NO994386L - 2-substituted benzoylcycloalkyl-1-carboxylic acid derivatives - Google Patents
2-substituted benzoylcycloalkyl-1-carboxylic acid derivativesInfo
- Publication number
- NO994386L NO994386L NO994386A NO994386A NO994386L NO 994386 L NO994386 L NO 994386L NO 994386 A NO994386 A NO 994386A NO 994386 A NO994386 A NO 994386A NO 994386 L NO994386 L NO 994386L
- Authority
- NO
- Norway
- Prior art keywords
- hydrogen
- substituted
- alkoxy
- hydroxy
- benzoylcycloalkyl
- Prior art date
Links
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- -1 cyano, nitro, phenyl Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 101100203601 Caenorhabditis elegans sor-3 gene Proteins 0.000 abstract 1
- 102100037652 Kynurenine 3-monooxygenase Human genes 0.000 abstract 1
- 108010033242 Kynurenine 3-monooxygenase Proteins 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001721 carbon Chemical group 0.000 abstract 1
- 229940125532 enzyme inhibitor Drugs 0.000 abstract 1
- 239000002532 enzyme inhibitor Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/18—Saturated compounds containing keto groups
- C07C62/20—Saturated compounds containing keto groups with a saturated six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C229/48—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms of the same non-condensed ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C233/60—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/82—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/62—Compounds containing any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylcarbamates
- C07C271/64—Y being a hydrogen or a carbon atom, e.g. benzoylcarbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/51—Y being a hydrogen or a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/30—Unsaturated compounds
- C07C62/38—Unsaturated compounds containing keto groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
2-(substituert benzoyl)-cykloalkyl-l-karboksylsyrer av formel (I) (I) hvor E er en Ci-C4 alkylenkjede i hvilken et karbonatom er eventuelt substituert; hver av R og R,, som er like eller forskjellige, er hydrogen, halogen, hydroksy, trifluormetyl, cyano, nitro, fenyl, benzyl, Ci-C6 alkyl, C,-C6 alkoksy, d-C6 alkyltio, SOR» eller S02R4; R2 er hydrogen eller -N(R7Rs) hvor hver av R7 og R« uavhengig er hydrogen, C]-C6 alkyl, benzyl, fenyl, hydroksy, CrC6 alkoksy, benzyloksy eller en av R7 og Rg er hydrogen og den andre er COR9; R3 er hydroksy, CrC6 alkoksy, fenoksy, benzyloksy eller en gruppe -N(Ri2Ri3); og farmasøytisk akseptable salter derav, har kynurenin-3- hydroksylasenzyminhibitoraktivitet.2- (substituted benzoyl) -cycloalkyl-1-carboxylic acids of formula (I) (I) wherein E is a C 1 -C 4 alkylene chain in which a carbon atom is optionally substituted; each of R and R 1, which are the same or different, are hydrogen, halogen, hydroxy, trifluoromethyl, cyano, nitro, phenyl, benzyl, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, d-C 6 alkylthio, SOR 3 or SO 2 R 4 ; R 2 is hydrogen or -N (R 7 R 5) where each of R 7 and R 6 is independently hydrogen, C 1 -C 6 alkyl, benzyl, phenyl, hydroxy, C 1 -C 6 alkoxy, benzyloxy or one of R 7 and R 9 is hydrogen and the other is COR 9; R3 is hydroxy, C1-C6 alkoxy, phenoxy, benzyloxy or a group -N (R12 R13); and pharmaceutically acceptable salts thereof, have kynurenine-3-hydroxylase enzyme inhibitor activity.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9705031.4A GB9705031D0 (en) | 1997-03-11 | 1997-03-11 | 2-substituted benzoyl-cycloalkyl-1-carboxylic acid derivatives |
| PCT/EP1998/000883 WO1998040344A1 (en) | 1997-03-11 | 1998-02-16 | 2-substituted benzoyl-cycloalkyl-1-carboxylic acid derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO994386D0 NO994386D0 (en) | 1999-09-10 |
| NO994386L true NO994386L (en) | 1999-11-02 |
Family
ID=10809053
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO994386A NO994386L (en) | 1997-03-11 | 1999-09-10 | 2-substituted benzoylcycloalkyl-1-carboxylic acid derivatives |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0973720A1 (en) |
| JP (1) | JP2001514634A (en) |
| KR (1) | KR20000076096A (en) |
| CN (1) | CN1252049A (en) |
| AU (1) | AU6497998A (en) |
| CA (1) | CA2283184A1 (en) |
| EA (1) | EA199900809A1 (en) |
| GB (1) | GB9705031D0 (en) |
| HU (1) | HUP0001023A3 (en) |
| IL (1) | IL131676A0 (en) |
| NO (1) | NO994386L (en) |
| PL (1) | PL335601A1 (en) |
| TW (1) | TW407146B (en) |
| WO (1) | WO1998040344A1 (en) |
| ZA (1) | ZA981972B (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1424333A1 (en) * | 2002-11-28 | 2004-06-02 | Newron Pharmaceuticals S.p.A. | Halothenoyl-cyclopropane-1-carboxylic acid derivatives |
| EP1475385A1 (en) * | 2003-05-05 | 2004-11-10 | Newron Pharmaceuticals S.p.A. | Glycoside derivatives of 2-(3,4-dichlorobenzoyl)-cycopropane-1-carboxylic acid |
| EP1475088A1 (en) * | 2003-05-05 | 2004-11-10 | Newron Pharmaceuticals S.p.A. | Use of kynurenine-3-hydroxylase inhibitors for the preparation of medicaments for the treatment of l-dopa induced movement disorders, dyskinesias, drug addiction, pain and cataract |
| EP3130583B1 (en) * | 2012-04-05 | 2024-01-03 | CHDI Foundation, Inc. | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
| CN103373911B (en) * | 2012-04-27 | 2016-12-14 | 中国科学院上海有机化学研究所 | Single fluoro cyclopropanes compound and its preparation method and application |
| CN104119246A (en) * | 2013-04-26 | 2014-10-29 | 中国科学院上海有机化学研究所 | Cyclopropane derivatives, and preparation method and application thereof |
| EP3049077A4 (en) | 2013-09-26 | 2017-02-15 | CHDI Foundation, Inc. | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
| JP6449893B2 (en) * | 2013-09-26 | 2019-01-09 | シーエイチディーアイ ファウンデーション，インコーポレーテッド | Kynurenin-3-monooxygenase inhibitor, pharmaceutical composition, and methods of use thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3655667A (en) * | 1968-04-04 | 1972-04-11 | Smith Kline French Lab | 1-(2-benzoylcyclopropylmethyl)-4-phenylpiperazines |
-
1997
- 1997-03-11 GB GBGB9705031.4A patent/GB9705031D0/en active Pending
-
1998
- 1998-02-16 IL IL13167698A patent/IL131676A0/en unknown
- 1998-02-16 CA CA002283184A patent/CA2283184A1/en not_active Abandoned
- 1998-02-16 EA EA199900809A patent/EA199900809A1/en unknown
- 1998-02-16 PL PL98335601A patent/PL335601A1/en unknown
- 1998-02-16 HU HU0001023A patent/HUP0001023A3/en unknown
- 1998-02-16 WO PCT/EP1998/000883 patent/WO1998040344A1/en not_active Ceased
- 1998-02-16 EP EP98910685A patent/EP0973720A1/en not_active Withdrawn
- 1998-02-16 CN CN98804144A patent/CN1252049A/en active Pending
- 1998-02-16 KR KR1019997008184A patent/KR20000076096A/en not_active Withdrawn
- 1998-02-16 JP JP53912398A patent/JP2001514634A/en not_active Withdrawn
- 1998-02-16 AU AU64979/98A patent/AU6497998A/en not_active Abandoned
- 1998-02-26 TW TW087102847A patent/TW407146B/en active
- 1998-03-09 ZA ZA981972A patent/ZA981972B/en unknown
-
1999
- 1999-09-10 NO NO994386A patent/NO994386L/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001514634A (en) | 2001-09-11 |
| ZA981972B (en) | 1998-09-09 |
| EP0973720A1 (en) | 2000-01-26 |
| CA2283184A1 (en) | 1998-09-17 |
| HUP0001023A3 (en) | 2001-03-28 |
| PL335601A1 (en) | 2000-05-08 |
| AU6497998A (en) | 1998-09-29 |
| EA199900809A1 (en) | 2000-08-28 |
| GB9705031D0 (en) | 1997-04-30 |
| KR20000076096A (en) | 2000-12-26 |
| NO994386D0 (en) | 1999-09-10 |
| WO1998040344A1 (en) | 1998-09-17 |
| HUP0001023A2 (en) | 2000-09-28 |
| TW407146B (en) | 2000-10-01 |
| CN1252049A (en) | 2000-05-03 |
| IL131676A0 (en) | 2001-03-19 |
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