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NO996178L - 4-aminopyrrol(3,2-d)pyrimidiner som neuropeptid y- reseptorantagonister - Google Patents

4-aminopyrrol(3,2-d)pyrimidiner som neuropeptid y- reseptorantagonister

Info

Publication number
NO996178L
NO996178L NO996178A NO996178A NO996178L NO 996178 L NO996178 L NO 996178L NO 996178 A NO996178 A NO 996178A NO 996178 A NO996178 A NO 996178A NO 996178 L NO996178 L NO 996178L
Authority
NO
Norway
Prior art keywords
neuropeptide
aminopyrrole
pyrimidines
receptor antagonists
excess
Prior art date
Application number
NO996178A
Other languages
English (en)
Other versions
NO996178D0 (no
Inventor
Robert Lee Dow
Marlys Hammond
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of NO996178D0 publication Critical patent/NO996178D0/no
Publication of NO996178L publication Critical patent/NO996178L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Det er beskrevet forbindelser med formel (I) som er effektive for behandling av tilstander assosiert med et overskudd av neuropeptid Y.
NO996178A 1997-08-05 1999-12-14 4-aminopyrrol(3,2-d)pyrimidiner som neuropeptid y- reseptorantagonister NO996178L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5473497P 1997-08-05 1997-08-05
PCT/IB1998/001053 WO1999007703A1 (en) 1997-08-05 1998-07-10 4-AMINOPYRROLE(3,2-d) PYRIMIDINES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS

Publications (2)

Publication Number Publication Date
NO996178D0 NO996178D0 (no) 1999-12-14
NO996178L true NO996178L (no) 2000-02-14

Family

ID=21993163

Family Applications (1)

Application Number Title Priority Date Filing Date
NO996178A NO996178L (no) 1997-08-05 1999-12-14 4-aminopyrrol(3,2-d)pyrimidiner som neuropeptid y- reseptorantagonister

Country Status (32)

Country Link
US (1) US6187778B1 (no)
EP (1) EP1003744B1 (no)
JP (1) JP3711238B2 (no)
KR (1) KR20010022583A (no)
CN (1) CN1264381A (no)
AP (1) AP9801312A0 (no)
AT (1) ATE296825T1 (no)
AU (1) AU7927498A (no)
BG (1) BG104107A (no)
BR (1) BR9811844A (no)
CA (1) CA2293621C (no)
CO (1) CO4960634A1 (no)
DE (1) DE69830409T2 (no)
EA (1) EA200000098A1 (no)
ES (1) ES2241146T3 (no)
GT (1) GT199800114A (no)
HR (1) HRP980434A2 (no)
HU (1) HUP0002956A3 (no)
ID (1) ID24300A (no)
IL (1) IL133430A0 (no)
IS (1) IS5294A (no)
MA (1) MA24629A1 (no)
NO (1) NO996178L (no)
OA (1) OA11277A (no)
PA (1) PA8456601A1 (no)
PE (1) PE106199A1 (no)
PL (1) PL338575A1 (no)
SA (1) SA98190435A (no)
TN (1) TNSN98148A1 (no)
TR (1) TR200000333T2 (no)
WO (1) WO1999007703A1 (no)
ZA (1) ZA986968B (no)

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HUP0203895A3 (en) * 1999-12-24 2004-09-28 Aventis Pharma Ltd West Mallin Substituted azaindoles and pharmaceutical compositions containing them and their use
GB0117396D0 (en) 2001-07-17 2001-09-05 Glaxo Group Ltd Chemical compounds
GB0308208D0 (en) 2003-04-09 2003-05-14 Glaxo Group Ltd Chemical compounds
RU2389731C2 (ru) 2004-06-02 2010-05-20 Такеда Фармасьютикал Компани Лимитед Конденсированное гетероциклическое соединение
AU2005264998A1 (en) 2004-06-17 2006-01-26 Wyeth The present invention relates to methods of making Gonadotropin Releasing Hormone ('GnRH') (also known as Leutinizing Hormone Releasing Hormone) receptor antagonists
RU2007101544A (ru) 2004-06-17 2008-08-10 Уайт (Us) Антагонисты рецепторов высвобождающего гонадотропин гормона
JP2008508358A (ja) * 2004-08-02 2008-03-21 オーエスアイ・ファーマスーティカルズ・インコーポレーテッド アリール−アミノ置換ピロロピリミジンマルチキナーゼ阻害化合物
MY179032A (en) 2004-10-25 2020-10-26 Cancer Research Tech Ltd Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
CA2596013C (en) * 2005-01-28 2012-06-05 Daewoong Pharmaceutical Co., Ltd. Benzoimidazole derivatives and pharmaceutical composition comprising the same
KR20060087386A (ko) * 2005-01-28 2006-08-02 주식회사 대웅제약 신규 벤조이미다졸 유도체 및 이를 함유하는 약제학적조성물
US7538113B2 (en) 2005-02-18 2009-05-26 Wyeth 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
US7534796B2 (en) 2005-02-18 2009-05-19 Wyeth Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor
US7582634B2 (en) 2005-02-18 2009-09-01 Wyeth 7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
AU2006235200A1 (en) * 2005-04-15 2006-10-19 Regenertech Pty Limited Use of Neuropeptide Y (NPY) and agonists and antagonists thereof for tissue regeneration
US7531542B2 (en) 2005-05-18 2009-05-12 Wyeth Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor
US7582636B2 (en) 2005-05-26 2009-09-01 Wyeth Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor
WO2007007910A1 (ja) * 2005-07-13 2007-01-18 Banyu Pharmaceutical Co., Ltd. ヘテロ環置換ベンズイミダゾール誘導体
UY29825A1 (es) * 2005-10-03 2007-05-31 Astrazeneca Ab Derivados sustituidos de 3h-imidazol-(4,5 b (beta))piridina-2-il benzoatos y benzamidas, composiciones farmacéuticas que los contienen y aplicaciones
AR057525A1 (es) * 2005-10-03 2007-12-05 Astrazeneca Ab Compuestos inhibidores selectivos de gsk3 y un proceso para su preparacion
US20070129364A1 (en) * 2005-12-07 2007-06-07 Han-Qing Dong Pyrrolopyridine kinase inhibiting compounds
EP1963315B1 (en) * 2005-12-22 2014-10-08 Cancer Research Technology Limited Enzyme inhibitors
MX2008010611A (es) 2006-02-17 2008-11-12 Pfizer Ltd Derivados de 3-desazapurina como moduladores de receptores similares a toll.
JP5606734B2 (ja) 2006-04-25 2014-10-15 アステックス、セラピューティックス、リミテッド 医薬化合物
PL2054405T3 (pl) 2006-07-11 2014-03-31 Dae Woong Pharma Nowe pochodne biarylobenzimidazolu i zawierająca je kompozycja farmaceutyczna
KR101134239B1 (ko) 2006-07-11 2012-04-10 주식회사 대웅제약 신규한 바이아릴 벤조이미다졸 유도체 및 이를 함유하는 약학 조성물
CL2007002617A1 (es) 2006-09-11 2008-05-16 Sanofi Aventis Compuestos derivados de pirrolo[2,3-b]pirazin-6-ilo; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar inflamacion de las articulaciones, artritis reumatoide, tumores, linfoma de las celulas del manto.
WO2008121064A1 (en) * 2007-03-30 2008-10-09 Astrazeneca Ab New imidazo[4,5-b]pyridine-6-halo-7-aryl/heteroaryl compounds 705
DE102007027800A1 (de) 2007-06-16 2008-12-18 Bayer Healthcare Ag Substituierte bicyclische Heteroaryl-Verbindungen und ihre Verwendung
ES2522365T3 (es) 2007-10-11 2014-11-14 Astrazeneca Ab Derivados de pirrolo [2,3-D] pirimidina como inhibidores de proteína quinasas B
JP2011509290A (ja) 2008-01-11 2011-03-24 ナトコ ファーマ リミテッド 抗癌剤としてのピラゾロ[3,4‐d]ピリミジン誘導体
HUE047357T2 (hu) 2011-04-01 2020-04-28 Astrazeneca Ab Gyógyászati kezelés
ES2762250T5 (es) 2011-11-30 2023-01-05 Astrazeneca Ab Tratamiento combinado del cáncer
AU2013204533B2 (en) 2012-04-17 2017-02-02 Astrazeneca Ab Crystalline forms
CA3120866A1 (en) * 2018-11-30 2020-06-04 Nimbus Lakshmi, Inc. Tyk2 inhibitors and uses thereof

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DE2818676A1 (de) * 1978-04-27 1979-11-08 Troponwerke Gmbh & Co Kg Substituierte 5,6-dimethylpyrrolo 2,3-d pyrimidine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
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Also Published As

Publication number Publication date
ATE296825T1 (de) 2005-06-15
CO4960634A1 (es) 2000-09-25
PL338575A1 (en) 2000-11-06
AP9801312A0 (en) 2000-01-30
OA11277A (en) 2003-07-29
PA8456601A1 (es) 2000-05-24
AU7927498A (en) 1999-03-01
BG104107A (bg) 2000-08-31
NO996178D0 (no) 1999-12-14
DE69830409D1 (de) 2005-07-07
JP3711238B2 (ja) 2005-11-02
HRP980434A2 (en) 1999-04-30
CN1264381A (zh) 2000-08-23
WO1999007703A1 (en) 1999-02-18
KR20010022583A (ko) 2001-03-26
EA200000098A1 (ru) 2000-08-28
ES2241146T3 (es) 2005-10-16
JP2001512729A (ja) 2001-08-28
EP1003744B1 (en) 2005-06-01
ZA986968B (en) 2000-02-04
US6187778B1 (en) 2001-02-13
IS5294A (is) 1999-12-10
EP1003744A1 (en) 2000-05-31
BR9811844A (pt) 2000-08-08
IL133430A0 (en) 2001-04-30
TR200000333T2 (tr) 2000-05-22
CA2293621C (en) 2003-12-30
PE106199A1 (es) 1999-11-02
GT199800114A (es) 2000-01-18
HUP0002956A3 (en) 2002-01-28
DE69830409T2 (de) 2006-01-26
SA98190435A (ar) 2005-12-03
ID24300A (id) 2000-07-13
HUP0002956A2 (hu) 2001-08-28
CA2293621A1 (en) 1999-02-18
MA24629A1 (fr) 1999-04-01
TNSN98148A1 (fr) 2005-03-15

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