NO922169L - Antisensoligonukleotidinhibisjon av papillomavirus - Google Patents
Antisensoligonukleotidinhibisjon av papillomavirusInfo
- Publication number
- NO922169L NO922169L NO92922169A NO922169A NO922169L NO 922169 L NO922169 L NO 922169L NO 92922169 A NO92922169 A NO 92922169A NO 922169 A NO922169 A NO 922169A NO 922169 L NO922169 L NO 922169L
- Authority
- NO
- Norway
- Prior art keywords
- oligonucleotide
- oligonucleotides
- papillomavirus
- papilloma
- messenger
- Prior art date
Links
- 108091034117 Oligonucleotide Proteins 0.000 title abstract 10
- 241001631646 Papillomaviridae Species 0.000 title abstract 3
- 230000005764 inhibitory process Effects 0.000 title 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 3
- 230000000692 anti-sense effect Effects 0.000 abstract 2
- 108020004999 messenger RNA Proteins 0.000 abstract 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 abstract 1
- 206010013710 Drug interaction Diseases 0.000 abstract 1
- 208000009608 Papillomavirus Infections Diseases 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 238000009395 breeding Methods 0.000 abstract 1
- 230000001488 breeding effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 208000003154 papilloma Diseases 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Oligonukleotider og ollgonukleotidanaloger er tllvele- brakt og har evne for antlsenslnterakBjon med messenger-RKA fra paplllomavirus. Slike oligo- nukleotlder eller oligonukleotidanaloger kan bli anvendt for diagnostikk og terapeutiske midler samt for forskning. I henhold til foretrukne utførelsesformer er ollgonukleotld eller ollgonukleotidanaloger tllvele- brakt og disse er hybridlserbare med et messenger-RNA fra et paplllomavirus. Oligonukleotldet eller oligo- nukleotldanalogen kan også inhlbere funksjonen av RNA og er derfor nyttig for terapi for Infeksjoner med silke paplllomavirus. Deler av papillomavlruset blir målsøkt for antisensangrep. Ollgonukleotidene kan derfor fortrinnsvis hybridlsere med E2-, El-, E7- eller E6-7-messenger RNA.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45519689A | 1989-12-04 | 1989-12-04 | |
| PCT/US1990/007067 WO1991008313A1 (en) | 1989-12-04 | 1990-12-03 | Antisense oligonucleotide inhibition of papillomavirus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO922169D0 NO922169D0 (no) | 1992-06-01 |
| NO922169L true NO922169L (no) | 1992-07-27 |
Family
ID=26781834
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO92922169A NO922169L (no) | 1989-12-04 | 1992-06-01 | Antisensoligonukleotidinhibisjon av papillomavirus |
Country Status (1)
| Country | Link |
|---|---|
| NO (1) | NO922169L (no) |
-
1992
- 1992-06-01 NO NO92922169A patent/NO922169L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO922169D0 (no) | 1992-06-01 |
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|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |