NO984877L - Substituerte isokinolin-3-karboksylsyreamider, deres fremstilling og deres anvendelse som legemiddel - Google Patents

Substituerte isokinolin-3-karboksylsyreamider, deres fremstilling og deres anvendelse som legemiddel

Info

Publication number: NO984877L
Authority: NO; Norway
Prior art keywords: drug; preparation; carboxylic acid; acid amides; substituted isoquinoline
Prior art date: 1997-10-20

Application number

NO984877A

Other languages

English (en)

Other versions

NO312365B1 (no

NO984877D0 (no

Inventor

Klaus Weidmann

Karl-Heinz Baringhaus

Georg Tschank

Ulrich Werner

Original Assignee

Hoechst Marion Roussel De Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-20

Filing date

1998-10-19

Publication date

1999-04-21

1998-10-19 Application filed by Hoechst Marion Roussel De Gmbh filed Critical Hoechst Marion Roussel De Gmbh

1998-10-19 Publication of NO984877D0 publication Critical patent/NO984877D0/no

1999-04-21 Publication of NO984877L publication Critical patent/NO984877L/no

2002-04-29 Publication of NO312365B1 publication Critical patent/NO312365B1/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Urology & Nephrology (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Dermatology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Reproductive Health (AREA)
Epidemiology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Toxicology (AREA)
Hematology (AREA)
Obesity (AREA)
Gastroenterology & Hepatology (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)

NO19984877A 1997-10-20 1998-10-19 Substituerte isokinolin-3-karboksylsyreamider, deres fremstilling og deres anvendelse til fremstilling av legemiddel NO312365B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19746287A DE19746287A1 (de)	1997-10-20	1997-10-20	Substituierte Isochinolin-2-Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel

Publications (3)

Publication Number	Publication Date
NO984877D0 NO984877D0 (no)	1998-10-19
NO984877L true NO984877L (no)	1999-04-21
NO312365B1 NO312365B1 (no)	2002-04-29

Family

ID=7846053

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19984877A NO312365B1 (no)	1997-10-20	1998-10-19	Substituerte isokinolin-3-karboksylsyreamider, deres fremstilling og deres anvendelse til fremstilling av legemiddel

Country Status (24)

Country	Link
US (1)	US6093730A (no)
EP (2)	EP0911340B1 (no)
JP (2)	JP3782591B2 (no)
KR (1)	KR100618922B1 (no)
CN (1)	CN1117079C (no)
AR (1)	AR013696A1 (no)
AT (2)	ATE299148T1 (no)
AU (1)	AU755714B2 (no)
BR (1)	BR9804504B1 (no)
CA (2)	CA2250664A1 (no)
CZ (1)	CZ337298A3 (no)
DE (3)	DE19746287A1 (no)
DK (2)	DK1538160T3 (no)
ES (2)	ES2245471T3 (no)
HU (1)	HUP9802422A3 (no)
ID (1)	ID21115A (no)
IL (1)	IL126638A0 (no)
NO (1)	NO312365B1 (no)
NZ (1)	NZ332363A (no)
PL (1)	PL192354B1 (no)
PT (1)	PT911340E (no)
SG (1)	SG87776A1 (no)
TR (1)	TR199802106A3 (no)
ZA (1)	ZA989505B (no)

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US7618940B2 (en)	2002-12-06	2009-11-17	Fibrogen, Inc.	Fat regulation
US8124582B2 (en)	2002-12-06	2012-02-28	Fibrogen, Inc.	Treatment of diabetes
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JP5202327B2 (ja) *	2005-12-09	2013-06-05	アムジエン・インコーポレーテツド	プロリルヒドロキシラーゼ阻害活性を示すキノロンベースの化合物、およびこの組成物、およびこの使用
EP2044028B1 (en)	2006-01-27	2012-05-16	Fibrogen, Inc.	Cyanoisoquinoline compounds that stabilize hypoxia inducible factor (hif)
US7745461B1 (en)	2006-02-27	2010-06-29	Alcon Research, Ltd.	Method of treating dry eye disorders
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KR101084635B1 (ko)	2006-04-04	2011-11-18	피브로겐, 인크.	Ｈｉｆ 조절제로서 피롤로- 및 티아졸로-피리딘 화합물
PT3357911T (pt)	2006-06-26	2022-07-11	Akebia Therapeutics Inc	Inibidores da prolil-hidroxilase e métodos de utilização
WO2008076427A2 (en)	2006-12-18	2008-06-26	Amgen Inc.	Naphthalenone compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof
US8048892B2 (en)	2006-12-18	2011-11-01	Amgen Inc.	Azaquinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof
US7569726B2 (en)	2007-04-18	2009-08-04	Amgen Inc.	Indanone derivatives that inhibit prolyl hydroxylase
ES2442847T3 (es)	2007-04-18	2014-02-13	Amgen, Inc	Quinolonas y azaquinolonas que inhiben la prolil hidroxilasa
EP2150251B9 (en)	2007-05-04	2013-02-27	Amgen, Inc	Thienopyridine and thiazolopyridine derivatives that inhibit prolyl hydroxylase activity
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US8962530B2 (en) *	2007-06-27	2015-02-24	Regents Of The University Of Colorado	Inflammatory bowel disease therapies
CN101497584B (zh) *	2008-01-29	2010-12-22	首都医科大学	异喹啉-3-甲酰氨基酸苄酯及其制备和应用
SI2294066T1 (sl)	2008-04-28	2014-12-31	Janssen Pharmaceutica N.V.	Benzoimidazoli kot inhibitorji prolil-hidroksilaze
AU2009314155B2 (en)	2008-11-14	2015-10-08	Fibrogen, Inc.	Thiochromene derivatives as HIF hydroxylase inhibitors
KR101850661B1 (ko) *	2009-07-17	2018-04-19	니뽄 다바코 산교 가부시키가이샤	트리아졸로피리딘 화합물, 그리고 그 프롤릴 수산화효소 저해제 및 에리트로포이에틴 생성 유도제로서의 작용
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ES2606631T3 (es) *	2011-07-22	2017-03-24	Beijing Betta Pharmaceuticals Co., Ltd	Formas polimeróficas de compuestos como inhibidor de la prolila hidroxilasa, y usos de los mismos
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JP6129217B2 (ja)	2012-03-09	2017-05-17	フィブロジェンインコーポレイテッド	Ｈｉｆヒドロキシラーゼインヒビターとしての４−ヒドロキシ−イソキノリン化合物
ES2905898T3 (es)	2012-07-16	2022-04-12	Fibrogen Inc	Formas cristalinas de un inhibidor de prolil hidroxilasa
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US9822135B2 (en)	2012-10-30	2017-11-21	H. Lee Moffitt Cancer Center And Research Institute, Inc.	STAT3 dimerization inhibitors
KR102233081B1 (ko)	2013-01-24	2021-03-29	피브로겐, 인크.	〔[1-시아노-5-(4-클로로페녹시)-4-하이드록시-아이소퀴놀린-3-카보닐]-아미노〕-아세트산의 결정 형태
ES2786924T3 (es)	2013-06-06	2020-10-14	Fibrogen Inc	Formulaciones farmacéuticas que comprenden un inhibidor de hidroxilasa del HIF
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KR20200112872A (ko) *	2018-01-09	2020-10-05	코넬 유니버시티	장기 섬유증의 예방 및 치료
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1997
- 1997-10-20 DE DE19746287A patent/DE19746287A1/de not_active Withdrawn
1998
- 1998-10-16 ES ES98119591T patent/ES2245471T3/es not_active Expired - Lifetime
- 1998-10-16 AT AT98119591T patent/ATE299148T1/de active
- 1998-10-16 ES ES05004047T patent/ES2328156T3/es not_active Expired - Lifetime
- 1998-10-16 EP EP98119591A patent/EP0911340B1/de not_active Expired - Lifetime
- 1998-10-16 DK DK05004047T patent/DK1538160T3/da active
- 1998-10-16 DK DK98119591T patent/DK0911340T3/da active
- 1998-10-16 DE DE59812907T patent/DE59812907D1/de not_active Expired - Lifetime
- 1998-10-16 AR ARP980105164A patent/AR013696A1/es unknown
- 1998-10-16 NZ NZ332363A patent/NZ332363A/xx unknown
- 1998-10-16 ID IDP981374A patent/ID21115A/id unknown
- 1998-10-16 AT AT05004047T patent/ATE432940T1/de active
- 1998-10-16 DE DE59814365T patent/DE59814365D1/de not_active Expired - Lifetime
- 1998-10-16 PT PT98119591T patent/PT911340E/pt unknown
- 1998-10-16 EP EP05004047A patent/EP1538160B1/de not_active Expired - Lifetime
- 1998-10-18 IL IL12663898A patent/IL126638A0/xx unknown
- 1998-10-19 NO NO19984877A patent/NO312365B1/no not_active IP Right Cessation
- 1998-10-19 HU HU9802422A patent/HUP9802422A3/hu unknown
- 1998-10-19 CZ CZ983372A patent/CZ337298A3/cs unknown
- 1998-10-19 BR BRPI9804504-0A patent/BR9804504B1/pt not_active IP Right Cessation
- 1998-10-19 TR TR1998/02106A patent/TR199802106A3/tr unknown
- 1998-10-19 US US09/174,558 patent/US6093730A/en not_active Expired - Lifetime
- 1998-10-19 ZA ZA989505A patent/ZA989505B/xx unknown
- 1998-10-19 AU AU89413/98A patent/AU755714B2/en not_active Expired
- 1998-10-19 JP JP29701198A patent/JP3782591B2/ja not_active Expired - Lifetime
- 1998-10-19 KR KR1019980043578A patent/KR100618922B1/ko not_active Expired - Lifetime
- 1998-10-19 CA CA002250664A patent/CA2250664A1/en not_active Abandoned
- 1998-10-20 CN CN98121000A patent/CN1117079C/zh not_active Expired - Lifetime
- 1998-10-20 PL PL329274A patent/PL192354B1/pl unknown
- 1998-10-20 CA CA2251647A patent/CA2251647C/en not_active Expired - Lifetime
- 1998-10-20 SG SG9804225A patent/SG87776A1/en unknown
2005
- 2005-09-02 JP JP2005254578A patent/JP4691419B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ES2245471T3 (es)	2006-01-01
DE59814365D1 (de)	2009-07-16
BR9804504B1 (pt)	2009-01-13
EP0911340A3 (de)	1999-07-07
CN1117079C (zh)	2003-08-06
HU9802422D0 (en)	1998-12-28
HK1019605A1 (en)	2000-02-18
CA2250664A1 (en)	1999-04-20
EP0911340A2 (de)	1999-04-28
TR199802106A2 (xx)	1999-05-21
JP3782591B2 (ja)	2006-06-07
DK0911340T3 (da)	2005-11-07
EP1538160B1 (de)	2009-06-03
HUP9802422A3 (en)	2002-02-28
PL192354B1 (pl)	2006-10-31
DE59812907D1 (de)	2005-08-11
KR100618922B1 (ko)	2007-04-25
DE19746287A1 (de)	1999-04-22
TR199802106A3 (tr)	1999-05-21
JP2006056894A (ja)	2006-03-02
BR9804504A (pt)	2001-05-22
CZ337298A3 (cs)	1999-05-12
PT911340E (pt)	2005-09-30
AR013696A1 (es)	2001-01-10
DK1538160T3 (da)	2009-10-05
IL126638A0 (en)	1999-08-17
JPH11302257A (ja)	1999-11-02
ATE432940T1 (de)	2009-06-15
EP1538160A1 (de)	2005-06-08
ES2328156T3 (es)	2009-11-10
PL329274A1 (en)	1999-04-26
AU8941398A (en)	1999-05-06
SG87776A1 (en)	2002-04-16
CN1218802A (zh)	1999-06-09
KR19990037182A (ko)	1999-05-25
EP0911340B1 (de)	2005-07-06
NZ332363A (en)	2000-04-28
CA2251647C (en)	2011-08-30
ID21115A (id)	1999-04-22
HUP9802422A2 (hu)	1999-08-30
US6093730A (en)	2000-07-25
JP4691419B2 (ja)	2011-06-01
ZA989505B (en)	1999-04-20
NO312365B1 (no)	2002-04-29
NO984877D0 (no)	1998-10-19
CA2251647A1 (en)	1999-04-20
AU755714B2 (en)	2002-12-19
ATE299148T1 (de)	2005-07-15

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2018-11-12	MK1K	Patent expired