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NO996243L - Retentatkromatografi og proteinchipsrekker med anvendelse innen biologi og medisin - Google Patents

Retentatkromatografi og proteinchipsrekker med anvendelse innen biologi og medisin

Info

Publication number
NO996243L
NO996243L NO996243A NO996243A NO996243L NO 996243 L NO996243 L NO 996243L NO 996243 A NO996243 A NO 996243A NO 996243 A NO996243 A NO 996243A NO 996243 L NO996243 L NO 996243L
Authority
NO
Norway
Prior art keywords
biology
medicine
applications
retentate chromatography
protein chip
Prior art date
Application number
NO996243A
Other languages
English (en)
Other versions
NO996243D0 (no
Inventor
William T Hutchens
Tai-Tung Yip
Original Assignee
Ciphergen Biosystems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciphergen Biosystems Inc filed Critical Ciphergen Biosystems Inc
Publication of NO996243D0 publication Critical patent/NO996243D0/no
Publication of NO996243L publication Critical patent/NO996243L/no

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    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00Methods of screening libraries
    • C40B30/04Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/02Details
    • H01J49/04Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
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Families Citing this family (480)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ267842A (en) * 1993-05-28 1997-09-22 Baylor College Medicine Apparatus for measuring molecular mass (by mass spectrometry) in which the sample is ionised on the sample holder and desorbed therefrom by laser pulses
US20020037517A1 (en) * 1993-05-28 2002-03-28 Hutchens T. William Methods for sequencing biopolymers
CA2229986C (en) * 1995-06-20 2014-10-21 Johannes Schumacher Process and device for determining the activity of enzymes in liquids, or the concentration and/or activity of inhibitors in liquids
US20030027126A1 (en) 1997-03-14 2003-02-06 Walt David R. Methods for detecting target analytes and enzymatic reactions
US7622294B2 (en) 1997-03-14 2009-11-24 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
NZ516848A (en) * 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
CA2302147C (en) * 1997-09-03 2008-05-13 Biovation Limited Methods for protein screening
EP1965213A3 (en) 1998-02-04 2009-07-15 Invitrogen Corporation Microarrays and uses therefor
US6406921B1 (en) * 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US20020119579A1 (en) * 1998-07-14 2002-08-29 Peter Wagner Arrays devices and methods of use thereof
US20030138973A1 (en) * 1998-07-14 2003-07-24 Peter Wagner Microdevices for screening biomolecules
US6576478B1 (en) * 1998-07-14 2003-06-10 Zyomyx, Inc. Microdevices for high-throughput screening of biomolecules
US6780582B1 (en) * 1998-07-14 2004-08-24 Zyomyx, Inc. Arrays of protein-capture agents and methods of use thereof
US6867289B1 (en) * 1998-10-26 2005-03-15 Board Of Regents, The University Of Texas Systems Thio-modified aptamer synthetic methods and compositions
US20060172925A1 (en) * 1998-10-26 2006-08-03 Board Of Regents, The University Of Texas System Thio-siRNA aptamers
US20040242521A1 (en) * 1999-10-25 2004-12-02 Board Of Regents, The University Of Texas System Thio-siRNA aptamers
AU774776B2 (en) * 1999-04-15 2004-07-08 University Of Virginia Patent Foundation Proteome mining
CA2368247A1 (en) 1999-04-27 2000-11-09 Ciphergen Biosystems, Inc. Probes for a gas phase ion spectrometer
US6555813B1 (en) 1999-04-29 2003-04-29 Ciphergen Biosystems, Inc. Probes with hydrophobic coatings for gas phase ion spectrometers
WO2000079268A2 (en) * 1999-06-18 2000-12-28 Biacore Ab Method and apparatus for assaying a drug candidate to estimate a pharmacokinetic parameter associated therewith
US20090233806A1 (en) * 1999-07-06 2009-09-17 Carr Francis J Protein isolation and analysis
ATE308386T1 (de) * 1999-07-26 2005-11-15 Harvard Apparatus Inc Oberflächenbeschichtetes gehäuse zur probenvorbereitung
US6713309B1 (en) 1999-07-30 2004-03-30 Large Scale Proteomics Corporation Microarrays and their manufacture
US7179638B2 (en) 1999-07-30 2007-02-20 Large Scale Biology Corporation Microarrays and their manufacture by slicing
US7138254B2 (en) 1999-08-02 2006-11-21 Ge Healthcare (Sv) Corp. Methods and apparatus for performing submicroliter reactions with nucleic acids or proteins
AU7103500A (en) * 1999-09-01 2001-03-26 Medalys Corporation High throughput chemical profiling
AU7826500A (en) * 1999-09-01 2001-03-26 Medalys Corporation Automated test agent profiling system
US6869572B1 (en) * 1999-09-13 2005-03-22 Millipore Corporation High density cast-in-place sample preparation card
US6783929B1 (en) * 1999-11-02 2004-08-31 Chiron Corporation Biological sample component purification and differential display
US6936424B1 (en) * 1999-11-16 2005-08-30 Matritech, Inc. Materials and methods for detection and treatment of breast cancer
ATE340025T1 (de) * 2000-01-06 2006-10-15 Caliper Life Sciences Inc Vorrichtungen und verfahren für hochdurchsatz- probenentnahme und analyse
DE10000629C5 (de) * 2000-01-10 2010-06-02 november Aktiengesellschaft, Gesellschaft für Molekulare Medizin Verfahren zur Identifizierung einer auf einen festen Körper aufgebrachten Markierung
US20030087265A1 (en) * 2000-01-21 2003-05-08 Edward Sauter Specific microarrays for breast cancer screening
MXPA02007665A (es) * 2000-02-08 2004-08-23 Univ Michigan Trazado de despliegue diferencial de proteinas.
CA2401118A1 (en) 2000-02-23 2001-08-30 Zyomyx, Inc. Microfluidic devices and methods
US6815215B2 (en) * 2000-02-28 2004-11-09 Hitachi, Ltd. Method of recovering a plurality of nucleic acids by an identical stationary phase and an apparatus thereof
US6569383B1 (en) * 2000-03-11 2003-05-27 Intrinsic Bioprobes, Inc. Bioactive chip mass spectrometry
US7351540B1 (en) * 2000-03-17 2008-04-01 Merck Patent Gmbh Protein isolation and analysis
CA2301451A1 (en) * 2000-03-20 2001-09-21 Thang T. Pham Method for analysis of analytes by mass spectrometry
CN1654956A (zh) 2000-05-04 2005-08-17 耶鲁大学 用于筛选蛋白活性的高密度蛋白阵列
JP2003536073A (ja) * 2000-06-05 2003-12-02 カイロン コーポレイション プロテオミクス分析を実施するためのマイクロアレイ
US7148058B2 (en) 2000-06-05 2006-12-12 Chiron Corporation Protein microarrays on mirrored surfaces for performing proteomic analyses
US7153682B2 (en) * 2000-06-05 2006-12-26 Chiron Corporation Microarrays on mirrored substrates for performing proteomic analyses
MXPA02012167A (es) * 2000-06-19 2004-08-19 Correlogic Systems Inc Metodo heuristico de clasificacion.
SG144731A1 (en) * 2000-07-18 2008-08-28 Correlogic Systems Inc A process for discriminating between biological states based on hidden patterns from biological data
EP1178317B1 (en) 2000-07-24 2004-11-10 Health Research, Inc. Method for detection of prostate specific membrane antigen in serum
US6379550B1 (en) * 2000-07-24 2002-04-30 Health Research, Inc. Method for detecting PSA and its molecular forms using thiophilic gel
US6610499B1 (en) * 2000-08-31 2003-08-26 The Regents Of The University Of California Capillary array and related methods
CA2421368A1 (en) * 2000-09-05 2002-03-14 Illumina, Inc. Cellular arrays comprising encoded cells
EP1331996A2 (en) * 2000-09-18 2003-08-06 Harvard College METHOD AND DEVICE FOR GRADIENT GENERATION
CA2320549A1 (en) * 2000-09-25 2002-03-25 Eastern Virginia Medical College Biomarkers of transitional cell carcinoma of the bladder
CA2425434A1 (en) * 2000-10-11 2002-04-18 Tina Morris Methods for characterizing molecular interactions using affinity capture tandem mass spectrometry
DE10054055A1 (de) * 2000-10-31 2002-05-23 Nmi Univ Tuebingen Verfahren zur Analyse von Proteinen
JP3375941B2 (ja) 2000-11-24 2003-02-10 科学技術振興事業団 高効率抗体スクリーニング法
US6585646B2 (en) * 2000-11-29 2003-07-01 Hermetic Diagnostics, Inc. Screening test and procedure using skin patches
US7091046B2 (en) * 2000-12-11 2006-08-15 Hk Pharmaceuticals, Inc. Multiplexed protein expression and activity assay
WO2002048716A2 (en) * 2000-12-14 2002-06-20 Paul Stroobant Differential phage capture proteomics
US20020119490A1 (en) * 2000-12-26 2002-08-29 Aebersold Ruedi H. Methods for rapid and quantitative proteome analysis
US20020115056A1 (en) 2000-12-26 2002-08-22 Goodlett David R. Rapid and quantitative proteome analysis and related methods
US7691645B2 (en) * 2001-01-09 2010-04-06 Agilent Technologies, Inc. Immunosubtraction method
US20030129666A1 (en) * 2001-01-09 2003-07-10 Mitsubishi Pharma Corporation Novel proteome analysis method and devices therefor
US6969757B2 (en) * 2001-01-26 2005-11-29 Syngenta Participations Ag Differential labeling for quantitative analysis of complex protein mixtures
US7166436B2 (en) 2001-01-26 2007-01-23 Syngenta Participations, Ag Differential labeling for quantitative analysis of complex protein mixtures
US20020169562A1 (en) * 2001-01-29 2002-11-14 Gregory Stephanopoulos Defining biological states and related genes, proteins and patterns
US7297501B2 (en) * 2001-02-02 2007-11-20 University Of Pennsylvania Method and devices for running reactions on a target plate for MALDI mass spectrometry
US7332286B2 (en) * 2001-02-02 2008-02-19 University Of Pennsylvania Peptide or protein microassay method and apparatus
JP3640387B2 (ja) * 2001-02-27 2005-04-20 独立行政法人理化学研究所 レーザーアブレーションを用いた高分子の分析方法およびそのシステム
WO2002073180A1 (en) * 2001-03-08 2002-09-19 Ruo-Pan Huang An antibody-based protein array system
US20030228639A1 (en) * 2001-03-19 2003-12-11 Wright George L Prostate cancer markers
AU2002306768A1 (en) * 2001-03-20 2002-10-03 Ortho-Clinical Diagnostics, Inc. Expression profiles and methods of use
EP1565747B1 (en) * 2001-03-29 2013-11-27 Cellect Technologies Corp. Method and system for separating and sorting particles
US7524635B2 (en) * 2003-04-17 2009-04-28 Biosite Incorporated Methods and compositions for measuring natriuretic peptides and uses thereof
US20030219734A1 (en) * 2001-04-13 2003-11-27 Biosite Incorporated Polypeptides related to natriuretic peptides and methods of their identification and use
US6777239B2 (en) 2001-04-17 2004-08-17 Xenoport, Inc. Epitope-captured antibody display
US20020155587A1 (en) 2001-04-20 2002-10-24 Sequenom, Inc. System and method for testing a biological sample
US20020160421A1 (en) * 2001-04-30 2002-10-31 George Jackowski Method for monitoring and validating stress induction of disease state
CN1527720A (zh) * 2001-05-11 2004-09-08 Ү³��ѧ 利用蛋白组芯片全面分析蛋白活性
WO2002097392A2 (en) * 2001-05-25 2002-12-05 Waters Investments Limited Sample concentration maldi plates for maldi mass spectrometry
US7053366B2 (en) 2001-05-25 2006-05-30 Waters Investments Limited Desalting plate for MALDI mass spectrometry
US7723123B1 (en) 2001-06-05 2010-05-25 Caliper Life Sciences, Inc. Western blot by incorporating an affinity purification zone
US20020197729A1 (en) * 2001-06-21 2002-12-26 Fuji Photo Film Co., Ltd. Biochemical analysis unit and method for manufacturing the same
AU2002316372A1 (en) * 2001-06-22 2003-01-08 Symyx Technologies, Inc. Inverse chromatography methods and apparatus for evaluation of interactions between modifying agents and receptors
CA2452690C (en) * 2001-06-29 2016-08-16 Veri-Q, Inc. Methods and compositions for determining the purity of and purifying chemically synthesized nucleic acids
US7297553B2 (en) 2002-05-28 2007-11-20 Nanosphere, Inc. Method for attachment of silylated molecules to glass surfaces
US6800449B1 (en) * 2001-07-13 2004-10-05 Syngenta Participations Ag High throughput functional proteomics
AU2002322458A1 (en) * 2001-07-13 2003-01-29 Nanosphere, Inc. Method for immobilizing molecules onto surfaces
WO2003079402A2 (en) * 2001-07-17 2003-09-25 Ciphergen Biosystems, Inc. Latex based adsorbent chip
US7517496B2 (en) * 2001-07-17 2009-04-14 Bio-Rad Laboratories, Inc. Latex based adsorbent chip
WO2003011285A1 (en) * 2001-08-01 2003-02-13 Merck & Co., Inc. BENZIMIDAZO[4,5-f]ISOQUINOLINONE DERIVATIVES
GB0120131D0 (en) * 2001-08-17 2001-10-10 Micromass Ltd Maldi target plate
US7297556B2 (en) * 2001-08-30 2007-11-20 Vermillion, Inc. Method of diagnosing nephrotic syndrome
ATE346952T1 (de) * 2001-09-03 2006-12-15 Kyowa Hakko Kogyo Kk Verfahren zur bestimmung eines zielproteins eines arzneistoffs
GB2379737A (en) * 2001-09-05 2003-03-19 Univ Geneve Diagnostic method for spongiform encephalopathy disease
US20040171026A1 (en) * 2001-09-05 2004-09-02 Hochstrasser Denis Francois Diagnostic method for transmissible spongiform encephalopathies
US20030068655A1 (en) * 2001-09-12 2003-04-10 Protiveris, Inc. Microcantilever apparatus and methods for detection of enzymes
US20040043436A1 (en) * 2001-09-21 2004-03-04 Antonia Vlahou Biomarkers of transitional cell carcinoma of the bladder
US6756586B2 (en) * 2001-10-15 2004-06-29 Vanderbilt University Methods and apparatus for analyzing biological samples by mass spectrometry
US20050064446A1 (en) * 2001-11-01 2005-03-24 Minerva Biotechnologies Corporation Detection of binding species with colloidal and non-colloidal structures
US7842498B2 (en) 2001-11-08 2010-11-30 Bio-Rad Laboratories, Inc. Hydrophobic surface chip
WO2003062444A2 (en) * 2001-11-13 2003-07-31 Emory University Array systems and methods
US20030091976A1 (en) * 2001-11-14 2003-05-15 Ciphergen Biosystems, Inc. Methods for monitoring polypeptide production and purification using surface enhanced laser desorption/ionization mass spectrometry
US20030162190A1 (en) * 2001-11-15 2003-08-28 Gorenstein David G. Phosphoromonothioate and phosphorodithioate oligonucleotide aptamer chip for functional proteomics
CA2467248A1 (en) * 2001-11-20 2003-05-30 Exact Sciences Corporation Automated sample preparation methods and devices
US7132244B2 (en) * 2001-11-21 2006-11-07 Syn X Pharma, Inc. Betaine/GABA transport protein biopolymer marker indicative of insulin resistance
US7179605B2 (en) * 2001-11-23 2007-02-20 Nanogen Inc. Fibronectin precursor biopolymer markers indicative of alzheimer's disease
US6946653B2 (en) 2001-11-27 2005-09-20 Ciphergen Biosystems, Inc. Methods and apparatus for improved laser desorption ionization tandem mass spectrometry
WO2003049602A2 (en) * 2001-12-11 2003-06-19 University Of Medicine And Dentistry Of New Jersey Diagnostic methods for protein profiling
SE0202398D0 (sv) * 2001-12-11 2002-08-13 Thomas Laurell Target plate and use thereof for improved analysis
WO2003054514A2 (en) * 2001-12-19 2003-07-03 Rett Corporation Novel parallel throughput system
US20030116501A1 (en) * 2001-12-21 2003-06-26 Council Of Scientific And Industrial Research Process for preparing immobilized nano-sized metal particles
WO2003065043A2 (en) * 2002-01-29 2003-08-07 King's College London An Institute Incorporated By Royal Charter Of Strand Identification and relative quantification of proteins
US7094579B2 (en) * 2002-02-13 2006-08-22 Xoma Technology Ltd. Eukaryotic signal sequences for prokaryotic expression
GB0203768D0 (en) * 2002-02-18 2002-04-03 Univ Geneve Diagnostic method for stroke
US20050153360A1 (en) * 2002-02-18 2005-07-14 Hochstrasser Denis F. Diagnostic method for stroke
EP1485461A4 (en) * 2002-02-21 2005-06-22 Eastern Virginia Med School PROTEIN BIOMARKERS DISTINGUISHING PROSTATE CANCER OF NON-MALIGNIC CELLS
US7504364B2 (en) * 2002-03-01 2009-03-17 Receptors Llc Methods of making arrays and artificial receptors
WO2003077851A2 (en) * 2002-03-11 2003-09-25 Hk Pharmaceuticals, Inc. Compounds and methods for analyzing the proteome
US20030228709A1 (en) * 2002-03-25 2003-12-11 Kozlowski Roland Zbignieiw Arrays
US6803566B2 (en) 2002-04-16 2004-10-12 Ut-Battelle, Llc Sampling probe for microarray read out using electrospray mass spectrometry
AU2003224515A1 (en) * 2002-05-03 2003-11-17 Dsm Ip Assets B.V. Process for the monitoring of contaminant removal during the purification process of a pharmaceutical product produced by a host cell
EP1499890B1 (en) * 2002-05-07 2010-04-28 The Research Foundation of State University of New York High throughput method to identify biomolecule delivery formulations
US7618788B2 (en) * 2002-05-10 2009-11-17 Millipore Corporation Proteome epitope tags and methods of use thereof in protein modification analysis
US20040052412A1 (en) * 2002-05-10 2004-03-18 Large Scale Biology Corporation Satellite image enhancement and feature identification using information theory radial-basis bio-marker filter
US7460960B2 (en) * 2002-05-10 2008-12-02 Epitome Biosystems, Inc. Proteome epitope tags and methods of use thereof in protein modification analysis
US7138230B2 (en) 2002-12-06 2006-11-21 Renovar, Inc. Systems and methods for characterizing kidney diseases
US20040029191A1 (en) * 2002-05-17 2004-02-12 Ciphergen Biosystems, Inc. Detection of kinase substrates and products using ion mass spectrometry
US20040033613A1 (en) * 2002-05-30 2004-02-19 Zwick Michael G. Saliva-based protein profiling
AU2003231947A1 (en) * 2002-05-31 2003-12-19 Aaron Diamond Aids Research Center Defensins: use as antiviral agents
ATE321851T1 (de) * 2002-06-07 2006-04-15 Sophion Bioscience As Screening-verfahren
WO2004001377A2 (en) * 2002-06-20 2003-12-31 Paul Stroobant Improved methods for performing differential capture proteomics
JP4380535B2 (ja) 2002-06-28 2009-12-09 キヤノン株式会社 プローブ担体および該プローブ担体の分析方法
EP1519189A4 (en) * 2002-06-28 2007-07-25 Canon Kk METHOD FOR ANALYZING PROBE CARRIER BY TIME-OF-FLIGHT MASS SPECTROMETRY AND SECONDARY ION EMISSION
US20040137491A1 (en) * 2002-06-28 2004-07-15 Tadashi Okamoto Method of analyzing probe carrier using time-of-flight secondary ion mass spectrometry
DE10329928A1 (de) * 2002-07-12 2004-02-05 Benq Corp., Kweishan Verfahren zur Aufbereitung von Biochips und Biochip
US7348184B2 (en) * 2002-07-24 2008-03-25 Bio-Rad Laboratories, Inc. Protein interaction difference mapping
GB0305796D0 (en) * 2002-07-24 2003-04-16 Micromass Ltd Method of mass spectrometry and a mass spectrometer
FR2842826B1 (fr) * 2002-07-25 2006-01-20 Centre Nat Rech Scient Procede de fabrication de puces biologiques
US7655474B2 (en) * 2002-07-29 2010-02-02 The United States Of America As Represented By The Secretary Of The Navy Trioxyethylene gold nanoclusters functionalized with a single DNA
AU2003261273A1 (en) * 2002-07-29 2004-02-16 Correlogic Systems, Inc. Quality assurance for high-throughput bioassay methods
WO2004013290A2 (en) * 2002-08-05 2004-02-12 Invitrogen Corporation Compositions and methods for molecular biology
WO2005017646A2 (en) * 2002-08-06 2005-02-24 The Johns Hopkins University System, software and methods for biomarker identification
KR101107765B1 (ko) * 2002-08-06 2012-01-25 싸이퍼젠 바이오시스템즈, 인코포레이티드 난소암의 검출을 위한 생물 마커의 용도
GB2391867A (en) * 2002-08-13 2004-02-18 Smartbead Technologies Ltd Analysis system using coded supports
US20050233473A1 (en) * 2002-08-16 2005-10-20 Zyomyx, Inc. Methods and reagents for surface functionalization
US7785799B2 (en) * 2002-08-16 2010-08-31 The Board Of Regents Of The University Of Texas System Compositions and methods related to flavivirus envelope protein domain III antigens
US7045366B2 (en) * 2003-09-12 2006-05-16 Ciphergen Biosystems, Inc. Photocrosslinked hydrogel blend surface coatings
AU2003270601A1 (en) * 2002-09-13 2004-04-30 Ciphergen Biosystems, Inc. Preparation and use of mixed mode solid substrates for chromatography adsorbents and biochip arrays
US20060292701A1 (en) * 2002-09-13 2006-12-28 Ciphergen Biosystems Inc. Photocrosslinked hydrogel blend surface coatings
WO2005003326A2 (en) * 2003-03-28 2005-01-13 Receptors Llc. Artificial receptors including reversibly immobilized building blocks and methods
US20050170385A1 (en) * 2002-09-16 2005-08-04 Receptors Llc Artificial receptors including gradients
US20040137481A1 (en) * 2002-09-16 2004-07-15 Receptors Llc Artificial receptor building blocks, components, and kits
US20060051802A1 (en) * 2002-09-16 2006-03-09 Receptors Llc Artificial receptors, building blocks, and methods
US20050037381A1 (en) * 2002-09-16 2005-02-17 Receptors Llc Artificial receptors, building blocks, and methods
US20050136483A1 (en) * 2003-09-03 2005-06-23 Receptors Llc Nanodevices employing combinatorial artificial receptors
US20050037429A1 (en) * 2003-03-28 2005-02-17 Receptors Llc Artificial receptors including reversibly immobilized building blocks and methods
KR20050070034A (ko) * 2002-10-04 2005-07-05 미쯔비시 웰 파마 가부시키가이샤 질량 분석용 플레이트, 그 제조 방법 및 그 용도
EP1552300B1 (en) * 2002-10-15 2011-07-20 Abmetrix, Inc. Sets of digital antibodies directed against short epitopes, and methods using same
CA2749227A1 (en) * 2002-10-16 2005-01-13 Board Of Regents Of The University Of Texas System Bead bound combinatorial oligonucleoside phosphorothioate and phosphorodithioate aptamer libraries
AU2003274368B2 (en) 2002-10-30 2008-11-20 Proteome Sciences Plc. Diagnostic method for transmissible spongiform encephalopathies (prion diseases)
US7122384B2 (en) * 2002-11-06 2006-10-17 E. I. Du Pont De Nemours And Company Resonant light scattering microparticle methods
US20030153013A1 (en) * 2002-11-07 2003-08-14 Ruo-Pan Huang Antibody-based protein array system
EP1565570A4 (en) * 2002-11-12 2005-12-28 Becton Dickinson Co DIAGNOSIS OF SEPTICEMIA OR SIRS USING BIOMARKER PROFILES
US20040096917A1 (en) * 2002-11-12 2004-05-20 Becton, Dickinson And Company Diagnosis of sepsis or SIRS using biomarker profiles
CA2505785A1 (en) * 2002-11-12 2004-05-27 Becton, Dickinson And Company Diagnosis of sepsis or sirs using biomarker profiles
WO2004043238A2 (en) * 2002-11-14 2004-05-27 Ciphergen Biosystems, Inc. Biomarkers for intra-amniotic inflammation
US7846748B2 (en) * 2002-12-02 2010-12-07 The University Of North Carolina At Chapel Hill Methods of quantitation and identification of peptides and proteins
DE10258674A1 (de) * 2002-12-13 2004-06-24 Sunyx Surface Nanotechnologies Gmbh Verfahren zur Herstellung eines Probenträgers für die MALDI-Massenspektrometrie
AU2003294377A1 (en) 2002-12-18 2004-07-29 Ciphergen Biosystems, Inc. Serum biomarkers in lung cancer
US7422865B2 (en) * 2003-01-13 2008-09-09 Agilent Technologies, Inc. Method of identifying peptides in a proteomic sample
DE602004030212D1 (de) 2003-01-16 2011-01-05 Caprotec Bioanalytics Gmbh Verfahren zur identifizierung von auf arzneimittel nicht-zielgerichteten proteinen
US6909981B2 (en) * 2003-01-27 2005-06-21 Ciphergen Biosystems, Inc. Data management system and method for processing signals from sample spots
US7046357B2 (en) * 2003-01-30 2006-05-16 Ciphergen Biosystems, Inc. Apparatus for microfluidic processing and reading of biochip arrays
GB2413892B (en) * 2003-02-10 2007-01-31 Waters Investments Ltd A sample preparation plate for mass spectrometry
WO2004073492A2 (en) * 2003-02-14 2004-09-02 Massachusetts Eye And Ear Infirmary Chlamydia pneumoniae associated chronic intraocular disorders and treatment thereof
DE10311384A1 (de) * 2003-03-11 2004-09-30 Universität Potsdam Nachweisverfahren für pflanzliche Moleküle
GB0305656D0 (en) * 2003-03-12 2003-04-16 Bioinvent Int Ab Screening assay
CA2519086A1 (en) * 2003-03-14 2004-09-23 Kitakyushu Foundation For The Advancement Of Industry Science And Techno Logy Biological molecule-immobilized chip and its use
HRP20050809A2 (en) * 2003-03-25 2006-02-28 Instraction Gmbh Method for selectively binding a substrate to sorbents by way of at least bivalent bonds
CA2521034A1 (en) * 2003-04-02 2004-10-21 Merck & Co., Inc. Mass spectrometry data analysis techniques
US6977370B1 (en) 2003-04-07 2005-12-20 Ciphergen Biosystems, Inc. Off-resonance mid-IR laser desorption ionization
CA2522709A1 (en) 2003-04-17 2004-11-04 Ciphergen Biosystems, Inc. Polypeptides related to natriuretic peptides and methods of their identification and use
EP1616180A4 (en) * 2003-04-22 2006-07-19 Ciphergen Biosystems Inc ANALYSIS PROCESS FOR HOST CELL PROTEINS
WO2004097368A2 (en) * 2003-04-28 2004-11-11 Ciphergen Biosystems, Inc. Improved immunoassays
US20040219589A1 (en) * 2003-04-29 2004-11-04 Taehoon Lee Ligand profiling and identification
WO2005039381A2 (en) * 2003-05-05 2005-05-06 Drug Risk Solutions, L.L.C. Compositions and processes for analysis of pharmacologic agents in biological samples
US7425700B2 (en) * 2003-05-22 2008-09-16 Stults John T Systems and methods for discovery and analysis of markers
US20040236603A1 (en) * 2003-05-22 2004-11-25 Biospect, Inc. System of analyzing complex mixtures of biological and other fluids to identify biological state information
WO2005032455A2 (en) * 2003-05-23 2005-04-14 Board Of Regents Combinatorially selected phosphorodithioate aptamer targeting ap-1
EP1635693A2 (en) * 2003-05-23 2006-03-22 Board Of Regents, The University Of Texas System High throughput screening of aptamer libraries for specific binding to proteins on viruses and other pathogens
US20040241668A1 (en) * 2003-05-30 2004-12-02 Amorese Douglas A. Ligand array assays that include a low surface tension fluid wash step and compositions for practicing the same
US20040241742A1 (en) * 2003-05-30 2004-12-02 Peck Bill J. Ligand array processing methods that include a low surface tension fluid deposition step and compositions for practicing the same
US20040241880A1 (en) * 2003-05-30 2004-12-02 Leproust Eric M. Ligand array assays having reduced fluorescent dye degradation and compositions for practicing the same
US20040248323A1 (en) 2003-06-09 2004-12-09 Protometrix, Inc. Methods for conducting assays for enzyme activity on protein microarrays
US20050100967A1 (en) * 2003-07-11 2005-05-12 Science & Technology Corporation @ Unm Detection of endometrial pathology
US20050032113A1 (en) * 2003-07-17 2005-02-10 Mitsubishi Pharma Corporation Membrane protein library for proteome analysis and method for preparing same
US20050118611A1 (en) * 2003-07-24 2005-06-02 Board Of Regents, The University Of Texas System Thioaptamers enable discovery of physiological pathways and new therapeutic strategies
US20050026304A1 (en) * 2003-07-30 2005-02-03 Laurakay Bruhn Microarray based affinity purification and analysis device coupled with secondary analysis technologies
MXPA06001170A (es) * 2003-08-01 2006-05-15 Correlogic Systems Inc Caracteristicas proteomicas de suero de alta resolucion multiples para deteccion de cancer de ovarios.
US20050037424A1 (en) * 2003-08-13 2005-02-17 Schembri Carol T. Selectable length linear microarrays
CA2536062A1 (en) * 2003-08-18 2005-03-03 Tethys Bioscience, Inc. Methods for reducing complexity of a sample using small epitope antibodies
WO2005019875A2 (en) * 2003-08-22 2005-03-03 Stratos Biosystems, Llc Electrowetting sample presentation device
WO2005023981A2 (en) * 2003-09-09 2005-03-17 Zephyr Proteomix Ltd. Libraries of chimeric cellulose binding proteins and methods of use thereof
AU2004276760B2 (en) * 2003-09-22 2010-03-04 Becton, Dickinson And Company Quantification of analytes using internal standards
US20050084867A1 (en) * 2003-10-15 2005-04-21 Caren Michael P. Hybridization and scanning apparatus
US20050084866A1 (en) * 2003-10-15 2005-04-21 Caren Michael P. Methods and apparatus for sample mixing
WO2005047851A2 (en) * 2003-10-15 2005-05-26 The Trustees Of Columbia University In The City Of New York Device for measuring nanometer level pattern-dependent binding reactions
US8137548B2 (en) * 2003-10-17 2012-03-20 Zirchrom Separations, Inc. Chelator-modified inorganic oxide particles
US20050112650A1 (en) * 2003-10-20 2005-05-26 Ciphergen Biosystems, Inc. Reactive polyurethane-based polymers
AU2004286240A1 (en) 2003-10-23 2005-05-12 University Of Pittsburgh Of The Commonwealth System Of Higher Education Biomarkers for amyotrophic lateral sclerosis
WO2005040163A1 (en) * 2003-10-28 2005-05-06 Dr. Reddy's Laboratories Ltd Heterocyclic compounds that block the effects of advanced glycation end products (age)
JP2007510928A (ja) * 2003-11-06 2007-04-26 エス アール ユー バイオシステムズ,インコーポレイテッド 高密度アミン機能化表面
EP1694816B1 (en) 2003-11-07 2013-08-28 Ciphergen Biosystems, Inc. Biomarkers for alzheimer's disease
US20050112588A1 (en) * 2003-11-25 2005-05-26 Caren Michael P. Methods and apparatus for analyzing arrays
US20050158745A1 (en) * 2003-11-25 2005-07-21 Ye Jack Z. Methods and compositions for detection of nasopharyngeal carcinoma
WO2005055812A2 (en) 2003-12-05 2005-06-23 Ciphergen Biosystems, Inc. Serum biomarkers for chagas disease
EP1724281B1 (en) * 2003-12-23 2013-02-13 Biokit S.A. Pathogenic infection detection compositions and methods
DE102004062281A1 (de) * 2003-12-29 2005-07-28 Siemens Ag Verfahren und Spotting-Lösung zum Herstellen von Microarrays
US7183544B2 (en) * 2003-12-31 2007-02-27 Ciphergen Biosystems Inc. Bi-functional polymer chip
US20050181398A1 (en) * 2004-01-16 2005-08-18 Fung Eric T. Specific detection of host response protein clusters
EP1715948B1 (en) * 2004-01-20 2016-11-23 Pall Corporation Chromatographic material for the absorption of proteins at physiological ionic strength
US20050181513A1 (en) * 2004-02-18 2005-08-18 Viorica Lopez-Avila Methods and compositions for assessing a sample by MAILDI mass spectrometry
US20050178959A1 (en) * 2004-02-18 2005-08-18 Viorica Lopez-Avila Methods and compositions for assessing a sample by maldi mass spectrometry
US8003934B2 (en) * 2004-02-23 2011-08-23 Andreas Hieke Methods and apparatus for ion sources, ion control and ion measurement for macromolecules
US7138642B2 (en) * 2004-02-23 2006-11-21 Gemio Technologies, Inc. Ion source with controlled superposition of electrostatic and gas flow fields
US20050202485A1 (en) * 2004-03-03 2005-09-15 Ye Jack Z. Method and compositions for detection of liver cancer
US20050233400A1 (en) * 2004-03-03 2005-10-20 Weiner Carl P Proteomic method for predicting success of rescue cerclage
US20060275923A1 (en) * 2004-03-23 2006-12-07 Hammond David J Methods for reducing the range in concentrations of analyte species in a sample
EP1580559B1 (en) * 2004-03-23 2013-12-25 Bio-Rad Laboratories, Inc. Methods for reducing the variance between analyte concentrations taken from complex sample mixtures
EP1731905A4 (en) * 2004-03-31 2012-08-22 Shionogi & Co MASS ANALYSIS METHOD WITH FINE METAL PARTICLES
EP1745149A4 (en) 2004-04-15 2008-08-06 Univ Florida NEURALE PROTEINS AS BIOMARKERS FOR INJURY TO THE NERVOUS SYSTEM AND OTHER NEURAL DISORDERS
GB0408351D0 (en) * 2004-04-15 2004-05-19 Plasso Technology Ltd Reversible binding surface
US20050239134A1 (en) * 2004-04-21 2005-10-27 Board Of Regents, The University Of Texas System Combinatorial selection of phosphorothioate single-stranded DNA aptamers for TGF-beta-1 protein
WO2005103281A2 (en) 2004-04-26 2005-11-03 Children's Medical Center Corporation Platelet biomarkers for the detection of disease
US20050244973A1 (en) * 2004-04-29 2005-11-03 Predicant Biosciences, Inc. Biological patterns for diagnosis and treatment of cancer
US7749716B2 (en) * 2004-05-18 2010-07-06 Vermilllion, Inc. Methods of detecting a fragment of neurosecretory protein VGF for diagnosing alzheimer's disease
US20060003204A1 (en) * 2004-07-01 2006-01-05 Callahan Christopher W Controlling fuel cell fuel purge in response to recycle fuel blower operating conditions
DK2199801T3 (da) 2004-07-14 2013-08-05 Univ California Biomarkører til tidlig påvisning af ovariecancer
US7943294B2 (en) * 2004-07-30 2011-05-17 Hologic, Inc. Methods for detecting oncofetal fibronectin
WO2006028930A2 (en) * 2004-09-03 2006-03-16 Receptors Llc Combinatorial artificial receptors including tether building blocks on scaffolds
US7985715B2 (en) * 2004-09-11 2011-07-26 Receptors Llc Combinatorial artificial receptors including peptide building blocks
WO2006034278A2 (en) * 2004-09-21 2006-03-30 Matritech, Inc. Methods and compositions for detecting cancer using components of the u2 spliceosomal particle
WO2006047417A2 (en) 2004-10-21 2006-05-04 University Of Florida Research Foundation, Inc. Detection of cannabinoid receptor biomarkers and uses thereof
US7572596B2 (en) 2004-12-02 2009-08-11 University Of Pittsburgh Of The Commonwealth System Of Higher Education Modulation of the neuroendoctrine system as a therapy for motor neuron disease
US7332296B2 (en) * 2004-12-02 2008-02-19 Wright State University Screening assay for enzymes involved in pathophysiology using SELDI-TOF mass spectrometry
AU2005313995A1 (en) * 2004-12-08 2006-06-15 Lyotropic Therapeutics, Inc. Compositions for binding to assay substrata and methods of using
US20060128031A1 (en) * 2004-12-15 2006-06-15 Robotti Karla M Addressable recovery of bound analytes from an evanescent wave sensor
ATE501267T1 (de) * 2005-01-06 2011-03-15 Eastern Virginia Med School Apolipoprotein-a-ii-isoform als biomarker für prostatakrebs
US20060157647A1 (en) * 2005-01-18 2006-07-20 Becton, Dickinson And Company Multidimensional liquid chromatography/spectrometry
JP4829252B2 (ja) * 2005-01-25 2011-12-07 オシロジー リミテッド ライアビリティ カンパニー 異なる熱容量を有する微小流体試料用の温度制御装置
DE602006018578D1 (de) 2005-01-28 2011-01-13 Childrens Medical Center Diagnose- und prognoseverfahren von blasenkrebs.
US7358485B2 (en) * 2005-02-08 2008-04-15 Perkinelmer Las, Inc. Zirconia toughened alumina composition and use in ion and electron optical systems
EP1861704A2 (en) * 2005-02-09 2007-12-05 Correlogic Systems, Inc. Identification of bacteria and spores
US20060183863A1 (en) * 2005-02-14 2006-08-17 Ciphergen Biosystems, Inc. Zwitterionic polymers
US20060234265A1 (en) * 2005-03-21 2006-10-19 Jim Richey Microarrays having multi-functional, compartmentalized analysis areas and methods of use
EP1869230B1 (en) * 2005-03-23 2017-08-30 Bio-Rad Laboratories, Inc. Method for purifying proteins
US20090247421A1 (en) * 2005-03-23 2009-10-01 Egisto Boschetti Diverse chemical libraries bound to small particles with paramagnetic properties
US7754861B2 (en) 2005-03-23 2010-07-13 Bio-Rad Laboratories, Inc. Method for purifying proteins
AU2006232370B2 (en) * 2005-04-01 2011-10-06 Banyan Biomarkers Biomakers of liver injury
US8048638B2 (en) * 2005-04-01 2011-11-01 University Of Florida Research Foundation, Inc. Biomarkers of liver injury
CA2605143A1 (en) * 2005-04-15 2006-10-26 Becton, Dickinson And Company Diagnosis of sepsis
US20070087387A1 (en) * 2005-04-21 2007-04-19 Prasad Devarajan Method for the Early Detection of Renal Disease Using Proteomics
JP4577083B2 (ja) * 2005-04-28 2010-11-10 味の素株式会社 クローン病の診断方法
US7622273B2 (en) * 2005-05-11 2009-11-24 Gibbs Bernard F Method for chemical and enzymatic treatment of posttranslationally modified proteins bound to a protein chip
US20080312514A1 (en) * 2005-05-12 2008-12-18 Mansfield Brian C Serum Patterns Predictive of Breast Cancer
WO2006124644A2 (en) * 2005-05-12 2006-11-23 Board Of Regents, The University Of Texas System Protein and antibody profiling using small molecule microarrays
WO2006125094A2 (en) * 2005-05-18 2006-11-23 Board Of Regents, The University Of Texas System Combinatorial selection of phosphorothioate aptamers for rnases
WO2006138325A2 (en) * 2005-06-16 2006-12-28 Vermillion, Inc. Fragment of neurosecretory protein vgf as a biomarker for alzheimer's disease
EP1896493A1 (en) 2005-06-17 2008-03-12 North Carolina A & T State University A device including a proteinaceous factor, a recombinant proteinaceous factor, and a nucleotide sequence encoding the proteinaceous factor
GB0512401D0 (en) * 2005-06-17 2005-07-27 Randox Lab Ltd Method
WO2007002069A2 (en) * 2005-06-21 2007-01-04 Anthony Goncalves Serum biomarkers for breast cancer
EP2993474B1 (en) 2005-06-24 2019-06-12 Vermillion, Inc. Biomarkers for ovarian cancer: beta-2 microglobulin
US7514267B1 (en) * 2005-08-19 2009-04-07 Stcunm Detection systems utilizing supported lipid bilayers
US20070048786A1 (en) * 2005-09-01 2007-03-01 Arnon Chait Systems and methods for fractionation of protein mixtures
WO2007033253A1 (en) * 2005-09-14 2007-03-22 Symyx Technologies, Inc. High throughput chemical speciation
US7972802B2 (en) * 2005-10-31 2011-07-05 University Of Washington Lipoprotein-associated markers for cardiovascular disease
ES2356080T3 (es) 2005-11-10 2011-04-04 Bristol-Myers Squibb Pharma Company Moesina, caveolina y proteina 1 asociada a yes como marcadores de respuesta a dasatinib en canceres de mama.
US7889347B2 (en) * 2005-11-21 2011-02-15 Plexera Llc Surface plasmon resonance spectrometer with an actuator driven angle scanning mechanism
US7463358B2 (en) 2005-12-06 2008-12-09 Lumera Corporation Highly stable surface plasmon resonance plates, microarrays, and methods
WO2007070809A2 (en) * 2005-12-12 2007-06-21 Mcgill University Biomarkers for babesia
US20090215085A1 (en) * 2006-01-27 2009-08-27 Eastern Virginia Medical School Proteomic Fingerprinting of Human IVF-Derived Embryos: Identification of Biomarkers of Developmental Potential
EP2375254A1 (en) 2006-02-17 2011-10-12 The Children's Medical Center Corporation Free NGAL as a biomarker for cancer
DE102006009083B4 (de) * 2006-02-28 2018-05-30 Bruker Daltonik Gmbh Massenspektrometrische Bestimmung der Aktivität von Blutenzymen
US20070254378A1 (en) * 2006-03-06 2007-11-01 Bio-Rad Laboratories, Inc. Chelating monomers and polymers
US8097425B2 (en) * 2006-03-10 2012-01-17 Tethys Bioscience, Inc. Multiplex protein fractionation
EP1996949A4 (en) 2006-03-11 2010-01-20 Univ Leland Stanford Junior BETA-2 MICROGLOBULIN AS A BIOMARKER FOR PERIPHERAL ARTERY DISEASE
US7855057B2 (en) * 2006-03-23 2010-12-21 Millipore Corporation Protein splice variant/isoform discrimination and quantitative measurements thereof
WO2007127011A2 (en) * 2006-03-29 2007-11-08 Cangen Biotechnologies, Inc. Apparatus and method for filtration to enhance the detection of peaks
KR100754399B1 (ko) * 2006-04-05 2007-08-31 삼성전자주식회사 단일 챔버를 이용한 세포 파괴 및 핵산의 정제 방법 및장치
AU2007314524A1 (en) * 2006-04-21 2008-05-08 Dublin City University Differential expression profiling analysis of cell culture phenotypes and the uses thereof
US8084734B2 (en) * 2006-05-26 2011-12-27 The George Washington University Laser desorption ionization and peptide sequencing on laser induced silicon microcolumn arrays
US8945941B2 (en) * 2006-05-26 2015-02-03 Brandeis University Tissue sample preparation and MALDI MS imaging thereof
US20080193772A1 (en) * 2006-07-07 2008-08-14 Bio-Rad Laboratories, Inc Mass spectrometry probes having hydrophobic coatiings
JP2009543862A (ja) 2006-07-14 2009-12-10 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ガンのバイオマーカーおよびその使用方法
US7879799B2 (en) * 2006-08-10 2011-02-01 Institute For Systems Biology Methods for characterizing glycoproteins and generating antibodies for same
AU2007293777B2 (en) 2006-09-07 2014-03-20 Otago Innovation Limited Biomarkers
WO2008055080A2 (en) * 2006-10-31 2008-05-08 Sru Biosystems, Inc. Method for blocking non-specific protein binding on a functionalized surface
US20080187928A1 (en) * 2006-12-29 2008-08-07 The Salk Institute For Biological Studies Methods for enhancing exercise performance
GB0700475D0 (en) * 2007-01-10 2007-02-21 Cole Polytechnique Federale De Ionization device
JP2010521496A (ja) 2007-03-14 2010-06-24 ノップ ニューロサイエンシーズ、インク. キラル精製置換ベンゾチアゾールジアミンの合成
US8221984B2 (en) 2007-03-27 2012-07-17 Vermillion, Inc. Biomarkers for ovarian cancer
US20100113746A1 (en) * 2007-04-23 2010-05-06 Arvind Mallinath Lali Process for purification of immunoglobulins using a pseudobioaffinity adsorbent
AU2008251381B2 (en) 2007-05-11 2014-10-30 The Johns Hopkins University Biomarkers for melanoma
WO2008154238A1 (en) * 2007-06-06 2008-12-18 Siemens Healthcare Diagnostics Inc. Predictive diagnostics for kidney disease
US20090017460A1 (en) * 2007-06-15 2009-01-15 Wyeth Differential expression profiling analysis of cell culture phenotypes and uses thereof
EP2190448B1 (en) 2007-06-22 2016-04-20 Children's Medical Center Corporation Methods and uses thereof of a fragment of saposin a
US8664358B2 (en) 2007-06-29 2014-03-04 Vermillion, Inc. Predictive markers for ovarian cancer
EP2183592A4 (en) * 2007-08-08 2011-03-16 Renovar Inc SYSTEMS AND METHOD FOR CHARACTERIZING LUPUS ERYTHEMATODES
JP2009047956A (ja) * 2007-08-21 2009-03-05 Sony Corp 撮像装置
US20090060786A1 (en) * 2007-08-29 2009-03-05 Gibum Kim Microfluidic apparatus for wide area microarrays
WO2009058331A2 (en) 2007-10-29 2009-05-07 Vermilllion, Inc. Biomarkers for the detection of early stage ovarian cancer
EP3536336A1 (en) 2007-11-30 2019-09-11 Siemens Healthcare Diagnostics Inc. Adiponectin receptor fragments and methods of use
US8004669B1 (en) 2007-12-18 2011-08-23 Plexera Llc SPR apparatus with a high performance fluid delivery system
WO2009086215A2 (en) * 2007-12-21 2009-07-09 Wyeth Pathway analysis of cell culture phenotypes and uses thereof
EP2255188B1 (en) 2008-02-29 2016-08-24 Imec Biosensor for the detection of neurotransmitters
EP2269060B1 (en) 2008-03-10 2016-08-17 Lineagen, Inc. Copd biomarker signatures
JP2011516038A (ja) 2008-03-12 2011-05-26 オタゴ イノベーション リミテッド バイオマーカー
CA2715914C (en) 2008-03-12 2019-01-22 Otago Innovation Limited Insulin signal peptide fragment biomarkers
US20110008903A1 (en) * 2008-03-27 2011-01-13 Valerie Paradis Methods and kits for determining the occurrence of a liver disease in a subject
US8669113B2 (en) 2008-04-03 2014-03-11 Becton, Dickinson And Company Advanced detection of sepsis
CN102076355B (zh) 2008-04-29 2014-05-07 Abbvie公司 双重可变结构域免疫球蛋白及其用途
US8673644B2 (en) 2008-05-13 2014-03-18 Battelle Memorial Institute Serum markers for type II diabetes mellitus
WO2009149124A1 (en) * 2008-06-02 2009-12-10 Bio-Rad Laboratories, Inc. Mass spectrometric detection of material transferred to a surface
TW201008580A (en) 2008-06-03 2010-03-01 Abbott Lab Dual variable domain immunoglobulin and uses thereof
CA2729340C (en) * 2008-06-26 2017-07-11 Cytosorbents, Inc. Removal of myoglobin from blood and/or physiological fluids
US8241861B1 (en) 2008-07-08 2012-08-14 Insilicos, Llc Methods and compositions for diagnosis or prognosis of cardiovascular disease
WO2010123720A1 (en) 2009-04-23 2010-10-28 Siemens Healthcare Diagnostics Inc. Monomeric and dimeric forms of adiponectin receptor fragments and methods of use
DK2324360T3 (en) 2008-08-11 2018-05-14 Banyan Biomarkers Inc BIOMARKET DETECTION METHOD AND ASSAY OF NEUROLOGICAL CONDITION
US20110138935A1 (en) * 2008-08-12 2011-06-16 Wako Pure Chemical Industries, Ltd. Polymer for filler for preprocessing column
US20110190356A1 (en) 2008-08-19 2011-08-04 Knopp Neurosciences Inc. Compositions and Methods of Using (R)- Pramipexole
EP2687609B1 (en) 2008-11-10 2017-01-04 The United States of America, as represented by The Secretary, Department of Health and Human Services Method for treating solid tumor
CA2740192C (en) * 2008-12-01 2019-12-31 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for detection of complement fixing antibodies
US8349325B2 (en) 2008-12-23 2013-01-08 Abbott Laboratories Soluble FMS-like tyrosine kinase-1 (sFLT-1) antibody and related composition, kit, methods of using, and materials and method for making
US20110251099A1 (en) 2008-12-30 2011-10-13 Sudha Visvanathan SERUM MARKERS PREDICTING CLINICAL RESPONSE TO ANTI-TNFa ANTIBODIES IN PATIENTS WITH ANKYLOSING SPONDYLITIS
EP2382466B1 (en) 2008-12-30 2016-03-09 Children's Medical Center Corporation Method of predicting acute appendicitis
DE102009004371A1 (de) * 2009-01-08 2010-07-15 Papst Licensing Gmbh & Co. Kg Vorrichtung und Verfahren zum Messen der Aktivität von Enzymen nach Inhibitorentzug
WO2010079253A2 (es) 2009-01-09 2010-07-15 Proyecto De Biomedicina Cima, S.L. Biomarcadores para el diagnóstico de fibrosis
US8110796B2 (en) 2009-01-17 2012-02-07 The George Washington University Nanophotonic production, modulation and switching of ions by silicon microcolumn arrays
WO2010087985A2 (en) 2009-01-28 2010-08-05 Yale University Novel markers for detection of complications resulting from in utero encounters
US8268264B2 (en) 2009-02-09 2012-09-18 Caprotec Bioanalytics Gmbh Devices, systems and methods for separating magnetic particles
WO2010093872A2 (en) 2009-02-13 2010-08-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Molecular-based method of cancer diagnosis and prognosis
EP2233580A1 (en) * 2009-03-05 2010-09-29 The Ohio State University Rapid genotyping of SNPs
EP2403531A4 (en) 2009-03-05 2013-02-27 Abbott Lab IL-17 BINDING PROTEINS
US9490113B2 (en) * 2009-04-07 2016-11-08 The George Washington University Tailored nanopost arrays (NAPA) for laser desorption ionization in mass spectrometry
CA2759247C (en) * 2009-04-21 2018-05-08 Excellims Corporation Intelligently controlled spectrometer methods and apparatus
NZ743040A (en) 2009-05-20 2020-01-31 Xyleco Inc Bioprocessing
JP5991916B2 (ja) * 2009-05-29 2016-09-14 ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム 自己免疫性t細胞の単離および処理のためのペプトイドリガンド
KR20120122869A (ko) * 2009-06-02 2012-11-07 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 신경변성 질환을 갖는 대상에서 항체에 의해 인식되는 소분자의 확인법
KR101099089B1 (ko) 2009-06-12 2011-12-27 한국항공대학교산학협력단 다층 버스 바를 이용한 미세입자 분류기 및 그 제조방법
EP2459742B1 (en) 2009-07-29 2016-04-06 Pharnext New diagnostic tools for alzheimer disease
DE102009040186A1 (de) * 2009-09-07 2011-03-24 Dionex Benelux B.V. Chromatografieverfahren
US8759259B2 (en) * 2009-10-16 2014-06-24 The Board Of Regents Of The University Of Texas System Compositions and methods for producing cyclic peptoid libraries
US8415619B2 (en) 2009-11-13 2013-04-09 University of Glascgow Methods and systems for mass spectrometry
US8304248B2 (en) 2009-11-16 2012-11-06 Torres Anthony R Protein separation via ion-exchange chromatography and associated methods, systems, and devices
EP3925670A1 (en) 2009-12-17 2021-12-22 Children's Medical Center, Corp. Saposin-a derived peptides and uses thereof
AU2011354597B2 (en) 2010-01-26 2016-09-22 Bioregency Inc. Compositions and methods relating to argininosuccinate synthetase
US20110229921A1 (en) * 2010-03-18 2011-09-22 Abbott Laboratories METHODS OF ASSAYING URINARY NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (uNGAL) IN THE PROGNOSIS OF CADAVERIC KIDNEY TRANSPLANT FUNCTION IN A PATIENT, INCLUDING A PATIENT DIAGNOSED WITH DELAYED GRAFT FUNCTION (DGF), A METHOD OF ASSAYING uNGAL IN THE ASSESSMENT OF RISK OF DGF IN A PATIENT DIAGNOSED WITH EARLY GRAFT FUNCTION (EGF), AND RELATED KITS
WO2013040142A2 (en) 2011-09-16 2013-03-21 Iogenetics, Llc Bioinformatic processes for determination of peptide binding
US10706955B2 (en) 2010-03-23 2020-07-07 Iogenetics, Llc Bioinformatic processes for determination of peptide binding
EP3508854A1 (en) 2010-04-27 2019-07-10 The Regents of The University of California Cancer biomarkers and methods of use thereof
KR101848225B1 (ko) 2010-05-14 2018-04-12 애브비 인코포레이티드 Il-1 결합 단백질
WO2011149943A1 (en) 2010-05-24 2011-12-01 Ventana Midical Systems, Inc. Method for differentiation of non-small cellung carcinoma
US9551714B2 (en) 2010-06-25 2017-01-24 Abbott Laboratories Materials and methods for assay of anti-hepatitis C virus (HCV) antibodies
US20120009196A1 (en) 2010-07-08 2012-01-12 Abbott Laboratories Monoclonal antibodies against hepatitis c virus core protein
UY33492A (es) 2010-07-09 2012-01-31 Abbott Lab Inmunoglobulinas con dominio variable dual y usos de las mismas
EP3246335A3 (en) 2010-07-19 2017-12-27 Otago Innovation Limited Signal biomarkers
PE20131412A1 (es) 2010-08-03 2014-01-19 Abbvie Inc Inmunoglobulinas con dominio variable dual y usos de las mismas
EP2625292B1 (en) 2010-10-07 2018-12-05 The General Hospital Corporation Biomarkers of cancer
US9746481B2 (en) 2010-10-14 2017-08-29 The Johns Hopkins University Biomarkers of brain injury
US20120115244A1 (en) 2010-11-09 2012-05-10 Abbott Laboratories Materials and methods for immunoassay of pterins
DE102010054767B4 (de) * 2010-12-16 2013-02-21 Previpharma Ag Verfahren zur Trennung, Aufkonzentration und/oder Reinigung von (Blut)Plasmaprotein, Viren oder Virenbestandteilen
BR112013015944A2 (pt) 2010-12-21 2018-06-19 Abbvie Inc imunoglobulinas de domínio duplo variável il-1 alpha e beta biespecífico e seus usos.
CA2766675A1 (en) * 2011-02-07 2012-08-07 Laboratory Corporation Of America Holdings Methods and systems for multiplex analysis of biomolecules by liquid chromatography-mass spectrometry
JP2014515012A (ja) 2011-03-15 2014-06-26 ユニヴァーシティー オブ ユタ リサーチ ファウンデーション 血管関連黄斑症およびその症状の診断および治療方法
JP6010110B2 (ja) 2011-04-20 2016-10-19 アクセス メディカル システムズ,リミティド 発光重合体の反復増幅
JP2014518624A (ja) 2011-05-12 2014-08-07 ザ・ジョンズ・ホプキンス・ユニバーシティー ニューログラニン診断キットのためのアッセイ試薬
US9024254B2 (en) 2011-06-03 2015-05-05 Purdue Research Foundation Enclosed desorption electrospray ionization probes and method of use thereof
KR20140147797A (ko) 2011-06-27 2014-12-30 더 잭슨 래보라토리 암 및 자가면역 질환의 치료 방법 및 조성물
US11107600B2 (en) * 2011-10-10 2021-08-31 Siemens Medical Solutions Usa, Inc. Rare-earth metal halide scintillators with reduced hygroscopicity and method of making the same
WO2013055911A1 (en) 2011-10-14 2013-04-18 Dana-Farber Cancer Institute, Inc. Znf365/zfp365 biomarker predictive of anti-cancer response
UY34410A (es) 2011-10-24 2013-05-31 Abbvie Inc Inmunoligantes biespecificos dirigidos contra tnf
TW201323440A (zh) 2011-10-24 2013-06-16 Abbvie Inc 抗骨硬化素(sclerostin)之免疫結合物
MX354547B (es) 2011-11-14 2018-03-09 Alfasigma Spa Ensayos y métodos para seleccionar un regimen de tratamiento para un sujeto con depresión.
US9512096B2 (en) 2011-12-22 2016-12-06 Knopp Biosciences, LLP Synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
EP3560509B1 (en) 2011-12-22 2024-01-31 Children's Medical Center Corporation Saposin-a derived peptides and uses thereof
US8993248B2 (en) 2011-12-31 2015-03-31 Abbott Laboratories Truncated human vitamin D binding protein and mutation and fusion thereof and related materials and methods of use
SG11201403746SA (en) 2012-01-05 2014-07-30 Boston Medical Ct Corp Slit-robo signaling for diagnosis and treatment of kidney disease
EP2805167B1 (en) 2012-01-20 2020-04-22 Adelaide Research & Innovation Pty Ltd Biomarkers for gastric cancer and uses thereof
CA2862499C (en) 2012-01-24 2020-10-27 Cd Diagnostics, Inc. System for detecting infection in synovial fluid
US9404923B2 (en) 2012-02-07 2016-08-02 Intuitive Biosciences, Inc. Mycobacterium tuberculosis specific peptides for detection of infection or immunization in non-human primates
DK2828282T3 (en) 2012-03-20 2018-03-05 Otago Innovation Ltd Biomarkers
EP2831119A1 (en) 2012-03-28 2015-02-04 F. Hoffmann-La Roche AG Anti-hcmv idiotypic antibodies and uses thereof
AU2013277971B2 (en) 2012-06-22 2018-11-15 Htg Molecular Diagnostics, Inc. Molecular malignancy in melanocytic lesions
UY34905A (es) 2012-07-12 2014-01-31 Abbvie Inc Proteínas de unión a il-1
WO2014014353A1 (en) 2012-07-18 2014-01-23 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno New classification method for spectral data
CA2884737A1 (en) 2012-08-16 2014-02-20 The Trustees Of Columbia University In The City Of New York Diagnostic markers of indolent prostate cancer
AU2013202668B2 (en) 2012-12-24 2014-12-18 Adelaide Research & Innovation Pty Ltd Inhibition of cancer growth and metastasis
EP2943775A4 (en) * 2013-01-10 2016-11-16 Bio Rad Laboratories CHROMATOGRAPHY SYSTEM WITH LED-BASED LIGHT SOURCE
US9662313B2 (en) 2013-02-28 2017-05-30 Knopp Biosciences Llc Compositions and methods for treating amyotrophic lateral sclerosis in responders
ES2705702T3 (es) * 2013-03-13 2019-03-26 Us Gov Sec Navy Técnica de imagen nanoplasmónica para el mapeo espacio-temporal de las secreciones de células únicas en tiempo real
WO2014143343A1 (en) 2013-03-14 2014-09-18 Abbott Laboratories Hcv core lipid binding domain monoclonal antibodies
BR112015023355A8 (pt) 2013-03-14 2018-01-30 Abbott Lab antígenos recombinantes ns3 de hcv e mutantes dos mesmos para detecção de anticorpos aprimorada.
BR112015023239A8 (pt) 2013-03-14 2018-04-17 Abbott Lab ensaio de combinação de anticorpo-antígeno de hcv e métodos e composições para uso do mesmo
AU2014236882B2 (en) 2013-03-14 2019-01-31 The Board Of Trustees Of The Leland Stanford Junior University Methods of detecting donor-specific antibodies and systems for practicing the same
US9005901B2 (en) 2013-03-15 2015-04-14 Abbott Laboratories Assay with internal calibration
US9157910B2 (en) 2013-03-15 2015-10-13 Abbott Laboratories Assay with increased dynamic range
WO2014147509A1 (en) 2013-03-20 2014-09-25 Koninklijke Philips N.V. Clinical decision support (cds) for radiotherapy in prostate cancer
ES2755490T3 (es) 2013-04-15 2020-04-22 Becton Dickinson Co Dispositivo de extracción de fluidos biológicos y sistema de separación de fluidos biológicos
CA2914918C (en) 2013-05-10 2023-10-10 Johns Hopkins University Compositions and methods for ovarian cancer assessment having improved specificity
ES3043076T3 (en) 2013-07-12 2025-11-24 Areteia Therapeutics Inc Treating elevated levels of eosinophils and/or basophils
US9468630B2 (en) 2013-07-12 2016-10-18 Knopp Biosciences Llc Compositions and methods for treating conditions related to increased eosinophils
JP6611710B2 (ja) 2013-07-17 2019-11-27 ザ・ジョンズ・ホプキンス・ユニバーシティ 脳損傷の検出および転帰についてのマルチプロテインバイオマーカー測定法
US9763918B2 (en) 2013-08-13 2017-09-19 Knopp Biosciences Llc Compositions and methods for treating chronic urticaria
EP3038467B1 (en) 2013-08-13 2020-07-29 Knopp Biosciences LLC Compositions and methods for treating plasma cell disorders and b-cell prolymphocytic disorders
CA2923228C (en) * 2013-09-24 2023-03-07 Obdulio PILOTO Detectable array that can bind and detect multiple analytes and use thereof in diagnostic methods
WO2015073709A2 (en) 2013-11-14 2015-05-21 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Detection of atherosclerotic cardiovascular disease risk and heart failure risk
WO2015092020A2 (en) 2013-12-20 2015-06-25 Université de Lausanne Diagnostic, prognostic and therapeutic uses of long noncoding rnas for heart disease and regenerative medicine
US10398772B2 (en) 2014-01-08 2019-09-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Ras pathways as markers of protection against HIV and methods to improve vaccine efficacy
EP3134546A4 (en) 2014-04-24 2017-12-06 Dana-Farber Cancer Institute, Inc. Tumor suppressor and oncogene biomarkers predictive of anti-immune checkpoint inhibitor response
WO2015200697A1 (en) 2014-06-25 2015-12-30 The General Hospital Corporation Targeting human satellite ii (hsatii)
WO2015200833A2 (en) 2014-06-27 2015-12-30 Abbott Laboratories COMPOSITIONS AND METHODS FOR DETECTING HUMAN PEGIVIRUS 2 (HPgV-2)
CZ2014631A3 (cs) 2014-09-16 2016-03-30 Petr Novák Způsob modifikace povrchů bílkovinami pro prekoncentraci analytu pro desorpčně- ionizační techniky hmotnostní spektrometrie a imunochemické eseje
US10222386B2 (en) 2014-09-19 2019-03-05 The Johns Hopkins University Biomarkers of congnitive dysfunction
EP3210144B1 (en) 2014-10-24 2020-10-21 Koninklijke Philips N.V. Medical prognosis and prediction of treatment response using multiple cellular signaling pathway activities
EP3210142B1 (en) 2014-10-24 2020-09-16 Koninklijke Philips N.V. Assessment of tgf-cellular signaling pathway activity using mathematical modelling of target gene expression
ES2857953T3 (es) 2014-10-24 2021-09-29 Koninklijke Philips Nv Pronóstico médico y predicción de la respuesta al tratamiento usando las actividades de múltiples rutas de señalización celular
ES2828713T3 (es) 2014-10-29 2021-05-27 Abbott Lab Ensayos de detección de anticuerpos anti-VHC objeto usando péptidos de captura NS3
WO2016090323A1 (en) 2014-12-05 2016-06-09 Prelude, Inc. Dcis recurrence and invasive breast cancer
US9607816B2 (en) 2014-12-17 2017-03-28 Micromass Uk Limited Two-dimensional separation and imaging technique for the rapid analysis of biological samples
GB2535835B (en) * 2014-12-17 2019-09-04 Micromass Ltd A two-dimensional separation and imaging technique for the rapid analysis of biological samples
US11041865B2 (en) 2015-02-20 2021-06-22 The Johns Hopkins University Biomarkers of myocardial injury
WO2016149522A1 (en) * 2015-03-18 2016-09-22 Bio-Rad Laboratories, Inc. Sample analysis systems and methods
KR101821747B1 (ko) * 2015-05-13 2018-01-24 한국과학기술연구원 고속 액체 크로마토그래피 장치 및 이를 이용한 물질 스크리닝 방법
US20180140626A1 (en) 2015-05-14 2018-05-24 Joslin Diabetes Center, Inc. Retinol-binding protein 3 (rbp3) as a protective factor in non-diabetic retinal degeneration
EP3320132A4 (en) 2015-07-10 2018-11-21 West Virginia University Markers of stroke and stroke severity
CA2994416A1 (en) 2015-08-04 2017-02-09 Cd Diagnostics, Inc. Methods for detecting adverse local tissue reaction (altr) necrosis
DK3334837T3 (da) 2015-08-14 2021-02-15 Koninklijke Philips Nv Vurdering af nfkb-cellulær signaleringsvejaktivitet under anvendelse af matematisk modellering af målgenekspression
US10527613B2 (en) 2015-11-10 2020-01-07 The Board Of Trustees Of The Leland Stanford Junior University Biomarker detection methods and systems and kits for practicing same
EP3387154A4 (en) 2015-12-09 2019-05-15 Intuitive Biosciences, Inc. AUTOMATED SILVER FINISHING SYSTEM
EP3386594B1 (en) 2015-12-11 2023-05-03 The General Hospital Corporation Combination of a platelet-derived growth factor receptor alpha inhibitor and a histone lysine demethylase inhibitor for treating drug-tolerant glioblastoma
CN105590079B (zh) * 2015-12-23 2018-02-16 上海百傲科技股份有限公司 一种多张生物芯片透射信号连续自动识读的方法及设备
WO2017123933A1 (en) 2016-01-15 2017-07-20 Massachusetts Eye And Ear Infirmary Secreted p-glycoprotein is a non-invasive biomarker of chronic rhinosinusitis
US11306362B2 (en) 2016-02-08 2022-04-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Gene signature predictive of hepatocellular carcinoma response to transcatheter arterial chemoembolization (TACE)
US20200200735A9 (en) 2016-02-22 2020-06-25 Ursure, Inc. System and method for detecting therapeutic agents to monitor adherence to a treatment regimen
WO2018081649A1 (en) 2016-10-28 2018-05-03 Banyan Biomarkers, Inc. Antibodies to ubiquitin c-terminal hydrolase l1 (uch-l1) and glial fibrillary acidic protein (gfap) and related methods
EP3529596B1 (en) 2016-11-11 2025-08-13 Ascendant DX, LLC Compositions and methods for diagnosing and differentiating systemic juvenile idiopathic arthritis and kawasaki disease
EP4553501A3 (en) * 2016-12-30 2025-09-03 Università degli Studi di Bari "Aldo Moro" Method of bio-functionalization of a gate electrode of a field-effect transistor sensor with a sam and blocking of non-specific binding
WO2018136553A1 (en) 2017-01-18 2018-07-26 Genentech, Inc. Idiotypic antibodies against anti-pd-l1 antibodies and uses thereof
EP4407317A3 (en) 2017-03-31 2024-10-23 Charles River Laboratories, Inc. Articles and methods involving detection of binding
CN107315851B (zh) * 2017-05-19 2020-06-23 中国科学院长春光学精密机械与物理研究所 一种宽光谱极紫外多层膜的鲁棒性膜系设计方法
CN107024436A (zh) * 2017-05-27 2017-08-08 北京环境特性研究所 一种分析药物对细胞作用点的方法
KR20200040803A (ko) 2017-08-16 2020-04-20 메디뮨 엘엘씨 아토피 피부염의 치료 및 치료 선택을 위한 조성물 및 방법
KR102702206B1 (ko) 2017-09-25 2024-09-02 프레드 허친슨 캔서 센터 고효율의 표적화된 원위치 게놈 전체 프로파일링
US12276670B2 (en) 2017-09-29 2025-04-15 The General Hospital Corporation Methods for identifying and treating adrenomyeloneuropathy (AMN)
EP3461915A1 (en) 2017-10-02 2019-04-03 Koninklijke Philips N.V. Assessment of jak-stat1/2 cellular signaling pathway activity using mathematical modelling of target gene expression
EP3461916A1 (en) 2017-10-02 2019-04-03 Koninklijke Philips N.V. Assessment of jak-stat3 cellular signaling pathway activity using mathematical modelling of target gene expression
EP3502279A1 (en) 2017-12-20 2019-06-26 Koninklijke Philips N.V. Assessment of mapk-ap 1 cellular signaling pathway activity using mathematical modelling of target gene expression
KR101921628B1 (ko) * 2018-01-15 2018-11-26 한국과학기술연구원 고속 액체 크로마토그래피 장치 및 이를 이용한 물질 스크리닝 방법
CA3090652A1 (en) 2018-02-06 2019-08-15 The General Hospital Corporation Repeat rna as biomarkers of tumor immune response
CN108715844A (zh) * 2018-04-11 2018-10-30 河北工业大学 一种仿生矿化固定化酶和辅因子的制备方法及仿生矿化固定化酶和辅因子
EP3803415A1 (en) 2018-06-04 2021-04-14 Avon Products, Inc. Protein biomarkers for identifying and treating aging skin and skin conditions
EP3850368A4 (en) 2018-09-14 2022-11-23 Prelude Corporation PROCEDURE FOR SELECTING THE TREATMENT OF SUBJECTS AT RISK FOR INVASIVE BREAST CANCER
EP3677693A1 (en) 2019-01-03 2020-07-08 Ecole Polytechnique Federale De Lausanne (EPFL) EPFL-TTO Transpochimeric gene trancripts (tcgts) as cancer biomarkers
US12295933B2 (en) 2019-03-25 2025-05-13 Massachusetts Eye And Ear Infirmary Methods and compositions to treat and diagnose diseases or pathologies associated with inflammation of the sinuses and nasal cavity
US20220260592A1 (en) * 2019-05-10 2022-08-18 Quest Diagnostics Investments Llc MULTIPLEX ASSAY FOR DETERMINING THE ß-AMYLOID 42/40 RATIO IN HUMAN PLASMA SPECIMENS
KR20240137114A (ko) 2019-08-05 2024-09-19 시어 인코퍼레이티드 샘플 제조, 데이터 생성, 및 단백질 코로나 분석을 위한 시스템 및 방법
MX2022003691A (es) 2019-09-27 2022-04-26 Regeneron Pharma Espectrometria de masas nativa acoplada a cromatografia de interaccion hidrofobica para analisis de anticuerpos.
WO2022020359A1 (en) 2020-07-24 2022-01-27 The Regents Of The University Of Michigan Compositions and methods for detecting and treating high grade subtypes of uterine cancer
EP4222498A4 (en) 2020-09-29 2024-10-16 The Johns Hopkins University INTEGRATED PROTEOMIC BIOMARKERS FOR THE DETECTION OF AGGRESSIVE PROSTATE CANCER
EP4343004A3 (en) 2020-10-19 2024-09-11 Dana-Farber Cancer Institute, Inc. Germline biomarkers of clinical response and benefit to immune checkpoint inhibitor therapy
US12426782B2 (en) 2020-11-06 2025-09-30 The Board Of Trustees Of The Leland Stanford Junior University Systems and temporal alignment methods for evaluation of gestational age and time to delivery
WO2022182949A2 (en) 2021-02-25 2022-09-01 Lung Therapeutics, Inc. Biomarkers for the treatment of interstitial lung disease
WO2022198071A1 (en) * 2021-03-18 2022-09-22 Complete Omics Inc. Methods and systems for detecting and quantifying large number of molecule biomarkers from a body fluid sample
WO2022248574A1 (en) 2021-05-28 2022-12-01 Centre Hospitalier Universitaire Vaudois (C.H.U.V.) Novel incrna controlling cardiac fibrosis
WO2023122723A1 (en) 2021-12-23 2023-06-29 The Broad Institute, Inc. Panels and methods for diagnosing and treating lung cancer
JP7804498B2 (ja) * 2022-03-18 2026-01-22 住友理工株式会社 ポリイソプレンの質量分析方法
US20230305019A1 (en) * 2022-03-28 2023-09-28 The Board Of Trustees Of The Leland Stanford Junior University Microprobe-capture in-emitter elution-electrospray ionization
CN115078570B (zh) * 2022-05-30 2024-05-28 郑州大学第一附属医院 Tau蛋白639位硫氰酸氨基酸修饰在快速质谱法检测阿尔茨海默症中的应用
WO2024102852A2 (en) 2022-11-08 2024-05-16 The Brigham And Women's Hospital, Inc. Ultrasensitive assays for detection of orf1p in biofluids
WO2025106804A1 (en) 2023-11-16 2025-05-22 Massachusetts Institute Of Technology Compositions and methods for characterizing hepatocyte stress
WO2025217069A1 (en) 2024-04-08 2025-10-16 Beth Israel Deaconess Medical Center, Inc. Compositions and methods for treating cardiotoxicity

Family Cites Families (117)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU17923A1 (no) * 1962-04-02
US3288604A (en) * 1964-09-03 1966-11-29 Xerox Corp Imaging method using an element having a glass overcoating
US3669841A (en) * 1970-02-11 1972-06-13 Monsanto Co Attachment of enzymes to siliceous materials
US3896661A (en) * 1974-01-09 1975-07-29 Stanford Research Inst Method of coupling thin layer chromatograph with mass spectrometer
DE2654057B1 (de) * 1976-11-29 1978-04-27 Varian Mat Gmbh Verfahren zur Ionisierung von organischen Substanzen,sowie dieses Verfahren benutzendes Analysegeraet
US4126554A (en) 1977-09-02 1978-11-21 Analtech, Inc. Selectively marked thin-layer chromatographic plate
US4313906A (en) * 1979-08-17 1982-02-02 Whatman, Inc. Two dimensional two phase thin layer chromatography plate and method
US4313908A (en) 1980-10-20 1982-02-02 Exxon Research & Engineering Co. Catalytic reactor having bed bypass
US4752562A (en) 1981-01-23 1988-06-21 Baxter Travenol Laboratories, Inc. Detection of serum antibody and surface antigen by radial partition immunoassay
US4444879A (en) * 1981-01-29 1984-04-24 Science Research Center, Inc. Immunoassay with article having support film and immunological counterpart of analyte
DE3125335A1 (de) 1981-06-27 1983-01-13 Alfred Prof. Dr. 4400 Münster Benninghoven Verfahren zur analyse von gasen und fluessigkeiten
SE8200442L (sv) * 1982-01-27 1983-07-28 Forsvarets Forsknings Forfarande vid detektion av organiska molekyler, sasom biomolekyler
JPS6042653A (ja) * 1983-08-17 1985-03-06 Shionogi & Co Ltd クロマトグラフィ−・プレ−ト
US4489477A (en) * 1984-02-23 1984-12-25 Northern Telecom Limited Method for screening laser diodes
JPS61187237A (ja) * 1985-02-14 1986-08-20 Toshiba Corp パタ−ン形成方法
US4820648A (en) * 1985-08-21 1989-04-11 Spectros Limited Methods for use in the mass analysis of chemical samples
JPS6251144A (ja) * 1985-08-29 1987-03-05 Hitachi Ltd 質量分析計
US4988879A (en) * 1987-02-24 1991-01-29 The Board Of Trustees Of The Leland Stanford Junior College Apparatus and method for laser desorption of molecules for quantitation
US4963263A (en) 1988-03-24 1990-10-16 Terrapin Technologies, Inc. Method of identity analyte-binding peptides
IE81146B1 (en) 1987-10-13 2000-05-03 Terrapin Tech Inc Method to produce immunodiagnostic reagents
US5338659A (en) 1991-04-02 1994-08-16 Terrapin Technologies, Inc. Method for determining analyte concentration by cross-reactivity profiling
US5300425A (en) 1987-10-13 1994-04-05 Terrapin Technologies, Inc. Method to produce immunodiagnostic reagents
US5133866A (en) 1988-03-24 1992-07-28 Terrapin Technologies, Inc. Method to identify analyte-bending ligands
US4891321A (en) * 1987-10-21 1990-01-02 Hubscher Thomas T Apparatus for performing determinations of immune reactants in biological fluids
GB8810400D0 (en) 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
ATE167301T1 (de) * 1988-03-24 1998-06-15 Terrapin Tech Inc Gruppe von getrennten peptiden
US5340474A (en) 1988-03-24 1994-08-23 Terrapin Technologies, Inc. Panels of analyte-binding ligands
US5010175A (en) 1988-05-02 1991-04-23 The Regents Of The University Of California General method for producing and selecting peptides with specific properties
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5037611A (en) * 1988-11-29 1991-08-06 Icr Research Associates, Inc. Sample handling technique
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
GB2235529B (en) 1989-08-23 1993-07-28 Finnigan Mat Ltd Method of preparing samples for laser spectrometry analysis
US5118937A (en) 1989-08-22 1992-06-02 Finnigan Mat Gmbh Process and device for the laser desorption of an analyte molecular ions, especially of biomolecules
US5045694A (en) 1989-09-27 1991-09-03 The Rockefeller University Instrument and method for the laser desorption of ions in mass spectrometry
US5035022A (en) * 1989-12-08 1991-07-30 Joseph Iuliano Device for applying coatings to objects having irregular shapes and/or diverse surfaces
US5366862A (en) * 1990-02-14 1994-11-22 Receptor Laboratories, Inc. Method for generating and screening useful peptides
US5288644A (en) 1990-04-04 1994-02-22 The Rockefeller University Instrument and method for the sequencing of genome
AU8081491A (en) 1990-06-01 1991-12-31 Cetus Corporation Compositions and methods for identifying biologically active molecules
IE66205B1 (en) 1990-06-14 1995-12-13 Paul A Bartlett Polypeptide analogs
US5723286A (en) 1990-06-20 1998-03-03 Affymax Technologies N.V. Peptide library and screening systems
US5650489A (en) 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
US5135627A (en) * 1990-10-15 1992-08-04 Soane Technologies, Inc. Mosaic microcolumns, slabs, and separation media for electrophoresis and chromatography
US5308749A (en) * 1991-01-25 1994-05-03 Eastman Kodak Company Method of preparing biologically active reagents from succinimide-containing polymers, analytical element and methods of use
ATE269401T1 (de) 1991-04-10 2004-07-15 Scripps Research Inst Bibliotheken heterodimerer rezeptoren mittels phagemiden
US5846708A (en) * 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
US5382793A (en) * 1992-03-06 1995-01-17 Hewlett-Packard Company Laser desorption ionization mass monitor (LDIM)
US5372719A (en) * 1992-03-30 1994-12-13 Perseptive Biosystems, Inc. Molecular imaging
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
ATE427493T1 (de) 1992-05-29 2009-04-15 Univ Rockefeller Verfahren zur bestimmung der folge von peptiden unter verwendung eines massenspektrometers
CA2140257A1 (en) 1992-07-27 1994-02-03 Lawrence M. Kauvar Sorbent families
US5288514A (en) 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
AU689755B2 (en) 1992-09-22 1998-04-09 Biofocus Discovery Limited Recombinant viruses displaying a nonviral polypeptide on their external surface
US5376249A (en) 1992-11-25 1994-12-27 Perseptive Biosystems, Inc. Analysis utilizing isoelectric focusing
ATE267877T1 (de) 1993-01-07 2004-06-15 Sequenom Inc Dns - sequenzierung durch massenspektronomie
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
DE69430909T2 (de) 1993-03-19 2003-02-27 Sequenom, Inc. Dns-sequenzbestimmung durch massenspektrometrie auf dem weg des abbaus mit exonuklease
US5356784A (en) 1993-03-30 1994-10-18 Terrapin Technologies, Inc. Determination of concentration by affinity titration
US6020208A (en) * 1994-05-27 2000-02-01 Baylor College Of Medicine Systems for surface-enhanced affinity capture for desorption and detection of analytes
US20020037517A1 (en) * 1993-05-28 2002-03-28 Hutchens T. William Methods for sequencing biopolymers
NZ267842A (en) * 1993-05-28 1997-09-22 Baylor College Medicine Apparatus for measuring molecular mass (by mass spectrometry) in which the sample is ionised on the sample holder and desorbed therefrom by laser pulses
AU7212494A (en) 1993-06-25 1995-01-17 Affymax Technologies N.V. Hybridization and sequencing of nucleic acids
WO1995011995A1 (en) 1993-10-26 1995-05-04 Affymax Technologies N.V. Arrays of nucleic acid probes on biological chips
US5496545A (en) * 1993-08-11 1996-03-05 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
GB9317193D0 (en) * 1993-08-18 1993-10-06 Zeneca Ltd Method
AU7648994A (en) * 1993-09-09 1995-03-27 Imutec Pharma Inc. Immunomodulating compositions from bile
US6071610A (en) * 1993-11-12 2000-06-06 Waters Investments Limited Enhanced resolution matrix-laser desorption and ionization TOF-MS sample surface
US5587293A (en) 1994-01-06 1996-12-24 Terrapin Technologies, Inc. Method to identify binding partners
US5539083A (en) 1994-02-23 1996-07-23 Isis Pharmaceuticals, Inc. Peptide nucleic acid combinatorial libraries and improved methods of synthesis
US5538897A (en) 1994-03-14 1996-07-23 University Of Washington Use of mass spectrometry fragmentation patterns of peptides to identify amino acid sequences in databases
ES2151057T3 (es) * 1994-03-23 2000-12-16 Penn State Res Found Procedimiento para la identificacion de elementos de bibliotecas combinatorias.
US5502022A (en) * 1994-05-16 1996-03-26 Biosepra, Inc. Chromatography adsorbents utilizing mercapto heterocyclic ligands
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5498545A (en) * 1994-07-21 1996-03-12 Vestal; Marvin L. Mass spectrometer system and method for matrix-assisted laser desorption measurements
US5599668A (en) * 1994-09-22 1997-02-04 Abbott Laboratories Light scattering optical waveguide method for detecting specific binding events
US6030917A (en) * 1996-07-23 2000-02-29 Symyx Technologies, Inc. Combinatorial synthesis and analysis of organometallic compounds and catalysts
US5985356A (en) * 1994-10-18 1999-11-16 The Regents Of The University Of California Combinatorial synthesis of novel materials
US6419881B1 (en) * 1994-10-18 2002-07-16 Symyx Technologies, Inc. Combinatorial arrays of organometallic compounds and catalysts
US6440745B1 (en) * 1994-10-18 2002-08-27 Symyx Technologies Combinatorial synthesis and screening of organometallic compounds and catalysts
US6004617A (en) * 1994-10-18 1999-12-21 The Regents Of The University Of California Combinatorial synthesis of novel materials
US5830645A (en) 1994-12-09 1998-11-03 The Regents Of The University Of California Comparative fluorescence hybridization to nucleic acid arrays
US6207369B1 (en) * 1995-03-10 2001-03-27 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
CA2216963C (en) * 1995-04-06 2010-06-22 Regeneron Pharmaceuticals, Inc. Tie-2 ligands, methods of making and uses thereof
US5741462A (en) * 1995-04-25 1998-04-21 Irori Remotely programmable matrices with memories
US5624711A (en) * 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
US5770272A (en) * 1995-04-28 1998-06-23 Massachusetts Institute Of Technology Matrix-bearing targets for maldi mass spectrometry and methods of production thereof
WO1996036986A1 (en) * 1995-05-19 1996-11-21 Perseptive Biosystems, Inc. Methods and apparatus for sequencing polymers with a statistical certainty using mass spectrometry
WO1996037777A1 (en) 1995-05-23 1996-11-28 Nelson Randall W Mass spectrometric immunoassay
US6316266B1 (en) * 1995-06-07 2001-11-13 Arizona State University Board Of Regents Sample presentation apparatus for mass spectrometry
US6004770A (en) * 1995-06-07 1999-12-21 Arizona State University Board Of Regents Sample presentation apparatus for mass spectrometry
US6093541A (en) * 1995-06-07 2000-07-25 Arizona State University Board Of Regents Mass spectrometer having a derivatized sample presentation apparatus
ATE305969T1 (de) 1995-06-07 2005-10-15 Univ Arizona Probengeber für massenspektrometrie
AU5766596A (en) 1995-08-04 1997-03-05 Charles Faraud S.A. Device for packaging and storing ready-made meals
ATE216594T1 (de) 1995-09-01 2002-05-15 Univ Washington Interaktive molekulare konjugate
GB9517926D0 (en) * 1995-09-01 1995-11-01 Biocine Spa Binding protein
GB9518429D0 (en) * 1995-09-08 1995-11-08 Pharmacia Biosensor A rapid method for providing kinetic and structural data in molecular interaction analysis
US5716825A (en) * 1995-11-01 1998-02-10 Hewlett Packard Company Integrated nucleic acid analysis system for MALDI-TOF MS
US5705813A (en) * 1995-11-01 1998-01-06 Hewlett-Packard Company Integrated planar liquid handling system for maldi-TOF MS
US5808300A (en) * 1996-05-10 1998-09-15 Board Of Regents, The University Of Texas System Method and apparatus for imaging biological samples with MALDI MS
US5780232A (en) 1996-05-28 1998-07-14 Atom Sciences, Inc. DNA sequencing, mapping, and diagnostic processes using hybridization and stable isotope labels of DNA
US5985153A (en) * 1996-06-07 1999-11-16 Immunivest Corporation Magnetic separation apparatus and methods employing an internal magnetic capture gradient and an external transport force
US6136182A (en) * 1996-06-07 2000-10-24 Immunivest Corporation Magnetic devices and sample chambers for examination and manipulation of cells
US6790366B2 (en) * 1996-06-07 2004-09-14 Immunivest Corporation Magnetic separation apparatus and methods
US6660159B1 (en) * 1996-06-07 2003-12-09 Immunivest Corporation Magnetic separation apparatus and methods
US6441901B2 (en) * 1996-07-23 2002-08-27 Symyx Technologies, Inc. Optical systems and methods for rapid screening of libraries of different materials
US5821060A (en) 1996-08-02 1998-10-13 Atom Sciences, Inc. DNA sequencing, mapping, and diagnostic processes using hybridization chips and unlabeled DNA
CA2267897C (en) * 1996-10-09 2005-12-06 Symyx Technologies Infrared spectroscopy and imaging of libraries
US5854486A (en) * 1996-12-27 1998-12-29 R. T. Hodgson Method and apparatus for MALDI mass spectrometry
US5882496A (en) * 1997-02-27 1999-03-16 The Regents Of The University Of California Porous silicon structures with high surface area/specific pore size
NZ516848A (en) * 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
US6207370B1 (en) * 1997-09-02 2001-03-27 Sequenom, Inc. Diagnostics based on mass spectrometric detection of translated target polypeptides
US6127005A (en) * 1999-01-08 2000-10-03 Rutgers University Method of thermally glazing an article
WO2000054309A1 (en) * 1999-03-09 2000-09-14 The Scripps Research Institute Improved desorption/ionization of analytes from porous light-absorbing semiconductor
DE19937438C2 (de) * 1999-08-07 2001-09-13 Bruker Daltonik Gmbh Kopplung Dünnschicht-Chromatographie und Massenspektrometrie (TLC/MS)
KR20040054609A (ko) * 2001-02-16 2004-06-25 싸이퍼젠 바이오시스템즈, 인코포레이티드 유전자 발현 프로파일을 단백질 발현 프로파일과연관시키는 방법
US7155127B2 (en) * 2001-08-15 2006-12-26 Nippon Telegraph And Telephone Corporation Optical communication system, optical communication unit, and optical transceiving package
US6977517B2 (en) * 2002-05-20 2005-12-20 Finisar Corporation Laser production and product qualification via accelerated life testing based on statistical modeling

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