[go: up one dir, main page]

NO982264L - Inhibitor av cyklofilinrotamaseaktivitet - Google Patents

Inhibitor av cyklofilinrotamaseaktivitet

Info

Publication number
NO982264L
NO982264L NO982264A NO982264A NO982264L NO 982264 L NO982264 L NO 982264L NO 982264 A NO982264 A NO 982264A NO 982264 A NO982264 A NO 982264A NO 982264 L NO982264 L NO 982264L
Authority
NO
Norway
Prior art keywords
inhibitor
cyclophilin
rotamase activity
enzyme activity
cyclophilin rotamase
Prior art date
Application number
NO982264A
Other languages
English (en)
Norwegian (no)
Other versions
NO982264D0 (no
Inventor
Joseph P Steiner
Gregory S Hamilton
Salomon H Snyder
Original Assignee
Guilford Pharm Inc
Univ Johns Hopkins Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guilford Pharm Inc, Univ Johns Hopkins Med filed Critical Guilford Pharm Inc
Publication of NO982264D0 publication Critical patent/NO982264D0/no
Publication of NO982264L publication Critical patent/NO982264L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO982264A 1995-11-20 1998-05-18 Inhibitor av cyklofilinrotamaseaktivitet NO982264L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56068595A 1995-11-20 1995-11-20
PCT/US1996/017677 WO1997018828A1 (fr) 1995-11-20 1996-11-15 Inhibiteurs d'activite de cyclophiline rotamase

Publications (2)

Publication Number Publication Date
NO982264D0 NO982264D0 (no) 1998-05-18
NO982264L true NO982264L (no) 1998-07-20

Family

ID=24238888

Family Applications (1)

Application Number Title Priority Date Filing Date
NO982264A NO982264L (no) 1995-11-20 1998-05-18 Inhibitor av cyklofilinrotamaseaktivitet

Country Status (18)

Country Link
US (2) US6444643B1 (fr)
EP (1) EP0880358B1 (fr)
JP (1) JP3089350B2 (fr)
KR (1) KR19990071482A (fr)
CN (1) CN1123360C (fr)
AT (1) ATE246510T1 (fr)
AU (1) AU714482B2 (fr)
BR (1) BR9611624A (fr)
CA (1) CA2238050C (fr)
CZ (1) CZ154098A3 (fr)
DE (1) DE69629392T2 (fr)
ES (1) ES2206608T3 (fr)
LV (1) LV12125B (fr)
MX (1) MX9804011A (fr)
NO (1) NO982264L (fr)
PL (1) PL327994A1 (fr)
TR (1) TR199800890T2 (fr)
WO (1) WO1997018828A1 (fr)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3089350B2 (ja) * 1995-11-20 2000-09-18 ギルフォード ファーマシューティカルズ インコーポレイテッド シクロフィリンロタマーゼ活性の阻害剤
PA8442401A1 (es) * 1996-12-09 2000-05-24 Guilford Pharm Inc Inhibidores polipropilos de ciclofilina
US6852496B1 (en) 1997-08-12 2005-02-08 Oregon Health And Science University Methods of screening for agents that promote nerve cell growth
AU8918998A (en) * 1997-08-26 1999-03-16 Wisconsin Alumni Research Foundation Non-immunosuppressive cyclosporins and their use in the prevention and treatmentof hiv infection
US5968921A (en) 1997-10-24 1999-10-19 Orgegon Health Sciences University Compositions and methods for promoting nerve regeneration
US6927208B1 (en) * 1998-07-01 2005-08-09 Debiopharm S.A. Cyclosporin with improved activity profile
US6030825A (en) * 1998-08-19 2000-02-29 Incyte Pharmaceuticals, Inc. Cyclophilin-type peptidyl-prolyl cis/trans isomerase
RU2222343C2 (ru) * 1998-09-23 2004-01-27 МААС БАЙОЛЭБ, ЛЛСи Нейроиммунофилины для селективной противолучевой защиты нейронов
AP2001002113A0 (en) * 1998-09-23 2001-06-30 Marcus Keep Neuroimmunophilins for selective neuronal radioprotection.
AU775412B2 (en) 1999-04-08 2004-07-29 Advanced Cancer Therapeutics, Inc. Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
US8114850B2 (en) 1999-04-08 2012-02-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
US7960540B2 (en) 1999-04-08 2011-06-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
US6734211B1 (en) 1999-07-09 2004-05-11 Oregon Health & Sciences University Compositions and methods for promoting nerve regeneration
MXPA02002578A (es) 1999-09-08 2002-10-23 Guilford Pharm Inc Compuestos de union a ciclofilina no peptidicos, y su uso.
CA2435829A1 (fr) 2001-01-25 2002-08-01 Guilford Pharmaceuticals Inc. Composes de liaison de la cyclophiline carboxylique trisubstituee et leur utilisation
US6593362B2 (en) 2001-05-21 2003-07-15 Guilford Pharmaceuticals Inc. Non-peptidic cyclophilin binding compounds and their use
US20030068321A1 (en) * 2001-09-07 2003-04-10 Guilford Pharmaceuticals, Inc. Methods of effecting neuronal activity
US20040204340A1 (en) * 2003-04-11 2004-10-14 Guilford Pharmaceuticals, Inc. Polyprolyl inhibitors of cyclophilin
US6952041B2 (en) 2003-07-25 2005-10-04 Robert Bosch Gmbh Anchors for microelectromechanical systems having an SOI substrate, and method of fabricating same
AU2005261838A1 (en) * 2004-07-13 2006-01-19 Novartis Ag Cyclosporins to treat Alzheimer's disease
US7196161B2 (en) * 2004-10-01 2007-03-27 Scynexis Inc. 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection
WO2006039668A2 (fr) * 2004-10-01 2006-04-13 Scynexis, Inc Derives de cyclosporine 3-ether et 3-thioether substitues utilises dans le traitement et la prevention d'une infection par hepatite c
CA2609980C (fr) * 2005-05-27 2015-10-13 Queen's University At Kingston Traitement de troubles du repliement des proteines
EP1931696B1 (fr) * 2005-09-30 2011-02-16 Scynexis, Inc. Derives d'arylalkyle et d'heteroarylalkyle de cyclosporine a utilises pour traiter et prevenir une infection virale
ATE502633T1 (de) 2006-05-19 2011-04-15 Scynexis Inc Cyclosporins zur behandlung und vorbeugung von augenerkrankungen
JP2009539292A (ja) * 2006-06-02 2009-11-12 ぺリション、クロード、アニー 活性電子の管理
WO2008069917A2 (fr) * 2006-11-20 2008-06-12 Scynexis, Inc. Nouveaux peptides cycliques
US20080255038A1 (en) * 2007-04-11 2008-10-16 Samuel Earl Hopkins Pharmaceutical compositions
WO2009042892A1 (fr) 2007-09-26 2009-04-02 Oregon Health & Science University Undécapeptides cycliques et leurs dérivés comme thérapies pour la sclérose en plaques
US9090671B2 (en) * 2008-06-06 2015-07-28 Scynexis, Inc. Macrocyclic peptides
EP2307446A4 (fr) * 2008-07-30 2012-11-07 Isotechnika Pharma Inc Molécules analogues de la cyclosporine non immunosuppressives
US8555875B2 (en) * 2008-12-23 2013-10-15 Map Pharmaceuticals, Inc. Inhalation devices and related methods for administration of sedative hypnotic compounds
US8536114B2 (en) * 2008-12-31 2013-09-17 Scynexis, Inc. Macrocycles
US9200038B2 (en) 2010-12-15 2015-12-01 Ciclofilin Pharmaceuticals Corp. Cyclosporine analogue molecules modified at amino acid 1 and 3

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0056782B1 (fr) * 1981-01-09 1984-08-01 Sandoz Ag Cyclosporines
EP0194972B1 (fr) * 1985-03-11 1992-07-29 Sandoz Ag Cyclosporines
US4722999A (en) 1985-05-03 1988-02-02 Yale University Cyclophilin
US4764503A (en) * 1986-11-19 1988-08-16 Sandoz Ltd. Novel cyclosporins
US4798823A (en) 1987-06-03 1989-01-17 Merck & Co., Inc. New cyclosporin analogs with modified "C-9 amino acids"
US4885276A (en) 1987-06-03 1989-12-05 Merck & Co., Inc. Cyclosporin analogs with modified "C-9 amino acids"
ATE110784T1 (de) * 1987-06-19 1994-09-15 Sandoz Ag Zyklische peptolide.
US4914188A (en) * 1987-11-16 1990-04-03 Merck & Co., Inc. Novel 6-position cyclosporin analogs as non-immunosuppressive antagonists of cyclosporin binding to cyclophilin
US5100899A (en) * 1989-06-06 1992-03-31 Roy Calne Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof
US5284826A (en) * 1989-07-24 1994-02-08 Sandoz Ltd. 0-hydroxyethyl and acyloxyethyl derivatives of [ser]8 cyclosporins
US5122511A (en) * 1990-02-27 1992-06-16 Merck & Co., Inc. Immunosuppressive cyclosporin analogs with modified amino acids at position-8
US5385915A (en) 1990-05-16 1995-01-31 The Rockefeller University Treatment of amyloidosis associated with Alzheimer disease using modulators of protein phosphorylation
US5192773A (en) 1990-07-02 1993-03-09 Vertex Pharmaceuticals, Inc. Immunosuppressive compounds
FI111730B (fi) * 1990-11-02 2003-09-15 Novartis Ag Menetelmä ei-immunosuppressiivisen syklosporiinin valmistamiseksi
US5321009A (en) 1991-04-03 1994-06-14 American Home Products Corporation Method of treating diabetes
US5898029A (en) 1994-04-12 1999-04-27 The John Hopkins University Direct influences on nerve growth of agents that interact with immunophilins in combination with neurotrophic factors
US5614547A (en) * 1995-06-07 1997-03-25 Guilford Pharmaceuticals Inc. Small molecule inhibitors of rotamase enzyme
US5859031A (en) 1995-06-07 1999-01-12 Gpi Nil Holdings, Inc. Small molecule inhibitors of rotamase enzyme activity
JP3089350B2 (ja) * 1995-11-20 2000-09-18 ギルフォード ファーマシューティカルズ インコーポレイテッド シクロフィリンロタマーゼ活性の阻害剤

Also Published As

Publication number Publication date
CN1123360C (zh) 2003-10-08
AU714482B2 (en) 2000-01-06
NO982264D0 (no) 1998-05-18
ES2206608T3 (es) 2004-05-16
LV12125A (lv) 1998-09-20
PL327994A1 (en) 1999-01-04
JP3089350B2 (ja) 2000-09-18
US20030013645A1 (en) 2003-01-16
DE69629392T2 (de) 2004-06-24
EP0880358A1 (fr) 1998-12-02
CA2238050A1 (fr) 1997-05-29
DE69629392D1 (de) 2003-09-11
JPH09143198A (ja) 1997-06-03
WO1997018828A1 (fr) 1997-05-29
LV12125B (en) 1998-12-20
CA2238050C (fr) 2010-09-28
MX9804011A (es) 1998-09-30
BR9611624A (pt) 1999-06-01
EP0880358B1 (fr) 2003-08-06
KR19990071482A (ko) 1999-09-27
CZ154098A3 (cs) 1998-12-16
AU7721096A (en) 1997-06-11
US6444643B1 (en) 2002-09-03
ATE246510T1 (de) 2003-08-15
TR199800890T2 (xx) 1998-08-21
CN1207043A (zh) 1999-02-03
EP0880358A4 (fr) 2001-04-18

Similar Documents

Publication Publication Date Title
NO982264D0 (no) Inhibitorer av cyklofilinrotamaseaktivitet
ES2131457A1 (es) Pequeños inhibidores de moleculas de la actividad de enzimas de rotamasa.
ES2194596A1 (es) Actividad de inhibidores de enzima rotamasa
NZ507720A (en) Effecting neuronal activity with heterocyclic thioesters and ketones
TR200001644T2 (tr) Rotamaz enzim aktivtesinin küçük molekülle inhibitörleri
NO981903L (no) SmÕ-molekylµre inhibitorer for rotamase enzymaktivitet
EA199900140A1 (ru) Гетероциклические эфиры и амиды
MXPA99006120A (es) Sulfonamidas n-enlazadas de tioesteres heterociclicos.
WO1999043651A3 (fr) Inhibiteurs d'enzymes phospholipases
NZ508838A (en) Heterocyclic compounds as inhibitors of rotamase enzymes
EA199900511A1 (ru) N-связанные мочевины и карбаматы сложных гетероциклических тиоэфиров
AR010744A1 (es) Inhibidores polipropilos de ciclofilina
NO992268L (no) N-bundne sulfonamider av heterocykliske tioestere
ES2170628B1 (es) Pequeños inhibidores de moleculas de la actividad de enzimas de rotamasa
AR004113A1 (es) Inhibidores de actividad de enzima rotamasa.
TR199801226A2 (xx) Rotamaz enzim etkinliği inhibitörleri.
ZA968984B (en) Small molecule inhibitors of rotamase enzyme activity.

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application