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NO984164L - Bioconjugates of manganese or iron complexes consisting of nitrogen-containing macrocyclic ligands effective as catalysts for the dismutation of superoxide - Google Patents

Bioconjugates of manganese or iron complexes consisting of nitrogen-containing macrocyclic ligands effective as catalysts for the dismutation of superoxide

Info

Publication number
NO984164L
NO984164L NO984164A NO984164A NO984164L NO 984164 L NO984164 L NO 984164L NO 984164 A NO984164 A NO 984164A NO 984164 A NO984164 A NO 984164A NO 984164 L NO984164 L NO 984164L
Authority
NO
Norway
Prior art keywords
bioconjugates
dismutation
superoxide
catalysts
manganese
Prior art date
Application number
NO984164A
Other languages
Norwegian (no)
Other versions
NO984164D0 (en
Inventor
William L Neumann
Dennis P Riley
Randy H Weiss
Susan L Henke
Patrick J Lennon
Karl W Aston
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1996/012767 external-priority patent/WO1997006824A2/en
Application filed by Monsanto Co filed Critical Monsanto Co
Publication of NO984164D0 publication Critical patent/NO984164D0/en
Publication of NO984164L publication Critical patent/NO984164L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D259/00—Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/02—Iron compounds
    • C07F15/025—Iron compounds without a metal-carbon linkage

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Biokonjugater av mimikker av superoksid dismutase (SOD) med lav molekylvekt representert ved formel (I) hvori R, R', R,, R1,, R2, R'2, R3, R'3, RA, RV RS. R's, R«. Rr6, R,, R'7> Rg, R'x, R9, R'9> X, Y, Z, M og n er som definert heri er beskrevet. Disse er nødvendige som tereapeutiske midler for infiammatoriske sykdomstilstander og forstyrrelser, så som ischemisk/reperfusjonsskade, slag, aterosklerose og alle andre tilstander med oksidant-indusert vevsskade.Bioconjugates of low molecular weight superoxide dismutase (SOD) mimics represented by formula (I) wherein R, R ', R ,, R1, R2, R'2, R3, R'3, RA, RV RS. R's, R's. R 6, R 7, R 7, R 9, R 9, R 9, R 9, X, Y, Z, M and n are as defined herein. These are necessary as therapeutic agents for infiammatory disease states and disorders, such as ischemic / reperfusion injury, stroke, atherosclerosis, and all other conditions with oxidant-induced tissue damage.

NO984164A 1996-03-13 1998-09-10 Bioconjugates of manganese or iron complexes consisting of nitrogen-containing macrocyclic ligands effective as catalysts for the dismutation of superoxide NO984164L (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1334896P 1996-03-13 1996-03-13
PCT/US1996/012767 WO1997006824A2 (en) 1995-08-17 1996-08-14 Bioconjugates of manganese complexes and their application as catalysts
PCT/US1997/002566 WO1997033877A1 (en) 1996-03-13 1997-03-04 Bioconjugates of manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide

Publications (2)

Publication Number Publication Date
NO984164D0 NO984164D0 (en) 1998-09-10
NO984164L true NO984164L (en) 1998-11-06

Family

ID=21759507

Family Applications (1)

Application Number Title Priority Date Filing Date
NO984164A NO984164L (en) 1996-03-13 1998-09-10 Bioconjugates of manganese or iron complexes consisting of nitrogen-containing macrocyclic ligands effective as catalysts for the dismutation of superoxide

Country Status (11)

Country Link
EP (1) EP0891338A1 (en)
JP (1) JP2000508625A (en)
KR (1) KR19990087784A (en)
CN (1) CN1225631A (en)
AU (1) AU1962497A (en)
BR (1) BR9708179A (en)
CA (1) CA2249011A1 (en)
CZ (1) CZ271198A3 (en)
IL (1) IL125889A0 (en)
NO (1) NO984164L (en)
WO (1) WO1997033877A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6127356A (en) 1993-10-15 2000-10-03 Duke University Oxidant scavengers
US6214817B1 (en) * 1997-06-20 2001-04-10 Monsanto Company Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity
US6180620B1 (en) 1997-06-20 2001-01-30 G.D. Searle & Co. Analgesic methods using synthetic catalysts for the dismutation of superoxide radicals
EP1045851B1 (en) 1997-11-03 2003-04-23 Duke University Substituted porphyrins
EP1616869B1 (en) 1999-01-25 2012-04-04 National Jewish Health Substituted porphyrins and their therapeutic use
WO2000054784A1 (en) * 1999-03-15 2000-09-21 Abdurafik Bakhramovich Akbarov Complex comprising the coordination compound manganese, its medical effects and the mode of its production
JP2003500174A (en) * 1999-05-27 2003-01-07 フアルマシア・コーポレーシヨン Biomaterials modified with superoxide dismutase mimics
US20050176790A1 (en) 2001-02-28 2005-08-11 Johannes Bartholomaus Pharmaceutical salts
WO2002098431A1 (en) 2001-06-01 2002-12-12 National Jewish Medical And Research Center Oxidant scavengers for treatment of diabetes or use in transplantation or induction of immune tolerance
WO2003103680A1 (en) 2002-06-07 2003-12-18 Duke University Substituted porphyrins
EP2300032A4 (en) 2008-05-13 2012-12-05 Univ Kansas METAL ABSTRACTIONSPEPTID (MAP) DAY AND RELEVANT PROCEDURES
ES2600469T3 (en) 2008-05-23 2017-02-09 National Jewish Health A compound for use in the treatment of lesions associated with exposure to phosgene gas or chlorine gas
US9187735B2 (en) 2012-06-01 2015-11-17 University Of Kansas Metal abstraction peptide with superoxide dismutase activity

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0524161A1 (en) * 1991-07-19 1993-01-20 Monsanto Company Manganese complexes of nitrogen containing macrocyclic ligands effective as catalysts for dismutating superoxide
CA2103554C (en) * 1991-12-10 2002-07-30 Garry E. Kiefer Bicyclopolyazamacrocyclocarboxylic acid complexes, their conjugates, processes for their preparation, and use as contrast agents
US5747026A (en) * 1993-10-15 1998-05-05 University Of Alabama At Birmingham Research Foundation Antioxidants
AU6031096A (en) * 1995-06-05 1996-12-24 Duke University Nitrosylated and nitrated superoxide oxidants and reductants
US6525041B1 (en) * 1995-06-06 2003-02-25 Pharmacia Corporation Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
JPH11507621A (en) * 1995-06-07 1999-07-06 モンサント カンパニー Process for producing substituted polyaza macrocycles

Also Published As

Publication number Publication date
IL125889A0 (en) 1999-04-11
NO984164D0 (en) 1998-09-10
CZ271198A3 (en) 1999-01-13
WO1997033877A1 (en) 1997-09-18
CN1225631A (en) 1999-08-11
CA2249011A1 (en) 1997-09-18
JP2000508625A (en) 2000-07-11
AU1962497A (en) 1997-10-01
BR9708179A (en) 1999-07-27
EP0891338A1 (en) 1999-01-20
KR19990087784A (en) 1999-12-27

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