[go: up one dir, main page]

NO971136L - Aminoalkyl- og acylaminoalkyleter, fremgangsmåte for fremstilling derav og anvendelse som bradykinin-reseptor antagonister - Google Patents

Aminoalkyl- og acylaminoalkyleter, fremgangsmåte for fremstilling derav og anvendelse som bradykinin-reseptor antagonister

Info

Publication number
NO971136L
NO971136L NO971136A NO971136A NO971136L NO 971136 L NO971136 L NO 971136L NO 971136 A NO971136 A NO 971136A NO 971136 A NO971136 A NO 971136A NO 971136 L NO971136 L NO 971136L
Authority
NO
Norway
Prior art keywords
aminoalkyl
acylaminoalkyl
ether
preparation
receptor antagonists
Prior art date
Application number
NO971136A
Other languages
English (en)
Other versions
NO971136D0 (no
Inventor
Holger Heitsch
Adalbert Wagner
Klaus Wirth
Bernward Schoelkens
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of NO971136D0 publication Critical patent/NO971136D0/no
Publication of NO971136L publication Critical patent/NO971136L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Det er beskrevet aminoalkyl- og acylaminoalkyleter som utmerker seg ved en hoy affinitet for bradykinin-B2-reseptoren og forbedret vannopploselighet. Disse aminoalkyl- og acylaminoalkyleterene kan beskrives ved folgende generelle formel (1) O (CH2)fT N ^R^ (I) hvor R', r2, R^ alkyl, aryl, alkylaryl, halogen, hydrogen, cykloalkyl, CHO, CO-0- alkyl, COGH; R*^, R^, hydrogen, halogen, alkoksy, nitro, cyano, S-alkyl; n cr et tall fra 1 til 8; R° er hydrogen, alkyl, alkylalkenyl, a!kylar>l; R^ er hydrogen og en substituert eller usubstituert acylrest. Likeledes er det beskrevet en fremgangsmåte for fremstilling av forbindelsen med formel (I).
NO971136A 1996-03-13 1997-03-12 Aminoalkyl- og acylaminoalkyleter, fremgangsmåte for fremstilling derav og anvendelse som bradykinin-reseptor antagonister NO971136L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19609827A DE19609827A1 (de) 1996-03-13 1996-03-13 Aminoalkyl- und Acylaminoalkylether, Verfahren zu deren Herstellung und ihre Verwendung als Bradykinin-Rezeptorantagonisten

Publications (2)

Publication Number Publication Date
NO971136D0 NO971136D0 (no) 1997-03-12
NO971136L true NO971136L (no) 1997-09-15

Family

ID=7788139

Family Applications (1)

Application Number Title Priority Date Filing Date
NO971136A NO971136L (no) 1996-03-13 1997-03-12 Aminoalkyl- og acylaminoalkyleter, fremgangsmåte for fremstilling derav og anvendelse som bradykinin-reseptor antagonister

Country Status (26)

Country Link
US (1) US6140341A (no)
EP (1) EP0795547B1 (no)
JP (1) JP4317597B2 (no)
KR (1) KR970065521A (no)
AR (1) AR006189A1 (no)
AT (1) ATE192738T1 (no)
AU (1) AU1621797A (no)
BR (1) BR9701267A (no)
CA (1) CA2199771A1 (no)
CZ (1) CZ76697A3 (no)
DE (2) DE19609827A1 (no)
DK (1) DK0795547T3 (no)
ES (1) ES2148858T3 (no)
GR (1) GR3033415T3 (no)
HR (1) HRP970138A2 (no)
HU (1) HUP9700566A1 (no)
ID (1) ID16217A (no)
IL (1) IL120427A0 (no)
NO (1) NO971136L (no)
PL (1) PL318923A1 (no)
PT (1) PT795547E (no)
SI (1) SI0795547T1 (no)
SK (1) SK32097A3 (no)
TR (1) TR199700184A2 (no)
TW (1) TW363891B (no)
ZA (1) ZA972129B (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207679B1 (en) 1997-06-19 2001-03-27 Sepracor, Inc. Antimicrobial agents uses and compositions related thereto
US6376670B1 (en) 1997-06-19 2002-04-23 Sepracor Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
US6103905A (en) * 1997-06-19 2000-08-15 Sepracor, Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
EP0991623A2 (en) 1997-06-19 2000-04-12 Sepracor, Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
EP1914236A1 (en) 2002-04-10 2008-04-23 Ortho-McNeil Pharmaceutical, Inc. Novel heteroaryl alkylamide derivatives useful as bradykinin receptor modulators
ITMI20021247A1 (it) * 2002-06-07 2003-12-09 Menarini Ricerche Spa Antagonisti basici non peptidici della bradichinina e loro impiego informulazioni farmaceutiche
TWI407960B (zh) 2007-03-23 2013-09-11 Jerini Ag 小分子緩激肽ｂ２受體調節劑
US8076516B2 (en) 2007-11-01 2011-12-13 Acucela, Inc. Amine derivative compounds for treating ophthalmic diseases and disorders
SI3713928T1 (sl) 2017-11-24 2022-09-30 Pharvaris Netherlands B.V. Novi antagonisti receptorja bradikinina B2
AR118982A1 (es) 2019-05-23 2021-11-17 Pharvaris Gmbh Antagonistas cíclicos del receptor b2 de bradiquinina
AR118983A1 (es) 2019-05-23 2021-11-17 Pharvaris Gmbh Antagonistas cíclicos del receptor b2 de bradiquinina
EP4203919B1 (en) 2021-08-05 2024-01-31 Pharvaris GmbH Lipid-based composition for oral administration of bradykinin b2-receptor antagonists
US20250268887A1 (en) 2022-03-25 2025-08-28 Pharvaris Gmbh Therapeutic uses of bradykinin b2-receptor antagonists
TW202345810A (zh) 2022-03-25 2023-12-01 瑞士商帕法瑞斯有限責任公司 包含緩激肽ｂ２受體拮抗劑之固態延長釋放組成物
CA3250835A1 (en) 2022-03-25 2023-09-28 Pharvaris Gmbh SOLID COMPOSITION COMPRISING SOLUBILIZED BRADYKININ B2 RECEPTOR ANTAGONISTS

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5216165A (en) * 1990-10-03 1993-06-01 American Home Products Corporation N-substituted aminoquinolines as analgesic agents
US5288725A (en) * 1992-10-15 1994-02-22 Merck & Co., Inc. Pyrroloquinoline Bradykinin antagonist
AU680870B2 (en) * 1993-04-28 1997-08-14 Astellas Pharma Inc. New heterocyclic compounds
US6756388B1 (en) * 1993-10-12 2004-06-29 Pfizer Inc. Benzothiophenes and related compounds as estrogen agonists
KR970707098A (ko) * 1994-10-27 1997-12-01 후지야마 아키라 브라디키닌 길항제로서 피리도피리미돈, 퀴놀린 및 융합된 N-헤테로사이클(Pyridopyrimidones, quinolines and fused N-heterocycles as bradykinin antagonists)
FR2735128B1 (fr) * 1995-06-07 1997-07-25 Fournier Ind & Sante Nouveaux composes de benzenesulfonamide, leur procede de preparation et utilisation en therapeutique.
FR2737892B1 (fr) * 1995-08-17 1997-10-24 Fournier Ind & Sante Nouveaux composes de benzenesulfonamide, procede de preparation et utilisation en therapeutique

Also Published As

Publication number Publication date
SI0795547T1 (en) 2000-10-31
EP0795547A1 (de) 1997-09-17
SK32097A3 (en) 1998-01-14
TR199700184A2 (xx) 1997-10-21
PL318923A1 (en) 1997-09-15
JP4317597B2 (ja) 2009-08-19
TW363891B (en) 1999-07-11
CZ76697A3 (en) 1997-10-15
IL120427A0 (en) 1997-07-13
ZA972129B (en) 1997-09-15
PT795547E (pt) 2000-10-31
ES2148858T3 (es) 2000-10-16
MX9701857A (es) 1997-09-30
AR006189A1 (es) 1999-08-11
DE19609827A1 (de) 1997-09-18
AU1621797A (en) 1997-09-18
KR970065521A (ko) 1997-10-13
BR9701267A (pt) 1999-01-12
HRP970138A2 (en) 1998-04-30
JPH101472A (ja) 1998-01-06
DK0795547T3 (da) 2000-09-18
ATE192738T1 (de) 2000-05-15
HU9700566D0 (en) 1997-04-28
DE59701617D1 (de) 2000-06-15
EP0795547B1 (de) 2000-05-10
GR3033415T3 (en) 2000-09-29
NO971136D0 (no) 1997-03-12
US6140341A (en) 2000-10-31
CA2199771A1 (en) 1997-09-13
ID16217A (id) 1997-09-11
HUP9700566A1 (hu) 2000-08-28

Similar Documents

Publication Publication Date Title
NO971136L (no) Aminoalkyl- og acylaminoalkyleter, fremgangsmåte for fremstilling derav og anvendelse som bradykinin-reseptor antagonister
HRP20000182B1 (en) Processes and intermediates for preparing anti-cancer compounds
IE810210L (en) Preparing proline derivatives.
NO20054300L (no) Prosess for fremstilling av fenetylaminderivater
Molina et al. Iminophosphorane-mediated imidazole ring formation: A new and general entry to aplysinopsin-type alkaloids of marine origin.
PT80942A (fr) Procede de preparation de nouveaux derives du pyrrole
EP0127877A3 (en) Process for preparing cyanhydrine derivatives containing phosphorus
NO990335L (no) Arylsykloalkankarboksylestere, anvendelse derav, farmas°ytiske sammensetninger og fremstilling
EP2393779A2 (en) Process for the synthesis of cleistanthin
NZ201514A (en) 1-phenyl-2-substituted aminocarbonyl indole compounds and pharmaceutical compositions
CA1055032A (en) Process for the preparation of thieno (3,2-c) pyridine and thieno (2,3-c) pyridine
ES8606228A1 (es) Un procedimiento para separar los antipodas opticos de 1-pi-ridil-alquil-4-aril-piperazinas
NO960441L (no) Benzopyraner og farmasöytiske forbindelser inneholdende dem
DE3468104D1 (en) New aryloxypropanolamine derivatives, process for the preparation thereof, pharmaceutical compositions and therapeutic use
Atkins et al. Pseudohalogen chemistry. XI. Some aspects of the chemistry of α-thiocyanato-β-dicarbonyl compounds
CA2263268A1 (en) Process for the preparation of 3-amino-2-hydroxy-1-propyl ethers
Sharma et al. Studies on Fused. BETA.-Lactams: Synthesis of 1-Aza Analogs of Cephem.
Tasaka et al. Synthesis of 2‐phenylimidazo [2, 1‐b] benzothiazole derivatives as modulators of multidrug resistance for tumor cells
RO83468B (ro) Procedeu de obtinere a derivatilor de 5, 6, 7, 7a-tetrahidro-4h-tieno(3, 2-c)-piridin-2-onei
SU640663A3 (ru) Способ получени производных нитрохиназолинона
Dunn et al. Sulphur Analogues of Deoxyvasicinone
Wang et al. A Novel Synthesis of Thieno [2, 3-C] pyrazole
CA1193255A (en) Benzylazone derivatives
SE8502973L (sv) Framstellning av aminderivat
JPS5470277A (en) Hydroxyindole derivatives