NO930505D0 - Nye azaindoler, fremgangsmaate for deres fremstilling og farmasoeytiske preparater derav - Google Patents
Nye azaindoler, fremgangsmaate for deres fremstilling og farmasoeytiske preparater deravInfo
- Publication number
- NO930505D0 NO930505D0 NO930505A NO930505A NO930505D0 NO 930505 D0 NO930505 D0 NO 930505D0 NO 930505 A NO930505 A NO 930505A NO 930505 A NO930505 A NO 930505A NO 930505 D0 NO930505 D0 NO 930505D0
- Authority
- NO
- Norway
- Prior art keywords
- cycloalkyl
- alkyl
- optionally substituted
- preparation
- phenyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 150000002475 indoles Chemical class 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- -1 R5 and R6 denote H Chemical group 0.000 abstract 2
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Chemical compound CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000006350 alkyl thio alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000000879 anti-atherosclerotic effect Effects 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 230000000055 hyoplipidemic effect Effects 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 229930192474 thiophene Natural products 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9201701A FR2687402B1 (fr) | 1992-02-14 | 1992-02-14 | Nouveaux azaindoles, procedes de preparation et medicaments les contenant. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO930505D0 true NO930505D0 (no) | 1993-02-12 |
| NO930505L NO930505L (no) | 1993-08-16 |
Family
ID=9426663
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO93930505A NO930505L (no) | 1992-02-14 | 1993-02-12 | Nye azaindoler, fremgangsmaate for deres fremstilling og farmasoeytiske preparater derav |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US5338849A (no) |
| EP (1) | EP0557171B1 (no) |
| JP (1) | JPH061788A (no) |
| KR (1) | KR930017905A (no) |
| AT (1) | ATE125257T1 (no) |
| AU (1) | AU658475B2 (no) |
| CA (1) | CA2089470A1 (no) |
| CZ (1) | CZ16893A3 (no) |
| DE (1) | DE69300268T2 (no) |
| DK (1) | DK0557171T3 (no) |
| ES (1) | ES2076827T3 (no) |
| FR (1) | FR2687402B1 (no) |
| GR (1) | GR3017614T3 (no) |
| HR (1) | HRP930180A2 (no) |
| HU (1) | HUT64067A (no) |
| IL (1) | IL104573A0 (no) |
| LT (1) | LT3065B (no) |
| LV (1) | LV10453B (no) |
| MA (1) | MA22797A1 (no) |
| MX (1) | MX9300745A (no) |
| NO (1) | NO930505L (no) |
| NZ (1) | NZ245869A (no) |
| OA (1) | OA09775A (no) |
| SI (1) | SI9300076A (no) |
| SK (1) | SK9093A3 (no) |
| TN (1) | TNSN93016A1 (no) |
| ZA (1) | ZA93844B (no) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9226855D0 (en) * | 1992-12-23 | 1993-02-17 | Erba Carlo Spa | Vinylene-azaindole derivatives and process for their preparation |
| US5547966A (en) * | 1993-10-07 | 1996-08-20 | Bristol-Myers Squibb Company | Aryl urea and related compounds |
| KR20000057137A (ko) | 1996-11-19 | 2000-09-15 | 스티븐 엠. 오드레 | 아릴 및 헤테로아릴로 치환된 융합 피롤 항염증제 |
| TR200001079T2 (tr) | 1997-10-20 | 2000-07-21 | F.Hoffmann-La Roche Ag | Bisiklik kinaz inhibitörleri. |
| AU765802B2 (en) * | 1997-12-16 | 2003-10-02 | Warner-Lambert Company | 1-substituted-1-aminomethyl-cycloalkane derivatives (=gabapentin analogues), their preparation and their use in the treatment of neurological disorders |
| US6187777B1 (en) | 1998-02-06 | 2001-02-13 | Amgen Inc. | Compounds and methods which modulate feeding behavior and related diseases |
| CN1615873A (zh) | 1999-12-24 | 2005-05-18 | 阿文蒂斯药物有限公司 | 氮杂吲哚类化合物 |
| GB0115109D0 (en) * | 2001-06-21 | 2001-08-15 | Aventis Pharma Ltd | Chemical compounds |
| US7268230B2 (en) * | 2002-02-01 | 2007-09-11 | Astrazeneca Ab | Quinazoline compounds |
| GB0207637D0 (en) * | 2002-04-02 | 2002-05-15 | Karobio Ab | Novel compound |
| SE0301372D0 (sv) * | 2003-05-09 | 2003-05-09 | Astrazeneca Ab | Novel compounds |
| PL1696920T3 (pl) * | 2003-12-19 | 2015-03-31 | Plexxikon Inc | Związki i sposoby opracowywania modulatorów Ret |
| US20070066641A1 (en) * | 2003-12-19 | 2007-03-22 | Prabha Ibrahim | Compounds and methods for development of RET modulators |
| KR101298951B1 (ko) | 2004-03-30 | 2013-09-30 | 버텍스 파마슈티칼스 인코포레이티드 | Ｊａｋ 및 기타 단백질 키나제의 억제제로서 유용한아자인돌 |
| US20060058339A1 (en) * | 2004-06-17 | 2006-03-16 | Ibrahim Prabha N | Compounds modulating c-kit activity and uses therefor |
| US7498342B2 (en) * | 2004-06-17 | 2009-03-03 | Plexxikon, Inc. | Compounds modulating c-kit activity |
| US7361764B2 (en) | 2004-07-27 | 2008-04-22 | Sgx Pharmaceuticals, Inc. | Pyrrolo-pyridine kinase modulators |
| EP1778687A2 (en) * | 2004-07-27 | 2007-05-02 | SGX Pharmaceuticals, Inc. | Fused ring heterocycle kinase modulators |
| US7626021B2 (en) * | 2004-07-27 | 2009-12-01 | Sgx Pharmaceuticals, Inc. | Fused ring heterocycle kinase modulators |
| CA2573362A1 (en) | 2004-07-27 | 2006-02-09 | Sgx Pharmaceuticals, Inc. | Pyrrolo-pyridine kinase modulators |
| KR101913531B1 (ko) * | 2004-07-28 | 2018-10-30 | 다케다 야쿠힌 고교 가부시키가이샤 | 피롤로〔2,3-ｃ〕피리딘 화합물, 그 제조 방법 및 용도 |
| US20060183758A1 (en) * | 2005-02-17 | 2006-08-17 | Cb Research And Development, Inc. | Method for synthesis of AZA-annelated pyrroles, thiophenes, and furans |
| US7846941B2 (en) * | 2005-05-17 | 2010-12-07 | Plexxikon, Inc. | Compounds modulating c-kit and c-fms activity and uses therefor |
| MX2007016463A (es) * | 2005-06-22 | 2008-03-04 | Plexxikon Inc | Derivados de pirrolo [2,3-b] piridina como inhibidores de proteina cinasa. |
| TWI423976B (zh) * | 2006-01-17 | 2014-01-21 | Vertex Pharma | 適合作為傑納斯激酶（ｊａｎｕｓ ｋｉｎａｓｅ）抑制劑之氮雜吲哚 |
| WO2008063888A2 (en) | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
| US7872018B2 (en) | 2006-12-21 | 2011-01-18 | Plexxikon, Inc. | Compounds and methods for kinase modulation, and indications therefor |
| PE20121126A1 (es) * | 2006-12-21 | 2012-08-24 | Plexxikon Inc | Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa |
| EP2815750A1 (en) | 2006-12-21 | 2014-12-24 | Vertex Pharmaceuticals Incorporated | 5-cyano-4-(pyrrolo [2,3b] pyridine-3-yl)-pyrimidine derivatives useful as protein kinase inhibitors |
| WO2008079909A1 (en) * | 2006-12-21 | 2008-07-03 | Plexxikon, Inc. | Pyrrolo [2,3-b] pyridines as kinase modulators |
| AU2008276063B2 (en) | 2007-07-17 | 2013-11-28 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| FR2946340B1 (fr) | 2009-06-05 | 2011-06-24 | Galderma Res & Dev | Nouveaux n-phenyl acetamie, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant. |
| FR2946342B1 (fr) | 2009-06-05 | 2011-06-24 | Galderma Res & Dev | Nouveaux derives de dioxo-imidazolidine, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant. |
| FR2946346B1 (fr) | 2009-06-05 | 2011-05-20 | Galderma Res & Dev | Nouveaux derives dioxo-imidazolidine, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant. |
| FR2946345B1 (fr) | 2009-06-05 | 2011-05-20 | Galderma Res & Dev | Nouveaux derives dioxo-imidazolidine, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant. |
| BRPI1008709B8 (pt) * | 2009-04-03 | 2021-05-25 | Hoffmann La Roche | dispersão sólida, formulação, composição e comprimido compreendendo {3-[5-(4-cloro-fenil)-1h-pirrol[2,3-b]piridina-3-carbonil]-2,4-diflúor-fenil}-amida do ácido propano-1-sulfônico |
| PE20120508A1 (es) | 2009-06-17 | 2012-05-09 | Vertex Pharma | Inhibidores de la replicacion de los virus de la gripe |
| US8329724B2 (en) | 2009-08-03 | 2012-12-11 | Hoffmann-La Roche Inc. | Process for the manufacture of pharmaceutically active compounds |
| US20110112127A1 (en) | 2009-11-06 | 2011-05-12 | Plexxikon, Inc. | Compounds and methods for kinase modulation, and indications therefor |
| EP2590982B1 (en) * | 2010-07-09 | 2017-08-23 | The Walter and Eliza Hall Institute of Medical Research | Protein kinase inhibitors and methods of treatment |
| WO2012083117A1 (en) | 2010-12-16 | 2012-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| MY162950A (en) | 2011-02-07 | 2017-07-31 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
| AR085279A1 (es) | 2011-02-21 | 2013-09-18 | Plexxikon Inc | Formas solidas de {3-[5-(4-cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico |
| UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
| US9150570B2 (en) | 2012-05-31 | 2015-10-06 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
| SG10201804026WA (en) | 2013-11-13 | 2018-06-28 | Vertex Pharma | Inhibitors of influenza viruses replication |
| SI3421468T1 (sl) | 2013-11-13 | 2021-03-31 | Vertex Pharmaceuticals Incorporated | Postopki za pripravo inhibitorjev replikacije virusov influence |
| WO2016183116A1 (en) | 2015-05-13 | 2016-11-17 | Vertex Pharmaceuticals Incorporated | Methods of preparing inhibitors of influenza viruses replication |
| EP3294735B8 (en) | 2015-05-13 | 2022-01-05 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1261179A (fr) * | 1959-02-04 | 1961-05-19 | Chimiotherapie Lab Franc | 12-aza déserpidine et son procédé de préparation |
| US3354174A (en) * | 1964-02-19 | 1967-11-21 | Sterling Drug Inc | 1-and 2-benzimidazolyl-lower-alkylamidoximes, amidines-, and guanidines |
| NZ221717A (en) * | 1986-09-10 | 1990-08-28 | Sandoz Ltd | Azaindole and indolizine derivatives and pharmaceutical compositions |
| DE3882732T2 (de) * | 1987-02-10 | 1993-12-02 | Abbott Lab | Indol, Benzofuran, Benzothiophen enthaltende, Lipoxygenase hemmende Verbindungen. |
| US5153226A (en) * | 1989-08-31 | 1992-10-06 | Warner-Lambert Company | Acat inhibitors for treating hypocholesterolemia |
| WO1991004027A1 (en) * | 1989-09-15 | 1991-04-04 | Pfizer Inc. | New n-aryl and n-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat) |
| DE4022414A1 (de) * | 1990-07-13 | 1992-01-16 | Bayer Ag | Substituierte pyrrolo-pyridine |
| FR2674522B1 (fr) * | 1991-03-26 | 1993-07-16 | Lipha | Nouveaux derives de l'indole, procedes de preparation et medicaments les contenant. |
-
1992
- 1992-02-14 FR FR9201701A patent/FR2687402B1/fr not_active Expired - Fee Related
-
1993
- 1993-02-01 IL IL104573A patent/IL104573A0/xx unknown
- 1993-02-04 US US08/013,427 patent/US5338849A/en not_active Expired - Fee Related
- 1993-02-08 ZA ZA93844A patent/ZA93844B/xx unknown
- 1993-02-09 NZ NZ245869A patent/NZ245869A/en unknown
- 1993-02-10 OA OA60340A patent/OA09775A/fr unknown
- 1993-02-10 CZ CZ93168A patent/CZ16893A3/cs unknown
- 1993-02-11 MX MX9300745A patent/MX9300745A/es unknown
- 1993-02-12 HU HU9300372A patent/HUT64067A/hu unknown
- 1993-02-12 NO NO93930505A patent/NO930505L/no unknown
- 1993-02-12 AT AT93400366T patent/ATE125257T1/de not_active IP Right Cessation
- 1993-02-12 ES ES93400366T patent/ES2076827T3/es not_active Expired - Lifetime
- 1993-02-12 TN TNTNSN93016A patent/TNSN93016A1/fr unknown
- 1993-02-12 SK SK9093A patent/SK9093A3/sk unknown
- 1993-02-12 DK DK93400366.6T patent/DK0557171T3/da active
- 1993-02-12 EP EP93400366A patent/EP0557171B1/fr not_active Expired - Lifetime
- 1993-02-12 LV LVP-93-119A patent/LV10453B/en unknown
- 1993-02-12 LT LTIP339A patent/LT3065B/lt not_active IP Right Cessation
- 1993-02-12 SI SI19939300076A patent/SI9300076A/sl unknown
- 1993-02-12 HR HR930180A patent/HRP930180A2/hr not_active Application Discontinuation
- 1993-02-12 MA MA23089A patent/MA22797A1/fr unknown
- 1993-02-12 CA CA002089470A patent/CA2089470A1/en not_active Abandoned
- 1993-02-12 JP JP5023965A patent/JPH061788A/ja active Pending
- 1993-02-12 AU AU33005/93A patent/AU658475B2/en not_active Ceased
- 1993-02-12 DE DE69300268T patent/DE69300268T2/de not_active Expired - Fee Related
- 1993-02-13 KR KR1019930001980A patent/KR930017905A/ko not_active Withdrawn
-
1995
- 1995-10-04 GR GR950402727T patent/GR3017614T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2076827T3 (es) | 1995-11-01 |
| AU3300593A (en) | 1993-08-19 |
| SI9300076A (en) | 1993-09-30 |
| GR3017614T3 (en) | 1996-01-31 |
| LV10453A (lv) | 1995-02-20 |
| ZA93844B (en) | 1994-08-08 |
| DK0557171T3 (da) | 1995-12-04 |
| ATE125257T1 (de) | 1995-08-15 |
| MA22797A1 (fr) | 1993-10-01 |
| DE69300268D1 (de) | 1995-08-24 |
| NO930505L (no) | 1993-08-16 |
| TNSN93016A1 (fr) | 1994-03-17 |
| LV10453B (en) | 1995-10-20 |
| JPH061788A (ja) | 1994-01-11 |
| AU658475B2 (en) | 1995-04-13 |
| DE69300268T2 (de) | 1996-04-04 |
| HUT64067A (en) | 1993-11-29 |
| FR2687402A1 (fr) | 1993-08-20 |
| HU9300372D0 (en) | 1993-04-28 |
| IL104573A0 (en) | 1993-06-10 |
| EP0557171A1 (fr) | 1993-08-25 |
| FR2687402B1 (fr) | 1995-06-30 |
| CA2089470A1 (en) | 1993-08-15 |
| HRP930180A2 (en) | 1995-10-31 |
| EP0557171B1 (fr) | 1995-07-19 |
| LTIP339A (en) | 1994-06-15 |
| OA09775A (fr) | 1993-11-30 |
| NZ245869A (en) | 1995-05-26 |
| US5338849A (en) | 1994-08-16 |
| SK9093A3 (en) | 1993-09-08 |
| CZ16893A3 (en) | 1993-12-15 |
| MX9300745A (es) | 1993-09-01 |
| LT3065B (en) | 1994-10-25 |
| KR930017905A (ko) | 1993-09-20 |
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