OA11231A - Farnesyl transferase inhibtors in combinatin with hmg coa reductase inhibitors for the treatment of cancer - Google Patents

Farnesyl transferase inhibtors in combinatin with hmg coa reductase inhibitors for the treatment of cancer Download PDF

Info

Publication number: OA11231A
Authority: OA; OAPI
Prior art keywords: alkyl; phenyl; halo; amino; hydroxy
Prior art date: 1997-06-16

Application number

OA9900276A

Other languages

English (en)

Inventor

Shama Mohammed Kajiiji

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-06-16

Filing date

1999-12-10

Publication date

2003-05-26

1999-12-10 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2003-05-26 Publication of OA11231A publication Critical patent/OA11231A/en

Links

229940121710 HMGCoA reductase inhibitor Drugs 0.000 title claims abstract description 26
239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 title claims abstract description 26
206010028980 Neoplasm Diseases 0.000 title claims abstract description 25
201000011510 cancer Diseases 0.000 title claims abstract description 21
108010007508 Farnesyltranstransferase Proteins 0.000 title description 43
102000007317 Farnesyltranstransferase Human genes 0.000 title description 43
229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 title description 5
239000003112 inhibitor Substances 0.000 claims abstract description 44
241000124008 Mammalia Species 0.000 claims abstract description 13
125000000217 alkyl group Chemical group 0.000 claims description 73
-1 nitro, cyano, phenyl Chemical group 0.000 claims description 54
150000001875 compounds Chemical class 0.000 claims description 40
229910052739 hydrogen Inorganic materials 0.000 claims description 40
125000005843 halogen group Chemical group 0.000 claims description 31
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 28
239000001257 hydrogen Substances 0.000 claims description 25
239000000203 mixture Substances 0.000 claims description 25
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 23
125000001153 fluoro group Chemical group F* 0.000 claims description 16
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 16
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 15
239000008194 pharmaceutical composition Substances 0.000 claims description 15
125000001424 substituent group Chemical group 0.000 claims description 15
230000002159 abnormal effect Effects 0.000 claims description 14
230000010261 cell growth Effects 0.000 claims description 13
125000004093 cyano group Chemical group *C#N 0.000 claims description 13
150000002431 hydrogen Chemical group 0.000 claims description 12
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 12
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 10
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125000003670 adamantan-2-yl group Chemical group [H]C1([H])C(C2([H])[H])([H])C([H])([H])C3([H])C([*])([H])C1([H])C([H])([H])C2([H])C3([H])[H] 0.000 claims description 9
125000000623 heterocyclic group Chemical group 0.000 claims description 9
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 9
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 8
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QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 claims description 8
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QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 6
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125000000041 C6-C10 aryl group Chemical group 0.000 claims description 4
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BOZILQFLQYBIIY-UHFFFAOYSA-N mevastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CCC=C21 BOZILQFLQYBIIY-UHFFFAOYSA-N 0.000 claims description 3
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210000004197 pelvis Anatomy 0.000 description 1
239000000137 peptide hydrolase inhibitor Substances 0.000 description 1
239000008177 pharmaceutical agent Substances 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
229930006728 pinane Natural products 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
230000034918 positive regulation of cell growth Effects 0.000 description 1
239000002243 precursor Substances 0.000 description 1
230000003405 preventing effect Effects 0.000 description 1
235000004252 protein component Nutrition 0.000 description 1
239000003528 protein farnesyltransferase inhibitor Substances 0.000 description 1
238000010814 radioimmunoprecipitation assay Methods 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
230000035484 reaction time Effects 0.000 description 1
206010038038 rectal cancer Diseases 0.000 description 1
201000001275 rectum cancer Diseases 0.000 description 1
230000004044 response Effects 0.000 description 1
208000037803 restenosis Diseases 0.000 description 1
230000000979 retarding effect Effects 0.000 description 1
238000012216 screening Methods 0.000 description 1
230000019491 signal transduction Effects 0.000 description 1
150000004760 silicates Chemical class 0.000 description 1
201000000849 skin cancer Diseases 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
229960001790 sodium citrate Drugs 0.000 description 1
235000011083 sodium citrates Nutrition 0.000 description 1
210000004872 soft tissue Anatomy 0.000 description 1
239000008247 solid mixture Substances 0.000 description 1
241000894007 species Species 0.000 description 1
150000003432 sterols Chemical class 0.000 description 1
235000003702 sterols Nutrition 0.000 description 1
201000011549 stomach cancer Diseases 0.000 description 1
239000000126 substance Substances 0.000 description 1
239000000758 substrate Substances 0.000 description 1
239000000829 suppository Substances 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000006188 syrup Substances 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
229960001603 tamoxifen Drugs 0.000 description 1
230000036964 tight binding Effects 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
229940044693 topoisomerase inhibitor Drugs 0.000 description 1
210000000626 ureter Anatomy 0.000 description 1
206010046766 uterine cancer Diseases 0.000 description 1
208000037965 uterine sarcoma Diseases 0.000 description 1
210000001215 vagina Anatomy 0.000 description 1
229960003048 vinblastine Drugs 0.000 description 1
JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
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XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Hematology (AREA)
Oncology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

OA9900276A 1997-06-16 1999-12-10 Farnesyl transferase inhibtors in combinatin with hmg coa reductase inhibitors for the treatment of cancer OA11231A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US4963897P	1997-06-16	1997-06-16

Publications (1)

Publication Number	Publication Date
OA11231A true OA11231A (en)	2003-05-26

Family

ID=21960890

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA9900276A OA11231A (en)	1997-06-16	1999-12-10	Farnesyl transferase inhibtors in combinatin with hmg coa reductase inhibitors for the treatment of cancer

Country Status (37)

Country	Link
EP (1)	EP0986387B1 (no)
JP (1)	JP3713051B2 (no)
KR (1)	KR100392573B1 (no)
CN (1)	CN1259868A (no)
AP (1)	AP9801261A0 (no)
AR (1)	AR013090A1 (no)
AT (1)	ATE235905T1 (no)
BG (1)	BG103946A (no)
BR (1)	BR9810616A (no)
CA (1)	CA2294399C (no)
CO (1)	CO4950607A1 (no)
DE (1)	DE69812933T2 (no)
DK (1)	DK0986387T3 (no)
DZ (1)	DZ2518A1 (no)
EA (1)	EA199901043A1 (no)
ES (1)	ES2196559T3 (no)
GT (1)	GT199800081A (no)
HN (1)	HN1998000091A (no)
HR (1)	HRP980328B1 (no)
HU (1)	HUP0004624A3 (no)
ID (1)	ID23014A (no)
IL (1)	IL132765A0 (no)
IS (1)	IS5259A (no)
MA (1)	MA24569A1 (no)
NO (1)	NO996206L (no)
NZ (1)	NZ500662A (no)
OA (1)	OA11231A (no)
PA (1)	PA8453601A1 (no)
PE (1)	PE82899A1 (no)
PL (1)	PL337651A1 (no)
PT (1)	PT986387E (no)
SK (1)	SK169699A3 (no)
TN (1)	TNSN98088A1 (no)
TR (1)	TR199903074T2 (no)
UA (1)	UA57081C2 (no)
WO (1)	WO1998057633A1 (no)
ZA (1)	ZA985182B (no)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2331295A1 (en)	1998-05-12	1999-11-18	Warner-Lambert Company	Combinations of protein farnesyltransferase and hmg coa reductase inhibitors and their use to treat cancer
WO2000016778A1 (en) *	1998-09-24	2000-03-30	Merck & Co., Inc.	A method of treating cancer
EP1006113A1 (en) *	1998-12-02	2000-06-07	Pfizer Products Inc.	Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one and their use to inhibit abnormal cell growth
AU4988100A (en) *	1999-05-07	2000-11-21	Brigham And Women's Hospital	Use of hmgcoa reductase inhibitors in the prevention of diseases whose pathogenesis is dependent on neovascularization
US6710058B2 (en)	2000-11-06	2004-03-23	Bristol-Myers Squibb Pharma Company	Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors
WO2002050058A1 (en)	2000-12-19	2002-06-27	Pfizer Products Inc.	Crystal forms of 6-[(4-chloro-phenyl) -hydroxy-(-3-methyl- 3h-imidaol-4-yl) -methyl] -4-(3-ethynyl-phenyl) -1-methyl-1h- quinolin-2-one, 2,3- dihydroxybutanedioate salts and method of production
US6706724B2 (en)	2000-12-21	2004-03-16	Nitromed, Inc.	Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use
US20020151563A1 (en) *	2001-03-29	2002-10-17	Pfizer Inc.	Farnesyl transferase inhibitors in combination with HMG CoA reductase inhibitors for the inhibition of abnormal cell growth
US6740757B2 (en)	2001-08-29	2004-05-25	Pfizer Inc	Enantiomers of 6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3h-imidazol-4-yl)-methyl]-4-[3-(3-hydroxy-3-methyl-but-1-ynyl)-phenyl]-1-methyl-1h-quinolin-2-one and salts thereof, useful in the treatment of cancer
EP1555021A1 (en) *	2004-01-16	2005-07-20	National Health Research Institutes	Combinations of a mevalonate pathway inhibitor and a PPAR-gamma agonist for treating cancer
US8168667B2 (en)	2006-05-31	2012-05-01	Galapagos Nv	Imidazolidine derivatives, uses therefor, preparation thereof and compositions comprising such
GB2463514C (en)	2008-09-11	2018-09-26	Galapagos Nv	Imidazolidine compounds and uses therefor

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1997005902A1 (fr) *	1995-08-09	1997-02-20	Banyu Pharmaceutical Co., Ltd.	Composition medicinale

1998
- 1998-05-06 UA UA99126842A patent/UA57081C2/uk unknown
- 1998-06-05 EP EP98921688A patent/EP0986387B1/en not_active Expired - Lifetime
- 1998-06-05 ID IDW991597A patent/ID23014A/id unknown
- 1998-06-05 JP JP50403099A patent/JP3713051B2/ja not_active Expired - Fee Related
- 1998-06-05 AT AT98921688T patent/ATE235905T1/de not_active IP Right Cessation
- 1998-06-05 BR BR9810616-3A patent/BR9810616A/pt not_active Application Discontinuation
- 1998-06-05 TR TR1999/03074T patent/TR199903074T2/xx unknown
- 1998-06-05 DK DK98921688T patent/DK0986387T3/da active
- 1998-06-05 NZ NZ500662A patent/NZ500662A/en unknown
- 1998-06-05 WO PCT/IB1998/000881 patent/WO1998057633A1/en not_active Ceased
- 1998-06-05 CA CA002294399A patent/CA2294399C/en not_active Expired - Fee Related
- 1998-06-05 IL IL13276598A patent/IL132765A0/xx unknown
- 1998-06-05 PT PT98921688T patent/PT986387E/pt unknown
- 1998-06-05 PL PL98337651A patent/PL337651A1/xx unknown
- 1998-06-05 CN CN98805968A patent/CN1259868A/zh active Pending
- 1998-06-05 DE DE69812933T patent/DE69812933T2/de not_active Expired - Fee Related
- 1998-06-05 SK SK1696-99A patent/SK169699A3/sk unknown
- 1998-06-05 EA EA199901043A patent/EA199901043A1/ru unknown
- 1998-06-05 HU HU0004624A patent/HUP0004624A3/hu unknown
- 1998-06-05 ES ES98921688T patent/ES2196559T3/es not_active Expired - Lifetime
- 1998-06-05 KR KR10-1999-7011860A patent/KR100392573B1/ko not_active Expired - Fee Related
- 1998-06-09 HN HN1998000091A patent/HN1998000091A/es unknown
- 1998-06-11 AP APAP/P/1998/001261A patent/AP9801261A0/en unknown
- 1998-06-12 AR ARP980102812A patent/AR013090A1/es unknown
- 1998-06-12 PE PE1998000500A patent/PE82899A1/es not_active Application Discontinuation
- 1998-06-15 PA PA19988453601A patent/PA8453601A1/es unknown
- 1998-06-15 DZ DZ980128A patent/DZ2518A1/xx active
- 1998-06-15 GT GT199800081A patent/GT199800081A/es unknown
- 1998-06-15 MA MA25114A patent/MA24569A1/fr unknown
- 1998-06-15 TN TNTNSN98088A patent/TNSN98088A1/fr unknown
- 1998-06-15 ZA ZA9805182A patent/ZA985182B/xx unknown
- 1998-06-16 CO CO98034148A patent/CO4950607A1/es unknown
- 1998-06-16 HR HR980328A patent/HRP980328B1/xx not_active IP Right Cessation
1999
- 1999-11-19 IS IS5259A patent/IS5259A/is unknown
- 1999-12-03 BG BG103946A patent/BG103946A/bg unknown
- 1999-12-10 OA OA9900276A patent/OA11231A/en unknown
- 1999-12-15 NO NO996206A patent/NO996206L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
HUP0004624A3 (en)	2002-11-28
WO1998057633A1 (en)	1998-12-23
HUP0004624A2 (hu)	2001-10-28
ES2196559T3 (es)	2003-12-16
HRP980328B1 (en)	2002-06-30
NZ500662A (en)	2001-10-26
AU724676B2 (en)	2000-09-28
MA24569A1 (fr)	1998-12-31
KR20010013839A (ko)	2001-02-26
CA2294399C (en)	2004-03-16
PA8453601A1 (es)	2000-05-24
AP9801261A0 (en)	1999-12-11
ZA985182B (en)	1999-12-17
PE82899A1 (es)	1999-08-26
JP3713051B2 (ja)	2005-11-02
ATE235905T1 (de)	2003-04-15
JP2000513031A (ja)	2000-10-03
IS5259A (is)	1999-11-19
DK0986387T3 (da)	2003-07-14
GT199800081A (es)	1999-12-07
HRP980328A2 (en)	1999-04-30
CA2294399A1 (en)	1998-12-23
PT986387E (pt)	2003-06-30
AU7445998A (en)	1999-01-04
NO996206L (no)	2000-02-15
IL132765A0 (en)	2001-03-19
PL337651A1 (en)	2000-08-28
KR100392573B1 (ko)	2003-07-23
DE69812933D1 (de)	2003-05-08
DE69812933T2 (de)	2003-11-06
HN1998000091A (es)	1999-09-29
SK169699A3 (en)	2000-06-12
TNSN98088A1 (fr)	2005-03-15
UA57081C2 (uk)	2003-06-16
ID23014A (id)	1999-12-30
EP0986387A1 (en)	2000-03-22
CO4950607A1 (es)	2000-09-01
DZ2518A1 (fr)	2003-02-01
AR013090A1 (es)	2000-12-13
CN1259868A (zh)	2000-07-12
BG103946A (bg)	2000-07-31
NO996206D0 (no)	1999-12-15
TR199903074T2 (xx)	2000-05-22
EA199901043A1 (ru)	2000-06-26
EP0986387B1 (en)	2003-04-02
BR9810616A (pt)	2000-09-12

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