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NO971142L - Bis- (2-haloethyl) aminophenyl-substituted distamycin derivatives as antitumor and antiviral agents - Google Patents

Bis- (2-haloethyl) aminophenyl-substituted distamycin derivatives as antitumor and antiviral agents

Info

Publication number
NO971142L
NO971142L NO971142A NO971142A NO971142L NO 971142 L NO971142 L NO 971142L NO 971142 A NO971142 A NO 971142A NO 971142 A NO971142 A NO 971142A NO 971142 L NO971142 L NO 971142L
Authority
NO
Norway
Prior art keywords
antitumor
haloethyl
aminophenyl
bis
antiviral agents
Prior art date
Application number
NO971142A
Other languages
Norwegian (no)
Other versions
NO971142D0 (en
Inventor
Paolo Cozzi
Italo Beria
Laura Capolongo
Cristina Franzetti
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Publication of NO971142L publication Critical patent/NO971142L/en
Publication of NO971142D0 publication Critical patent/NO971142D0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Nye antitumor- og antivirale midler av formel (I) (I) hvor ner2, 3 eller4; én av R og Rj er hydrogen, C1-C4 alkyl, CF3 eller C]-C4 alkoksy og den andre er uavhengig CF3, C1-C4 alkyl eller C1-C4 alkoksy; og X er halogen; og saltene derav.Novel antitumor and antiviral agents of formula (I) (I) wherein ner 2, 3 or 4; one of R and Rj is hydrogen, C1-C4 alkyl, CF3 or C1-C4 alkoxy and the other is independently CF3, C1-C4 alkyl or C1-C4 alkoxy; and X is halogen; and the salts thereof.

NO971142A 1995-07-21 1997-03-12 Bis- (2-haloethyl) aminophenyl-substituted distamycin derivatives as antitumor and antiviral agents NO971142D0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9514993.6A GB9514993D0 (en) 1995-07-21 1995-07-21 Site specific phenyl nitrogen mustards
PCT/EP1996/002659 WO1997003957A1 (en) 1995-07-21 1996-06-19 Bis-(2-haloethyl)aminophenyl substituted distamycin derivatives as antitumor and antiviral agents

Publications (2)

Publication Number Publication Date
NO971142L true NO971142L (en) 1997-03-12
NO971142D0 NO971142D0 (en) 1997-03-12

Family

ID=10778062

Family Applications (1)

Application Number Title Priority Date Filing Date
NO971142A NO971142D0 (en) 1995-07-21 1997-03-12 Bis- (2-haloethyl) aminophenyl-substituted distamycin derivatives as antitumor and antiviral agents

Country Status (18)

Country Link
EP (1) EP0787126A1 (en)
JP (1) JPH10506410A (en)
KR (1) KR970706251A (en)
CN (1) CN1159183A (en)
AR (1) AR003456A1 (en)
AU (1) AU6357996A (en)
BR (1) BR9606528A (en)
CA (1) CA2199635A1 (en)
EA (1) EA000033B1 (en)
GB (1) GB9514993D0 (en)
HU (1) HUP9702393A3 (en)
IL (1) IL120342A0 (en)
MX (1) MX9701949A (en)
NO (1) NO971142D0 (en)
PL (1) PL319352A1 (en)
TW (1) TW367325B (en)
WO (1) WO1997003957A1 (en)
ZA (1) ZA965028B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6635417B1 (en) 1996-07-31 2003-10-21 California Institute Of Technology Complex formation between DSDNA and oligomer of cyclic heterocycles
EP0968186A1 (en) 1996-02-26 2000-01-05 California Institute Of Technology Improved polyamides for binding in the minor groove of double stranded dna
US5998140A (en) 1996-07-31 1999-12-07 The Scripps Research Institute Complex formation between dsDNA and oligomer of cyclic heterocycles
GB9623522D0 (en) * 1996-11-11 1997-01-08 Pharmacia & Upjohn Spa Benzoheterocycle distamycin derivatives process for preparing them and their use as antitumour and antiviral agents
GB9816652D0 (en) * 1998-07-30 1998-09-30 Pharmacia & Upjohn Spa Sulfurated distamycin derivatives process for preparing them and their use as antitumor agents
GB9907414D0 (en) * 1999-03-31 1999-05-26 Cancer Res Campaign Tech Improvements relating to prodrugs
US6559125B1 (en) 2000-01-28 2003-05-06 California Institute Of Technology Polyamide-alkylator conjugates and related products and method
AU2002312370A1 (en) 2001-06-13 2002-12-23 Roland W. Burli Antipathogenic benzamide compounds
US7498349B2 (en) 2002-08-02 2009-03-03 Genesoft Pharmaceuticals, Inc. Biaryl compounds having anti-infective activity
US7265129B2 (en) 2002-10-25 2007-09-04 Genesoft Pharmaceuticals, Inc. Anti-infective biaryl compounds
US7129214B2 (en) 2002-12-10 2006-10-31 Oscient Pharmaceuticals Corporation Antibacterial compounds having a (pyrrole carboxamide)-(benzamide)-(imidazole carboxamide) motif
EP2792355A1 (en) 2013-04-17 2014-10-22 Albert-Ludwigs-Universität Freiburg Compounds for use as bromodomain inhibitors
CN115414356A (en) * 2022-09-27 2022-12-02 广西科技大学 Application of indenopyrrole derivatives in preparation of antitumor pharmaceutical composition

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8612218D0 (en) * 1986-05-20 1986-06-25 Erba Farmitalia Site specific alkylating agents

Also Published As

Publication number Publication date
TW367325B (en) 1999-08-21
AR003456A1 (en) 1998-08-05
HUP9702393A3 (en) 1998-05-28
EP0787126A1 (en) 1997-08-06
ZA965028B (en) 1997-01-23
EA199700046A1 (en) 1997-12-30
KR970706251A (en) 1997-11-03
NO971142D0 (en) 1997-03-12
CA2199635A1 (en) 1997-02-06
GB9514993D0 (en) 1995-09-20
HUP9702393A2 (en) 1998-04-28
EA000033B1 (en) 1998-02-26
PL319352A1 (en) 1997-08-04
CN1159183A (en) 1997-09-10
JPH10506410A (en) 1998-06-23
BR9606528A (en) 1997-12-23
IL120342A0 (en) 1997-06-10
WO1997003957A1 (en) 1997-02-06
AU6357996A (en) 1997-02-18
MX9701949A (en) 1997-06-28

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