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NO975853L - Nye kationiske og polykationiske amfifile forbindelser, reagenser inneholdende slike samt deres anvendelse - Google Patents

Nye kationiske og polykationiske amfifile forbindelser, reagenser inneholdende slike samt deres anvendelse

Info

Publication number
NO975853L
NO975853L NO975853A NO975853A NO975853L NO 975853 L NO975853 L NO 975853L NO 975853 A NO975853 A NO 975853A NO 975853 A NO975853 A NO 975853A NO 975853 L NO975853 L NO 975853L
Authority
NO
Norway
Prior art keywords
amphiphilic compounds
new cationic
reagents containing
polycationic amphiphilic
polycationic
Prior art date
Application number
NO975853A
Other languages
English (en)
Other versions
NO975853D0 (no
Inventor
Erhard Fernholz
Herbert Von Der Eltz
Matthias Hinzpeter
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of NO975853D0 publication Critical patent/NO975853D0/no
Publication of NO975853L publication Critical patent/NO975853L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C219/08—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by a carboxylic acid having the esterifying carboxyl group bound to an acyclic carbon atom of an acyclic unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Nye kationiske og polykationiske amfifile forbindelser som er i stand til å danne aggregater med makromole- kyler, spesielt DNA eller RNA, og deres innføyelse i prokaryote eller eukaryote celler. Forbindelser med en spermyl- dioleoyloksypropylstruktur har vist seg som spesielt fordelaktige.
NO975853A 1995-06-14 1997-12-12 Nye kationiske og polykationiske amfifile forbindelser, reagenser inneholdende slike samt deres anvendelse NO975853L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19521412A DE19521412A1 (de) 1995-06-14 1995-06-14 Neue kationische und polykationische Amphiphile, diese enthaltende Reagenzien und deren Verwendung
PCT/EP1996/002541 WO1997000241A1 (de) 1995-06-14 1996-06-12 Neue kationische und polykationische amphiphile, diese enthaltende reagenzien und deren verwendung

Publications (2)

Publication Number Publication Date
NO975853D0 NO975853D0 (no) 1997-12-12
NO975853L true NO975853L (no) 1998-02-16

Family

ID=7764228

Family Applications (1)

Application Number Title Priority Date Filing Date
NO975853A NO975853L (no) 1995-06-14 1997-12-12 Nye kationiske og polykationiske amfifile forbindelser, reagenser inneholdende slike samt deres anvendelse

Country Status (14)

Country Link
US (1) US6060455A (no)
EP (1) EP0835238B1 (no)
JP (1) JPH11507659A (no)
KR (1) KR19990022909A (no)
CN (1) CN1193316A (no)
AT (1) ATE199246T1 (no)
AU (1) AU713587B2 (no)
CA (1) CA2224566A1 (no)
DE (2) DE19521412A1 (no)
HU (1) HUP9802738A3 (no)
IL (1) IL122530A0 (no)
NO (1) NO975853L (no)
RU (1) RU2179549C2 (no)
WO (1) WO1997000241A1 (no)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19631189A1 (de) * 1996-08-02 1998-02-05 Max Delbrueck Centrum Neuartige kationische Amphiphile für den liposomalen Gentransfer
DE19637043A1 (de) * 1996-09-12 1998-03-19 Boehringer Mannheim Gmbh Neue Aminoalkoholderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel und Reagenzien
US7097854B2 (en) 1996-09-12 2006-08-29 Medigene Oncology Gmbh Amino alcohol derivatives, process for their production and pharmaceutical preparations and reagents containing these compounds
FR2759382A1 (fr) 1997-02-10 1998-08-14 Transgene Sa Nouveaux composes et compositions les contenant utilisables pour le transfert d'au moins une substance therapeutiquement active, notamment un polynucleotide, dans une cellule cible et utilisation en therapie genique
FR2759367A1 (fr) * 1997-02-10 1998-08-14 Transgene Sa Glycerolipides cationiques et complexes de glycerolipides cationiques et de substances actives, notamment pour la transfection de cellules
US6235310B1 (en) 1997-04-04 2001-05-22 Valentis, Inc. Methods of delivery using cationic lipids and helper lipids
EP1003711B1 (de) * 1997-08-13 2001-11-07 Biontex Laboratories GmbH Neue lipopolyamine, deren darstellung und anwendung
ATE243045T1 (de) 1997-11-20 2003-07-15 Vical Inc Behandlung von krebs durch verwendung von zytokin-exprimierender polynukleotiden und zusammensetzungen dafür
CA2388053A1 (en) * 1999-10-08 2001-04-19 Nika Health Products Limited Cationic dosper virosomes
AU7868400A (en) 1999-10-08 2001-04-23 Alza Corporation Neutral-cationic lipid for nucleic acid and drug delivery
AU2637500A (en) * 1999-12-10 2001-06-18 Genzyme Corporation Cationic amphiphiles for intracellular delivery of therapeutic molecules
GB0106041D0 (en) * 2001-03-12 2001-05-02 Cancer Res Ventures Ltd Lipids and liposomes
RU2233834C2 (ru) * 2002-05-21 2004-08-10 Московская государственная академия тонкой химической технологии им. М.В. Ломоносова Катионные димерные амфифилы в качестве агентов трансфекции и способ их получения
AU2004246905B2 (en) * 2003-06-18 2010-01-21 Biolab Ltd. Sphingoid polyalkylamine conjugates for vaccination
KR100642200B1 (ko) 2004-06-08 2006-11-02 하숙태 겔상 보존제와 그 제조방법
DE102004057303A1 (de) * 2004-11-26 2006-06-01 Merck Patent Gmbh Stabile Kristallmodifikationen von DOTAP Chlorid
GB0720486D0 (en) * 2007-10-19 2007-11-28 Univ Edinburgh Cationic lipids
CN111909020A (zh) 2008-11-10 2020-11-10 阿布特斯生物制药公司 用于递送治疗剂的脂质和组合物
RU2409587C2 (ru) * 2009-03-04 2011-01-20 Государственное образовательное учреждение высшего профессионального образования "Московская государственная академия тонкой химической технологии имени М.В. Ломоносова" 1-гексадецил-5-(1-пиренбутил)-n-(l-орнитил)-l-глутамат бисхлорид
EP2467357B1 (en) * 2009-08-20 2016-03-30 Sirna Therapeutics, Inc. Novel cationic lipids with various head groups for oligonucleotide delivery
EP2575767B1 (en) 2010-06-04 2017-01-04 Sirna Therapeutics, Inc. Novel low molecular weight cationic lipids for oligonucleotide delivery
US10000445B2 (en) * 2011-05-20 2018-06-19 Merck Patent Gmbh Stable crystal modifications of DOTAP chloride
PT3597644T (pt) 2011-10-18 2021-11-03 Dicerna Pharmaceuticals Inc Lípidos catiónicos de amina e suas utilizações
NZ630990A (en) * 2012-03-16 2016-04-29 Merck Patent Gmbh Aminoacid lipids
EP2830594B1 (en) * 2012-03-27 2018-05-09 Sirna Therapeutics, Inc. DIETHER BASED BIODEGRADABLE CATIONIC LIPIDS FOR siRNA DELIVERY
GB2530224B (en) 2013-07-16 2020-08-05 Univ Leland Stanford Junior Enhancement of osteogenic potential of bone grafts
CN117285438A (zh) * 2022-08-12 2023-12-26 上海蓝鹊生物医药有限公司 含氮链状化合物、其制备方法、包含其的组合物和应用
CN116496193B (zh) * 2023-03-10 2026-01-02 圣诺生物医药技术(苏州)有限公司 一种氨基酸脂质形成的纳米递送系统及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4215146A (en) * 1977-08-18 1980-07-29 Pfizer Inc. Antiviral amine derivatives of glycerol and propanediols
US4166132A (en) * 1977-08-18 1979-08-28 Pfizer Inc. Antiviral amine derivatives of glycerol and propanediols
US5264618A (en) * 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
WO1993025673A1 (en) * 1992-06-04 1993-12-23 The Regents Of The University Of California In vivo gene therapy with intron-free sequence of interest
US5334761A (en) * 1992-08-28 1994-08-02 Life Technologies, Inc. Cationic lipids
US5747471A (en) * 1994-12-09 1998-05-05 Genzyme Corporation Cationic amphiphiles containing steroid lipophilic groups for intracellular delivery of therapeutic molecules

Also Published As

Publication number Publication date
DE19521412A1 (de) 1996-12-19
HUP9802738A3 (en) 2001-01-29
KR19990022909A (ko) 1999-03-25
RU2179549C2 (ru) 2002-02-20
NO975853D0 (no) 1997-12-12
MX9710078A (es) 1998-03-31
JPH11507659A (ja) 1999-07-06
WO1997000241A1 (de) 1997-01-03
AU713587B2 (en) 1999-12-02
CA2224566A1 (en) 1997-01-03
HUP9802738A2 (hu) 1999-03-29
US6060455A (en) 2000-05-09
CN1193316A (zh) 1998-09-16
EP0835238A1 (de) 1998-04-15
EP0835238B1 (de) 2001-02-21
IL122530A0 (en) 1998-06-15
DE59606469D1 (de) 2001-03-29
ATE199246T1 (de) 2001-03-15
AU6355396A (en) 1997-01-15

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