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NO993746L - A reversible, stoichiometric process for biomolecule conjugation - Google Patents

A reversible, stoichiometric process for biomolecule conjugation

Info

Publication number
NO993746L
NO993746L NO993746A NO993746A NO993746L NO 993746 L NO993746 L NO 993746L NO 993746 A NO993746 A NO 993746A NO 993746 A NO993746 A NO 993746A NO 993746 L NO993746 L NO 993746L
Authority
NO
Norway
Prior art keywords
reversible
stoichiometric process
biomolecule conjugation
biomolecule
conjugation
Prior art date
Application number
NO993746A
Other languages
Norwegian (no)
Other versions
NO993746D0 (en
Inventor
Hubert Koester
Andreas Ruppert
Original Assignee
Hubert Koester
Andreas Ruppert
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hubert Koester, Andreas Ruppert filed Critical Hubert Koester
Publication of NO993746D0 publication Critical patent/NO993746D0/en
Publication of NO993746L publication Critical patent/NO993746L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Sammensetninger som omfattes av minst to biopolymerer (f.eks. nukleinsyrer eller polypeptider), som er konjugert til en uoppløselig bærer ved hjelp av to forskjellige reversible koblinger, som er spaltbare under selektive betingelser, så vel som metoder og komponenter for å danne de samme.Compositions comprising at least two biopolymers (e.g., nucleic acids or polypeptides) conjugated to an insoluble carrier by two different reversible links, which are cleavable under selective conditions, as well as methods and components to form the same .

NO993746A 1997-02-04 1999-08-03 A reversible, stoichiometric process for biomolecule conjugation NO993746L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3716597P 1997-02-04 1997-02-04
PCT/US1998/002007 WO1998033808A2 (en) 1997-02-04 1998-02-04 A reversible stoichiometric process for conjugating biomolecules

Publications (2)

Publication Number Publication Date
NO993746D0 NO993746D0 (en) 1999-08-03
NO993746L true NO993746L (en) 1999-10-01

Family

ID=21892797

Family Applications (1)

Application Number Title Priority Date Filing Date
NO993746A NO993746L (en) 1997-02-04 1999-08-03 A reversible, stoichiometric process for biomolecule conjugation

Country Status (7)

Country Link
EP (1) EP1000081A2 (en)
JP (1) JP2001526776A (en)
AU (1) AU748806B2 (en)
CA (1) CA2284463A1 (en)
DE (1) DE19882066T1 (en)
NO (1) NO993746L (en)
WO (1) WO1998033808A2 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
US5830655A (en) 1995-05-22 1998-11-03 Sri International Oligonucleotide sizing using cleavable primers
US20030129589A1 (en) 1996-11-06 2003-07-10 Hubert Koster Dna diagnostics based on mass spectrometry
WO1998026095A1 (en) 1996-12-10 1998-06-18 Genetrace Systems Inc. Releasable nonvolatile mass-label molecules
US6225061B1 (en) 1999-03-10 2001-05-01 Sequenom, Inc. Systems and methods for performing reactions in an unsealed environment
US20020009394A1 (en) 1999-04-02 2002-01-24 Hubert Koster Automated process line
US7917301B1 (en) 2000-09-19 2011-03-29 Sequenom, Inc. Method and device for identifying a biological sample
US7668658B2 (en) 1999-10-13 2010-02-23 Sequenom, Inc. Methods for generating databases and databases for identifying polymorphic genetic markers
US6958214B2 (en) 2000-07-10 2005-10-25 Sequenom, Inc. Polymorphic kinase anchor proteins and nucleic acids encoding the same
US20020155587A1 (en) 2001-04-20 2002-10-24 Sequenom, Inc. System and method for testing a biological sample
ES2320431T3 (en) * 2001-07-16 2009-05-22 Caprotec Bioanalytics Gmbh CAPTURE COMPOUNDS, COLLECTIONS OF THE SAME AND METHODS TO ANALYZE THE PROTEOM AND COMPLEX COMPOSITIONS.
WO2003093296A2 (en) 2002-05-03 2003-11-13 Sequenom, Inc. Kinase anchor protein muteins, peptides thereof, and related methods
DE602004030212D1 (en) 2003-01-16 2011-01-05 Caprotec Bioanalytics Gmbh METHOD FOR THE IDENTIFICATION OF NON-TARGETED PROTEINS ON MEDICINAL PRODUCTS
US9394565B2 (en) 2003-09-05 2016-07-19 Agena Bioscience, Inc. Allele-specific sequence variation analysis
US7608394B2 (en) 2004-03-26 2009-10-27 Sequenom, Inc. Methods and compositions for phenotype identification based on nucleic acid methylation
CN101233240A (en) 2004-03-26 2008-07-30 斯昆诺有限公司 Base-specific cleavage of methylation-specific amplification products combined with mass analysis
JP5265762B2 (en) 2008-05-13 2013-08-14 ユニバーシティ・オブ・カンザス Metal Extraction Peptide (MAP) Tag and Related Methods
WO2013181461A2 (en) 2012-06-01 2013-12-05 University Of Kansas Metal abstraction peptide with superoxide dismutase activity
WO2019081680A1 (en) * 2017-10-25 2019-05-02 Institut Pasteur Immobilization of nucleic acids using an enzymatic his-tag mimic for diagnostic applications

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE177497T1 (en) * 1984-04-05 1986-11-27 Life Technologies Inc., Gaithersburg, Md. IMMOBILIZATION OF NUCLEIC ACIDS.
DE3644346A1 (en) * 1986-12-19 1987-05-21 Saeulentechnik Dr Ing Herbert Matrix-bound crown ether ligands as separating material in the affinity chromatography of nucleic acids
CA1335721C (en) * 1987-12-24 1995-05-30 Patrick E. Guire Biomolecule attached to a solid surface by means of a spacer and methods of attaching biomolecules to surfaces
WO1990001564A1 (en) * 1988-08-09 1990-02-22 Microprobe Corporation Methods for multiple target analyses through nucleic acid hybridization
US5410068A (en) * 1989-10-23 1995-04-25 Perseptive Biosystems, Inc. Succinimidyl trityl compounds and a process for preparing same
US5582981A (en) * 1991-08-14 1996-12-10 Gilead Sciences, Inc. Method for identifying an oligonucleotide aptamer specific for a target
ATE267877T1 (en) * 1993-01-07 2004-06-15 Sequenom Inc DNA SEQUENCING THROUGH MASS SPECTRONOMY
EP1457496B1 (en) * 1996-11-06 2014-01-15 Sequenom, Inc. High density immobilization of nucleic acids

Also Published As

Publication number Publication date
AU6141698A (en) 1998-08-25
JP2001526776A (en) 2001-12-18
DE19882066T1 (en) 2000-01-05
EP1000081A2 (en) 2000-05-17
WO1998033808A3 (en) 1999-02-25
NO993746D0 (en) 1999-08-03
AU748806B2 (en) 2002-06-13
CA2284463A1 (en) 1998-08-06
WO1998033808A2 (en) 1998-08-06

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