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NO985820L - Cytokinproduksjonsinhibitor, triazepinforbindelse og mellomprodukter for disse - Google Patents

Cytokinproduksjonsinhibitor, triazepinforbindelse og mellomprodukter for disse

Info

Publication number
NO985820L
NO985820L NO985820A NO985820A NO985820L NO 985820 L NO985820 L NO 985820L NO 985820 A NO985820 A NO 985820A NO 985820 A NO985820 A NO 985820A NO 985820 L NO985820 L NO 985820L
Authority
NO
Norway
Prior art keywords
cytokine production
heteroaryl
aryl
formula
intermediates
Prior art date
Application number
NO985820A
Other languages
English (en)
Other versions
NO985820D0 (no
Inventor
Yoshihisa Yamamoto
Masanori Shindo
Takeshi Nakamura
Original Assignee
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Tobacco Inc filed Critical Japan Tobacco Inc
Publication of NO985820D0 publication Critical patent/NO985820D0/no
Publication of NO985820L publication Critical patent/NO985820L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
    • C07D255/04—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Det er beskrevet en cytokinproduksjonsinhibitor omfattende en forbindelse med formel (O N B [U hvor R1 er aryl eller heteroaryl; B er en gruppe med formel (a) eller (b) N ¿ C¿ R / (aj /V2 hvor R2 er hydrogenatom, hydroksy, halogenatom og lignende; R4 er hydrogenatom eller halogenatom, eller R2 og R4 i kombinasjon danner karbonyl; R3 er lavere alkoksy, cykloalkyl, aryl, heteroaryl, -X-Y og lignende, hvor X er -(CH2)m-, -CO-, -COCH2-, -NHCHr, -CH2NH-, -OCH2- og lignende; Y er halogenatom, cykloalkyl, aryl eller hete- roaryl; R51 er -NHCONHR57 og lignende; R52 er hydrogenatom eller -COOR53; A er benzenring eller tiofenring, ny triazepinforbindelse og mellomprodukter for fremstilling av disse triazepinforbindelsene. Forbindelser med formel (I) undertrykker produksjonen av cytokin så som IL-6, TNF-ct, IL-8, IFNy, IL-2, GM-CSF og lignende, og er nyttig som cytokinproduksjonsinhibitorer eller antiinflammatoriske medikamenter.
NO985820A 1996-06-12 1998-12-11 Cytokinproduksjonsinhibitor, triazepinforbindelse og mellomprodukter for disse NO985820L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP17426896 1996-06-12
JP9523797 1997-03-28
PCT/JP1997/002016 WO1997047622A1 (en) 1996-06-12 1997-06-11 Cytokine production inhibitors, triazepine compounds, and intermediates thereof

Publications (2)

Publication Number Publication Date
NO985820D0 NO985820D0 (no) 1998-12-11
NO985820L true NO985820L (no) 1999-02-01

Family

ID=26436510

Family Applications (1)

Application Number Title Priority Date Filing Date
NO985820A NO985820L (no) 1996-06-12 1998-12-11 Cytokinproduksjonsinhibitor, triazepinforbindelse og mellomprodukter for disse

Country Status (9)

Country Link
EP (1) EP0934940A1 (no)
CN (1) CN1227555A (no)
AU (1) AU3106197A (no)
BR (1) BR9710453A (no)
CA (1) CA2258053A1 (no)
IL (1) IL127516A0 (no)
NO (1) NO985820L (no)
PL (1) PL330635A1 (no)
WO (1) WO1997047622A1 (no)

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ES2564318T3 (es) * 2009-11-05 2016-03-21 Glaxosmithkline Llc Inhibidor de bromodominio de benzodiazepina
WO2011054851A1 (en) * 2009-11-05 2011-05-12 Glaxosmithkline Llc Novel process
GB0919426D0 (en) * 2009-11-05 2009-12-23 Glaxosmithkline Llc Novel compounds
KR101424989B1 (ko) * 2009-11-05 2014-07-31 글락소스미스클라인 엘엘씨 벤조디아제핀 브로모도메인 억제제
AU2015203454B2 (en) * 2009-11-05 2017-02-23 Glaxosmithkline Llc Benzodiazepine bromodomain inhibitor
CA2799420C (en) * 2010-05-14 2018-10-02 Dana-Farber Cancer Institute, Inc. Compositions and methods for treating neoplasia, inflammatory disease and other disorders
JP5715241B2 (ja) * 2010-05-14 2015-05-07 ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド 新生物、炎症性疾患、およびその他の障害を治療するための組成物および方法
AU2015201727B2 (en) * 2010-05-14 2018-03-08 Dana-Farber Cancer Institute, Inc. Compositions and methods for treating neoplasia, inflammatory disease and other disorders
CA2799403C (en) 2010-05-14 2020-01-21 Dana-Farber Cancer Institute, Inc. Compositions and methods for treating leukemia
US9301962B2 (en) 2010-05-14 2016-04-05 Baylor College Of Medicine Male contraceptive compositions and methods of use
WO2011161031A1 (en) 2010-06-22 2011-12-29 Glaxosmithkline Llc Benzotriazolodiazepine compounds inhibitors of bromodomains
TWI583689B (zh) * 2010-08-04 2017-05-21 達納 法柏癌症學院有限公司 治療腫瘤形成、發炎疾病及其他病症之組成物及方法
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US9422292B2 (en) 2011-05-04 2016-08-23 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
US9328117B2 (en) 2011-06-17 2016-05-03 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
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CN102603743B (zh) 2012-02-24 2014-05-28 南京天易生物科技有限公司 抗肿瘤的氮杂苯并[f]薁衍生物其制备方法及其用途
WO2013184878A1 (en) 2012-06-06 2013-12-12 Constellation Pharmaceuticals, Inc. Benzo [b] isoxazoloazepine bromodomain inhibitors and uses thereof
TWI602820B (zh) 2012-06-06 2017-10-21 星宿藥物公司 溴域抑制劑及其用途
ES2628005T3 (es) 2012-08-16 2017-08-01 Bayer Pharma Aktiengesellschaft 2,3-Benzodiazepinas
JP6276277B2 (ja) 2012-09-28 2018-02-07 バイエル ファーマ アクチエンゲゼルシャフト Ｂｅｔタンパク質阻害性の５−アリールトリアゾロアゼピン
JP2016531113A (ja) 2013-07-25 2016-10-06 ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド 転写因子の阻害剤およびその使用
MX379463B (es) 2013-11-08 2025-03-10 Dana Farber Cancer Inst Inc Terapia de combinación para el cáncer usando inhibidores de la proteína bromodominio y extra-terminal.
MX2016009974A (es) 2014-01-31 2016-10-31 Dana Farber Cancer Inst Inc Derivados de diaminopirimidina bencensulfona y sus usos.
WO2015117087A1 (en) 2014-01-31 2015-08-06 Dana-Farber Cancer Institute, Inc. Uses of diazepane derivatives
RU2722179C2 (ru) 2014-02-28 2020-05-28 Тэнша Терапеутикс, Инк. Лечение состояний, ассоциированных с гиперинсулинемией
ES2725928T3 (es) 2014-06-20 2019-09-30 Constellation Pharmaceuticals Inc Formas cristalinas de 2-((4S)-6-(4-clorofenil)-1-metil-4H-benzo[c]isoxazolo[4,5-e]azepin-4-il)acetamida
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Also Published As

Publication number Publication date
BR9710453A (pt) 1999-08-17
EP0934940A1 (en) 1999-08-11
CN1227555A (zh) 1999-09-01
AU3106197A (en) 1998-01-07
IL127516A0 (en) 1999-10-28
WO1997047622A1 (en) 1997-12-18
NO985820D0 (no) 1998-12-11
PL330635A1 (en) 1999-05-24
CA2258053A1 (en) 1997-12-18

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