[go: up one dir, main page]

NO985975D0 - Blandinger og fremgangsmÕter for frembringelse av farmakologisk aktive preparater og anvendelser derav - Google Patents

Blandinger og fremgangsmÕter for frembringelse av farmakologisk aktive preparater og anvendelser derav

Info

Publication number
NO985975D0
NO985975D0 NO985975A NO985975A NO985975D0 NO 985975 D0 NO985975 D0 NO 985975D0 NO 985975 A NO985975 A NO 985975A NO 985975 A NO985975 A NO 985975A NO 985975 D0 NO985975 D0 NO 985975D0
Authority
NO
Norway
Prior art keywords
mixtures
methods
pharmacologically active
active preparations
producing pharmacologically
Prior art date
Application number
NO985975A
Other languages
English (en)
Other versions
NO985975L (no
Inventor
Sean Kerwin
Laurence H Hurley
Mark R Deluca
Iii Bob M Moore
Gregory R Mundy
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas filed Critical Univ Texas
Publication of NO985975D0 publication Critical patent/NO985975D0/no
Publication of NO985975L publication Critical patent/NO985975L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38Nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/38Heterocyclic compounds having sulfur as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/428Thiazoles condensed with carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62Benzothiazoles
    • C07D277/68Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Quinoline Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
NO985975A 1996-06-20 1998-12-18 Blandinger og fremgangsmÕter for frembringelse av farmakologisk aktive preparater og anvendelser derav NO985975L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1608896P 1996-06-20 1996-06-20
PCT/US1997/010643 WO1997048694A1 (en) 1996-06-20 1997-06-20 Compounds and methods for providing pharmacologically active preparations and uses thereof

Publications (2)

Publication Number Publication Date
NO985975D0 true NO985975D0 (no) 1998-12-18
NO985975L NO985975L (no) 1999-02-18

Family

ID=21775328

Family Applications (1)

Application Number Title Priority Date Filing Date
NO985975A NO985975L (no) 1996-06-20 1998-12-18 Blandinger og fremgangsmÕter for frembringelse av farmakologisk aktive preparater og anvendelser derav

Country Status (13)

Country Link
US (1) US6720344B2 (no)
EP (1) EP0912549A4 (no)
JP (1) JP2000514048A (no)
KR (1) KR20000022040A (no)
CN (1) CN1226245A (no)
AU (1) AU727708B2 (no)
BR (1) BR9711805A (no)
CA (1) CA2258822A1 (no)
HU (1) HUP9904567A3 (no)
IL (1) IL127559A0 (no)
NO (1) NO985975L (no)
PL (1) PL330814A1 (no)
WO (1) WO1997048694A1 (no)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0973513A4 (en) * 1996-10-23 2003-03-19 Zymogenetics Inc COMPILATIONS AND METHOD FOR TREATING BONE DEFICIENCY
US6376476B1 (en) 1996-12-13 2002-04-23 Zymogenetics Corporation Isoprenoid pathway inhibitors for stimulating bone growth
US6670398B2 (en) 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
CZ301985B6 (cs) 1997-05-14 2010-08-25 Atherogenics, Inc. Lécivo pro lécení kardiovaskulárního onemocnení na bázi monoesteru probukolu s jantarovou kyselinou
ES2248923T3 (es) * 1997-12-22 2006-03-16 PHARMACIA & UPJOHN COMPANY LLC 4-hydroxiquinolin-3-carboxamidas y hidrazidas como agentes antivirales.
US6462019B1 (en) 1998-07-10 2002-10-08 Osteoscreen, Inc. Inhibitors of proteasomal activity and production for stimulating bone growth
US6838436B1 (en) 1998-07-10 2005-01-04 Osteoscreen Inc. Inhibitors of proteasomal activity for stimulating bone growth
US6902721B1 (en) 1998-07-10 2005-06-07 Osteoscreen, Inc. Inhibitors of proteasomal activity for stimulating bone growth
US6780883B2 (en) 1998-11-05 2004-08-24 Warner-Lambert Company Amide inhibitors of microsomal triglyceride transfer protein
AU2001285311B2 (en) * 2000-08-29 2005-09-15 Biocon, Ltd Immunoregulatory compounds, derivatives thereof and their use
ATE448226T1 (de) 2000-09-01 2009-11-15 Novartis Vaccines & Diagnostic Aza heterocyclische derivate und ihre therapeutische verwendung
AP1666A (en) 2000-09-11 2006-09-29 Chiron Corp Quinolinone derivatives as tyrosine kinase inhibitors.
US7642278B2 (en) 2001-07-03 2010-01-05 Novartis Vaccines And Diagnostics, Inc. Indazole benzimidazole compounds
US8048924B2 (en) * 2001-08-29 2011-11-01 Biocon Limited Methods and compositions employing 4-aminophenylacetic acid compounds
CA2496164C (en) 2002-08-23 2010-11-09 Chiron Corporation Benzimidazole quinolinones and uses thereof
US7825132B2 (en) 2002-08-23 2010-11-02 Novartis Vaccines And Diagnostics, Inc. Inhibition of FGFR3 and treatment of multiple myeloma
MXPA05004754A (es) 2002-11-13 2005-08-02 Chiron Corp Metodos para tratar cancer y metodos relacionados.
TW200505450A (en) * 2003-02-03 2005-02-16 Janssen Pharmaceutica Nv Quinoline-derived amide modulators of vanilloid VR1 receptor
WO2005046683A1 (en) 2003-10-07 2005-05-26 Renovis, Inc. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
EP1682529A4 (en) 2003-11-07 2010-06-30 Novartis Vaccines & Diagnostic PROCESS FOR SYNTHESIS OF CHINOLINONE COMPOUNDS
CN1960731B (zh) 2004-02-20 2011-12-07 诺华疫苗和诊断公司 调节炎性和转移过程的方法
US8354427B2 (en) * 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
US7495103B2 (en) 2004-06-24 2009-02-24 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
US7932366B2 (en) * 2004-07-07 2011-04-26 Biocon Limited Synthesis of azo bonded immunoregulatory compounds
JP2008520744A (ja) 2004-11-19 2008-06-19 ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア 抗炎症性ピラゾロピリミジン
ES2525670T3 (es) 2005-01-27 2014-12-29 Novartis Ag Tratamiento de tumores metastatizados
US7576099B2 (en) 2005-02-28 2009-08-18 Renovis, Inc. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
EP1888556B1 (en) 2005-05-17 2011-10-26 Novartis AG Methods for synthesizing heterocyclic compounds
EP2772257A1 (en) 2005-11-29 2014-09-03 Novartis AG Formulations of quinolinones
EP1979367A2 (en) * 2005-12-24 2008-10-15 Vertex Pharmaceuticals Incorporated Quinolin-4-one derivatives as modulators of abc transporters
CA2635581C (en) 2005-12-28 2017-02-28 Vertex Pharmaceuticals Incorporated Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
CA2909277A1 (en) 2006-04-04 2007-10-11 Kevan M. Shokat Kinase antagonists
AU2007345526B2 (en) 2007-02-01 2013-02-28 Resverlogix Corp. Compounds for the prevention and treatment of cardiovascular diseases
WO2008118948A1 (en) 2007-03-26 2008-10-02 Atherogenics, Inc. Methods and compositions of derivatives of probucol for the treatment of diabetes
GB2467670B (en) 2007-10-04 2012-08-01 Intellikine Inc Chemical entities and therapeutic uses thereof
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
EP2240451B1 (en) 2008-01-04 2017-08-09 Intellikine, LLC Isoquinolinone derivatives substituted with a purine useful as PI3K inhibitors
WO2009114870A2 (en) * 2008-03-14 2009-09-17 Intellikine, Inc. Kinase inhibitors and methods of use
US8993580B2 (en) * 2008-03-14 2015-03-31 Intellikine Llc Benzothiazole kinase inhibitors and methods of use
HRP20150477T8 (hr) 2008-06-26 2016-10-21 Resverlogix Corp. Postupci dobivanja derivata kinazolona
US20110224223A1 (en) * 2008-07-08 2011-09-15 The Regents Of The University Of California, A California Corporation MTOR Modulators and Uses Thereof
WO2010006086A2 (en) 2008-07-08 2010-01-14 Intellikine, Inc. Kinase inhibitors and methods of use
US12458635B2 (en) 2008-08-13 2025-11-04 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administrations thereof
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
CA2738429C (en) 2008-09-26 2016-10-25 Intellikine, Inc. Heterocyclic kinase inhibitors
DK2358720T3 (en) 2008-10-16 2016-06-06 Univ California Heteroarylkinaseinhibitorer fused-ring
TWI465449B (zh) 2008-10-23 2014-12-21 Vertex Pharma 囊腫性纖維化跨膜傳導調節因子之調控因子
US8476431B2 (en) 2008-11-03 2013-07-02 Itellikine LLC Benzoxazole kinase inhibitors and methods of use
AU2010204106B2 (en) 2009-01-08 2014-05-08 Resverlogix Corp. Compounds for the prevention and treatment of cardiovascular disease
MX392179B (es) 2009-03-18 2025-03-21 Resverlogix Corp Nuevos agentes anti-inflamatorios.
SMT201700593T1 (it) 2009-03-20 2018-03-08 Vertex Pharma Procedimento per preparare modulatori di regolatore di conduttanza transmembrana di fibrosi cistica
TR201818390T4 (tr) 2009-04-22 2019-01-21 Resverlogix Corp Yeni̇ anti̇-i̇nflamatuvar ajanlar
JP5789252B2 (ja) 2009-05-07 2015-10-07 インテリカイン, エルエルシー 複素環式化合物およびその使用
WO2011047384A2 (en) 2009-10-16 2011-04-21 The Regents Of The University Of California Methods of inhibiting ire1
AU2011255218B2 (en) 2010-05-21 2015-03-12 Infinity Pharmaceuticals, Inc. Chemical compounds, compositions and methods for kinase modulation
WO2011153531A1 (en) 2010-06-04 2011-12-08 University Of South Florida Method of treating skeletal dysplasias using vessel dilator
AU2011311920B2 (en) 2010-10-08 2015-06-11 Laurel Therapeutics Ltd Novel substituted quinoline compounds as S-nitrosoglutathione reductase inhibitors
AU2011326427B2 (en) 2010-11-10 2016-01-07 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
US8802700B2 (en) 2010-12-10 2014-08-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
US9249132B2 (en) 2010-12-16 2016-02-02 Nivalis Therapeutics, Inc. Substituted bicyclic aromatic compounds as S-nitrosoglutathione reductase inhibitors
AR084824A1 (es) 2011-01-10 2013-06-26 Intellikine Inc Procesos para preparar isoquinolinonas y formas solidas de isoquinolinonas
TWI592411B (zh) 2011-02-23 2017-07-21 英特爾立秦有限責任公司 激酶抑制劑之組合及其用途
WO2013012918A1 (en) 2011-07-19 2013-01-24 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
HK1198443A1 (en) 2011-07-19 2015-04-24 无限药品股份有限公司 Heterocyclic compounds and uses thereof
WO2013032591A1 (en) 2011-08-29 2013-03-07 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
WO2013077921A2 (en) 2011-09-02 2013-05-30 The Regents Of The University Of California Substituted pyrazolo[3,4-d]pyrimidines and uses thereof
ES2745471T3 (es) 2011-11-01 2020-03-02 Resverlogix Corp Formulaciones orales de liberación inmediata para quinazolinonas sustituidas
JP2015511583A (ja) 2012-02-27 2015-04-20 バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated 薬学的組成物およびその投与
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US8828998B2 (en) 2012-06-25 2014-09-09 Infinity Pharmaceuticals, Inc. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
RU2015115631A (ru) 2012-09-26 2016-11-20 Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния Модулирование ire1
RU2702908C2 (ru) 2012-11-01 2019-10-14 Инфинити Фармасьютикалз, Инк. Лечение злокачественных опухолей с использованием модуляторов изоформ pi3-киназы
US9765039B2 (en) 2012-11-21 2017-09-19 Zenith Epigenetics Ltd. Biaryl derivatives as bromodomain inhibitors
US9073878B2 (en) 2012-11-21 2015-07-07 Zenith Epigenetics Corp. Cyclic amines as bromodomain inhibitors
EP2935253B1 (en) 2012-12-21 2018-08-01 Zenith Epigenetics Ltd. Novel heterocyclic compounds as bromodomain inhibitors
US9481667B2 (en) 2013-03-15 2016-11-01 Infinity Pharmaceuticals, Inc. Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
WO2015051241A1 (en) 2013-10-04 2015-04-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
EA201690713A1 (ru) 2013-10-04 2016-08-31 Инфинити Фармасьютикалз, Инк. Гетероциклические соединения и их применения
SG11201607705XA (en) 2014-03-19 2016-10-28 Infinity Pharmaceuticals Inc Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders
US20150320755A1 (en) 2014-04-16 2015-11-12 Infinity Pharmaceuticals, Inc. Combination therapies
WO2016025496A1 (en) * 2014-08-11 2016-02-18 Lacerta Technologies Inc. Platelet factor 4 for use in the treatment of bone diseases
MX2017001981A (es) 2014-09-11 2017-12-12 Univ California Inhibidores de diana de rapamicina en celulas de mamifero de complejo 1 (mtorc1).
US9708348B2 (en) 2014-10-03 2017-07-18 Infinity Pharmaceuticals, Inc. Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof
CA2963945C (en) 2014-10-07 2023-01-10 Vertex Pharmaceuticals Incorporated Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator
KR102662814B1 (ko) 2015-03-13 2024-05-03 리스버로직스 코퍼레이션 보체 관련 질환을 치료하기 위한 조성물 및 치료 방법
US10399946B2 (en) 2015-09-10 2019-09-03 Laurel Therapeutics Ltd. Solid forms of an S-Nitrosoglutathione reductase inhibitor
CN114230571B (zh) 2015-09-14 2025-07-08 无限药品股份有限公司 异喹啉酮的固体形式、其制备方法、包含其的组合物及其使用方法
WO2017161116A1 (en) 2016-03-17 2017-09-21 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
US10919914B2 (en) 2016-06-08 2021-02-16 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
CN109640999A (zh) 2016-06-24 2019-04-16 无限药品股份有限公司 组合疗法
CN118978535A (zh) 2018-05-01 2024-11-19 锐新医药公司 作为mTOR抑制剂的C40-、C28-及C-32连接的雷帕霉素类似物
MX2020011564A (es) 2018-05-01 2021-01-29 Revolution Medicines Inc Analogos de rapamicina unidos a c26 como inhibidores de mtor.
CN114105902B (zh) * 2018-12-28 2023-11-03 中山大学 噻唑苯甲酰胺衍生物及其在制备抗骨质疏松药物中的应用
CA3256390A1 (en) 2022-05-25 2023-11-30 Revolution Medicines, Inc. CANCER TREATMENT METHODS USING AN MTOR INHIBITOR

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1148908A (en) * 1965-04-19 1969-04-16 Sumitomo Chemical Co Indole derivatives and processes for making them
LU63457A1 (no) * 1970-07-06 1971-11-12
US4054574A (en) 1976-05-24 1977-10-18 Velsicol Chemical Corporation 1-Benzothiazolyl-5-amino-imidazolidinones
DE2943125A1 (de) * 1979-10-25 1981-05-14 Troponwerke GmbH & Co KG, 5000 Köln Verfahren zur herstellung von 1-(4-chlorbenzoyl)-5-methoxy-2-methyl-3-indol acetoxyessigsaeure
FR2509728A1 (fr) * 1981-07-17 1983-01-21 Roussel Uclaf Nouveaux derives de la quinoleine, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant
US4560549A (en) * 1983-08-24 1985-12-24 Lever Brothers Company Method of relieving pain and inflammatory conditions employing substituted salicylamides
US4607053A (en) * 1984-05-17 1986-08-19 E. R. Squibb & Sons, Inc. Arylhydroxamates useful as antiallergy agents
FR2566407B1 (fr) * 1984-06-25 1986-09-26 Roussel Uclaf Nouveaux derives de l'isoxazoloquinoleine, procede de preparation, application a titre de medicaments, et compositions les renfermant
JPS61225168A (ja) * 1985-03-30 1986-10-06 Nippon Tokushu Noyaku Seizo Kk 新規ベンズアミド、その製法及び殺虫剤
FR2583404B1 (fr) * 1985-06-17 1990-04-13 Pechiney Uranium Procede de separation, par precipitation, du molybdene contenu dans des solutions de nitrate d'uranyle.
JPS62114976A (ja) * 1985-11-13 1987-05-26 Nippon Tokushu Noyaku Seizo Kk 新規ベンズイミデ−ト類及び殺虫殺ダニ剤
EP0261459A3 (de) * 1986-09-09 1988-05-11 Nihon Tokushu Noyaku Seizo K.K. Neue N-Benzothiazolylamide
EP0271668B1 (de) 1986-10-22 1991-12-18 Gesellschaft für Biotechnologische Forschung mbH (GBF) Wachstumstimulierendes Material, Herstellungsverfahren und therapeutische Zusammensetzung
FI91859C (fi) * 1987-06-17 1994-08-25 Eisai Co Ltd Analogiamenetelmä antiallergisena aineena aktiivisen bentsotiatsolijohdannaisen valmistamiseksi
EP0338066A1 (en) * 1987-10-30 1989-10-25 Aktiebolaget Hässle 2-pyridinylmethyl (sulfinyl or thio)benzimidazoles for treatment of diseases related to bone loss
JPH01203325A (ja) * 1988-02-08 1989-08-16 Takeda Chem Ind Ltd 骨粗鬆症予防治療剤
US4970318A (en) 1988-05-24 1990-11-13 Pfizer Inc. Aromatic and heterocyclic carboxamide derivatives as antineoplastic agents
US4874864A (en) * 1988-05-24 1989-10-17 Pfizer Inc. Benzamide protease inhibitors
CA2015473C (en) 1989-04-28 1998-04-14 Iwao Kinoshita Triphenylmethane derivatives
SE8902076D0 (sv) * 1989-06-09 1989-06-09 Pharmacia Ab Derivatives of quinoline-3-carboxanilide
WO1990015801A1 (en) 1989-06-22 1990-12-27 Pfizer Inc. Substituted sulfonamides and related compounds in the treatment of asthma, arthritis and related diseases
JPH03130216A (ja) * 1989-07-21 1991-06-04 Takeda Chem Ind Ltd 骨吸収抑制剤
JPH03181465A (ja) * 1989-12-11 1991-08-07 Takeda Chem Ind Ltd キノリン誘導体
JPH0717589B2 (ja) 1990-01-22 1995-03-01 ファイザー製薬株式会社 新規1,3―ジカルボニル化合物およびその組成物
DE4014171A1 (de) 1990-05-03 1991-11-07 Basf Ag Cyanochinolinverbindungen
ATE139700T1 (de) * 1991-02-15 1996-07-15 Takeda Chemical Industries Ltd Mit einem zellwachstumsfaktor bewirkte anregung von wachstum im knocheninneren
US5525695A (en) 1991-10-15 1996-06-11 The Dow Chemical Company Elastic linear interpolymers
US6277537B1 (en) 1991-12-06 2001-08-21 Eastman Kodak Company Dye diffusion image separation systems with thermal solvents
TW366342B (en) * 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
WO1994003432A1 (en) * 1992-08-07 1994-02-17 The Government Of The United States As Represented By The Secretary, Department Of Health And Human Services Polyhydroxylated naphthyl 2-carboxylate, and quinolyl and isoquinolyl 3-carboxylate derivatives as protein tyrosine kinase inhibitors
US5322847A (en) 1992-11-05 1994-06-21 Pfizer Inc. Azabenzimidazoles in the treatment of asthma, arthritis and related diseases
US5482949A (en) * 1993-03-19 1996-01-09 Eli Lilly And Company Sulfonate derivatives of 3-aroylbenzo[b]thiophenes
ATE180674T1 (de) * 1993-03-29 1999-06-15 Zymogenetics Inc Osteoblastswachstumfordernde zusammensetzungen die pdgf und vitamin-d enthalten
GB9307014D0 (en) 1993-04-02 1993-05-26 Laporte Plc Protecting group for use in oligodeoxyribonucleotide synthesis
US5468587A (en) 1993-06-08 1995-11-21 Eastman Kodak Company Hydrogen bond accepting groups on thermal solvents for image separation systems
US5430144A (en) * 1993-07-26 1995-07-04 Merck & Co., Inc. Benzo-fused lactams promote release of growth hormone
US5545735A (en) * 1993-10-04 1996-08-13 Merck & Co., Inc. Benzo-Fused Lactams promote release of growth hormone
US5389646A (en) * 1993-12-30 1995-02-14 Zymogenetics, Inc. Methods for treatment and prevention of bone loss using 2,3-benzopyrans
US5478847A (en) * 1994-03-02 1995-12-26 Eli Lilly And Company Methods of use for inhibiting bone loss and lowering serum cholesterol
US5637598A (en) * 1994-11-18 1997-06-10 Eli Lilly And Company Methods of inhibiting bone loss
US5665890A (en) 1995-03-14 1997-09-09 President And Fellows Of Harvard College Stereoselective ring opening reactions
US5635197A (en) * 1995-03-21 1997-06-03 Eli Lilly And Company Treatment and prevention of prostatic cancer metastasis
US5550134A (en) * 1995-05-10 1996-08-27 Eli Lilly And Company Methods for inhibiting bone loss
AU716716B2 (en) 1995-07-17 2000-03-02 Medivir Uk Ltd Cysteine protease inhibitors for use in treatment of IgE mediated allergic diseases
US5780300A (en) 1995-09-29 1998-07-14 Yale University Manipulation of non-terminally differentiated cells using the notch pathway
PL327617A1 (en) * 1995-10-23 1998-12-21 Zymogenetics Inc Compositions for and methods of treating osseous insufficiency
JP4129994B2 (ja) 1996-03-25 2008-08-06 財団法人化学及血清療法研究所 組織因子凝固系インヒビター含有血管新生阻害剤
US5945365A (en) 1996-05-20 1999-08-31 Fina Technology, Inc. Stereorigid bis-fluorenyl metallocenes
FR2754818B1 (fr) 1996-10-23 1999-03-05 Cird Galderma Nouveaux derives bi-aromatiques du dibenzofuranne et leur utilisation en medecine humaine ou veterinaire ainsi qu'en cosmetique
US6077669A (en) 1997-11-04 2000-06-20 Becton Dickinson And Company Kit and method for fluorescence based detection assay
US5943585A (en) 1997-12-19 1999-08-24 Advanced Micro Devices, Inc. Trench isolation structure having low K dielectric spacers arranged upon an oxide liner incorporated with nitrogen

Also Published As

Publication number Publication date
CN1226245A (zh) 1999-08-18
CA2258822A1 (en) 1997-12-24
AU3791797A (en) 1998-01-07
AU727708B2 (en) 2000-12-21
PL330814A1 (en) 1999-06-07
EP0912549A1 (en) 1999-05-06
BR9711805A (pt) 2002-01-15
WO1997048694A1 (en) 1997-12-24
EP0912549A4 (en) 2002-01-02
US6720344B2 (en) 2004-04-13
NO985975L (no) 1999-02-18
KR20000022040A (ko) 2000-04-25
HUP9904567A3 (en) 2001-10-29
IL127559A0 (en) 1999-10-28
HUP9904567A2 (hu) 2000-05-28
JP2000514048A (ja) 2000-10-24
US20030119791A1 (en) 2003-06-26

Similar Documents

Publication Publication Date Title
NO985975D0 (no) Blandinger og fremgangsmÕter for frembringelse av farmakologisk aktive preparater og anvendelser derav
DE69635841D1 (de) Integriertes magnetisches schwebe- und drehsystem
DE69634852D1 (de) Modulaire stuhlkonstruktion und zusammenbauverfahren
ATE367150T1 (de) Arzneimittel
FI952033L (fi) Farmakologisesti aktiiviset pyrrolopyrimidiinijohdannaiset
DE69625368D1 (de) Schweisshemmende deodorierende präparaten
NO990965D0 (no) Terapeutiske fremgangsmÕter og blandinger som inneholder isoflavoner
FR2744442B1 (fr) Preparation du 1,1,1,3,3-pentachlorobutane et du 1,1,1,3,3,-pentafluorobutane
DK0839039T4 (da) Paroxetinpræparater med styret frigivelse
DK0729956T3 (da) Benzothi9phenforbindelser, emllemprodukter, præparater og fremgangsmåder
IL121298A (en) N-(4-aryl-thiazol-2-yl)-sulphonamide derivatives and their uses
EE9800298A (et) Farmatseutiliselt kasulikud ühendid
DE69836329D1 (de) Schneller und hochverstärkender operationsverstärker
DE59707298D1 (de) Desodorierende zubereitungen
DE69726655D1 (de) Vibrationskreisel und Herstellungsverfahren
DE69614692D1 (de) Leistungsangetriebenes selbstprüfungsverfahren
IS5062A (is) Lyfjablöndur sem innihalda afleiður N-súlfonýlindólíns
DE69713155D1 (de) Halbleiteranordnung und herstellungsverfahren
DK0826679T3 (da) Naphthylforbindelser og -præparater
NO973980D0 (no) Imiadazolderivater og medisinsk preparat
AU2662799A (en) Modified pharmacologically active agents and improved therapeutic methods employing same
IT1290923B1 (it) Sacchetto e metodo per la produzione dello stesso.
DE59603621D1 (de) Leukoindigo-präparationen in granulatform
NO983556D0 (no) Formulering og anvendelse
NO982549D0 (no) 5-naftalen-1-yl-1,3-dioksan-derivater, fremstilling og terapeutisk anvendelse derav

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application