[go: up one dir, main page]

NO970716L - Sekvens-spesifikke bindingsoligomerer for nukleinsyrer og deres anvendelse i antisense-strategier - Google Patents

Sekvens-spesifikke bindingsoligomerer for nukleinsyrer og deres anvendelse i antisense-strategier

Info

Publication number
NO970716L
NO970716L NO970716A NO970716A NO970716L NO 970716 L NO970716 L NO 970716L NO 970716 A NO970716 A NO 970716A NO 970716 A NO970716 A NO 970716A NO 970716 L NO970716 L NO 970716L
Authority
NO
Norway
Prior art keywords
sequence
nucleic acids
specific binding
antisense strategies
binding oligomers
Prior art date
Application number
NO970716A
Other languages
English (en)
Inventor
Piet Andre Maurits Herdewijn
Arthur Albert Edgard Aerschot
Original Assignee
Stichting Rega V Z W
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stichting Rega V Z W filed Critical Stichting Rega V Z W
Publication of NO970716L publication Critical patent/NO970716L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Oppfinnelsen vedrører oligomerer bestående full- stendig eller delvis av 1,5-anhydroheksitol-nukleo- sidanaloger representert ved den generelle formel (I), hvori B er en heterocyklisk ring som er avle- det fra en pyrimidin- eller purinbase, såsom cyto- sin, 5-metylcytosin, uracil og tymin, eller deaza- derivater derav, eller adenin, guanin, 2,6-diamino- purin, hypoxantin og xantin, eller deaza-derivater derav.
NO970716A 1994-08-17 1997-02-17 Sekvens-spesifikke bindingsoligomerer for nukleinsyrer og deres anvendelse i antisense-strategier NO970716L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP94202342 1994-08-17
US49515295A 1995-06-27 1995-06-27
PCT/EP1995/003248 WO1996005213A1 (en) 1994-08-17 1995-08-14 Sequence-specific binding oligomers for nucleic acids and their use in antisense strategies

Publications (1)

Publication Number Publication Date
NO970716L true NO970716L (no) 1997-02-17

Family

ID=26136490

Family Applications (1)

Application Number Title Priority Date Filing Date
NO970716A NO970716L (no) 1994-08-17 1997-02-17 Sekvens-spesifikke bindingsoligomerer for nukleinsyrer og deres anvendelse i antisense-strategier

Country Status (10)

Country Link
EP (1) EP0777676A1 (no)
JP (1) JP2000505778A (no)
CN (1) CN1158618A (no)
AU (1) AU3384595A (no)
CA (1) CA2196306A1 (no)
FI (1) FI970598A0 (no)
HU (1) HUT77509A (no)
NO (1) NO970716L (no)
NZ (1) NZ292140A (no)
WO (1) WO1996005213A1 (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1874397A (en) * 1996-02-16 1997-09-02 Stichting Rega Vzw Hexitol containing oligonucleotides and their use in antisense strategies
US7205106B1 (en) 2001-07-20 2007-04-17 Roche Molecular Systems, Inc. Association of polymorphisms in IL4-related genes with autoimmune disease
WO2003057910A2 (en) 2002-01-08 2003-07-17 Roche Diagnostics Gmbh Use of silica material in an amplification reaction
ATE319699T1 (de) * 2002-12-20 2006-03-15 Hoffmann La Roche Mannitol- und glucitolderivate
US7560231B2 (en) 2002-12-20 2009-07-14 Roche Molecular Systems, Inc. Mannitol and glucitol derivatives
EP1431297A1 (en) * 2002-12-20 2004-06-23 Boehringer Mannheim Gmbh Mannitol and glucitol derivatives
CA2463719A1 (en) 2003-04-05 2004-10-05 F. Hoffmann-La Roche Ag Nucleotide analogs with six membered rings
EP1466919A1 (en) * 2003-04-05 2004-10-13 Roche Diagnostics GmbH Nucleotide analogs with six membered rings
WO2006047842A2 (en) * 2004-11-08 2006-05-11 K.U. Leuven Research And Development Modified nucleosides for rna interference
EP2265627A2 (en) * 2008-02-07 2010-12-29 Isis Pharmaceuticals, Inc. Bicyclic cyclohexitol nucleic acid analogs

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL9300058A (nl) * 1992-06-18 1994-01-17 Stichting Rega V Z W 1,5-anhydrohexitol nucleoside analoga en farmaceutisch gebruik daarvan.
US5314893A (en) * 1993-01-25 1994-05-24 Bristol-Myers Squibb Co. Antiviral tetrahydropyrans

Also Published As

Publication number Publication date
FI970598A7 (fi) 1997-02-12
CN1158618A (zh) 1997-09-03
WO1996005213A1 (en) 1996-02-22
JP2000505778A (ja) 2000-05-16
MX9701111A (es) 1998-03-31
FI970598L (fi) 1997-02-12
HUT77509A (hu) 1998-05-28
CA2196306A1 (en) 1996-02-22
EP0777676A1 (en) 1997-06-11
FI970598A0 (fi) 1997-02-12
AU3384595A (en) 1996-03-07
NZ292140A (en) 1998-02-26

Similar Documents

Publication Publication Date Title
NZ507913A (en) Novel nucleosides having bicyclic sugar moiety
AU692658B2 (en) Nucleoside derivatives with photolabile protective groups
WO2002069903A3 (en) Nucleosides, preparation thereof and use as inhibitors of rna viral polymerases
WO1996018634B1 (de) Nucleosid-derivate mit photolabilen schutzgruppen
WO2000066604A3 (en) L-ribo-lna analogues
NO970716L (no) Sekvens-spesifikke bindingsoligomerer for nukleinsyrer og deres anvendelse i antisense-strategier
DE3751947D1 (de) Nucleosidderivate und ihre Verwendung in der Oligonucleotid-Synthese
DE3850571D1 (de) 2',3'-dideoxyribofuranoxid-derivate.
KR950032263A (ko) 2'-에테르 그룹을 갖는 뉴클레오사이드 및 올리고 뉴클레오타이드
RU2000129663A (ru) Новые нуклеозиды, имеющие бициклическую сахарную группировку
FI101793B1 (fi) Menetelmä uusien, terapeuttisesti käyttökelpoisten 9-purinyylifosfonihappojohdannaisten valmistamiseksi
CA2084790A1 (en) Endonucleases
EP1165560A4 (en) 2-HYDROXY METHYLCYCLOPROPYLIDENMETHYL PURINE AND -PYRIMIDINE AS AN ANTIVIRAL ACTIVE SUBSTANCES
DE60101223D1 (de) Antivirale pyrimidin nucleoside derivate
DE69110854D1 (de) Antivirusderivate von (Phosphonmethoxy)Methoxy Purin/Pyrimidin.
ES2166081T3 (es) Derivados de nucleosidos con grupos protectores fotolabiles.
EP0219838A3 (en) Carbocyclic purine nucleosides, their production and use
Nagatsugi et al. A new reactive nucleoside analogue for highly reactive and selective cross-linking reaction to cytidine under neutral conditions
JP2001517659A5 (no)
EP1204415A4 (en) ANALOGS OF 5 (E) BROMOVINYLURACILS AND RELATED PYRIMIDINE NUCLEOSIDES AS ANTIVIRAL AGENTS AND METHODS OF USE
ATE238334T1 (de) Nucleosid-derivate mit photolabilen schutzgruppen
Bergmeier et al. Synthesis and antiviral activity of novel aza-acyclonucleosides
Boesen et al. Preparation and antiviral properties of new acyclic, achiral nucleoside analogues: 1-or 9-[3-hydroxy-2-(hydroxymethyl) prop-1-enyl] nucleobases and 1-or 9-[2, 3-dihydroxy-2-(hydroxymethyl) propyl] nucleobases
NO924861L (no) Endonukleaser
RU97108066A (ru) Производные нуклеозидов и способ их получения