NO983528L - Dihydrobenzofuran og relaterte forbindelser anvendelig som anti-inflammatoriske midler - Google Patents
Dihydrobenzofuran og relaterte forbindelser anvendelig som anti-inflammatoriske midlerInfo
- Publication number
- NO983528L NO983528L NO983528A NO983528A NO983528L NO 983528 L NO983528 L NO 983528L NO 983528 A NO983528 A NO 983528A NO 983528 A NO983528 A NO 983528A NO 983528 L NO983528 L NO 983528L
- Authority
- NO
- Norway
- Prior art keywords
- atoms
- branched
- straight
- dihydrobenzofuran
- cyclic alkyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- HBEDSQVIWPRPAY-UHFFFAOYSA-N 2,3-dihydrobenzofuran Chemical compound C1=CC=C2OCCC2=C1 HBEDSQVIWPRPAY-UHFFFAOYSA-N 0.000 title 2
- 229940121363 anti-inflammatory agent Drugs 0.000 title 1
- 239000002260 anti-inflammatory agent Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 125000004429 atom Chemical group 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000005518 carboxamido group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
Abstract
En forbindelse som har struktur (A) hvor (a)n er fra l til ca. 3; (b)X velges fra gruppen bestående av O, S, SO eller SO3; (c)Y er uavhengig hydrogen eller rett, forgrenet eller cyklisk alkyl eller aralkyl som har fra l til ca. 3 karbonatomer; eller Yene er bundet sammen for å danne en alkanylring som har fra 3 til ca. 7 atomer; (d)Z er hydrogen eller rett, forgrenet eller cy- klisk alkyl som har fra 3 til ca. 10 atomer forskjellig fra hydrogen; (e)^ og R2 er hver uavhengig hydrogen eller rett, forgrenet eller cyklisk alkyl, usubstituert eller substituert, karboksyl, karboksamido, al- koksykarbonyl eller alkylkarbonyl; og (f) Het er en he- teroarylgruppe bestående av en eller flere ringer inne- holdende fra ca. 5 til ca. 8 atomer i ringene og hvor minst en ring har minst ett heteroatom valgt fra O, N eller S. Farmasøytiske sammensetninger som omfatter slike forbindelser, og fremgangsmåter for å behandle inflammasjon eller smerte ved å bruke slike forbindelser.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/595,120 US5686471A (en) | 1996-02-01 | 1996-02-01 | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
| PCT/US1997/001312 WO1997028155A1 (en) | 1996-02-01 | 1997-01-30 | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO983528D0 NO983528D0 (no) | 1998-07-31 |
| NO983528L true NO983528L (no) | 1998-09-28 |
Family
ID=24381819
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO983528A NO983528L (no) | 1996-02-01 | 1998-07-31 | Dihydrobenzofuran og relaterte forbindelser anvendelig som anti-inflammatoriske midler |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5686471A (no) |
| EP (1) | EP0904272B1 (no) |
| JP (1) | JP3164157B2 (no) |
| KR (1) | KR100322943B1 (no) |
| CN (1) | CN1072668C (no) |
| AT (1) | ATE236900T1 (no) |
| AU (1) | AU730292B2 (no) |
| BR (1) | BR9707342A (no) |
| CA (1) | CA2244199A1 (no) |
| DE (1) | DE69720718T2 (no) |
| DK (1) | DK0904272T3 (no) |
| ES (1) | ES2196301T3 (no) |
| MX (1) | MX9806253A (no) |
| NO (1) | NO983528L (no) |
| WO (1) | WO1997028155A1 (no) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE445838T1 (de) | 2001-07-25 | 2009-10-15 | Raptor Pharmaceutical Inc | Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke |
| DE102004002235B4 (de) * | 2004-01-15 | 2007-04-26 | OCé PRINTING SYSTEMS GMBH | Puffereinrichtung mit einem Vorratspuffer zur Aufnahme einer mit variierender Geschwindigkeit zugeführten Bedruckstoffbahn bei einer elektrografischen Druckeinrichtung |
| CA2789097C (en) | 2005-04-28 | 2017-02-21 | Proteus Digital Health, Inc. | Pharma-informatics system |
| JP2010503710A (ja) | 2006-09-18 | 2010-02-04 | ラプトール ファーマシューティカル インコーポレイテッド | 受容体関連タンパク質（ｒａｐ）結合体の投与による肝障害の処置 |
| NZ616673A (en) | 2009-02-20 | 2014-08-29 | To Bbb Holding B V | Glutathione-based drug delivery system |
| ES2942923T3 (es) | 2009-05-06 | 2023-06-07 | Laboratory Skin Care Inc | Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6019305B2 (ja) * | 1976-07-02 | 1985-05-15 | ウェルファイド株式会社 | ジヒドロベンゾフラン誘導体 |
| IT1093805B (it) * | 1978-01-31 | 1985-07-26 | Erba Carlo Spa | Derivati del 2h-benzofuran-3-one e procedimento per la loro preparazione |
| US4470440A (en) * | 1982-09-30 | 1984-09-11 | Thor Harry A | Impact producing tool |
| DE3777366D1 (de) * | 1986-12-27 | 1992-04-16 | Takeda Chemical Industries Ltd | 2,3-dihydro-cumaron-derivate, ihre herstellung und verwendung. |
| US5234926A (en) * | 1987-03-20 | 1993-08-10 | Allergan, Inc. | Disubstituted acetylenes bearing heteroaromatic and heterobicyclic groups having retinoid like activity |
| US4833254A (en) | 1987-05-11 | 1989-05-23 | The Board Of Regents For The Oklahoma Agricultural And Mechanical Colleges Acting For And On Behalf Of Oklahoma State University | Heteroarotinoids as anticancer agents |
| US4849428A (en) * | 1987-11-23 | 1989-07-18 | The Procter & Gamble Company | Cyclic anti-inflammatory derivatives of di-tert-butylphenol compounds, compositions and use |
| JP2855341B2 (ja) * | 1988-06-10 | 1999-02-10 | 武田薬品工業株式会社 | 新規２―置換クマラン誘導体 |
| US4966907A (en) * | 1988-08-12 | 1990-10-30 | Merck & Co., Inc. | 6-substituted 5-hydroxy-2,3-dihydrobenzofurans as inhibitors of leukotriene biosynthesis |
| FR2645537B1 (fr) * | 1989-04-05 | 1994-03-04 | Fabre Medicament Pierre | Nouveaux sulfonamides derives d'acides benzocycliques ou benzoheterocycliques, leur preparation et leur application en therapeutique |
| US4975457A (en) * | 1989-09-25 | 1990-12-04 | Merck & Co., Inc. | Trans 2,3-disubstituted-2,3-dihydro-5-hydroxy-benzofurans as inhibitors of leukotriene biosynthesis |
| WO1991007396A1 (fr) * | 1989-11-17 | 1991-05-30 | Meiji Milk Products Co., Ltd. | Derive de benzofurane, procede de preparation de ce derive et produit pharmaceutique contenant ce derive comme ingredient actif |
| US5091533A (en) * | 1990-03-12 | 1992-02-25 | Merck Frosst Canada, Inc. | 5-hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors |
| NZ237566A (en) * | 1990-03-27 | 1994-03-25 | Smithkline Beecham Corp | Substituted amide and hydroxyamine derivatives and pharmaceutical compositions |
| JPH10506615A (ja) * | 1994-07-27 | 1998-06-30 | ザ、プロクター、エンド、ギャンブル、カンパニー | 抗炎症剤として有用なジヒドロベンゾフラン及び関連化合物 |
| US5684002A (en) * | 1994-09-07 | 1997-11-04 | The Procter & Gamble Company | Dihydorbenzofuran and related compounds useful as anti-inflammatory agents |
-
1996
- 1996-02-01 US US08/595,120 patent/US5686471A/en not_active Expired - Fee Related
-
1997
- 1997-01-30 WO PCT/US1997/001312 patent/WO1997028155A1/en not_active Ceased
- 1997-01-30 CN CN97192017A patent/CN1072668C/zh not_active Expired - Fee Related
- 1997-01-30 DE DE69720718T patent/DE69720718T2/de not_active Expired - Fee Related
- 1997-01-30 AT AT97904017T patent/ATE236900T1/de not_active IP Right Cessation
- 1997-01-30 EP EP97904017A patent/EP0904272B1/en not_active Expired - Lifetime
- 1997-01-30 CA CA002244199A patent/CA2244199A1/en not_active Abandoned
- 1997-01-30 ES ES97904017T patent/ES2196301T3/es not_active Expired - Lifetime
- 1997-01-30 JP JP52776097A patent/JP3164157B2/ja not_active Expired - Fee Related
- 1997-01-30 BR BR9707342A patent/BR9707342A/pt not_active Application Discontinuation
- 1997-01-30 DK DK97904017T patent/DK0904272T3/da active
- 1997-01-30 AU AU18431/97A patent/AU730292B2/en not_active Ceased
- 1997-01-30 KR KR1019980705953A patent/KR100322943B1/ko not_active Expired - Fee Related
-
1998
- 1998-07-31 NO NO983528A patent/NO983528L/no not_active Application Discontinuation
- 1998-08-03 MX MX9806253A patent/MX9806253A/es not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1072668C (zh) | 2001-10-10 |
| DE69720718D1 (de) | 2003-05-15 |
| KR100322943B1 (ko) | 2002-05-09 |
| JPH11503468A (ja) | 1999-03-26 |
| NO983528D0 (no) | 1998-07-31 |
| AU1843197A (en) | 1997-08-22 |
| EP0904272A1 (en) | 1999-03-31 |
| ES2196301T3 (es) | 2003-12-16 |
| ATE236900T1 (de) | 2003-04-15 |
| AU730292B2 (en) | 2001-03-01 |
| MX9806253A (es) | 1998-11-30 |
| US5686471A (en) | 1997-11-11 |
| EP0904272B1 (en) | 2003-04-09 |
| JP3164157B2 (ja) | 2001-05-08 |
| CA2244199A1 (en) | 1997-08-07 |
| CN1210534A (zh) | 1999-03-10 |
| KR19990082225A (ko) | 1999-11-25 |
| WO1997028155A1 (en) | 1997-08-07 |
| DK0904272T3 (da) | 2003-07-21 |
| DE69720718T2 (de) | 2003-12-18 |
| BR9707342A (pt) | 1999-07-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |