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WO1998033808A3 - A reversible stoichiometric process for conjugating biomolecules - Google Patents

A reversible stoichiometric process for conjugating biomolecules Download PDF

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Publication number
WO1998033808A3
WO1998033808A3 PCT/US1998/002007 US9802007W WO9833808A3 WO 1998033808 A3 WO1998033808 A3 WO 1998033808A3 US 9802007 W US9802007 W US 9802007W WO 9833808 A3 WO9833808 A3 WO 9833808A3
Authority
WO
WIPO (PCT)
Prior art keywords
reversible
stoichiometric process
conjugating biomolecules
conjugating
biomolecules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1998/002007
Other languages
French (fr)
Other versions
WO1998033808A2 (en
Inventor
Hubert Koster
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CA002284463A priority Critical patent/CA2284463A1/en
Priority to DE19882066T priority patent/DE19882066T1/en
Priority to EP98906096A priority patent/EP1000081A2/en
Priority to JP53319598A priority patent/JP2001526776A/en
Priority to AU61416/98A priority patent/AU748806B2/en
Publication of WO1998033808A2 publication Critical patent/WO1998033808A2/en
Publication of WO1998033808A3 publication Critical patent/WO1998033808A3/en
Priority to NO993746A priority patent/NO993746L/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Compositions comprised of at least two biopolymers (e.g., nucleic acids or polypeptides), which are conjugated to an insoluble support by two different reversible linkages, which are cleavable under selective conditions, as well as methods and components for producing the same are described.
PCT/US1998/002007 1997-02-04 1998-02-04 A reversible stoichiometric process for conjugating biomolecules Ceased WO1998033808A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA002284463A CA2284463A1 (en) 1997-02-04 1998-02-04 A reversible stoichiometric process for conjugating biomolecules
DE19882066T DE19882066T1 (en) 1997-02-04 1998-02-04 Reversible stoichiometric method for conjugating biomolecules
EP98906096A EP1000081A2 (en) 1997-02-04 1998-02-04 A reversible stoichiometric process for conjugating biomolecules
JP53319598A JP2001526776A (en) 1997-02-04 1998-02-04 Reversible stoichiometric process for binding biomolecules
AU61416/98A AU748806B2 (en) 1997-02-04 1998-02-04 A reversible stoichiometric process for conjugating biomolecules
NO993746A NO993746L (en) 1997-02-04 1999-08-03 A reversible, stoichiometric process for biomolecule conjugation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3716597P 1997-02-04 1997-02-04
US60/037,165 1997-02-04

Publications (2)

Publication Number Publication Date
WO1998033808A2 WO1998033808A2 (en) 1998-08-06
WO1998033808A3 true WO1998033808A3 (en) 1999-02-25

Family

ID=21892797

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/002007 Ceased WO1998033808A2 (en) 1997-02-04 1998-02-04 A reversible stoichiometric process for conjugating biomolecules

Country Status (7)

Country Link
EP (1) EP1000081A2 (en)
JP (1) JP2001526776A (en)
AU (1) AU748806B2 (en)
CA (1) CA2284463A1 (en)
DE (1) DE19882066T1 (en)
NO (1) NO993746L (en)
WO (1) WO1998033808A2 (en)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6949633B1 (en) 1995-05-22 2005-09-27 Sequenom, Inc. Primers useful for sizing nucleic acids
US6958214B2 (en) 2000-07-10 2005-10-25 Sequenom, Inc. Polymorphic kinase anchor proteins and nucleic acids encoding the same
US7074563B2 (en) 1995-03-17 2006-07-11 Sequenom, Inc. Mass spectrometric methods for detecting mutations in a target nucleic acid
US7132519B2 (en) 1996-12-10 2006-11-07 Sequenom, Inc. Releasable nonvolatile mass-label molecules
US7198893B1 (en) 1996-11-06 2007-04-03 Sequenom, Inc. DNA diagnostics based on mass spectrometry
US7332275B2 (en) 1999-10-13 2008-02-19 Sequenom, Inc. Methods for detecting methylated nucleotides
US7432342B2 (en) 2002-05-03 2008-10-07 Sequenom, Inc. Kinase anchor protein muteins, peptides thereof and related documents
US7608394B2 (en) 2004-03-26 2009-10-27 Sequenom, Inc. Methods and compositions for phenotype identification based on nucleic acid methylation
US8975082B2 (en) 2008-05-13 2015-03-10 University Of Kansas Metal abstraction peptide (MAP) tag and associated methods
US9034798B2 (en) 2003-01-16 2015-05-19 Caprotec Bioanalytics Gmbh Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
US9187735B2 (en) 2012-06-01 2015-11-17 University Of Kansas Metal abstraction peptide with superoxide dismutase activity
US9249456B2 (en) 2004-03-26 2016-02-02 Agena Bioscience, Inc. Base specific cleavage of methylation-specific amplification products in combination with mass analysis
US9394565B2 (en) 2003-09-05 2016-07-19 Agena Bioscience, Inc. Allele-specific sequence variation analysis

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6225061B1 (en) 1999-03-10 2001-05-01 Sequenom, Inc. Systems and methods for performing reactions in an unsealed environment
US20020009394A1 (en) 1999-04-02 2002-01-24 Hubert Koster Automated process line
US7917301B1 (en) 2000-09-19 2011-03-29 Sequenom, Inc. Method and device for identifying a biological sample
US20020155587A1 (en) 2001-04-20 2002-10-24 Sequenom, Inc. System and method for testing a biological sample
DK1485707T3 (en) * 2001-07-16 2009-05-11 Caprotec Bioanalytics Gmbh Collection compounds, assemblies thereof and methods for analyzing the proteome and complex compositions
WO2019081680A1 (en) * 2017-10-25 2019-05-02 Institut Pasteur Immobilization of nucleic acids using an enzymatic his-tag mimic for diagnostic applications

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985004674A1 (en) * 1984-04-05 1985-10-24 Life Technologies, Inc. Immobilization of nucleic acids
DE3644346A1 (en) * 1986-12-19 1987-05-21 Saeulentechnik Dr Ing Herbert Matrix-bound crown ether ligands as separating material in the affinity chromatography of nucleic acids
WO1989005616A1 (en) * 1987-12-24 1989-06-29 Bio-Metric Systems, Inc. Biocompatible coatings
WO1990001564A1 (en) * 1988-08-09 1990-02-22 Microprobe Corporation Methods for multiple target analyses through nucleic acid hybridization
US5410068A (en) * 1989-10-23 1995-04-25 Perseptive Biosystems, Inc. Succinimidyl trityl compounds and a process for preparing same
US5547835A (en) * 1993-01-07 1996-08-20 Sequenom, Inc. DNA sequencing by mass spectrometry
US5582981A (en) * 1991-08-14 1996-12-10 Gilead Sciences, Inc. Method for identifying an oligonucleotide aptamer specific for a target
WO1998020020A2 (en) * 1996-11-06 1998-05-14 Sequenom, Inc. High density immobilization of nucleic acids

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985004674A1 (en) * 1984-04-05 1985-10-24 Life Technologies, Inc. Immobilization of nucleic acids
DE3644346A1 (en) * 1986-12-19 1987-05-21 Saeulentechnik Dr Ing Herbert Matrix-bound crown ether ligands as separating material in the affinity chromatography of nucleic acids
WO1989005616A1 (en) * 1987-12-24 1989-06-29 Bio-Metric Systems, Inc. Biocompatible coatings
WO1990001564A1 (en) * 1988-08-09 1990-02-22 Microprobe Corporation Methods for multiple target analyses through nucleic acid hybridization
US5410068A (en) * 1989-10-23 1995-04-25 Perseptive Biosystems, Inc. Succinimidyl trityl compounds and a process for preparing same
US5582981A (en) * 1991-08-14 1996-12-10 Gilead Sciences, Inc. Method for identifying an oligonucleotide aptamer specific for a target
US5547835A (en) * 1993-01-07 1996-08-20 Sequenom, Inc. DNA sequencing by mass spectrometry
WO1998020020A2 (en) * 1996-11-06 1998-05-14 Sequenom, Inc. High density immobilization of nucleic acids

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ARSHADY E: "BEADED POLYMER SUPPORTS AND GELS II. PHYSICO-CHEMICAL CRITERIA AND FUNCTIONALIZATION", JOURNAL OF CHROMATOGRAPHY, vol. 586, no. 2, 22 November 1991 (1991-11-22), pages 199 - 219, XP000247969 *
P.D.GERSHON ET AL.: "Stable Chelating Linkage for Reversible Immobilization of Oligohistidine Tagged Proteins in the BIAcore Surface Plasmon Resonance Detector.", JOURNAL OF IMMUNOLOGICAL METHODS, vol. 183, 1995, pages 65 - 76, XP002081778 *
PON R T ET AL: "DERIVATIZATION OF CONTROLLED PORE GLASS BEADS FOR SOLID PHASE OLIGONUCLEOTIDE SYNTHESIS", BIOTECHNIQUES, vol. 6, no. 8, 1 January 1988 (1988-01-01), pages 768 - 770, 773 - 775, XP000562920 *
SCOUTEN W H ET AL: "REVERSIBLE IMMOBILIZATION OF ANTIBODIES ON MAGNETIC BEADS", ANALYTICAL BIOCHEMISTRY, vol. 205, no. 2, 1 September 1992 (1992-09-01), pages 313 - 318, XP000296795 *

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7419787B2 (en) 1995-03-17 2008-09-02 Sequenom, Inc. Mass spectrometric methods for detecting mutations in a target nucleic acid
US7074563B2 (en) 1995-03-17 2006-07-11 Sequenom, Inc. Mass spectrometric methods for detecting mutations in a target nucleic acid
US6949633B1 (en) 1995-05-22 2005-09-27 Sequenom, Inc. Primers useful for sizing nucleic acids
US7501251B2 (en) 1996-11-06 2009-03-10 Sequenom, Inc. DNA diagnostics based on mass spectrometry
US7198893B1 (en) 1996-11-06 2007-04-03 Sequenom, Inc. DNA diagnostics based on mass spectrometry
US7132519B2 (en) 1996-12-10 2006-11-07 Sequenom, Inc. Releasable nonvolatile mass-label molecules
US7332275B2 (en) 1999-10-13 2008-02-19 Sequenom, Inc. Methods for detecting methylated nucleotides
US6958214B2 (en) 2000-07-10 2005-10-25 Sequenom, Inc. Polymorphic kinase anchor proteins and nucleic acids encoding the same
US7432342B2 (en) 2002-05-03 2008-10-07 Sequenom, Inc. Kinase anchor protein muteins, peptides thereof and related documents
US9034798B2 (en) 2003-01-16 2015-05-19 Caprotec Bioanalytics Gmbh Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
US9394565B2 (en) 2003-09-05 2016-07-19 Agena Bioscience, Inc. Allele-specific sequence variation analysis
US7608394B2 (en) 2004-03-26 2009-10-27 Sequenom, Inc. Methods and compositions for phenotype identification based on nucleic acid methylation
US9249456B2 (en) 2004-03-26 2016-02-02 Agena Bioscience, Inc. Base specific cleavage of methylation-specific amplification products in combination with mass analysis
US8975082B2 (en) 2008-05-13 2015-03-10 University Of Kansas Metal abstraction peptide (MAP) tag and associated methods
US9096652B2 (en) 2008-05-13 2015-08-04 University Of Kansas Metal abstraction peptide (MAP) tag and associated methods
US9187735B2 (en) 2012-06-01 2015-11-17 University Of Kansas Metal abstraction peptide with superoxide dismutase activity

Also Published As

Publication number Publication date
JP2001526776A (en) 2001-12-18
DE19882066T1 (en) 2000-01-05
EP1000081A2 (en) 2000-05-17
AU6141698A (en) 1998-08-25
WO1998033808A2 (en) 1998-08-06
NO993746D0 (en) 1999-08-03
CA2284463A1 (en) 1998-08-06
NO993746L (en) 1999-10-01
AU748806B2 (en) 2002-06-13

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