[go: up one dir, main page]

NZ232278A - N-(aryl-, thienyl- or furanyl-substituted alkyl) pyrrole-2-carboxylic acid derivatives and medicaments - Google Patents

N-(aryl-, thienyl- or furanyl-substituted alkyl) pyrrole-2-carboxylic acid derivatives and medicaments

Info

Publication number
NZ232278A
NZ232278A NZ232278A NZ23227890A NZ232278A NZ 232278 A NZ232278 A NZ 232278A NZ 232278 A NZ232278 A NZ 232278A NZ 23227890 A NZ23227890 A NZ 23227890A NZ 232278 A NZ232278 A NZ 232278A
Authority
NZ
New Zealand
Prior art keywords
compound
formula
pyrrole
unsubstituted
acid
Prior art date
Application number
NZ232278A
Other languages
English (en)
Inventor
Roger Alan Parker
George Ku
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of NZ232278A publication Critical patent/NZ232278A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
NZ232278A 1989-01-31 1990-01-29 N-(aryl-, thienyl- or furanyl-substituted alkyl) pyrrole-2-carboxylic acid derivatives and medicaments NZ232278A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30414189A 1989-01-31 1989-01-31

Publications (1)

Publication Number Publication Date
NZ232278A true NZ232278A (en) 1992-07-28

Family

ID=23175237

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ232278A NZ232278A (en) 1989-01-31 1990-01-29 N-(aryl-, thienyl- or furanyl-substituted alkyl) pyrrole-2-carboxylic acid derivatives and medicaments

Country Status (17)

Country Link
EP (1) EP0381141B1 (no)
JP (1) JP2841305B2 (no)
KR (1) KR0139288B1 (no)
CN (1) CN1022754C (no)
AR (1) AR245694A1 (no)
AT (1) ATE135702T1 (no)
AU (1) AU629290B2 (no)
CA (1) CA2008616C (no)
DE (1) DE69025967T2 (no)
ES (1) ES2087093T3 (no)
FI (1) FI900464A7 (no)
HU (1) HU209290B (no)
IL (1) IL93187A (no)
NO (1) NO174887C (no)
NZ (1) NZ232278A (no)
PT (1) PT93009A (no)
ZA (1) ZA90554B (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5015651A (en) * 1988-01-07 1991-05-14 E. I. Du Pont De Nemours And Company Treatment of hypertension with 1,2,4-angiotensin II antagonists
AU625688B2 (en) * 1989-01-31 1992-07-16 Merrell Dow Pharmaceuticals Inc. Method of using aryl- or heteroaryl-1-alkyl-pyrrole-2- carboxylic acid compounds in the treatment of interleukin-1 mediated conditions
BR112012000606A2 (pt) * 2009-07-10 2016-11-22 Brigham & Womens Hospital análogos de etomidato que não inibem a síntese de esteróides adrenocorticais
CN102114430B (zh) * 2009-12-30 2013-06-05 上海睿智化学研究有限公司 催化剂、其制备方法及n-烷基吡咯衍生物的制备方法
IN2014DN06132A (no) 2012-01-13 2015-08-14 Gen Hospital Corp

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4112112A (en) * 1976-06-29 1978-09-05 Merck & Co., Inc. Pyrrolo[2,1-b] [3]benzazepines useful for producing a skeletal muscle relaxing or tranquilizing effect

Also Published As

Publication number Publication date
CN1044653A (zh) 1990-08-15
JPH02247165A (ja) 1990-10-02
NO174887B (no) 1994-04-18
AU629290B2 (en) 1992-10-01
NO174887C (no) 1994-07-27
FI900464A0 (fi) 1990-01-30
EP0381141B1 (en) 1996-03-20
HU209290B (en) 1994-04-28
PT93009A (pt) 1990-07-31
IL93187A0 (en) 1990-11-05
CN1022754C (zh) 1993-11-17
ATE135702T1 (de) 1996-04-15
AR245694A1 (es) 1994-02-28
NO900432L (no) 1990-08-01
JP2841305B2 (ja) 1998-12-24
EP0381141A2 (en) 1990-08-08
FI900464A7 (fi) 1990-08-01
KR0139288B1 (ko) 1998-05-15
DE69025967T2 (de) 1996-08-29
NO900432D0 (no) 1990-01-30
HU900592D0 (en) 1990-04-28
CA2008616C (en) 2000-07-18
EP0381141A3 (en) 1991-11-21
IL93187A (en) 1994-12-29
ZA90554B (en) 1990-10-31
DE69025967D1 (de) 1996-04-25
AU4875990A (en) 1990-08-09
KR900011725A (ko) 1990-08-02
HUT53868A (en) 1990-12-28
CA2008616A1 (en) 1990-07-31
ES2087093T3 (es) 1996-07-16

Similar Documents

Publication Publication Date Title
DE60225316T2 (de) Cyanoalkylamino-derivate als protease-hemmer
KR960009570B1 (ko) 이미다졸린 유도체 및 그의 제조방법
US5041554A (en) Novel aryl-or heteroaryl-1-alkyl-pyrrole-2-carboxylic acid compounds useful in treating interleukin-1 mediated conditions
JPH01301661A (ja) 新規ピリジル誘導体
FR2700472A1 (fr) Association synergisante ayant un effet antagoniste des récepteurs NK1 et NK2.
CA2008616C (en) Aryl- or heteroaryl-1-alkyl-pyrrole-2-carboxylic acid compounds useful in treating interleukin-1 mediated conditions
KR900006118B1 (ko) 4-퀴놀론 유도체의 제법
JPWO2019031471A1 (ja) 脂肪性肝疾患の治療剤及び肥満症の治療剤
US5039695A (en) Method of using aryl-or heteroaryl-1-alkyl-pyrrole-2-carboxylic acid compounds in the treatment of interleukin-1 mediated conditions
DE60107055T2 (de) Thienopyridinderivate zur verwendung als entzündungshemmende mittel
AU625688B2 (en) Method of using aryl- or heteroaryl-1-alkyl-pyrrole-2- carboxylic acid compounds in the treatment of interleukin-1 mediated conditions
US20090270494A1 (en) Salts of Dihydroxyanthraquinone Carboxylic Acids and Their Therapeutic Use
US5026861A (en) Substituted 1,5-dihydro-4-(N-methylhydroxylamino)-2H-pyrrol-2-ones
MXPA03005884A (es) Hemimaleato de amlodipina.
KR0171190B1 (ko) 신규 아스코르브산 유도체
CA2313302C (fr) Nouveaux inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP2917204A1 (fr) Derives de 1 h-indole-3-carboxamide et leurs utilisation comme antagonistes du p2y12
JPH05301865A (ja) 新規テトラヒドロフラン誘導体及びテトラヒドロチオフェン誘導体
FR2573761A1 (fr) Acylamino hydroxyalcanoyl amino et imino acides et esters a action therapeutique
US5109010A (en) Dibenzofuranyl substituted 1,5-dihydro-4-(N-methylhydroxylamino)-2H-pyrrol-2-ones
EP0410379A2 (en) Pharmaceutically active 3-aryl and 3-heteroaryl-2-fluoro-1-olefins
JP2000290280A (ja) フェニルアゾール化合物、製造法及び抗高脂血症薬
DE19624290A1 (de) Verwendungen von Pyrrolizin-Verbindungen in der Pharmazie
JPS60202820A (ja) 抗脂血剤
PT100774A (pt) "3-(tetrazolil substituidos)4-oxo-4h-pirido-{1,2-a}-pirimidinas, seus sais, composicoes farmaceuticas que as contem e processos para a sua preparacao"