AP2014007598A0 - Estra-1,3,5(10),16-tetraene-3-carboxamide derivatives, process for preparation thereof, pharmaceutical preparations comprising them, and use thereof for production of medicaments - Google Patents

Estra-1,3,5(10),16-tetraene-3-carboxamide derivatives, process for preparation thereof, pharmaceutical preparations comprising them, and use thereof for production of medicaments

Info

Publication number: AP2014007598A0
Authority: AP; ARIPO
Prior art keywords: estra; tetraene; medicaments; preparation; production
Prior art date: 2011-09-29

Application number

AP2014007598A

Other languages

English (en)

Inventor

Ulrich Bothe

Naomi Barak

Ingo Hartung

Original Assignee

Bayer Ip Gmbh

Bayer Pharma AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-09-29

Filing date

2012-09-24

Publication date

2014-04-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46963705&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP2014007598(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2012-09-24 Application filed by Bayer Ip Gmbh, Bayer Pharma AG filed Critical Bayer Ip Gmbh

2014-04-30 Publication of AP2014007598A0 publication Critical patent/AP2014007598A0/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Reproductive Health (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Urology & Nephrology (AREA)
Obesity (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Pulmonology (AREA)
Hematology (AREA)
Child & Adolescent Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AP2014007598A 2011-09-29 2012-09-24 Estra-1,3,5(10),16-tetraene-3-carboxamide derivatives, process for preparation thereof, pharmaceutical preparations comprising them, and use thereof for production of medicaments AP2014007598A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE102011083725A DE102011083725A1 (de)	2011-09-29	2011-09-29	Estra-1,3,5(10),16-tetraen-3-carboxamid-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln
PCT/EP2012/068803 WO2013045407A1 (de)	2011-09-29	2012-09-24	Estra-1,3,5(10),16-tetraen-3-carboxamid-derivate, verfahren zu ihrer herstellung, pharmazeutische präparate, die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln

Publications (1)

Publication Number	Publication Date
AP2014007598A0 true AP2014007598A0 (en)	2014-04-30

Family

ID=46963705

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AP2014007598A AP2014007598A0 (en)	2011-09-29	2012-09-24	Estra-1,3,5(10),16-tetraene-3-carboxamide derivatives, process for preparation thereof, pharmaceutical preparations comprising them, and use thereof for production of medicaments

Country Status (42)

Country	Link
US (1)	US9487554B2 (xx)
EP (1)	EP2760878B1 (xx)
JP (1)	JP5791810B2 (xx)
KR (1)	KR20140069013A (xx)
CN (1)	CN103827133B (xx)
AP (1)	AP2014007598A0 (xx)
AR (1)	AR088180A1 (xx)
AU (1)	AU2012314627B2 (xx)
BR (1)	BR112014007223A2 (xx)
CA (1)	CA2850047C (xx)
CL (1)	CL2014000775A1 (xx)
CO (1)	CO6920294A2 (xx)
CR (1)	CR20140144A (xx)
CU (1)	CU20140037A7 (xx)
CY (1)	CY1117123T1 (xx)
DE (1)	DE102011083725A1 (xx)
DK (1)	DK2760878T3 (xx)
DO (1)	DOP2014000059A (xx)
EA (1)	EA025518B9 (xx)
EC (1)	ECSP14013275A (xx)
ES (1)	ES2560257T3 (xx)
GT (1)	GT201400059A (xx)
HR (1)	HRP20160050T1 (xx)
HU (1)	HUE026645T2 (xx)
IL (1)	IL231755A (xx)
JO (1)	JO3122B1 (xx)
MA (1)	MA35455B1 (xx)
MX (1)	MX2014003823A (xx)
MY (1)	MY175804A (xx)
PE (1)	PE20141554A1 (xx)
PH (1)	PH12014500674A1 (xx)
PL (1)	PL2760878T3 (xx)
PT (1)	PT2760878E (xx)
RS (1)	RS54521B1 (xx)
SG (1)	SG11201400144SA (xx)
SI (1)	SI2760878T1 (xx)
TN (1)	TN2014000131A1 (xx)
TW (1)	TWI537284B (xx)
UA (1)	UA107550C2 (xx)
UY (1)	UY34356A (xx)
WO (1)	WO2013045407A1 (xx)
ZA (1)	ZA201401568B (xx)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AP2014008179A0 (en) *	2012-07-10	2014-12-31	Bayer Pharma AG	3-Substituted estra-1,3,5(10), 16-tetraene derivativess, methods for the production thereof, pharmaceutical preparations containing same, and use thereof for the production of medicaments
PE20151754A1 (es) *	2013-02-21	2015-12-20	Bayer Pharma AG	Estra-1,3,5(10),16-tetraeno-3-carboxamidas para la inhibicion de la 17b-hidroxiesteroide deshidrogenasa (akr1 c3)
ES2696848T3 (es) *	2014-09-11	2019-01-18	Bayer Pharma AG	Inhibidores de oestra-1,3,5(10),16-tetraeno AKR1C3 sustituido con 3-nitrógeno o azufre
US10167293B2 (en)	2016-05-26	2019-01-01	Bayer Pharma Aktiengesellschaft	[8-(phenylsulfonyl)-3,8-diazabicyclo[3.2.1]oct-3-yl](1H-1,2,3-triazol-4-yl)methanones
CZ307437B6 (cs)	2016-06-07	2018-08-22	Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i.	15β-substituované deriváty estronu jako selektivní inhibitory 17β-hydroxysteoiddehydrogenáz
EP3269373A1 (en)	2016-07-11	2018-01-17	Bayer Pharma Aktiengesellschaft	Low-dosed oral dosage form of an akr1c3 inhibitor for treatment of diseases
TW201825478A (zh)	2016-12-19	2018-07-16	德商拜耳製藥公司	［４－（苯基磺醯基）哌嗪－１－-基］（１ｈ－１，２，３－三唑－４-基）甲酮
EP3555101A2 (en)	2016-12-19	2019-10-23	Bayer Pharma Aktiengesellschaft	[(phenylsulfonyl)octahydro-epiminoisoindol-yl](1h-1,2,3-triazol-5-yl)methanones
WO2018114672A1 (en)	2016-12-19	2018-06-28	Bayer Pharma Aktiengesellschaft	[4-(phenylsulfonyl)piperazin-1-yl](1h-1,2,3-triazol-4-yl)methanones
EP3421483A1 (en)	2017-06-29	2019-01-02	Bayer Pharma Aktiengesellschaft	Novel steroidal 17-beta heteroaryl compounds as inhibitors of akr1c3
CN108503695B (zh) *	2018-03-09	2021-06-08	南方医科大学南方医院	基于GnRH多肽衍生物的示踪剂及其制备方法和应用
CN110693892A (zh) *	2018-07-09	2020-01-17	深圳艾欣达伟医药科技有限公司	化合物用于制备预防、治疗或改善疼痛的药物的用途
BR112021017377A2 (pt)	2019-03-06	2021-11-16	Propella Therapeutics Inc	Pró-fármacos de abiraterona
CN113683648B (zh) *	2021-08-26	2025-03-07	上海皓鸿生物医药科技有限公司	一种2’-氟-2’-脱氧尿苷的合成方法及其中间体

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US4632003A (en)	1985-07-15	1986-12-30	Kopp William L	Musical instrument sound quality enhancement device
CA2132449C (en) *	1992-03-31	2002-09-10	Susan E. Barrie	17 - substituted steroids useful in cancer treatment
US5604213A (en)	1992-03-31	1997-02-18	British Technology Group Limited	17-substituted steroids useful in cancer treatment
BR9908592A (pt)	1998-03-11	2001-04-24	Endorech Inc	Processo para inibir a atividade de 17ß-hidroxiesteróide desidrogenase tipo 5, composição farmacêutica, inibidor de 17ß-hidroxiesteróide desidrogenase tipo 5, processo para inibir 17ß-hidroxiesteróide desidrogenase tipo 3, inibidor de 17ß-hidroxiesteróide desidrogenase tipo 3, processos para tratar, ou reduzir o risco de desenvolver, câncer da próstata, hiperplasia prostática benigna, acne, seborréia, hirsutismo ou alopécia androgênica, sìndrome de ovário policìstico, câncer de mama, endometriose ou leiomioma, para inibir as secreções hormonais testiculares, para tratar puberdade precoce, e, kit
WO2005089256A2 (en) *	2004-03-12	2005-09-29	Entremed, Inc.	Antiangiogenic agents
AU2007327653B2 (en)	2006-11-30	2013-04-18	Solvay Pharmaceuticals Gmbh	Substituted estratrien derivatives as 17beta HSD inhibitors
GB2470700B (en)	2008-03-25	2012-08-08	Univ Maryland	C-17 heteroaryl steroidal CYP17 inhibitors
BRPI1008745A2 (pt)	2009-02-05	2019-09-17	Tokai Pharmaceuticals Inc	pró-fármacos de inibidores esteroidais de cyp17/antiandrogênios
EP2563803B1 (en)	2010-04-27	2016-03-09	Pharma Mar S.A.	Anticancer steroidal lactones unsaturated in position 7(8)

2011
- 2011-09-29 DE DE102011083725A patent/DE102011083725A1/de not_active Withdrawn
2012
- 2012-09-24 PT PT127666360T patent/PT2760878E/pt unknown
- 2012-09-24 PH PH1/2014/500674A patent/PH12014500674A1/en unknown
- 2012-09-24 KR KR1020147007566A patent/KR20140069013A/ko not_active Abandoned
- 2012-09-24 EP EP12766636.0A patent/EP2760878B1/de active Active
- 2012-09-24 BR BR112014007223A patent/BR112014007223A2/pt not_active Application Discontinuation
- 2012-09-24 DK DK12766636.0T patent/DK2760878T3/en active
- 2012-09-24 MX MX2014003823A patent/MX2014003823A/es unknown
- 2012-09-24 MY MYPI2014700715A patent/MY175804A/en unknown
- 2012-09-24 HR HRP20160050TT patent/HRP20160050T1/hr unknown
- 2012-09-24 WO PCT/EP2012/068803 patent/WO2013045407A1/de not_active Ceased
- 2012-09-24 ES ES12766636.0T patent/ES2560257T3/es active Active
- 2012-09-24 US US14/348,645 patent/US9487554B2/en not_active Expired - Fee Related
- 2012-09-24 UA UAA201404419A patent/UA107550C2/uk unknown
- 2012-09-24 AU AU2012314627A patent/AU2012314627B2/en not_active Ceased
- 2012-09-24 HU HUE12766636A patent/HUE026645T2/en unknown
- 2012-09-24 RS RS20160023A patent/RS54521B1/sr unknown
- 2012-09-24 PL PL12766636T patent/PL2760878T3/pl unknown
- 2012-09-24 CA CA2850047A patent/CA2850047C/en not_active Expired - Fee Related
- 2012-09-24 AP AP2014007598A patent/AP2014007598A0/xx unknown
- 2012-09-24 JP JP2014532337A patent/JP5791810B2/ja not_active Expired - Fee Related
- 2012-09-24 CN CN201280047810.1A patent/CN103827133B/zh not_active Expired - Fee Related
- 2012-09-24 EA EA201490653A patent/EA025518B9/ru not_active IP Right Cessation
- 2012-09-24 PE PE2014000441A patent/PE20141554A1/es active IP Right Grant
- 2012-09-24 SG SG11201400144SA patent/SG11201400144SA/en unknown
- 2012-09-24 SI SI201230440T patent/SI2760878T1/sl unknown
- 2012-09-27 JO JOP/2012/0285A patent/JO3122B1/ar active
- 2012-09-28 AR ARP120103610A patent/AR088180A1/es unknown
- 2012-09-28 TW TW101136042A patent/TWI537284B/zh not_active IP Right Cessation
- 2012-09-28 UY UY0001034356A patent/UY34356A/es not_active Application Discontinuation
2014
- 2014-02-28 ZA ZA2014/01568A patent/ZA201401568B/en unknown
- 2014-03-27 IL IL231755A patent/IL231755A/en active IP Right Grant
- 2014-03-27 MA MA36857A patent/MA35455B1/fr unknown
- 2014-03-28 TN TNP2014000131A patent/TN2014000131A1/en unknown
- 2014-03-28 CU CU2014000037A patent/CU20140037A7/es unknown
- 2014-03-28 CL CL2014000775A patent/CL2014000775A1/es unknown
- 2014-03-28 CO CO14066898A patent/CO6920294A2/es unknown
- 2014-03-28 EC ECSP14013275 patent/ECSP14013275A/es unknown
- 2014-03-28 GT GT201400059A patent/GT201400059A/es unknown
- 2014-03-28 CR CR20140144A patent/CR20140144A/es unknown
- 2014-03-28 DO DO2014000059A patent/DOP2014000059A/es unknown
2016
- 2016-01-18 CY CY20161100045T patent/CY1117123T1/el unknown

Also Published As

Publication number	Publication date
BR112014007223A2 (pt)	2017-04-04
TWI537284B (zh)	2016-06-11
AR088180A1 (es)	2014-05-14
MY175804A (en)	2020-07-09
CA2850047A1 (en)	2013-04-04
DK2760878T3 (en)	2016-01-25
AU2012314627B2 (en)	2016-08-18
EA025518B9 (ru)	2017-10-31
PE20141554A1 (es)	2014-10-24
TN2014000131A1 (en)	2015-07-01
HK1197414A1 (zh)	2015-01-16
SI2760878T1 (sl)	2016-02-29
AU2012314627A1 (en)	2014-04-10
MA35455B1 (fr)	2014-09-01
HRP20160050T1 (hr)	2016-02-12
ZA201401568B (en)	2016-11-30
DOP2014000059A (es)	2014-06-15
NZ622081A (en)	2015-10-30
UY34356A (es)	2013-04-30
CY1117123T1 (el)	2017-04-05
WO2013045407A1 (de)	2013-04-04
PT2760878E (pt)	2016-02-26
EP2760878A1 (de)	2014-08-06
TW201317253A (zh)	2013-05-01
JO3122B1 (ar)	2017-09-20
EA201490653A1 (ru)	2014-09-30
ES2560257T3 (es)	2016-02-18
ECSP14013275A (es)	2014-04-30
US20140249119A1 (en)	2014-09-04
CL2014000775A1 (es)	2014-08-18
EA025518B1 (ru)	2016-12-30
PL2760878T3 (pl)	2016-04-29
RS54521B1 (sr)	2016-06-30
CU20140037A7 (es)	2014-07-30
CN103827133B (zh)	2015-11-25
EP2760878B1 (de)	2015-10-28
HUE026645T2 (en)	2016-07-28
IL231755A (en)	2016-06-30
DE102011083725A1 (de)	2013-04-04
UA107550C2 (uk)	2015-01-12
KR20140069013A (ko)	2014-06-09
CR20140144A (es)	2014-05-16
GT201400059A (es)	2015-02-17
CO6920294A2 (es)	2014-04-10
PH12014500674A1 (en)	2021-08-09
SG11201400144SA (en)	2014-05-29
CA2850047C (en)	2016-03-29
JP5791810B2 (ja)	2015-10-07
MX2014003823A (es)	2014-06-04
JP2014527994A (ja)	2014-10-23
CN103827133A (zh)	2014-05-28
US9487554B2 (en)	2016-11-08

Publication	Publication Date	Title
ZA201401568B (en)	2016-11-30	Estra-1,3,5(10),16-tetraene-3-carboxamide derivatives, process for preparation thereof, pharmaceutical preparations comprising them, and use thereof for production of medicaments
IL223795A (en)	2015-11-30	History of Tetrahydro-Pyrido-Pyrimidine
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IL221160A (en)	2015-09-24	4,2,1-triazine-3-amine derivatives, a process for their preparation and use for drug preparation
IL227594A (en)	2015-11-30	History of Aminobutyric Replaced as Nephrilicin Inhibitors, their Preparation, Pharmaceutical Preparations Containing Them and Their Use in Medication Preparation
IL232308A (en)	2016-11-30	Compounds as modulators of atp-linked casting, pharmaceuticals containing them and their use in the preparation of drugs for the treatment of diseases and processes for their preparation
IL215065A (en)	2016-06-30	Proline derivatives, their preparation process, their pharmaceutical compositions and their uses in drug preparation
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