[go: up one dir, main page]

NO933599D0 - Heterosykliske aminer anvendelige i terapien av astma og inflammasjon i den respiratoriske trakt - Google Patents

Heterosykliske aminer anvendelige i terapien av astma og inflammasjon i den respiratoriske trakt

Info

Publication number
NO933599D0
NO933599D0 NO1993933599A NO933599A NO933599D0 NO 933599 D0 NO933599 D0 NO 933599D0 NO 1993933599 A NO1993933599 A NO 1993933599A NO 933599 A NO933599 A NO 933599A NO 933599 D0 NO933599 D0 NO 933599D0
Authority
NO
Norway
Prior art keywords
respiratory tract
asthma
inflammation
therapy
pct
Prior art date
Application number
NO1993933599A
Other languages
English (en)
Other versions
NO180165C (no
NO180165B (no
NO933599L (no
Inventor
Giorgio Long
Carmelo A Gandolfi
Gianpiero De Cillis
Roberto Di Domenico
Antonella Rossi
Licia Gallico
Original Assignee
Boehringer Mannheim Italia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Italia filed Critical Boehringer Mannheim Italia
Publication of NO933599D0 publication Critical patent/NO933599D0/no
Publication of NO933599L publication Critical patent/NO933599L/no
Publication of NO180165B publication Critical patent/NO180165B/no
Publication of NO180165C publication Critical patent/NO180165C/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO933599A 1991-04-09 1993-10-08 Heterocykliske aminer anvendelige i terapien av astma og inflammasjon i den respiratoriske trakt NO180165C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI910966A IT1245712B (it) 1991-04-09 1991-04-09 Ammine eterocicliche utili terapia dell'asma e dell'infiammazione delle vie aeree
PCT/EP1992/000724 WO1992018478A1 (en) 1991-04-09 1992-04-01 Heterocyclic amines useful in the therapy of asthma and inflammation of the respiratory tract

Publications (4)

Publication Number Publication Date
NO933599D0 true NO933599D0 (no) 1993-10-08
NO933599L NO933599L (no) 1993-11-12
NO180165B NO180165B (no) 1996-11-18
NO180165C NO180165C (no) 1997-02-26

Family

ID=11359495

Family Applications (1)

Application Number Title Priority Date Filing Date
NO933599A NO180165C (no) 1991-04-09 1993-10-08 Heterocykliske aminer anvendelige i terapien av astma og inflammasjon i den respiratoriske trakt

Country Status (20)

Country Link
US (1) US5453423A (no)
EP (1) EP0580633B1 (no)
JP (1) JP3218037B2 (no)
KR (1) KR100239168B1 (no)
AT (1) ATE167470T1 (no)
AU (1) AU653393B2 (no)
CA (1) CA2107115A1 (no)
DE (1) DE69225967T2 (no)
HU (2) HUT69702A (no)
IE (1) IE921117A1 (no)
IT (1) IT1245712B (no)
MX (1) MX9201621A (no)
NO (1) NO180165C (no)
NZ (1) NZ242282A (no)
PH (1) PH30438A (no)
PT (1) PT100352B (no)
RU (1) RU2108325C1 (no)
TW (1) TW212178B (no)
WO (1) WO1992018478A1 (no)
ZA (1) ZA922541B (no)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1255704B (it) * 1992-09-30 1995-11-10 Boehringer Mannheim Italia Ammine eterocicliche utili nella terapia dell'asma e dell'infiammazione delle vie aeree
IL115420A0 (en) 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives
US5859031A (en) * 1995-06-07 1999-01-12 Gpi Nil Holdings, Inc. Small molecule inhibitors of rotamase enzyme activity
US7056935B2 (en) 1995-06-07 2006-06-06 Gpi Nil Holdings, Inc. Rotamase enzyme activity inhibitors
GB9516709D0 (en) * 1995-08-15 1995-10-18 Zeneca Ltd Medicament
US5801197A (en) * 1995-10-31 1998-09-01 Gpi Nil Holdings, Inc. Rotamase enzyme activity inhibitors
GB9602166D0 (en) 1996-02-02 1996-04-03 Zeneca Ltd Aminoheterocyclic derivatives
EP0880501A1 (en) 1996-02-02 1998-12-02 Zeneca Limited Heterocyclic compounds useful as pharmaceutical agents
DE69718177T2 (de) * 1996-08-14 2003-10-23 Astrazeneca Ab, Soedertaelje Substituierte pyrimidinderivate und ihre pharmazeutische anwendung
NZ334389A (en) * 1996-08-28 2001-05-25 Ube Industries Cyclic amine derivatives
US6218424B1 (en) 1996-09-25 2001-04-17 Gpi Nil Holdings, Inc. Heterocyclic ketone and thioester compounds and uses
US5801187A (en) 1996-09-25 1998-09-01 Gpi-Nil Holdings, Inc. Heterocyclic esters and amides
US5786378A (en) * 1996-09-25 1998-07-28 Gpi Nil Holdings, Inc. Heterocyclic thioesters
UA56197C2 (uk) 1996-11-08 2003-05-15 Зенека Лімітед Гетероциклічні похідні
US6391880B1 (en) 1997-02-13 2002-05-21 Zeneca Limited Heterocyclic compounds useful as oxido-squalene cyclase inhibitors
AU5999698A (en) 1997-02-13 1998-09-08 Zeneca Limited Heterocyclic compounds useful as oxido-squalene cyclase inhibitors
US20010049381A1 (en) 1997-06-04 2001-12-06 Gpl Nil Holdings, Inc., Pyrrolidine derivative hair growth compositions and uses
US6271244B1 (en) 1998-06-03 2001-08-07 Gpi Nil Holdings, Inc. N-linked urea or carbamate of heterocyclic thioester hair growth compositions and uses
US6187784B1 (en) 1998-06-03 2001-02-13 Gpi Nil Holdings, Inc. Pipecolic acid derivative hair growth compositions and uses
US5945441A (en) 1997-06-04 1999-08-31 Gpi Nil Holdings, Inc. Pyrrolidine carboxylate hair revitalizing agents
US6274602B1 (en) 1998-06-03 2001-08-14 Gpi Nil Holdings, Inc. Heterocyclic thioester and ketone hair growth compositions and uses
US6187796B1 (en) 1998-06-03 2001-02-13 Gpi Nil Holdings, Inc. Sulfone hair growth compositions and uses
GB9715895D0 (en) 1997-07-29 1997-10-01 Zeneca Ltd Heterocyclic compounds
EP1085853A1 (en) 1998-06-03 2001-03-28 GPI NIL Holdings, Inc. Heterocyclic ester and amide hair growth compositions and uses
US6429215B1 (en) 1998-06-03 2002-08-06 Gpi Nil Holdings, Inc. N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
US6172087B1 (en) 1998-06-03 2001-01-09 Gpi Nil Holding, Inc. N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
US6399648B1 (en) 1998-08-14 2002-06-04 Gpi Nil Holdings, Inc. N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders
US6218423B1 (en) 1998-08-14 2001-04-17 Gpi Nil Holdings, Inc. Pyrrolidine derivatives for vision and memory disorders
US6335348B1 (en) 1998-08-14 2002-01-01 Gpi Nil Holdings, Inc. Nitrogen-containing linear and azepinyl/ compositions and uses for vision and memory disorders
US7338976B1 (en) 1998-08-14 2008-03-04 Gpi Nil Holdings, Inc. Heterocyclic esters or amides for vision and memory disorders
US6506788B1 (en) 1998-08-14 2003-01-14 Gpi Nil Holdings, Inc. N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders
US6384056B1 (en) 1998-08-14 2002-05-07 Gpi Nil Holdings, Inc. Heterocyclic thioesters or ketones for vision and memory disorders
US6376517B1 (en) 1998-08-14 2002-04-23 Gpi Nil Holdings, Inc. Pipecolic acid derivatives for vision and memory disorders
US6333340B1 (en) 1998-08-14 2001-12-25 Gpi Nil Holdings, Inc. Small molecule sulfonamides for vision and memory disorders
US6339101B1 (en) 1998-08-14 2002-01-15 Gpi Nil Holdings, Inc. N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders
US6337340B1 (en) 1998-08-14 2002-01-08 Gpi Nil Holdings, Inc. Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vision and memory disorders
US6395758B1 (en) 1998-08-14 2002-05-28 Gpi Nil Holdings, Inc. Small molecule carbamates or ureas for vision and memory disorders
US6462072B1 (en) 1998-09-21 2002-10-08 Gpi Nil Holdings, Inc. Cyclic ester or amide derivatives
RU2202539C2 (ru) * 1998-11-10 2003-04-20 Ф.Хоффманн-Ля Рош Аг Производные n-(4-карбамимидофенил)глицинамида, промежуточные соединения, способ получения и фармкомпозиция
GB9902989D0 (en) 1999-02-11 1999-03-31 Zeneca Ltd Heterocyclic derivatives
JP2000256396A (ja) * 1999-03-03 2000-09-19 Dainippon Pharmaceut Co Ltd 複素環式化合物およびその中間体ならびにエラスターゼ阻害剤
US6797820B2 (en) 1999-12-17 2004-09-28 Vicuron Pharmaceuticals Inc. Succinate compounds, compositions and methods of use and preparation
US6809093B2 (en) * 2000-10-17 2004-10-26 H. Lee Moffitt Cancer & Research Institute, Inc. 2-substituted heterocyclic compounds
US6693099B2 (en) 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
US6376514B1 (en) 2000-10-17 2002-04-23 The Procter & Gamble Co. Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof
WO2002066035A2 (en) * 2001-02-20 2002-08-29 Chugai Seiyaku Kabushiki Kaisha Azoles as malonyl-coa decarboxylase inhibitors useful as metabolic modulators
AR036053A1 (es) * 2001-06-15 2004-08-04 Versicor Inc Compuestos de n-formil-hidroxilamina, un proceso para su preparacion y composiciones farmaceuticas
ATE360014T1 (de) * 2001-06-15 2007-05-15 Vicuron Pharm Inc Bicyclische pyrrolidinverbindungen
DE10228132A1 (de) * 2002-06-24 2004-01-22 Arzneimittelwerk Dresden Gmbh Amide cyclischer Aminosäuren als PDE 4 Inhibitoren
JP4769082B2 (ja) * 2003-12-17 2011-09-07 武田薬品工業株式会社 ウレア誘導体、その製造法及び用途
US7767677B2 (en) 2004-09-20 2010-08-03 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
AR051094A1 (es) 2004-09-20 2006-12-20 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa
CA2580844A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as mediators of stearoyl-coa desaturase
US7919496B2 (en) 2004-09-20 2011-04-05 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-CoA desaturase enzymes
JP4958785B2 (ja) 2004-09-20 2012-06-20 ゼノン・ファーマシューティカルズ・インコーポレイテッド 複素環誘導体およびステアロイル−CoAデサチュラーゼインヒビターとしてのそれらの使用
CN101084211A (zh) 2004-09-20 2007-12-05 泽农医药公司 杂环衍生物及其作为治疗剂的用途
WO2006034441A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
EP2540296A1 (en) 2005-06-03 2013-01-02 Xenon Pharmaceuticals Inc. Arminothiazole derivatives as human stearoyl-coa desaturase inhibitors
EA201201081A1 (ru) * 2010-02-05 2013-03-29 Мерк Патент Гмбх Производные гетарил[1,8]нафтиридина

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1216119B (it) * 1988-03-17 1990-02-22 Boehringer Biochemia Srl Beta_carbonil_carbossiamidi di 1,3_tiazolidine.
EP0348541B1 (en) * 1988-06-29 1992-04-01 YASON S.r.l N-carbethoxy-4-thiazolidine-carboxylic acid, process for its preparation and its use as medicament
FR2663026B1 (fr) * 1990-06-07 1992-08-07 Synthelabo Derives de [(1-arylpyrrolidin-2-yl) methyl] piperazine, leur preparation et leur application en therapeutique.
FR2669029B1 (fr) * 1990-11-14 1994-09-02 Adir Nouveaux derives de la n-benzoyl proline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2680508B1 (fr) * 1991-08-20 1995-03-03 Adir Nouveaux composes amidiques des 1-(alcoxybenzyl)piperazines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
JPH06506450A (ja) 1994-07-21
IT1245712B (it) 1994-10-14
ITMI910966A0 (it) 1991-04-09
IE921117A1 (en) 1992-10-21
NZ242282A (en) 1993-07-27
JP3218037B2 (ja) 2001-10-15
PT100352B (pt) 1999-06-30
ITMI910966A1 (it) 1992-10-09
ATE167470T1 (de) 1998-07-15
WO1992018478A1 (en) 1992-10-29
NO180165C (no) 1997-02-26
EP0580633A1 (en) 1994-02-02
TW212178B (no) 1993-09-01
EP0580633B1 (en) 1998-06-17
HU9302701D0 (en) 1993-12-28
CA2107115A1 (en) 1992-10-10
DE69225967D1 (de) 1998-07-23
PT100352A (pt) 1993-07-30
NO180165B (no) 1996-11-18
HU211968A9 (en) 1996-01-29
DE69225967T2 (de) 1999-02-18
KR100239168B1 (en) 2000-02-01
AU1447592A (en) 1992-11-17
RU2108325C1 (ru) 1998-04-10
US5453423A (en) 1995-09-26
AU653393B2 (en) 1994-09-29
HUT69702A (en) 1995-09-28
ZA922541B (en) 1993-10-08
NO933599L (no) 1993-11-12
MX9201621A (es) 1992-10-01
PH30438A (en) 1997-05-09

Similar Documents

Publication Publication Date Title
NO180165C (no) Heterocykliske aminer anvendelige i terapien av astma og inflammasjon i den respiratoriske trakt
NO306111B1 (no) Pyrazoler og pyrazolopyrimidiner med CRF antagonist aktivitet
RU93058261A (ru) Гетероциклические амины, используемые в терапии астмы и воспаления респираторного тракта
BG103399A (en) New heterocycle-substituted benzamides and their application for the treatment of diseases
DE69229674D1 (de) 5-ht4 rezeptor antagonisten
TR199801180T2 (xx) Aneljestik etkiye sahip yeni bile�ikler.
EE03829B1 (et) Bensonaftüridiinid, nende kasutamine bronhiaalravimi valmistamiseks ning neid sisaldav ravim
NO982989L (no) Anvendelse av inhibitorer av den cellulµre Na+/H+-utbytteren (NHE) for fremstilling av et medikament for respiratorstimulering
TW238305B (no)
ES2097822T3 (es) Nuevos derivados de piridina, su procedimiento de produccion y su utilizacion como medicamentos.
DK0743940T3 (da) Nye forbindelser med analgetisk og local-anæstetisk virkning
DK0583271T3 (da) Arylmorpholin, fremstilling og anvendelse
DE69525633D1 (de) Chinoxalinderivate und ihre therapeutische verwendbarkeit
DK0728138T3 (da) Anthracyclinderivater
NO923226L (no) Nytt beta-fenylisoserinderivat, dets fremstilling og anvendelse
HUT76801A (en) 3-substituted 3h-2,3-benzodiazepine derivatives, their preparation and medicaments containing them
DK1119501T3 (da) Apparat til organisering af den kombinerede brug af topiske aerosoler og orale medikamenter
NO941084D0 (no) Neuroleptiske 2-substituerte perhydro-1-H-pyrido[1,2-aÅpyraziner
DE69131353D1 (de) Indolderivate

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees

Free format text: LAPSED IN OCTOBER 2003