NO982976L - N-acylaminoalkylhydrazinkarboksimidamider - Google Patents
N-acylaminoalkylhydrazinkarboksimidamiderInfo
- Publication number
- NO982976L NO982976L NO982976A NO982976A NO982976L NO 982976 L NO982976 L NO 982976L NO 982976 A NO982976 A NO 982976A NO 982976 A NO982976 A NO 982976A NO 982976 L NO982976 L NO 982976L
- Authority
- NO
- Norway
- Prior art keywords
- carbon atoms
- composition
- group containing
- inhibiting
- protein
- Prior art date
Links
- 239000000203 mixture Substances 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 230000032683 aging Effects 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 108010005094 Advanced Glycation End Products Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 235000021120 animal protein Nutrition 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000004132 cross linking Methods 0.000 abstract 1
- 235000013305 food Nutrition 0.000 abstract 1
- 235000018102 proteins Nutrition 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Inks, Pencil-Leads, Or Crayons (AREA)
- Fats And Perfumes (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Steroid Compounds (AREA)
Abstract
Foreliggende oppfinnelse vedrører preparater og fremgangsmåter for inhibering av ikke-enzymatisk kryss- binding (proteinaldring) under anven- delse av forbindelser med formel (I) H H H l l l H,N-N-C-N-alk-N-C-R II II NH O d) hvor alk er en rettkjedet eller for- grenet alkylengruppe som inneholder fra 2 til 8 karbonatomer, og R er en lavere alkylgruppe som inneholder fra l til 6 karbonatomer, og deres biologisk eller farmasøytisk akseptable syreaddi- sjonssalter. Følgelig er det beskrevet et preparat som omfatter disse N-acyl- aminoalkylhydrazinkarboksimidamider, og som er i stand til å inhibere dannelsen av sluttprodukter av fremskredet glyko- sylering av målproteiner. Fremgangs- måten omfatter å bringe målproteinet i kontakt med preparatet. Man forestiller seg både industrielle og terapeutiske applikasjoner for oppfinnelsen, etter- som matødeleggelse og dyreprotein- aldring kan behandles.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US922095P | 1995-12-26 | 1995-12-26 | |
| US61840796A | 1996-03-19 | 1996-03-19 | |
| US08/771,959 US5877217A (en) | 1995-12-26 | 1996-12-23 | N-acylaminoalkyl-hydrazinecarboximidamides |
| PCT/US1996/020810 WO1997023447A1 (en) | 1995-12-26 | 1996-12-26 | N-acylaminoalkylhydrazinecarboximidamides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO982976D0 NO982976D0 (no) | 1998-06-26 |
| NO982976L true NO982976L (no) | 1998-08-26 |
Family
ID=27358809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO982976A NO982976L (no) | 1995-12-26 | 1998-06-26 | N-acylaminoalkylhydrazinkarboksimidamider |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0888293B1 (no) |
| JP (1) | JP2000502684A (no) |
| CN (1) | CN1209117A (no) |
| AT (1) | ATE215068T1 (no) |
| AU (1) | AU720796B2 (no) |
| BR (1) | BR9612304A (no) |
| CA (1) | CA2241746A1 (no) |
| DE (1) | DE69620253T2 (no) |
| DK (1) | DK0888293T3 (no) |
| ES (1) | ES2174132T3 (no) |
| NO (1) | NO982976L (no) |
| NZ (1) | NZ326238A (no) |
| PT (1) | PT888293E (no) |
| TW (1) | TW502012B (no) |
| WO (1) | WO1997023447A1 (no) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
| DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
| DE102005035891A1 (de) | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
| KR101452915B1 (ko) | 2006-05-04 | 2014-10-21 | 베링거 인겔하임 인터내셔날 게엠베하 | 다형태 |
| PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
| EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
| PE20140960A1 (es) | 2008-04-03 | 2014-08-15 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
| KR20190016601A (ko) | 2008-08-06 | 2019-02-18 | 베링거 인겔하임 인터내셔날 게엠베하 | 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료 |
| UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
| MX2011002558A (es) | 2008-09-10 | 2011-04-26 | Boehringer Ingelheim Int | Terapia de combinacion para el tratamiento de diabetes y estados relacionados. |
| US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
| AU2009331471B2 (en) | 2008-12-23 | 2015-09-03 | Boehringer Ingelheim International Gmbh | Salt forms of organic compound |
| AR074990A1 (es) | 2009-01-07 | 2011-03-02 | Boehringer Ingelheim Int | Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina |
| KR20120107080A (ko) | 2009-11-27 | 2012-09-28 | 베링거 인겔하임 인터내셔날 게엠베하 | 리나글립틴과 같은 ｄｐｐ－ｉｖ 억제제를 사용한 유전자형 검사된 당뇨병 환자의 치료 |
| KR101927068B1 (ko) | 2010-05-05 | 2018-12-10 | 베링거 인겔하임 인터내셔날 게엠베하 | 체중 감소 치료에 후속하는 dpp-4 억제제에 의한 순차적 병용 요법 |
| KR20220025926A (ko) | 2010-06-24 | 2022-03-03 | 베링거 인겔하임 인터내셔날 게엠베하 | 당뇨병 요법 |
| AR083878A1 (es) | 2010-11-15 | 2013-03-27 | Boehringer Ingelheim Int | Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento |
| CN103781788B (zh) | 2011-07-15 | 2016-08-17 | 勃林格殷格翰国际有限公司 | 经取代的喹唑啉、其制备及其在药物组合物中的用途 |
| US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
| JP6224084B2 (ja) | 2012-05-14 | 2017-11-01 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 糸球体上皮細胞関連障害及び／又はネフローゼ症候群の治療に用いるｄｐｐ−４阻害薬としてのキサンチン誘導体 |
| WO2013171166A1 (en) | 2012-05-14 | 2013-11-21 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp-4 inhibitor for use in the treatment of sirs and/or sepsis |
| WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
| JP6615109B2 (ja) | 2014-02-28 | 2019-12-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｄｐｐ−４阻害薬の医学的使用 |
| MX390363B (es) | 2016-06-10 | 2025-03-20 | Boehringer Ingelheim Int | Combinacion de linagliptina y metformina |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4758583A (en) * | 1984-03-19 | 1988-07-19 | The Rockefeller University | Method and agents for inhibiting protein aging |
-
1996
- 1996-12-26 ES ES96945113T patent/ES2174132T3/es not_active Expired - Lifetime
- 1996-12-26 BR BR9612304A patent/BR9612304A/pt unknown
- 1996-12-26 DK DK96945113T patent/DK0888293T3/da active
- 1996-12-26 AT AT96945113T patent/ATE215068T1/de not_active IP Right Cessation
- 1996-12-26 NZ NZ326238A patent/NZ326238A/xx unknown
- 1996-12-26 CA CA002241746A patent/CA2241746A1/en not_active Abandoned
- 1996-12-26 WO PCT/US1996/020810 patent/WO1997023447A1/en not_active Ceased
- 1996-12-26 EP EP96945113A patent/EP0888293B1/en not_active Expired - Lifetime
- 1996-12-26 AU AU13560/97A patent/AU720796B2/en not_active Ceased
- 1996-12-26 CN CN96199999A patent/CN1209117A/zh active Pending
- 1996-12-26 DE DE69620253T patent/DE69620253T2/de not_active Expired - Fee Related
- 1996-12-26 JP JP09523883A patent/JP2000502684A/ja active Pending
- 1996-12-26 PT PT96945113T patent/PT888293E/pt unknown
-
1997
- 1997-01-09 TW TW086100168A patent/TW502012B/zh active
-
1998
- 1998-06-26 NO NO982976A patent/NO982976L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ326238A (en) | 1999-11-29 |
| AU1356097A (en) | 1997-07-17 |
| DE69620253D1 (en) | 2002-05-02 |
| DE69620253T2 (de) | 2002-09-19 |
| EP0888293A1 (en) | 1999-01-07 |
| WO1997023447A1 (en) | 1997-07-03 |
| NO982976D0 (no) | 1998-06-26 |
| CA2241746A1 (en) | 1997-07-03 |
| PT888293E (pt) | 2002-07-31 |
| ES2174132T3 (es) | 2002-11-01 |
| EP0888293B1 (en) | 2002-03-27 |
| BR9612304A (pt) | 1999-07-13 |
| TW502012B (en) | 2002-09-11 |
| AU720796B2 (en) | 2000-06-15 |
| DK0888293T3 (da) | 2002-04-22 |
| ATE215068T1 (de) | 2002-04-15 |
| CN1209117A (zh) | 1999-02-24 |
| JP2000502684A (ja) | 2000-03-07 |
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