[go: up one dir, main page]

NO980016L - Makrolider - Google Patents

Makrolider

Info

Publication number
NO980016L
NO980016L NO980016A NO980016A NO980016L NO 980016 L NO980016 L NO 980016L NO 980016 A NO980016 A NO 980016A NO 980016 A NO980016 A NO 980016A NO 980016 L NO980016 L NO 980016L
Authority
NO
Norway
Prior art keywords
positions
acid residue
macrocyclic ring
macrolides
iii
Prior art date
Application number
NO980016A
Other languages
English (en)
Other versions
NO980016D0 (no
Inventor
Theodor Fehr
Lukas Oberer
Valerie Quesniaux Ryffel
Jean-Jacques Sanglier
Walter Schuler
Richard Sedrani
Original Assignee
Ciba Geigy Ag
Novartis Erfind Verwalt Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9513596.8A external-priority patent/GB9513596D0/en
Priority claimed from GBGB9515495.1A external-priority patent/GB9515495D0/en
Application filed by Ciba Geigy Ag, Novartis Erfind Verwalt Gmbh filed Critical Ciba Geigy Ag
Publication of NO980016D0 publication Critical patent/NO980016D0/no
Publication of NO980016L publication Critical patent/NO980016L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Transplantation (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

En ny klasse av makrolider, der i) posisjonene 2 til og med 6 av den makrocykliske ringen blir tilveiebragt med en pipe- ridazinylkarboksylsyrerest; og/eller ii) posisjonene 7 til og med 9 av den makrocykliske ringen blir tilveiebragt med en aro- matisk a-aminosyrerest; og/eller iii) posisjonene 10 til og med 12 av den makrocykliske ringen blir tilveiebragt med en alifatisk a-aminosyrerest, omfatter fortrinnsvis to, eller særlig alle tre av de karakteristiske strukturtrekkene i), ii) og iii), mer spesifikt en forbindelse med formel IX
NO980016A 1995-07-04 1998-01-02 Makrolider NO980016L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9513596.8A GB9513596D0 (en) 1995-07-04 1995-07-04 Organic compounds
GBGB9515495.1A GB9515495D0 (en) 1995-07-28 1995-07-28 Organic compounds
PCT/EP1996/002952 WO1997002285A1 (en) 1995-07-04 1996-07-04 Macrolides

Publications (2)

Publication Number Publication Date
NO980016D0 NO980016D0 (no) 1998-01-02
NO980016L true NO980016L (no) 1998-03-02

Family

ID=26307320

Family Applications (1)

Application Number Title Priority Date Filing Date
NO980016A NO980016L (no) 1995-07-04 1998-01-02 Makrolider

Country Status (17)

Country Link
EP (1) EP0836616A1 (no)
JP (1) JPH11509092A (no)
KR (1) KR19990028724A (no)
CN (1) CN1193979A (no)
AR (1) AR006514A1 (no)
AU (1) AU708004B2 (no)
BR (1) BR9609324A (no)
CA (1) CA2224715A1 (no)
CO (1) CO4750713A1 (no)
CZ (1) CZ424297A3 (no)
HU (1) HUP9802320A3 (no)
IL (1) IL122844A0 (no)
NO (1) NO980016L (no)
PL (1) PL324346A1 (no)
SK (1) SK498A3 (no)
TR (1) TR199800001T1 (no)
WO (1) WO1997002285A1 (no)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6124453A (en) * 1995-07-04 2000-09-26 Novartis Ag Macrolides
GB9811854D0 (en) * 1998-06-02 1998-07-29 Ciba Geigy Ag Organic compounds
US7368423B1 (en) * 2001-12-05 2008-05-06 The Scripps Research Institute Composition and method for treating chronic allograft rejection
WO2006115509A2 (en) 2004-06-24 2006-11-02 Novartis Vaccines And Diagnostics Inc. Small molecule immunopotentiators and assays for their detection
AR054778A1 (es) 2005-06-17 2007-07-18 Novartis Ag Uso de sangliferina en hcv
US8067024B2 (en) 2006-02-10 2011-11-29 Medtronic Vascular, Inc. Medical devices to prevent or inhibit restenosis
CN101289440B (zh) * 2007-06-29 2010-08-25 中国热带农业科学院热带生物技术研究所 一种多烯大环类化合物及其制备方法与应用
WO2010034243A1 (en) * 2008-09-24 2010-04-01 Shanghai Institute Of Organic Chemistry, Chinese Academy Of Sciences Novel gene cluster
EP2533784B1 (en) 2010-02-09 2015-04-22 Neurovive Pharmaceutical AB Sanglifehrin based compounds
WO2011098808A1 (en) 2010-02-09 2011-08-18 Biotica Technology Limited Sanglifehrin based compounds
WO2011098805A1 (en) 2010-02-09 2011-08-18 Biotica Technology Limited Sanglifehrin based compounds
GB201008123D0 (en) 2010-05-17 2010-06-30 Biotica Tech Ltd Novel compounds
AR084217A1 (es) 2010-12-10 2013-05-02 Gilead Sciences Inc Inhibidores macrociclicos de virus flaviviridae
CA2822347C (en) * 2010-12-20 2019-11-05 Neurovive Pharmaceutical Ab Sanglifehrin derivatives and methods for their production
JO3063B1 (ar) 2011-03-29 2017-03-15 Neurovive Pharmaceutical Ab مركب مبتكر وطرق لانتاجه
GB201118334D0 (en) 2011-10-24 2011-12-07 Biotica Tech Ltd Novel dosage form
SG11201408047XA (en) * 2012-06-08 2015-01-29 Gilead Sciences Inc Macrocyclic inhibitors of flaviviridae viruses
US9090653B2 (en) 2012-06-08 2015-07-28 Gilead Sciences, Inc. Macrocyclic inhibitors of flaviviridae viruses
AR091279A1 (es) 2012-06-08 2015-01-21 Gilead Sciences Inc Inhibidores macrociclicos de virus flaviviridae
WO2018091634A1 (en) 2016-11-18 2018-05-24 Neurovive Pharmaceutical Ab Use of sanglifehrin macrocyclic analogues as anticancer compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9318144D0 (en) * 1993-09-01 1993-10-20 Sandoz Ltd Organic compounds
WO1995015328A1 (en) * 1993-11-30 1995-06-08 Abbott Laboratories Macrocyclic immunomodulators with novel cyclohexyl ring replacements

Also Published As

Publication number Publication date
TR199800001T1 (xx) 1998-04-21
EP0836616A1 (en) 1998-04-22
WO1997002285A1 (en) 1997-01-23
AR006514A1 (es) 1999-09-08
CO4750713A1 (es) 1999-03-31
CA2224715A1 (en) 1997-01-23
PL324346A1 (en) 1998-05-25
CZ424297A3 (cs) 1998-04-15
AU6519396A (en) 1997-02-05
MX9800217A (es) 1998-07-31
KR19990028724A (ko) 1999-04-15
SK498A3 (en) 1998-07-08
HUP9802320A3 (en) 1999-03-29
AU708004B2 (en) 1999-07-29
JPH11509092A (ja) 1999-08-17
HUP9802320A2 (hu) 1999-02-01
CN1193979A (zh) 1998-09-23
BR9609324A (pt) 1999-05-25
IL122844A0 (en) 1998-08-16
NO980016D0 (no) 1998-01-02

Similar Documents

Publication Publication Date Title
NO980016L (no) Makrolider
WO2002003984A3 (en) Anticonvulsant derivatives useful for treating and preventing the development of type ii diabetes mellitus and syndrome x
NO983487L (no) Derivater av camptothecin for anvendelse ved behandling av kreft
TW288011B (no)
EP0251304A3 (en) Glycosyl derivatives and use thereof
TW337977B (en) Low VOC liquid formulations of 1, 2-benzisothiazolin-3-one and method of manufacture
CA2327679A1 (en) Triphendioxazine dyestuffs for dyeing organic substrates
CA2247167A1 (en) 2-hetaroylcyclohexane-1,3-diones
DK0518558T3 (da) 1-methylcarbapenemderivater, deres fremstilling og deres anvendelse som antibiotika
WO1999003817A3 (en) Aliphatic propargylamines as cellular rescue agents
CA2267945A1 (en) Anticonvulsant derivatives useful in treating neuropathic pain
NO932431L (no) Fremgangsmaate og mellomprodukter for fremstilling av azabicyklo(2,2,2)oktan-3-iminer
EP1550651A4 (en) GLYZERINDERIVAT
DE60006825D1 (de) Serotonerge benzofurane
ES2000908A6 (es) Procedimiento para la fabricacion de nuevos derivados de alquilmercaptofenil-1,3,4-oxadiazol
ATE290574T1 (de) Farbmittelzubereitungen
BG104302A (en) Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids
ZA872664B (en) Six-membered heterocyclic derivatives of n'-substituted-n,n'-diacylhydrazines
CA2011642A1 (en) Benzoxazine dyes
EA199900684A1 (ru) Производные иминоазаантрациклинона для лечения амилоидоза
NO983527L (no) Dihydrobenzofuran og relaterte forbindelser anvendelig som anti-inflammatoriske midler
TW334337B (en) Preparation and composition for a compound of controlling and preventing phytopathogenic fungi
DK0832085T3 (da) Phosphinsyrederivater med metallopeptidaseinhiberende aktivitet
HK79595A (en) Heterocyclic pigments
CA2276310A1 (en) Process for the production of tetrazolylbenzopyrans