NO944567L - Cyklosporinholdige flytende preparater og fremgangsmåte ved deres fremstilling - Google Patents

Cyklosporinholdige flytende preparater og fremgangsmåte ved deres fremstilling

Info

Publication number: NO944567L
Authority: NO; Norway
Prior art keywords: cyclosporin; preparation; containing liquid; liquid preparations; compositions
Prior art date: 1993-11-30

Application number

NO944567A

Other languages

English (en)

Other versions

NO944567D0 (no

NO315932B1 (no

Inventor

Hatto Walch

Monika Fleck

Klaus Neuer

Original Assignee

Rentschler Arzneimittel

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-11-30

Filing date

1994-11-29

Publication date

1995-05-31

1994-11-29 Application filed by Rentschler Arzneimittel filed Critical Rentschler Arzneimittel

1994-11-29 Publication of NO944567D0 publication Critical patent/NO944567D0/no

1995-05-31 Publication of NO944567L publication Critical patent/NO944567L/no

2003-11-17 Publication of NO315932B1 publication Critical patent/NO315932B1/no

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 3
229930105110 Cyclosporin A Natural products 0.000 title abstract 3
108010036949 Cyclosporine Proteins 0.000 title abstract 3
229960001265 ciclosporin Drugs 0.000 title abstract 3
238000002360 preparation method Methods 0.000 title abstract 3
229930182912 cyclosporin Natural products 0.000 title abstract 2
239000007788 liquid Substances 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
239000000203 mixture Substances 0.000 abstract 3
239000004480 active ingredient Substances 0.000 abstract 1
235000014113 dietary fatty acids Nutrition 0.000 abstract 1
229930195729 fatty acid Natural products 0.000 abstract 1
239000000194 fatty acid Substances 0.000 abstract 1
150000004665 fatty acids Chemical class 0.000 abstract 1
238000007911 parenteral administration Methods 0.000 abstract 1
-1 polyoxyethylene glycerol Polymers 0.000 abstract 1
150000005846 sugar alcohols Polymers 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
General Chemical & Material Sciences (AREA)
Oil, Petroleum & Natural Gas (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Dispersion Chemistry (AREA)
Transplantation (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

NO19944567A 1993-11-30 1994-11-29 Cyklosporinholdige flytende preparater, nytt farmasöytisk preparat og fremgangsmåte ved fremstilling av preparatene samt deres anvendelse NO315932B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE4340781A DE4340781C3 (de)	1993-11-30	1993-11-30	Cyclosporin enthaltende flüssige Zubereitungen und Verfahren zu ihrer Herstellung
US08/347,289 US5614491A (en)	1993-11-30	1994-11-30	Liquid preparations containing cyclosporin and process for preparing same

Publications (3)

Publication Number	Publication Date
NO944567D0 NO944567D0 (no)	1994-11-29
NO944567L true NO944567L (no)	1995-05-31
NO315932B1 NO315932B1 (no)	2003-11-17

Family

ID=25931649

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19944567A NO315932B1 (no)	1993-11-30	1994-11-29	Cyklosporinholdige flytende preparater, nytt farmasöytisk preparat og fremgangsmåte ved fremstilling av preparatene samt deres anvendelse

Country Status (16)

Country	Link
US (1)	US5614491A (no)
EP (1)	EP0656212B1 (no)
JP (1)	JP4073503B2 (no)
AT (1)	ATE198833T1 (no)
CA (1)	CA2137025A1 (no)
CY (1)	CY2285B1 (no)
CZ (1)	CZ289316B6 (no)
DE (2)	DE4340781C3 (no)
DK (1)	DK0656212T3 (no)
ES (1)	ES2154661T3 (no)
FI (1)	FI111908B (no)
GR (1)	GR3035536T3 (no)
HU (1)	HU218934B (no)
NO (1)	NO315932B1 (no)
PT (1)	PT656212E (no)
SK (1)	SK282732B6 (no)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GEP20012547B (en) *	1995-08-25	2001-10-25	Sangstat Medical Corp	Oral Cyclosporin Formulation
US5827822A (en) *	1996-03-25	1998-10-27	Sangstat Medical Corporation	Cyclosporin a formulations as nanoparticles
US5834017A (en) *	1995-08-25	1998-11-10	Sangstat Medical Corporation	Oral cyclopsporin formulations
US5962019A (en) *	1995-08-25	1999-10-05	Sangstat Medical Corporation	Oral cyclosporin formulations
US5766629A (en) *	1995-08-25	1998-06-16	Sangstat Medical Corporation	Oral cyclosporin formulations
US5858401A (en) *	1996-01-22	1999-01-12	Sidmak Laboratories, Inc.	Pharmaceutical composition for cyclosporines
AU737053B2 (en)	1997-01-30	2001-08-09	Novartis Ag	Oil-free pharmaceutical compositions containing cyclosporin A
DK0969856T3 (da) *	1997-03-12	2005-05-02	Abbott Lab	Hydrofile, binære systemer til administrering af cyclosporin
US6346511B1 (en)	1997-09-08	2002-02-12	Panacea Biotec Limited	Pharmaceutical composition comprising cyclosporin
US6187747B1 (en)	1997-09-08	2001-02-13	Panacea Biotech Limited	Pharmaceutical composition comprising cyclosporin
US6008191A (en) *	1997-09-08	1999-12-28	Panacea Biotec Limited	Pharmaceutical compositions containing cyclosporin
AU754488B2 (en)	1998-09-17	2002-11-14	Bristol-Myers Squibb Company	Method for treating diabetes employing an aP2 inhibitor and combination
DK1154759T3 (da)	1998-12-30	2008-12-08	Dexcel Ltd	Dispergerbart koncentrat til indgift af cyclosporin
US6248363B1 (en) *	1999-11-23	2001-06-19	Lipocine, Inc.	Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US6761903B2 (en)	1999-06-30	2004-07-13	Lipocine, Inc.	Clear oil-containing pharmaceutical compositions containing a therapeutic agent
US6267985B1 (en)	1999-06-30	2001-07-31	Lipocine Inc.	Clear oil-containing pharmaceutical compositions
US6294192B1 (en)	1999-02-26	2001-09-25	Lipocine, Inc.	Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents
US7402559B2 (en) *	1999-03-24	2008-07-22	Msh Pharma, Incorporated	Composition and method of treatment for urogenital conditions
US6383471B1 (en)	1999-04-06	2002-05-07	Lipocine, Inc.	Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents
US6309663B1 (en)	1999-08-17	2001-10-30	Lipocine Inc.	Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents
US6982281B1 (en) *	2000-11-17	2006-01-03	Lipocine Inc	Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
US6458383B2 (en)	1999-08-17	2002-10-01	Lipocine, Inc.	Pharmaceutical dosage form for oral administration of hydrophilic drugs, particularly low molecular weight heparin
US20030236236A1 (en) *	1999-06-30	2003-12-25	Feng-Jing Chen	Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
US7732404B2 (en) *	1999-12-30	2010-06-08	Dexcel Ltd	Pro-nanodispersion for the delivery of cyclosporin
US7919113B2 (en) *	1999-12-30	2011-04-05	Yissum Research Development Company Of The Hebrew University Of Jerusalem	Dispersible concentrate lipospheres for delivery of active agents
ES2301618T3 (es) *	2001-01-25	2008-07-01	SMITH & NEPHEW, INC.	Sistema de contencion para restringir un componente protesico.
UA79766C2 (en) *	2001-12-14	2007-07-25	Yahotech Ag	Pharmaceutical formulation comprising cyclosporin and use thereof
JP5000848B2 (ja)	2002-05-21	2012-08-15	第一三共株式会社	グレリン含有医薬組成物
TW200409644A (en) *	2002-12-04	2004-06-16	Bio Max Inc	Improved carrier system for cyclosporin pharmaceutical compositions
US7842791B2 (en) *	2002-12-19	2010-11-30	Nancy Jean Britten	Dispersible pharmaceutical compositions
US20050059583A1 (en)	2003-09-15	2005-03-17	Allergan, Inc.	Methods of providing therapeutic effects using cyclosporin components
US20060003002A1 (en) *	2003-11-03	2006-01-05	Lipocine, Inc.	Pharmaceutical compositions with synchronized solubilizer release
ES2620326T3 (es)	2004-08-24	2017-06-28	Kangawa, Kenji	Preparación líquida de péptido fisiológicamente activo
US7288520B2 (en)	2005-07-13	2007-10-30	Allergan, Inc.	Cyclosporin compositions
US20070015691A1 (en)	2005-07-13	2007-01-18	Allergan, Inc.	Cyclosporin compositions
US20070015693A1 (en) *	2005-07-13	2007-01-18	Allergan, Inc.	Cyclosporin compositions
US7297679B2 (en) *	2005-07-13	2007-11-20	Allergan, Inc.	Cyclosporin compositions
US7202209B2 (en)	2005-07-13	2007-04-10	Allergan, Inc.	Cyclosporin compositions
US7276476B2 (en) *	2005-07-13	2007-10-02	Allergan, Inc.	Cyclosporin compositions
US7501393B2 (en) *	2005-07-27	2009-03-10	Allergan, Inc.	Pharmaceutical compositions comprising cyclosporins
US7745400B2 (en) *	2005-10-14	2010-06-29	Gregg Feinerman	Prevention and treatment of ocular side effects with a cyclosporin
US9839667B2 (en)	2005-10-14	2017-12-12	Allergan, Inc.	Prevention and treatment of ocular side effects with a cyclosporin
TW200932240A (en) *	2007-10-25	2009-08-01	Astellas Pharma Inc	Pharmaceutical composition containing lipophilic substance which inhibits IL-2 production
CA2718416C (en) *	2008-03-13	2018-01-02	Mallinckrodt Inc.	Multi-function, foot-activated controller for imaging system
US11304960B2 (en)	2009-01-08	2022-04-19	Chandrashekar Giliyar	Steroidal compositions
US9034858B2 (en)	2010-11-30	2015-05-19	Lipocine Inc.	High-strength testosterone undecanoate compositions
US9358241B2 (en)	2010-11-30	2016-06-07	Lipocine Inc.	High-strength testosterone undecanoate compositions
US20180153904A1 (en)	2010-11-30	2018-06-07	Lipocine Inc.	High-strength testosterone undecanoate compositions
US20120148675A1 (en)	2010-12-10	2012-06-14	Basawaraj Chickmath	Testosterone undecanoate compositions
JP2016528178A (ja) *	2013-06-03	2016-09-15	ジェニアスバイオメドインターナショナル	癌治療のための植物抽出物の新しい製剤
US9498485B2 (en)	2014-08-28	2016-11-22	Lipocine Inc.	Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters
US20170246187A1 (en)	2014-08-28	2017-08-31	Lipocine Inc.	(17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
US20160361322A1 (en)	2015-06-15	2016-12-15	Lipocine Inc.	Composition and method for oral delivery of androgen prodrugs
CA3078723A1 (en)	2016-11-28	2018-05-31	Nachiappan Chidambaram	Oral testosterone undecanoate therapy
US12150945B2 (en)	2018-07-20	2024-11-26	Lipocine Inc.	Liver disease

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI65914C (fi) *	1978-03-07	1984-08-10	Sandoz Ag	Foerfarande foer framstaellning av farmaceutiska kompositionerinnehaollande cyklosporin a
CH641356A5 (en) *	1979-02-27	1984-02-29	Sandoz Ag	Pharmaceutical compositions containing cyclosporin
GB8903804D0 (en) *	1989-02-20	1989-04-05	Sandoz Ltd	Improvements in or relating to organic compounds
SE8601624D0 (sv) *	1986-04-11	1986-04-11	Haessle Ab	New pharmaceutical preparations
HU201567B (en) *	1988-07-21	1990-11-28	Gyogyszerkutato Intezet	Process for production of intravenous medical compositions containing cyclosphorin
GB2222770B (en) *	1988-09-16	1992-07-29	Sandoz Ltd	Pharmaceutical compositions containing cyclosporins
FR2642650B1 (fr) *	1989-02-09	1994-12-09	Sandoz Sa	Nouvelles compositions pharmaceutiques a base de cyclosporines
HU208491B (en) *	1990-11-27	1993-11-29	Gyogyszerkutato Intezet	Process for producing oral pharmaceutical composition containing cyclosporin
GB9113872D0 (en) *	1991-06-27	1991-08-14	Sandoz Ag	Improvements in or relating to organic compounds
US5206219A (en) *	1991-11-25	1993-04-27	Applied Analytical Industries, Inc.	Oral compositions of proteinaceous medicaments
DE4230876A1 (de) *	1992-03-17	1993-09-23	Asta Medica Ag	Druckgaspackungen unter verwendung von polyoxyethylen-glyceryl-oleaten
ES2168271T3 (es) *	1992-09-25	2002-06-16	Novartis Ag	Composiciones farmaceuticas que contienen ciclosporinas.

1993
- 1993-11-30 DE DE4340781A patent/DE4340781C3/de not_active Expired - Fee Related
1994
- 1994-11-08 PT PT94117612T patent/PT656212E/pt unknown
- 1994-11-08 DK DK94117612T patent/DK0656212T3/da active
- 1994-11-08 DE DE59409644T patent/DE59409644D1/de not_active Expired - Fee Related
- 1994-11-08 AT AT94117612T patent/ATE198833T1/de not_active IP Right Cessation
- 1994-11-08 ES ES94117612T patent/ES2154661T3/es not_active Expired - Lifetime
- 1994-11-08 EP EP94117612A patent/EP0656212B1/de not_active Expired - Lifetime
- 1994-11-22 CZ CZ19942876A patent/CZ289316B6/cs not_active IP Right Cessation
- 1994-11-23 SK SK1423-94A patent/SK282732B6/sk not_active IP Right Cessation
- 1994-11-29 HU HU9403420A patent/HU218934B/hu not_active IP Right Cessation
- 1994-11-29 NO NO19944567A patent/NO315932B1/no not_active IP Right Cessation
- 1994-11-29 FI FI945619A patent/FI111908B/fi active
- 1994-11-30 US US08/347,289 patent/US5614491A/en not_active Expired - Lifetime
- 1994-11-30 JP JP29707494A patent/JP4073503B2/ja not_active Expired - Fee Related
- 1994-11-30 CA CA002137025A patent/CA2137025A1/en not_active Abandoned
2001
- 2001-03-09 GR GR20010400377T patent/GR3035536T3/el not_active IP Right Cessation
2002
- 2002-05-29 CY CY0200039A patent/CY2285B1/xx unknown

Also Published As

Publication number	Publication date
US5614491A (en)	1997-03-25
EP0656212A1 (de)	1995-06-07
SK142394A3 (en)	1995-06-07
EP0656212B1 (de)	2001-01-24
NO944567D0 (no)	1994-11-29
HU9403420D0 (en)	1995-02-28
GR3035536T3 (en)	2001-06-29
NO315932B1 (no)	2003-11-17
ES2154661T3 (es)	2001-04-16
JPH07252162A (ja)	1995-10-03
DE59409644D1 (de)	2001-03-01
CY2285B1 (en)	2003-07-04
DE4340781A1 (de)	1995-06-01
CA2137025A1 (en)	1995-05-31
FI945619L (fi)	1995-05-31
CZ289316B6 (cs)	2002-01-16
DK0656212T3 (da)	2001-04-09
HU218934B (hu)	2001-01-29
DE4340781C2 (de)	1995-11-09
DE4340781C3 (de)	2000-01-27
FI945619A0 (fi)	1994-11-29
FI111908B (fi)	2003-10-15
JP4073503B2 (ja)	2008-04-09
ATE198833T1 (de)	2001-02-15
PT656212E (pt)	2001-06-29
SK282732B6 (sk)	2002-11-06
CZ287694A3 (en)	1995-07-12
HUT68795A (en)	1995-07-28

Publication	Publication Date	Title
NO944567L (no)	1995-05-31	Cyklosporinholdige flytende preparater og fremgangsmåte ved deres fremstilling
MY111841A (en)	2001-01-31	Injectable liposomal pharmaceutical preparations
HK86593A (en)	1993-08-27	Pharmaceutical compositions containing cyclosporins
FI960032L (fi)	1996-02-09	Farmaseuttisia koostumuksia vaikeasti liukenevia aktiiviaineita varten
WO2002080976A3 (en)	2003-01-09	Hsa-free formulations of interferon-beta
ATE554750T1 (de)	2012-05-15	Hydrophobe pharmazeutische wirkstoffe enthaltende zubereitungen
DK0588539T3 (da)	1997-03-10	Stabiliserede farmaceutiske præparater indeholdende derivater af vitamin D2 og D3
HUT61989A (en)	1993-03-29	Process for producing 2-deoxy-2,3-didehydro-n-acetylneuraminic acid derivatives and analogs, as well as pharmaceutical compositions comprising same as active ingredient
ZA966067B (en)	1997-04-07	New pharmaceutical dosage formulations of fenofibrate and their applications
GR3004448T3 (no)	1993-03-31
CA2133175A1 (en)	1995-03-31	Rapamycin formulations for oral administration
EE03425B1 (et)	2001-06-15	Lihtsa koostise ja kõrge biosaadavusega tsüklosporiini preparaadid suu kaudu manustamiseks ja nende valmistamismeetod
NO20031901D0 (no)	2003-04-28	Farmasöytiske preparater
CA2109623A1 (en)	1993-01-07	Process for solubilizing difficultly soluble pharmaceutical actives
ATA27290A (de)	1998-05-15	Neue cyclosporin enthaltende galenische formulierungen
EP0317281A3 (en)	1989-08-09	Pharmaceutical formulations containing melphalan or melphalan hydrochloride, as well as melphalan and melphalan hydrochloride and processes for preparing them
HUP9801052A2 (hu)	1998-09-28	Orális ciklosporin készítmények
DK0648494T3 (da)	1999-08-09	Rapamycin-præparater til oral indgivelse
ZA978099B (en)	1998-03-27	Controlled release pharmaceutical compositions for the oral administration containing nifedipine as active substance.
IL87778A0 (en)	1989-03-31	Pharmaceutical compositions containing stabilized therapeutically active proteins and their preparation
UA74388C2 (uk)	2005-12-15	Фармацевтичні композиції тизоксаніду і нітазоксаніду
EP1084710A4 (en)	2004-10-06	DRUGS AGAINST MALE STERILITY
ATE136783T1 (de)	1996-05-15	Arzneimittel mit antineoplastischer wirkung enthaltend als wirkstoff octadecyl-(2-(n- methylpiperidino)-ethyl>-phosphat und verfahren zu dessen herstellung
HUT60737A (en)	1992-10-28	Process for producing new 1,4-dihydropyridine derivatives and pharmaceutical compositions comprising same as active ingredient
EP0265338A3 (en)	1989-04-05	Stable therapeutical compositions based on hydrophobic vegetable oil, and process for preparing them

Legal Events

Date	Code	Title	Description
2010-06-28	MM1K	Lapsed by not paying the annual fees