吲唑[螺]吡唑酮类化合物的合成方法
CN120019059A (zh) * 2022-07-29 2025-05-16 辉瑞公司 新型acc抑制剂
WO2025133948A1 (fr) * 2023-12-21 2025-06-26 Pfizer Inc. Inhibiteurs de l'acétyl coa-carboxylase (acc)

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007011809A1 (fr) * 2005-07-19 2007-01-25 Merck & Co., Inc. Derives de spirochromanone utilises en tant quinhibiteurs d'acetyle coenzyme a carboxylase
EP1911753A1 (fr) * 2005-07-29 2008-04-16 Takeda Pharmaceutical Company Limited Composé spiro-cyclique
WO2008065508A1 (fr) * 2006-11-29 2008-06-05 Pfizer Products Inc. Inhibiteurs de la spirocétoneacétyl-coa carboxylase
WO2008088689A1 (fr) * 2007-01-12 2008-07-24 Merck & Co., Inc. Dérivés substitués de spirochromanone en tant qu'inhibiteurs d'acc
WO2008125945A2 (fr) * 2007-04-12 2008-10-23 Pfizer Inc. Nouveaux derives de 3-amido-pyrrolo[3,4-c]pyrazole-5(1h,4h.6h) carbaldehyde
WO2009014455A1 (fr) * 2007-07-20 2009-01-29 Mark Jonathon Brownlee Système de prévision du temps de réponse à un courrier électronique
EP2123652A1 (fr) * 2007-02-20 2009-11-25 Takeda Pharmaceutical Company Limited Composé hétérocyclique
WO2009144554A1 (fr) * 2008-05-28 2009-12-03 Pfizer, Inc. Inhibiteurs de la pyrazolospirocétone acétl-coa carboxylase

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US984083A (en) 1910-03-28 1911-02-14 William J Faber Floor-plane.
PT901786E (pt) 1997-08-11 2007-08-07 Pfizer Prod Inc Disperções farmacêuticas sólidas com biodisponibilidade melhorada
CA2439152C (fr) 2001-02-28 2008-06-17 Merck & Co., Inc. Derives de piperidine acylee tels que les agonistes du recepteur 4 de la melanocortine
PL372887A1 (en) 2002-02-27 2005-08-08 Pfizer Products Inc. Acc inhibitors
US7105526B2 (en) 2002-06-28 2006-09-12 Banyu Pharmaceuticals Co., Ltd. Benzimidazole derivatives
WO2004092179A1 (fr) 2003-04-14 2004-10-28 Nippon Soda Co. Ltd. Derive spiro, procede de production et antioxydant
JP2005119987A (ja) 2003-10-15 2005-05-12 Ajinomoto Co Inc アシルスルホンアミド誘導体
WO2005113069A2 (fr) 2004-05-14 2005-12-01 Research Development Foundation Utilisation de curcumine et d'analogues de curcumine comme inhibiteurs de l'acc2
BRPI0510273A (pt) 2004-05-25 2007-10-30 Pfizer Prod Inc derivados de tetraazabenzo[e]azuleno e análogos destes
PA8660701A1 (es) 2005-02-04 2006-09-22 Pfizer Prod Inc Agonistas de pyy y sus usos
DE102006016566B4 (de) * 2005-09-22 2008-06-12 Beru Ag Zusammengesetzter Leiter, insbesondere für Glühkerzen für Dieselmotoren
ATE493412T1 (de) 2005-11-18 2011-01-15 Merck Sharp & Dohme Spirohydantoin-aryl-cgrp-rezeptorantagonisten
CN101384568B (zh) 2006-02-15 2012-12-12 雅培制药有限公司 乙酰辅酶a羧化酶(acc)抑制剂及其在糖尿病、肥胖症和代谢综合征中的应用
US7981904B2 (en) 2008-03-20 2011-07-19 Takeda Pharmaceutical Company Limited Acetyl CoA carboxylase inhibitors
CA2724603A1 (fr) * 2008-05-28 2009-12-03 Pfizer Inc. Inhibiteurs de la pyrazolospirocetone acetyl-coa carboxylase
WO2010002010A1 (fr) 2008-07-04 2010-01-07 Banyu Pharmaceutical Co.,Ltd. Nouveaux acides spirochromanone carboxyliques
CA2730493A1 (fr) 2008-07-14 2010-01-21 Cropsolution, Inc. Modulateurs de l'acetyl-coenzyme a carboxylase et procedes d'utilisation associes
EP2610254B1 (fr) * 2008-09-18 2015-11-25 Auspex Pharmaceuticals, Inc. Dérivés deutérés de benzoquinoline en tant qu'inhibiteurs du transporteur de monoamine vésiculaire 2
NZ599815A (en) 2009-11-10 2013-04-26 Pfizer N1-pyrazolospiroketone acetyl-coa carboxylase inhibitors
EP2499140A1 (fr) 2009-11-10 2012-09-19 Pfizer Inc. Inhibiteurs de n2-pyrazolospirocétone acétyl-coa carboxylase
JP5824055B2 (ja) * 2010-09-30 2015-11-25 ファイザー・インク Ｎ１−ピラゾロスピロケトンアセチル−ＣｏＡカルボキシラーゼ阻害剤
MX348860B (es) * 2011-04-22 2017-06-30 Pfizer Derivados de pirazoloespirocetona para usarse como inhibidores de acetil-coa carboxilasa.

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007011809A1 (fr) * 2005-07-19 2007-01-25 Merck & Co., Inc. Derives de spirochromanone utilises en tant quinhibiteurs d'acetyle coenzyme a carboxylase
EP1911753A1 (fr) * 2005-07-29 2008-04-16 Takeda Pharmaceutical Company Limited Composé spiro-cyclique
WO2008065508A1 (fr) * 2006-11-29 2008-06-05 Pfizer Products Inc. Inhibiteurs de la spirocétoneacétyl-coa carboxylase
WO2008088689A1 (fr) * 2007-01-12 2008-07-24 Merck & Co., Inc. Dérivés substitués de spirochromanone en tant qu'inhibiteurs d'acc
EP2123652A1 (fr) * 2007-02-20 2009-11-25 Takeda Pharmaceutical Company Limited Composé hétérocyclique
WO2008125945A2 (fr) * 2007-04-12 2008-10-23 Pfizer Inc. Nouveaux derives de 3-amido-pyrrolo[3,4-c]pyrazole-5(1h,4h.6h) carbaldehyde
WO2009014455A1 (fr) * 2007-07-20 2009-01-29 Mark Jonathon Brownlee Système de prévision du temps de réponse à un courrier électronique
WO2009144554A1 (fr) * 2008-05-28 2009-12-03 Pfizer, Inc. Inhibiteurs de la pyrazolospirocétone acétl-coa carboxylase

Also Published As

Publication number Publication date
NI201200089A (es) 2012-08-20
IL219373A (en) 2014-04-30
EP2676958B1 (fr) 2015-07-01
PE20121469A1 (es) 2012-11-01
RS53156B (sr) 2014-06-30
ZA201204231B (en) 2013-02-27
CU24077B1 (es) 2015-03-30
US8507681B2 (en) 2013-08-13
AR078944A1 (es) 2011-12-14
ES2444543T3 (es) 2014-02-25
CU20120071A7 (es) 2013-05-31
SI2499139T1 (sl) 2014-01-31
EA020153B1 (ru) 2014-09-30
EA201290191A1 (ru) 2012-12-28
CA2778886A1 (fr) 2011-05-19
JP5114610B1 (ja) 2013-01-09
WO2011058474A1 (fr) 2011-05-19
CN102695708A (zh) 2012-09-26
CR20120190A (es) 2012-05-24
CO6541569A2 (es) 2012-10-16
AU2010317501B2 (en) 2013-06-06
KR101478517B1 (ko) 2015-01-02
TW201127838A (en) 2011-08-16
CN102695708B (zh) 2014-10-15
MA33734B1 (fr) 2012-11-01
EP2676958A1 (fr) 2013-12-25
NZ599815A (en) 2013-04-26
TN2012000192A1 (fr) 2013-12-12
US8288405B2 (en) 2012-10-16
PL2499139T3 (pl) 2014-04-30
HK1173724A1 (en) 2013-05-24
KR101550557B1 (ko) 2015-09-04
IL219373A0 (en) 2012-06-28
US20140288111A1 (en) 2014-09-25
DOP2012000128A (es) 2012-08-31
ECSP12011880A (es) 2012-07-31
CA2778886C (fr) 2014-01-07
BR112012011072A2 (pt) 2017-06-20
EP2947082A1 (fr) 2015-11-25
DK2499139T3 (da) 2014-01-27
EP2499139A1 (fr) 2012-09-19
UY33020A (es) 2011-06-30
TWI394756B (zh) 2013-05-01
US20110111046A1 (en) 2011-05-12
AP2012006269A0 (en) 2012-06-30
WO2011058474A8 (fr) 2012-04-26
MX2012005429A (es) 2012-06-19
UA102336C2 (uk) 2013-06-25
KR20120099460A (ko) 2012-09-10
JP2013510192A (ja) 2013-03-21
US20130030181A1 (en) 2013-01-31
PH12012500903A1 (en) 2014-09-24
AU2010317501A1 (en) 2012-05-17
CL2012000999A1 (es) 2012-07-20
US20130296319A1 (en) 2013-11-07
HN2012000973A (es) 2015-03-02
US9139587B2 (en) 2015-09-22
PT2499139E (pt) 2014-02-10
KR20140034919A (ko) 2014-03-20
EP2499139B1 (fr) 2013-12-11
HRP20140025T1 (hr) 2014-02-14
GEP20146169B (en) 2014-09-25
US8802690B2 (en) 2014-08-12

Similar Documents

Publication Publication Date Title
AP3283A (en) N1-pyrazolospiroketone acetyl-coa carboxylase inhibitors
PT2621493T (pt) Inibidores de n1-pirazolospirocetona acetil-coa carboxilase
ZA201303882B (en) N1/n2-lactam acetyl-coa carboxylase inhibitors
GB2497438B (en) Level
ZA201204246B (en) Kinase inhibitors
ZA201203842B (en) Kinase inhibitors
IL198779A0 (en) Spiroketone acetyl-coa carboxylase inhibitors
EP2552208A4 (fr) Imidazolyl-imidazoles en tant qu'inhibiteurs de kinase
EP2552214A4 (fr) Pyrazolyl-pyrimidines utilisés en tant qu'inhibiteurs de kinase
EP2552211A4 (fr) Indazolyl-pyrimidines utilisés en tant qu'inhibiteurs de kinase
AP3499A (en) Pyrazolospiroketone derivatives for use as acetyl-coa carboxylase inhibitors
GB201009731D0 (en) Kinase inhibitors
GB0916010D0 (en) JMJD2 demethylase inhibitors
GB0914726D0 (en) Kinase inhibitors
GB201104990D0 (en) Screw-fix level
GB0902661D0 (en) Inhibitors
GB0903650D0 (en) Glyoalase inhibitors
GB0915927D0 (en) Novel inhibitors
GB201018597D0 (en) Inhibitors
GB201006605D0 (en) Novel inhibitors
GB201003502D0 (en) Novel inhibitors
GB201003936D0 (en) Novel inhibitors