NO921141D0 - Indolderivater, fremgangsmaate for deres fremstilling og anvendelse derav - Google Patents
Indolderivater, fremgangsmaate for deres fremstilling og anvendelse deravInfo
- Publication number
- NO921141D0 NO921141D0 NO921141A NO921141A NO921141D0 NO 921141 D0 NO921141 D0 NO 921141D0 NO 921141 A NO921141 A NO 921141A NO 921141 A NO921141 A NO 921141A NO 921141 D0 NO921141 D0 NO 921141D0
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- alkylamino
- phenyl
- benzyl
- optionally substituted
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 230000000879 anti-atherosclerotic effect Effects 0.000 abstract 1
- 230000003178 anti-diabetic effect Effects 0.000 abstract 1
- 239000003472 antidiabetic agent Substances 0.000 abstract 1
- 229940054051 antipsychotic indole derivative Drugs 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000000055 hyoplipidemic effect Effects 0.000 abstract 1
- 150000002475 indoles Chemical class 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229940127557 pharmaceutical product Drugs 0.000 abstract 1
- -1 polymethylene Polymers 0.000 abstract 1
- 125000005344 pyridylmethyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9103618A FR2674522B1 (fr) | 1991-03-26 | 1991-03-26 | Nouveaux derives de l'indole, procedes de preparation et medicaments les contenant. |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| NO921141D0 true NO921141D0 (no) | 1992-03-24 |
| NO921141L NO921141L (no) | 1992-09-28 |
| NO178260B NO178260B (no) | 1995-11-13 |
| NO178260C NO178260C (no) | 1996-02-21 |
Family
ID=9411107
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO921141A NO178260C (no) | 1991-03-26 | 1992-03-24 | Indolderivater, mellomproduktforbindelser for deres fremstilling, anvendelse derav samt farmasöytisk preparat |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5219859A (no) |
| EP (1) | EP0506532B1 (no) |
| JP (1) | JPH0597802A (no) |
| KR (1) | KR950007753B1 (no) |
| AT (1) | ATE111078T1 (no) |
| AU (1) | AU658609B2 (no) |
| CA (1) | CA2063170A1 (no) |
| CS (1) | CS89592A3 (no) |
| DE (1) | DE69200378T2 (no) |
| DK (1) | DK0506532T3 (no) |
| ES (1) | ES2064149T3 (no) |
| FR (1) | FR2674522B1 (no) |
| HU (1) | HUT65489A (no) |
| IE (1) | IE65366B1 (no) |
| IL (1) | IL101248A (no) |
| MA (1) | MA22474A1 (no) |
| MX (1) | MX9201365A (no) |
| NO (1) | NO178260C (no) |
| NZ (1) | NZ242078A (no) |
| OA (1) | OA09573A (no) |
| RU (1) | RU2074179C1 (no) |
| SI (1) | SI9210305A (no) |
| TN (1) | TNSN92022A1 (no) |
| YU (1) | YU30592A (no) |
| ZA (1) | ZA922163B (no) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2687402B1 (fr) * | 1992-02-14 | 1995-06-30 | Lipha | Nouveaux azaindoles, procedes de preparation et medicaments les contenant. |
| BR9306421A (pt) * | 1992-05-28 | 1998-09-15 | Pfizer | Novos derivados n-aril e n-heteroariluréia como inbidores da acilcoenzima a:colesterol aciltransferase (acat) |
| NZ250916A (en) * | 1993-02-27 | 1995-08-28 | Nihon Nohyaku Co Ltd | N-heteroaryl-n'-phenylureas, their use as acat inhibitors |
| IL109568A0 (en) * | 1993-05-19 | 1994-08-26 | Fujisawa Pharmaceutical Co | Urea derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof |
| US5952354A (en) * | 1993-07-21 | 1999-09-14 | American Home Products Corporation | Tris carbamic acid esters: inhibitors of cholesterol absorption |
| DE4401893A1 (de) * | 1994-01-24 | 1995-07-27 | Bayer Ag | Substituierte Arylharnstoffe |
| JP3720395B2 (ja) | 1994-09-20 | 2005-11-24 | 京都薬品工業株式会社 | 新規ヘテロ環誘導体、その製造方法およびその医薬用途 |
| CA2224062C (en) * | 1995-06-06 | 2001-09-04 | Pfizer Limited | Substituted n-(indole-2-carbonyl)-glycinamides and derivatives as glycogen phosphorylase inhibitors |
| DK0832066T3 (da) | 1995-06-06 | 2001-11-19 | Pfizer | Substituerede N-(indol-2-carbonyl)amider og derivater som glycogenphosphorylaseinhibitorer |
| KR100241643B1 (ko) * | 1995-06-06 | 2000-03-02 | 디. 제이. 우드 | 당뇨병치료제인 치환된 N-(인돌-2-카르보닐)-β-알라님아미드 및 그의 유도체 |
| NZ299242A (en) * | 1995-09-11 | 1997-12-19 | Nihon Nohyaku Co Ltd | N-phenyl-n'-(phenyl substituted imidazol-5-yl, -oxazol-4-yl, and -thiazol-4-yl)urea derivatives |
| PT866059E (pt) * | 1995-10-05 | 2002-03-28 | Kyoto Pharma Ind | Novos derivados heterociclicos e sua utilizacao medicina |
| CA2190041A1 (en) * | 1995-11-13 | 1997-05-14 | Shinya Inoue | Urea derivatives |
| DE122010000020I1 (de) * | 1996-04-25 | 2010-07-08 | Prosidion Ltd | Verfahren zur Senkung des Blutglukosespiegels in Säugern |
| FR2763334A1 (fr) * | 1997-05-13 | 1998-11-20 | Lipha | Derives anthraniliques |
| BR9814287A (pt) * | 1997-12-16 | 2000-10-03 | Warner Lambert Co | "4(3)-aminometil-(tio)piran 4(3) substituìdo ou derivados da piperidina (= análogos da gabapentina), sua preparação e seu uso no tratamento de desordens neurológicas" |
| AU765802B2 (en) * | 1997-12-16 | 2003-10-02 | Warner-Lambert Company | 1-substituted-1-aminomethyl-cycloalkane derivatives (=gabapentin analogues), their preparation and their use in the treatment of neurological disorders |
| HUP0100472A3 (en) * | 1997-12-16 | 2003-03-28 | Warner Lambert Co | Novel amines as pharmaceutical agents |
| SK282727B6 (sk) | 1997-12-19 | 2002-11-06 | Slovakofarma, A. S. | 1,3-Disubstituované močoviny - inhibítory ACAT a spôsob ich prípravy |
| US6277877B1 (en) | 2000-08-15 | 2001-08-21 | Pfizer, Inc. | Substituted n-(indole-2-carbonyl)glycinamides and derivates as glycogen phosphorylase inhibitors |
| AU4332302A (en) | 2000-11-02 | 2002-06-24 | Us Gov Health & Human Serv | Agents useful for reducing amyloid precursor protein and treating demantia and methods of use thereof |
| WO2003092670A1 (en) * | 2002-05-03 | 2003-11-13 | Warner-Lambert Company Llc | Bombesin antagonists |
| NZ538226A (en) * | 2002-07-17 | 2006-08-31 | Kyoto Pharma Ind | Indoline compounds having an acyl-coenzyme A: cholesterol acyl transferase (ACAT) and lipoperoxidation inhibitory activity and medicinal use thereof |
| US7595403B2 (en) | 2003-04-01 | 2009-09-29 | Eli Lilly And Company | Benzisothiazol-3-one-carboxylic acid amides as phospholipase inhibitors |
| RU2358734C2 (ru) * | 2003-08-29 | 2009-06-20 | Кова Ко., Лтд. | Способ стабилизации бляшки с высоким содержанием липидов и способ профилактики ее разрушения |
| BRPI0619263A2 (pt) | 2005-11-30 | 2011-09-27 | Hoffmann La Roche | indóis de 3-amino-1-arilpropila e indóis aza-substituìdos, métodos para prepará-los, composição farmacêutica e uso dos referidos indóis |
| ES2329413T3 (es) | 2005-11-30 | 2009-11-25 | F. Hoffmann-La Roche Ag | 3-amino-2-arilpropil azaindoles y usos de los mismos. |
| RU2361581C2 (ru) * | 2007-09-14 | 2009-07-20 | Закрытое Акционерное Общество "Мастерклон" | Фармацевтическая композиция, обладающая противодиабетической, гиполипидемической, гипогликемической и гипохолестеринемической активностью, способ ее получения и способы лечения указанных заболеваний |
| SK287385B6 (sk) | 2007-11-27 | 2010-08-09 | Hameln-Rds, A. S. | 1,3-Disubstituované močoviny, spôsob ich prípravy a použitia |
| CN104628621A (zh) * | 2015-01-22 | 2015-05-20 | 湖南华腾制药有限公司 | 一种氟取代吲哚衍生物的制备方法 |
| WO2018064465A1 (en) | 2016-09-29 | 2018-04-05 | The Regents Of The University Of California | Compounds for increasing neural plasticity |
| IL292109B2 (en) | 2017-06-26 | 2024-02-01 | Lunella Biotech Inc | MITOKETOSCINS: Mitochondrial-Based Therapies Targeting Reduction Metabolism in Cancer Cells |
| AU2020229779B9 (en) | 2019-02-27 | 2025-09-18 | The Regents Of The University Of California | Azepino-indoles and other heterocycles for treating brain disorders |
| MX2024007221A (es) | 2021-12-15 | 2024-08-27 | Delix Therapeutics Inc | Psicoplastogenos sustituidos con fenoxi y benciloxi y sus usos. |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55151505A (en) * | 1979-05-14 | 1980-11-26 | Kuraray Co Ltd | Indole agricultural and horticultural fungicide |
| CA1299174C (en) * | 1987-02-02 | 1992-04-21 | Michael Edward Flaugh | Alkylmelatonins |
| EP0375133A1 (en) * | 1988-11-14 | 1990-06-27 | The Upjohn Company | Alpha-amino-indole-3-acetic acids useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents |
| IE903206A1 (en) * | 1989-09-07 | 1991-03-13 | Abbott Lab | Indole-, benzofuran-, and benzothiophene-containing¹lipoxygenase-inhibiting compounds |
| WO1991004027A1 (en) * | 1989-09-15 | 1991-04-04 | Pfizer Inc. | New n-aryl and n-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat) |
| DE69114404T2 (de) * | 1990-08-13 | 1996-05-02 | Hoechst Roussel Pharma | 1-(Pyridinylalkyl)-1H-indole, -indoline und Analoge. |
| FR2680366B1 (fr) * | 1991-08-13 | 1995-01-20 | Adir | Nouveaux derives d'arylethylamines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
| WO1993005020A1 (en) * | 1991-09-06 | 1993-03-18 | Merck & Co., Inc. | Indoles as inhibitors of hiv reverse transcriptase |
-
1991
- 1991-03-26 FR FR9103618A patent/FR2674522B1/fr not_active Expired - Fee Related
-
1992
- 1992-03-16 IL IL10124892A patent/IL101248A/en not_active IP Right Cessation
- 1992-03-17 CA CA002063170A patent/CA2063170A1/en not_active Abandoned
- 1992-03-20 NZ NZ242078A patent/NZ242078A/en unknown
- 1992-03-20 AU AU13094/92A patent/AU658609B2/en not_active Ceased
- 1992-03-20 ES ES92400764T patent/ES2064149T3/es not_active Expired - Lifetime
- 1992-03-20 US US07/855,544 patent/US5219859A/en not_active Expired - Fee Related
- 1992-03-20 AT AT92400764T patent/ATE111078T1/de active
- 1992-03-20 DE DE69200378T patent/DE69200378T2/de not_active Expired - Fee Related
- 1992-03-20 DK DK92400764.4T patent/DK0506532T3/da active
- 1992-03-20 EP EP92400764A patent/EP0506532B1/fr not_active Expired - Lifetime
- 1992-03-23 MA MA22763A patent/MA22474A1/fr unknown
- 1992-03-24 NO NO921141A patent/NO178260C/no unknown
- 1992-03-24 IE IE920937A patent/IE65366B1/en not_active IP Right Cessation
- 1992-03-25 HU HU9200997A patent/HUT65489A/hu unknown
- 1992-03-25 CS CS92895A patent/CS89592A3/cs unknown
- 1992-03-25 JP JP4067252A patent/JPH0597802A/ja active Pending
- 1992-03-25 RU SU925011235A patent/RU2074179C1/ru active
- 1992-03-25 ZA ZA922163A patent/ZA922163B/xx unknown
- 1992-03-26 OA OA60177A patent/OA09573A/fr unknown
- 1992-03-26 KR KR1019920005020A patent/KR950007753B1/ko not_active Expired - Fee Related
- 1992-03-26 MX MX9201365A patent/MX9201365A/es not_active IP Right Cessation
- 1992-03-26 SI SI9210305A patent/SI9210305A/sl unknown
- 1992-03-26 TN TNTNSN92022A patent/TNSN92022A1/fr unknown
- 1992-03-26 YU YU30592A patent/YU30592A/sh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69200378T2 (de) | 1995-03-09 |
| ZA922163B (en) | 1993-09-27 |
| NO921141L (no) | 1992-09-28 |
| TNSN92022A1 (fr) | 1993-06-08 |
| IE920937A1 (en) | 1992-10-07 |
| ATE111078T1 (de) | 1994-09-15 |
| SI9210305A (en) | 1996-02-29 |
| FR2674522A1 (fr) | 1992-10-02 |
| MA22474A1 (fr) | 1992-10-01 |
| HU9200997D0 (en) | 1992-05-28 |
| DE69200378D1 (de) | 1994-10-13 |
| OA09573A (fr) | 1993-01-31 |
| IE65366B1 (en) | 1995-10-18 |
| CS89592A3 (en) | 1992-10-14 |
| MX9201365A (es) | 1992-10-01 |
| EP0506532A1 (fr) | 1992-09-30 |
| FR2674522B1 (fr) | 1993-07-16 |
| NO178260B (no) | 1995-11-13 |
| KR950007753B1 (ko) | 1995-07-14 |
| NO178260C (no) | 1996-02-21 |
| EP0506532B1 (fr) | 1994-09-07 |
| KR920018022A (ko) | 1992-10-21 |
| AU658609B2 (en) | 1995-04-27 |
| NZ242078A (en) | 1994-10-26 |
| JPH0597802A (ja) | 1993-04-20 |
| ES2064149T3 (es) | 1995-01-16 |
| HUT65489A (en) | 1994-06-28 |
| AU1309492A (en) | 1992-10-01 |
| US5219859A (en) | 1993-06-15 |
| YU30592A (sh) | 1994-12-28 |
| IL101248A (en) | 1996-12-05 |
| RU2074179C1 (ru) | 1997-02-27 |
| IL101248A0 (en) | 1992-11-15 |
| DK0506532T3 (da) | 1995-02-20 |
| CA2063170A1 (en) | 1992-09-27 |
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