[go: up one dir, main page]

NO971485L - Antineoplastiske kakao-ekstrakter, fremgangsmåter for fremstilling og anvendelse - Google Patents

Antineoplastiske kakao-ekstrakter, fremgangsmåter for fremstilling og anvendelse Download PDF

Info

Publication number
NO971485L
NO971485L NO971485A NO971485A NO971485L NO 971485 L NO971485 L NO 971485L NO 971485 A NO971485 A NO 971485A NO 971485 A NO971485 A NO 971485A NO 971485 L NO971485 L NO 971485L
Authority
NO
Norway
Prior art keywords
cocoa
procyanidin
extract
beans
polyphenols
Prior art date
Application number
NO971485A
Other languages
English (en)
Norwegian (no)
Other versions
NO971485D0 (no
Inventor
Jr Leo J Romanczyk
Jr John F Hammerstone
Margaret M Buck
Original Assignee
Mars Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23232689&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO971485(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Mars Inc filed Critical Mars Inc
Publication of NO971485D0 publication Critical patent/NO971485D0/no
Publication of NO971485L publication Critical patent/NO971485L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A61K31/78—Polymers containing oxygen of acrylic acid or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/577—Malvaceae (Mallow family)
    • A61K36/5777—Theobroma, e.g. cocao or cocoa
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
    • C07D311/62—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2 with oxygen atoms directly attached in position 3, e.g. anthocyanidins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Pyrane Compounds (AREA)
NO971485A 1994-10-03 1997-04-02 Antineoplastiske kakao-ekstrakter, fremgangsmåter for fremstilling og anvendelse NO971485L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/317,226 US5554645A (en) 1994-10-03 1994-10-03 Antineoplastic cocoa extracts and methods for making and using the same
PCT/US1995/012963 WO1996010404A1 (en) 1994-10-03 1995-10-03 Antineoplastic cocoa extracts, methods for making, using

Publications (2)

Publication Number Publication Date
NO971485D0 NO971485D0 (no) 1997-04-02
NO971485L true NO971485L (no) 1997-05-23

Family

ID=23232689

Family Applications (1)

Application Number Title Priority Date Filing Date
NO971485A NO971485L (no) 1994-10-03 1997-04-02 Antineoplastiske kakao-ekstrakter, fremgangsmåter for fremstilling og anvendelse

Country Status (26)

Country Link
US (13) US5554645A (et)
EP (2) EP0789568B1 (et)
JP (2) JPH10506903A (et)
CN (2) CN100357287C (et)
AP (1) AP9700952A0 (et)
AT (1) ATE346599T1 (et)
AU (1) AU696050B2 (et)
BG (1) BG101446A (et)
CA (1) CA2201310C (et)
CZ (1) CZ99197A3 (et)
DE (1) DE69535318T2 (et)
DK (1) DK0789568T3 (et)
EE (1) EE9700074A (et)
FI (1) FI971354A7 (et)
HU (1) HUT77366A (et)
IS (1) IS4456A (et)
LT (1) LT4322B (et)
LV (1) LV11819B (et)
MD (1) MD970165A (et)
MX (1) MX9702415A (et)
NO (1) NO971485L (et)
OA (1) OA10604A (et)
PL (1) PL187819B1 (et)
RU (1) RU2220719C2 (et)
SK (1) SK43497A3 (et)
WO (1) WO1996010404A1 (et)

Families Citing this family (127)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6777005B1 (en) * 1994-10-03 2004-08-17 Mars, Incorporated Foods containing a cocoa polyphenol additive
US5554645A (en) * 1994-10-03 1996-09-10 Mars, Incorporated Antineoplastic cocoa extracts and methods for making and using the same
US6187315B1 (en) 1995-03-03 2001-02-13 Atajje, Inc. Compositions and methods of treating cancer with tannin complexes
US6391310B1 (en) 1996-03-13 2002-05-21 Archer Daniels Midland Company Method of preparing and using isoflavones for the treatment of neurological symptoms
US6261565B1 (en) 1996-03-13 2001-07-17 Archer Daniels Midland Company Method of preparing and using isoflavones
US6696485B1 (en) 1996-04-02 2004-02-24 Mars, Incorporated Procyanidin and cyclo-oxygenase modulator compositions
US6297273B1 (en) * 1996-04-02 2001-10-02 Mars, Inc. Use of cocoa solids having high cocoa polyphenol content in tabletting compositions and capsule filling compositions
US6469053B1 (en) * 1996-04-02 2002-10-22 Mars Incorporated Use of procyanidins in the maintenance of vascular health and modulation of the inflammatory response
US6423743B1 (en) 1996-04-02 2002-07-23 Mars Incorporated Cocoa extract compounds and methods for making and using the same
PL329325A1 (en) * 1996-04-02 1999-03-29 Mars Inc Cocoa extract compounds, method of obtaining them and their application
US6905715B1 (en) 1996-09-06 2005-06-14 Mars, Incorporated Cocoa solids having a high cocoa procyanidin content
US6737088B1 (en) 1996-09-06 2004-05-18 Mars, Incorporated Cocoa extracts prepared from cocoa solids having high cocoa polyphenol contents
US7968140B2 (en) * 1997-09-08 2011-06-28 Mars, Incorporated Chocolates and chocolate liquor having an enhanced polyphenol content
US6015913A (en) * 1996-09-06 2000-01-18 Mars, Incorporated Method for producing fat and/or solids from cocoa beans
US6312753B1 (en) * 1996-09-06 2001-11-06 Mars, Incorporated Cocoa components, edible products having enriched polyphenol content, methods of making same and medical uses
US6558713B2 (en) * 1996-09-06 2003-05-06 Mars, Incorporated Health of a mammal by administering a composition containing at least one cocoa polyphenol ingredient
US6238673B1 (en) 1996-09-20 2001-05-29 The Howard Foundation Method of producing high flavonol content polyphenol compositions
JP2001506579A (ja) * 1996-09-20 2001-05-22 ザ・ハワード・ファウンデイション フラボノールを含有する補助食品
US6569446B1 (en) 1996-09-20 2003-05-27 The Howard Foundation Solubilization of flavonols
US6066350A (en) * 1997-02-07 2000-05-23 Cargill Incorporated Method and arrangement for processing cocoa mass
JP2001513505A (ja) * 1997-08-08 2001-09-04 エイティーエイジェイジェイイー インコーポレーテッド タンニン酸及びタンニン複合体により癌を治療する組成物及び方法
US6207842B1 (en) 1997-10-09 2001-03-27 Mars Incorporated Process for preparing procyanidin(4-6 or 4-8) oligomers and their derivatives
US8507018B2 (en) 1998-03-12 2013-08-13 Mars, Incorporated Products containing polyphenol(s) and L-arginine and methods of use thereof
ATE372972T1 (de) * 1998-03-12 2007-09-15 Mars Inc Produkte enthaltend polyphenol(e) und l-arginin zur stimulierung der stickstoffoxidproduktion
US6805883B2 (en) 1998-03-12 2004-10-19 Mars, Incorporated Food products containing polyphenol(s) and L-arginine to stimulate nitric oxide
AU4288799A (en) * 1998-06-18 2000-01-05 Meiji Seika Kaisha Ltd. Cocoa powder rich in polyphenols, process for producing the same and modified cocoa containing the same
US7011856B2 (en) * 1998-08-05 2006-03-14 Amino Up Chemical Co., Ltd. Composition for the treatment of symptoms and conditions associated with aging
US6576275B1 (en) * 1999-02-02 2003-06-10 Archer-Daniels-Midland Company Process for extracting polyphenolic antioxidants from purine-containing plants
US6190716B1 (en) * 1999-02-17 2001-02-20 Scott O. Galbreath, Jr. Method for preparing a grape derived product
US6156912A (en) * 1999-04-09 2000-12-05 Mars, Incorporated 88, 66, and 68 catechin and epicatechin dimers and methods for their preparation
US7015338B1 (en) 1999-04-15 2006-03-21 Mars Incorporated Synthetic methods for preparing procyanidin oligomers
ATE396983T1 (de) * 1999-04-23 2008-06-15 Kyowa Hakko Kogyo Kk Verfahren zur reinigung von proanthocyanidin- oligomeren
KR100319251B1 (ko) * 1999-06-30 2002-01-05 한수길 충치 억제 효능을 지닌 카카오 콩껍질 분획물의 제조방법
KR100509119B1 (ko) * 1999-07-16 2005-08-18 주식회사 엘지생활건강 프로시아니딘 올리고머를 유효성분으로 하는 약제
AU2289601A (en) * 1999-12-21 2001-07-03 Mars, Incorporated The use of procyanidins in the modulation of cytokine gene expression and protein secretion
ES2393667T3 (es) * 2000-03-10 2012-12-27 Kabushiki Kaisha Yakult Honsha Inhibidores de la actividad de la alfa-amilasa
US6524630B2 (en) 2000-03-22 2003-02-25 Mars, Incorporated Use of cocoa procyanidins combined with acelylsalicyclic acid as an anti-platelet therapy
CN1436047A (zh) 2000-04-14 2003-08-13 马尔斯公司 促进血管健康的组合物和方法
KR100353886B1 (ko) * 2000-04-26 2002-09-27 롯데제과주식회사 항산화 활성을 갖는 카카오 콩껍질 발효물의 제조방법
FR2808192A1 (fr) * 2000-04-28 2001-11-02 Oreal Epichatechine comme inhibiteur de no-synthase et utilisations
US6627232B1 (en) * 2000-06-09 2003-09-30 Mars Incorporated Method for extracting cocoa procyanidins
FR2810242B1 (fr) * 2000-06-16 2003-01-17 Nuxe Lab Composition cosmetique et/ou dermatologique a base d'extraits de cacao
FR2812873B1 (fr) * 2000-08-11 2003-08-01 Barry Callebaut France Procede de production de polyphenols a partir de feves de cacao
US6476241B1 (en) * 2000-09-05 2002-11-05 Mars Incorporated Synthesis of 4α-arylepicatechins
AU2002239764B2 (en) * 2000-11-03 2007-06-21 Proteotech, Inc. Methods of isolating amyloid-inhibiting compounds and use of compounds isolated from uncaria tomentosa and related plants
US7048941B2 (en) 2001-03-30 2006-05-23 New World Enterprizes, Inc. Chocolate composition as delivery system for nutrients and medications
EP1554572B1 (en) 2001-07-25 2009-10-14 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
KR100460103B1 (ko) * 2001-10-18 2004-12-04 롯데제과주식회사 카카오 콩 또는 콩껍질 분획물을 함유하는 소화기계 발암 억제제
US7514107B2 (en) * 2002-03-21 2009-04-07 Mars, Incorporated Treatment of diseases involving defective gap junctional communication
US20060093553A1 (en) * 2002-05-17 2006-05-04 Dang Nam H Cd26-based therapies for cancers and immune disease
US7067679B2 (en) * 2002-10-02 2006-06-27 Mars, Inc. Synthesis of dimeric, trimeric, tetrameric pentameric, and higher oligomeric epicatechin-derived procyanidins having 4,8-interflavan linkages and their use to inhibit cancer cell growth through cell cycle arrest
US20040071848A1 (en) * 2002-10-15 2004-04-15 Cargill Inc. Process for producing cocoa butter and cocoa powder by liquefied gas extraction
US7201934B2 (en) * 2002-10-15 2007-04-10 Cargill, Incorporated Dispersible cocoa products
US20040071847A1 (en) * 2002-10-15 2004-04-15 Cargill, Inc. Producing cocoa powders with different cocoa butter contents by liquefied gas extraction on substantially the same production line
US6936644B2 (en) * 2002-10-16 2005-08-30 Cookson Electronics, Inc. Releasable microcapsule and adhesive curing system using the same
US20040254357A1 (en) * 2002-12-19 2004-12-16 Zaloga Gary P. Fatty acid phenolic conjugates
WO2004113502A2 (en) * 2003-06-20 2004-12-29 Avalon Pharmaceuticals, Inc. Identification of therapeutic agents using genetic fingerprinting
CN1889944A (zh) * 2003-10-10 2007-01-03 马尔斯公司 ErbB2激酶过量表达相关疾病的治疗
US9675630B2 (en) * 2004-01-28 2017-06-13 Mars, Incorporated Compositions and methods of use of A-type procyanidins
AU2005209908A1 (en) * 2004-01-30 2005-08-18 Mars, Incorporated Methods and compositions for treating cancer
CA2559272C (en) 2004-03-12 2015-12-01 University Of Georgia Research Foundation, Inc. Novel peanut skin extract as a vaccine adjuvant
AU2005239890B2 (en) 2004-05-10 2011-08-18 Instituto Tecnologico Y De Estudios Superiores De Monterrey (Itesm) Cancer cell growth inhibition by black bean (Phaseolus vulgarisL) extracts
GB2414393B (en) * 2004-05-24 2008-06-11 Natraceutical Sa Process for producing cocoa polyphenol concentrate
US20060128939A1 (en) * 2004-12-03 2006-06-15 Vijayendra Kumar One pot process for making polymeric antioxidants
US8435576B2 (en) * 2005-01-28 2013-05-07 Barry Callebaut Ag Use of cocoa polyphenols for treating a prostate hyperplasia, a specific cocoa extract and applications
CN101287411B (zh) 2005-04-28 2013-03-06 普罗秋斯生物医学公司 药物信息系统及其用途
EP1728434B1 (en) * 2005-05-31 2008-12-24 Kraft Foods R & D, Inc. Process for the manufacture of a polyphenol-enriched composition from cocoa shell extraction
US20070004796A1 (en) * 2005-06-29 2007-01-04 Romanczyk Leo Jr Processes for the preparation of protected-(+)-catechin and (-)-epicatechin monomers, for coupling the protected monomers with an activated, protected epicatechin monomer, and for the preparation of epicatechin-(4B,8)-epicatechin or -catechin dimers and their digallates
WO2007002854A2 (en) 2005-06-29 2007-01-04 Mars, Incorporated Inducing peripheral blood vessel vasodilation
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
CA2620333A1 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
AU2006304787A1 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
EP2314289A1 (en) 2005-10-31 2011-04-27 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
ES2619157T3 (es) * 2005-12-23 2017-06-23 Mars, Incorporated Protección y mejora de la piel
US20100291260A1 (en) * 2006-01-17 2010-11-18 Barry Callebaut Ag Use of cacao polyphenols in beer production
JP2009527487A (ja) * 2006-02-16 2009-07-30 ザ ハーシー カンパニー ココア製品及び心血管状態を無糖ココアで処置する方法
ES2280141B1 (es) * 2006-02-27 2008-10-01 Natraceutical, S.A. "proceso para la obtencion de polvo de cacao rico en polifenoles y bajo contenido en materia grasa y polvo de cacao obtenido".
WO2007104035A1 (en) * 2006-03-08 2007-09-13 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP2021000A2 (en) 2006-05-09 2009-02-11 Braincells, Inc. Neurogenesis by modulating angiotensin
JP2009536667A (ja) 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド ５ｈｔ受容体介在性の神経新生
US20100009983A1 (en) * 2006-05-09 2010-01-14 Braincells, Inc. 5 ht receptor mediated neurogenesis
WO2007138118A1 (es) * 2006-05-25 2007-12-06 Natraceutical, S.A. Proceso de obtención de extractos de cacao con elevado contenido de polifenoles
CN101505745A (zh) 2006-06-15 2009-08-12 玛尔斯有限公司 改善认知功能的方法和组合物
AU2007275561B2 (en) * 2006-07-21 2013-12-19 Mars, Incorporated Improvement of arginase levels/activity
MX2009002496A (es) * 2006-09-08 2009-07-10 Braincells Inc Combinaciones que contienen un derivado de 4-acilaminopiridina.
EP2063905B1 (en) 2006-09-18 2014-07-30 Raptor Pharmaceutical Inc Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
US20080103165A1 (en) * 2006-09-19 2008-05-01 Braincells, Inc. Ppar mediated modulation of neurogenesis
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
CN100428933C (zh) * 2006-10-19 2008-10-29 华中农业大学 莲原花青素用于制备防治老年痴呆药物的用途
EP1913821A1 (en) 2006-10-20 2008-04-23 Kraft Foods R & D, Inc. Zweigniederlassung München Polyphenol-rich extract from plant material
US8609174B2 (en) 2006-11-17 2013-12-17 Barry Callebaut Ag Method for producing a soluble cocoa product from cocoa powder
WO2008059064A1 (en) 2006-11-17 2008-05-22 Barry Callebaut Ag Method for producing a soluble cocoa product from cocoa powder
GB0719545D0 (en) 2007-10-08 2007-11-14 Barry Callebaut Ag Novel use of cocoa extract
GB0719544D0 (en) 2007-10-08 2007-11-14 Barry Callebaut Ag Cocoa extract and use thereof
GB0719542D0 (en) 2007-10-08 2007-11-14 Barry Callebaut Ag Use of cocoa extract
US9114114B2 (en) 2007-06-21 2015-08-25 Mars, Inc. Edible products having a high cocoa polyphenol content and improved flavor and the milled cocoa extracts used therein
GB0719543D0 (en) 2007-10-08 2007-11-14 Barry Callebaut Ag Cocoa extract and novel use thereof
GB0724716D0 (en) 2007-12-19 2008-01-30 Barry Callebaut Ag Process
GB0801119D0 (en) 2008-01-22 2008-02-27 Barry Callebaut Ag Composition
WO2009099220A1 (ja) * 2008-02-07 2009-08-13 Meiji Seika Kaisha, Ltd. ポリフェノール高含有組成物の製造方法および製造装置
US20090263518A1 (en) 2008-04-17 2009-10-22 Barry Callebaut Ag Composition and Uses Thereof
AU2009201515B2 (en) * 2008-05-14 2011-05-19 Unilever Plc Frozen confectionery products
ES2383780T3 (es) * 2008-12-29 2012-06-26 Unilever N.V. Productos de confitería congelados que comprenden teobromina y cafeína
HUE059078T2 (hu) 2009-02-20 2022-10-28 Enhanx Biopharm Inc Glutation-alapú hatóanyagszállító rendszer
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
JP5789595B2 (ja) 2009-04-03 2015-10-07 ダイアナプラントサイエンシズ エス．アー．エス． 植物の細胞培養物からのプロシアニジンの産生および抽出
KR101909711B1 (ko) 2009-05-06 2018-12-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
EA201270249A1 (ru) * 2009-08-07 2012-07-30 Унилевер Н.В. Способ получения экстракта какавеллы
WO2011040969A1 (en) * 2009-09-30 2011-04-07 Massachusetts Institute Of Technology Compositions and methods for the treatment of atherosclerosis and other related diseases
JP5544863B2 (ja) 2009-12-17 2014-07-09 富士通株式会社 受信装置、受信方法及び受信プログラム
WO2011109764A1 (en) 2010-03-05 2011-09-09 Mars, Incorporated Palatable beverages and compositions with cocoa extract
US20110218241A1 (en) * 2010-03-06 2011-09-08 Cacao Bio-Technologies, Llc Antiviral epicatechins, epicatechin oligomers, or thiolated epicatechins from theobroma cacao for treatment of genital warts
WO2011144545A1 (en) 2010-05-19 2011-11-24 Unilever Nv Theobromine for increasing hdl-cholesterol
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
WO2012047817A1 (en) 2010-10-04 2012-04-12 Dianaplantsciences, Inc. Production and extraction of procyanidins from plant cells cultures
US9682112B2 (en) 2013-08-05 2017-06-20 Akay Flavours & Aromatics PVT. LTD Ultrasound-assisted continuous extraction for complete fragmentation of cocoa beans into fractions
EP3071544B1 (en) 2013-11-22 2022-07-06 Polnox Corporation Macromolecular antioxidants based on dual type moiety per molecule: structures methods of making and using the same
WO2016020854A1 (en) * 2014-08-08 2016-02-11 Rottapharm Biotech S.R.L. Purified cocoa beans extracts, production and use thereof for the treatment of central and peripheric human diseases
WO2016020853A1 (en) * 2014-08-08 2016-02-11 Rottapharm Biotech S.R.L. Purified cocoa beans and grape seeds extracts, production and use thereof for the treatment of central and peripheric human diseases
WO2016046375A1 (en) * 2014-09-25 2016-03-31 Institut National De La Sante Et De La Recherche Medicale (Inserm) Theobroma cacao extract for use in the treatment or prevention of receptor tyrosine kinases related disorders
CN106109512A (zh) * 2016-06-27 2016-11-16 郭迎庆 一种可可多酚咀嚼片的制备方法
WO2018160879A2 (en) 2017-03-01 2018-09-07 Polnox Corporation Macromolecular corrosion (mcin) inhibitors: structures, methods of making and using the same
US11173187B2 (en) * 2018-11-13 2021-11-16 Immortazyme Company Ltd. Concentrated oil-based polyphenol composition and a method of producing the oil-based polyphenol composition
CN113358592B (zh) * 2020-03-04 2023-06-06 福建医科大学 基于海藻酸钠-铂纳米粒子氧化酶活性的原花青素检测方法
CN114306320A (zh) * 2021-02-04 2022-04-12 汤臣倍健股份有限公司 一种下调衰老相关分泌表型的抗衰老植物多酚类药物及其应用
CN112870238B (zh) * 2021-02-04 2022-05-27 徐州奇诺医疗科技有限公司 可可提取物在制备抵抗衰老及抑制肿瘤的药物中的应用

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB14624A (et) 1900-01-01
US1750795A (en) 1926-01-04 1930-03-18 Defren George Process of treating cacao beans
US1855026A (en) 1927-08-15 1932-04-19 Monsanto Chemical Works Treatment of by-products of the cocoa and chocolate industries
GB345250A (en) 1929-10-07 1931-03-09 Monsanto Chemical Works Improvements in and relating to the recovery and purification of alkaloids from cocoa products
GB341000A (en) 1929-10-07 1931-01-07 Monsanto Chemical Works Process for recovering valuable products from cocoa by-products
US1925326A (en) 1929-11-13 1933-09-05 Battle Creek Food Company Theobromine extracting process
GB492714A (en) 1937-03-23 1938-09-23 British Ass Of Res For Cocoa C Preservation of organic materials, particularly oils and fats and bodies containing the same
US2176031A (en) 1939-04-01 1939-10-10 Musher Foundation Inc Retarding rancidity in glyceride oils
US2380158A (en) 1942-10-21 1945-07-10 Inredeco Inc Method of preparing a cocoa extract
GB562123A (en) 1942-10-21 1944-06-19 Inredeco Inc Improvements in method of preparing a cocoa extract
US2515794A (en) * 1946-05-15 1950-07-18 Moorehead Mfg Co Inc Method of preparing cocoa extracts
US2512663A (en) * 1947-04-25 1950-06-27 Choco Essence Inc Chocolate essence or extract
US2835585A (en) * 1953-07-10 1958-05-20 Gen Foods Corp Chocolate product and process therefor
GB751121A (en) 1953-07-10 1956-06-27 Gen Foods Corp Improvements in or relating to chocolate flavoring material
US2823124A (en) * 1955-02-14 1958-02-11 Limpert Bros Inc Process for preparation of chocolate extract or chocolate syrup from cocoa
US2954293A (en) * 1958-02-28 1960-09-27 Gen Foods Corp Preparation of chocolate flavoring
US2957769A (en) * 1958-04-03 1960-10-25 Gen Foods Corp Chocolate product and process therefor
US2965490A (en) * 1959-04-02 1960-12-20 Gen Foods Corp Flavor product and process
US3615659A (en) * 1968-08-28 1971-10-26 Wisconsin Research Associates Preparing a chocolate-flavored beverage
DE2055030C3 (de) 1970-11-09 1978-06-22 Dragoco Gerberding & Co Gmbh, 3450 Holzminden Verfahren zur Herstellung eines Kakaoextrakts
US4113886A (en) * 1977-09-28 1978-09-12 General Foods Corporation Membrane decaffeination
US4156030A (en) * 1977-12-29 1979-05-22 Societe D'assistance Technique Pour Produits Nestle S.A. Cocoa shell extract
DE2910539C2 (de) * 1978-11-10 1986-07-24 Iwatani Sangyo K.K., Osaka Verfahren zum Herstellen von Kakaopulver
US4237288A (en) 1979-05-17 1980-12-02 Societe D'assistance Technique Pour Produits Nestle S.A. Decaffeination of fatty materials
GB2095091B (en) 1981-03-20 1984-08-22 Nestle Sa Removal of xanthine stimulants from cocoa
US4861607A (en) * 1981-03-20 1989-08-29 Nestec S. A. Removal of xanthine stimulants from cocoa
US4390698A (en) 1981-05-21 1983-06-28 Societe D'assistance Technique Pour Produits Nestle S.A. Detheobromination of cocoa
US4407834A (en) 1981-05-21 1983-10-04 Societe D'assistance Technique Pour Produits Nestle S.A. Recovery of xanthine stimulants from aqueous media
JPS57206391A (en) 1981-06-12 1982-12-17 Morinaga & Co Ltd Preparation of flavonoid natural pigment by enzymic treatment
DE3125144C1 (de) 1981-06-26 1983-02-24 Lindt & Sprüngli AG, 8802 Kilchberg Verfahren zur Gewinnung von Nahrungsfasern fuer die Verbesserung der verdauungsfoerdernden Eigenschaften von Nahrungs- und Genussmitteln
CH641935A5 (fr) 1981-07-22 1984-03-30 Nestle Sa Procede d'elimination des composes stimulants du cacao.
JPS59169452A (ja) 1983-03-15 1984-09-25 Meiji Seika Kaisha Ltd カカオ豆の処理方法
US4532147A (en) * 1983-08-03 1985-07-30 General Foods Corporation Cacao product and process therefor
JPS6116982A (ja) * 1984-07-03 1986-01-24 Kikkoman Corp 抗酸化剤
NL8403748A (nl) * 1984-12-10 1986-07-01 Zaan Cacaofab Bv Cacaopoeder.
US4698360B1 (en) 1985-04-09 1997-11-04 D Investigations Pharmacologiq Plant extract with a proanthocyanidins content as therapeutic agent having radical scavenger effect and use thereof
US4755391A (en) 1986-01-22 1988-07-05 Hershey Foods Corporation Removal of methylxanthines from cacao materials
JP2527788B2 (ja) 1988-05-31 1996-08-28 株式会社ロッテ 口腔用組成物
IT1219732B (it) 1988-06-28 1990-05-24 Tecnofarmaci Spa Frazioni oligomeriche procianidoliche,loro procedimento di preparazione e composizioni farmaceutiche che le contengono
US4970090A (en) * 1988-09-26 1990-11-13 Mccormick & Company, Inc. Enhanced cocoa extract flavorings
KR910004494B1 (ko) 1988-10-21 1991-07-05 롯데제과 주식회사 카카오콩 껍질(cacao bean husk)의 수용성 추출물을 배합한 충치예방 츄잉껌의 제조방법
KR900007862A (ko) * 1988-11-10 1990-06-02 정보영 카카오 콩 껍질(cacao bean husk)추출물로부터 세파덱스 g-50(sephadex g-50)에의해 분획된 f-1, f-2의 글루칸 합성 저해물질
FR2643073B1 (fr) 1989-02-15 1991-08-16 Expansion Rech Phytochimie Procede de preparation d'extraits polyphenoliques de type flavane-3-ol purifies et extraits obtenus
US4956429A (en) * 1989-03-01 1990-09-11 Penick Corporation Method of making a coca leaf flavor extract
DE3908649A1 (de) 1989-03-16 1990-09-20 Jacobs Suchard Ag Verfahren zur herstellung eines loeslichen kakaoerzeugnisses
DE3912819A1 (de) 1989-04-19 1990-11-08 Jacobs Suchard Ag Verfahren zur herstellung von kakao-extrakt
US5211944A (en) * 1990-10-12 1993-05-18 Shaman Pharmaceuticals, Inc. Proanthocyanidin polymers having antiviral activity and methods of obtaining same
JP2857646B2 (ja) 1990-11-26 1999-02-17 キッコーマン株式会社 抗変異原性剤
US5391568A (en) 1992-07-10 1995-02-21 American Health Foundation Inhibition of lung tumorigenesis by administration of a polyphenol
JP3509891B2 (ja) * 1993-02-24 2004-03-22 サントリー株式会社 フラボノイド重合物およびこれを有効成分とするグルコシルトランスフェラーゼ阻害剤
DE4325532A1 (de) * 1993-07-29 1995-02-02 Schwabe Willmar Präparate aus Crataegus-Arten, Arzneimittel und ihre Verwendung zur Verhinderung des plötzlichen Herztodes sowie von reperfusionsbedingten cardiovaskulären Schädigungen
JP3095605B2 (ja) 1994-02-04 2000-10-10 明治製菓株式会社 抗酸化物質を含有する健康飲食品および抗酸化物質の製造法
JP3063818B2 (ja) 1994-04-01 2000-07-12 明治製菓株式会社 胃潰瘍予防飲食品
JPH0822848A (ja) 1994-07-08 1996-01-23 Tokai Rika Co Ltd コネクタ装置
US5554645A (en) * 1994-10-03 1996-09-10 Mars, Incorporated Antineoplastic cocoa extracts and methods for making and using the same
US6777005B1 (en) * 1994-10-03 2004-08-17 Mars, Incorporated Foods containing a cocoa polyphenol additive
JP3450080B2 (ja) 1995-02-01 2003-09-22 有限会社野々川商事 プロシアニジンを配合した健康食品および医薬品
JP3594152B2 (ja) 1996-02-08 2004-11-24 明治製菓株式会社 ストレスに対する適応形成を促進させる飲食品
JPH09224606A (ja) 1996-02-19 1997-09-02 Meiji Seika Kaisha Ltd 発ガン予防物質を含有する健康飲食品
JPH09234018A (ja) 1996-03-01 1997-09-09 Meiji Seika Kaisha Ltd 糖尿病合併症予防作用を有する飲食品
US6261565B1 (en) 1996-03-13 2001-07-17 Archer Daniels Midland Company Method of preparing and using isoflavones
US6297273B1 (en) * 1996-04-02 2001-10-02 Mars, Inc. Use of cocoa solids having high cocoa polyphenol content in tabletting compositions and capsule filling compositions
US6312753B1 (en) * 1996-09-06 2001-11-06 Mars, Incorporated Cocoa components, edible products having enriched polyphenol content, methods of making same and medical uses
US5912363A (en) 1997-08-29 1999-06-15 Interhealth Nutraceuticals Method for extraction of proanthocyanidins from plant material
EP1026164A1 (en) 1999-02-02 2000-08-09 ADM Cocoa B.V. Process for extracting polyphenolic antioxidants from purine-containing plants
KR100319251B1 (ko) * 1999-06-30 2002-01-05 한수길 충치 억제 효능을 지닌 카카오 콩껍질 분획물의 제조방법
US6524630B2 (en) * 2000-03-22 2003-02-25 Mars, Incorporated Use of cocoa procyanidins combined with acelylsalicyclic acid as an anti-platelet therapy
IT1317035B1 (it) 2000-05-30 2003-05-26 Sigma Tau Healthscience Spa Integratore ad attivita' antiossidante comprendente unaalcanoilcarnitina ed una associazione di polifenoli estratti dal
US6627232B1 (en) * 2000-06-09 2003-09-30 Mars Incorporated Method for extracting cocoa procyanidins

Also Published As

Publication number Publication date
AU696050B2 (en) 1998-08-27
FI971354A0 (fi) 1997-04-02
PL187819B1 (pl) 2004-10-29
US6156791A (en) 2000-12-05
CA2201310A1 (en) 1996-04-11
DE69535318T2 (de) 2007-06-21
LT4322B (lt) 1998-04-27
EP0789568A1 (en) 1997-08-20
US20020004523A1 (en) 2002-01-10
MD970165A (ro) 1999-01-31
MX9702415A (es) 1997-06-28
WO1996010404A1 (en) 1996-04-11
CN1654462A (zh) 2005-08-17
US20080269320A1 (en) 2008-10-30
US6479539B1 (en) 2002-11-12
US6517841B2 (en) 2003-02-11
EP0789568A4 (en) 1998-10-21
US5712305A (en) 1998-01-27
US6790966B2 (en) 2004-09-14
LT97077A (en) 1998-01-26
LV11819A (lv) 1997-08-20
US20080021227A1 (en) 2008-01-24
US20020049166A1 (en) 2002-04-25
US5891905A (en) 1999-04-06
HUT77366A (hu) 1998-03-30
NO971485D0 (no) 1997-04-02
ATE346599T1 (de) 2006-12-15
PL319756A1 (en) 1997-08-18
CN1134255C (zh) 2004-01-14
OA10604A (en) 2002-09-10
IS4456A (is) 1997-04-02
JP2009286796A (ja) 2009-12-10
BG101446A (bg) 1998-04-30
AU3891695A (en) 1996-04-26
CN1168632A (zh) 1997-12-24
LV11819B (en) 1997-12-20
AP9700952A0 (en) 1997-04-30
US20030176493A1 (en) 2003-09-18
FI971354L (fi) 1997-05-30
EE9700074A (et) 1997-10-15
JPH10506903A (ja) 1998-07-07
EP1759696A1 (en) 2007-03-07
US6562863B2 (en) 2003-05-13
RU2220719C2 (ru) 2004-01-10
CZ99197A3 (en) 1997-09-17
SK43497A3 (en) 1998-02-04
FI971354A7 (fi) 1997-05-30
US20040175448A1 (en) 2004-09-09
DK0789568T3 (da) 2007-04-10
US7820713B2 (en) 2010-10-26
CA2201310C (en) 2009-07-21
DE69535318D1 (de) 2007-01-11
US6225338B1 (en) 2001-05-01
CN100357287C (zh) 2007-12-26
EP0789568B1 (en) 2006-11-29
US5877206A (en) 1999-03-02
US5554645A (en) 1996-09-10

Similar Documents

Publication Publication Date Title
NO971485L (no) Antineoplastiske kakao-ekstrakter, fremgangsmåter for fremstilling og anvendelse
CA2250792C (en) Cocoa extract compounds and methods for making and using the same
US20050209171A1 (en) Treatment of periodontal disease
WO1997036597A1 (en) Cocoa extract compounds and methods for making and using the same
US6777005B1 (en) Foods containing a cocoa polyphenol additive
Rica et al. Romanczyk, Jr. et al.
KR100591953B1 (ko) 항신생물코코아추출물과그의제조방법및이용
MXPA00007491A (en) Remote platform independent dynamic multimedia engine
AU2005203665A1 (en) Cocoa extract compounds and methods for making and using the same
AU8364901A (en) Cocoa extract compounds and methods for making and using the same