NO881300L - Fremgangsmaate for fremstilling av terapeutisk aktive kinazolin-derivater. - Google Patents
Fremgangsmaate for fremstilling av terapeutisk aktive kinazolin-derivater.Info
- Publication number
- NO881300L NO881300L NO881300A NO881300A NO881300L NO 881300 L NO881300 L NO 881300L NO 881300 A NO881300 A NO 881300A NO 881300 A NO881300 A NO 881300A NO 881300 L NO881300 L NO 881300L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- hydrogen
- alkoxy
- alkylthio
- procedure
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 125000004414 alkyl thio group Chemical group 0.000 abstract 3
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000005110 aryl thio group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000004957 naphthylene group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C07D239/96—Two oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB878707053A GB8707053D0 (en) | 1987-03-25 | 1987-03-25 | Anti-tumour agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO881300D0 NO881300D0 (no) | 1988-03-24 |
| NO881300L true NO881300L (no) | 1988-09-26 |
Family
ID=10614570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO881300A NO881300L (no) | 1987-03-25 | 1988-03-24 | Fremgangsmaate for fremstilling av terapeutisk aktive kinazolin-derivater. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4981856A (no) |
| EP (1) | EP0284338B1 (no) |
| JP (1) | JP2577036B2 (no) |
| AT (1) | ATE98956T1 (no) |
| AU (1) | AU600105B2 (no) |
| CA (1) | CA1301756C (no) |
| DE (1) | DE3886435T2 (no) |
| DK (1) | DK167013B1 (no) |
| ES (1) | ES2061641T3 (no) |
| FI (1) | FI881340A7 (no) |
| GB (2) | GB8707053D0 (no) |
| GR (1) | GR3010208T3 (no) |
| IL (1) | IL85696A (no) |
| NO (1) | NO881300L (no) |
| NZ (1) | NZ224010A (no) |
| PT (1) | PT87074B (no) |
| ZA (1) | ZA881885B (no) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8727737D0 (en) * | 1987-11-26 | 1987-12-31 | Ici Plc | Antitumour agents |
| GB8809978D0 (en) * | 1988-04-27 | 1988-06-02 | Ici Plc | Anti-tumour agents |
| EP0365763A1 (en) * | 1988-09-30 | 1990-05-02 | Agouron Pharmaceuticals, Inc. | Antiproliferative cyclic compounds |
| GB8829296D0 (en) * | 1988-12-15 | 1989-01-25 | Ici Plc | Anti-tumour compounds |
| US5252573A (en) * | 1988-12-15 | 1993-10-12 | Imperial Chemical Industries Plc | Anti-tumor agents |
| US5160727A (en) * | 1990-02-13 | 1992-11-03 | Warner-Lambert Company | Tumor cell sensitization method using quinazolinedione derivatives |
| ZA913730B (en) * | 1990-05-30 | 1992-02-26 | Ici Plc | Anti-tumor compounds |
| GB9013615D0 (en) * | 1990-06-19 | 1990-08-08 | Wellcome Found | Pharmaceutical compounds |
| GB9105771D0 (en) * | 1991-03-19 | 1991-05-01 | Cancer Res Inst Royal | Anti-cancer compounds |
| US5145854A (en) * | 1991-11-27 | 1992-09-08 | Nair Madhavan G | 1-formyl-5,8,10-trideazafolates |
| GB9205320D0 (en) * | 1992-03-11 | 1992-04-22 | Ici Plc | Anti-tumour compounds |
| GB9205907D0 (en) * | 1992-03-18 | 1992-04-29 | Cancer Res Inst Royal | Anti-cancer compounds |
| US5430148A (en) * | 1992-03-31 | 1995-07-04 | Agouron Pharmaceuticals, Inc. | Antiproliferative quinazolines |
| GB9223352D0 (en) * | 1992-11-06 | 1992-12-23 | Ici Plc | Tricyclic compounds |
| DE4421884A1 (de) | 1994-06-23 | 1996-01-04 | Hoechst Ag | Verfahren zur Herstellung von Hydroxycarbonsäureaniliden |
| DE4427837A1 (de) | 1994-08-05 | 1996-02-08 | Hoechst Ag | Verfahren zur Herstellung von O-Acylglykolsäureaniliden |
| DE19504225A1 (de) | 1995-02-09 | 1996-08-14 | Hoechst Ag | Verfahren zur Herstellung von O-Acyloxycarbonsäureaniliden |
| US5739330A (en) * | 1996-02-05 | 1998-04-14 | Hoechst Celanese Corporation | Process for preparing quinazolones |
| GB9904275D0 (en) | 1999-02-24 | 1999-04-21 | Cancer Res Campaign Tech | Anti-cancer compounds |
| US7230000B1 (en) | 1999-10-27 | 2007-06-12 | Cytokinetics, Incorporated | Methods and compositions utilizing quinazolinones |
| US6545004B1 (en) | 1999-10-27 | 2003-04-08 | Cytokinetics, Inc. | Methods and compositions utilizing quinazolinones |
| US6753428B2 (en) * | 2001-11-20 | 2004-06-22 | Cytokinetics, Inc. | Process for the racemization of chiral quinazolinones |
| US7087418B2 (en) | 2001-12-19 | 2006-08-08 | Bristol-Myers Squibb Company | Pichia pastoris formate dehydrogenase and uses therefor |
| JP2005529076A (ja) * | 2002-02-15 | 2005-09-29 | サイトキネティクス・インコーポレーテッド | キナゾリノンの合成 |
| WO2003097053A1 (en) | 2002-05-09 | 2003-11-27 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| US7166595B2 (en) * | 2002-05-09 | 2007-01-23 | Cytokinetics, Inc. | Compounds, methods and compositions |
| US7038048B2 (en) | 2002-05-23 | 2006-05-02 | Cytokinetics, Inc. | 3H-pyridopyrimidin-4-one compounds, compositions, and methods of their use |
| CA2489367A1 (en) * | 2002-06-14 | 2003-12-24 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| WO2004009036A2 (en) * | 2002-07-23 | 2004-01-29 | Cytokinetics, Inc. | Compounds compositions and methods |
| WO2004018058A2 (en) * | 2002-08-21 | 2004-03-04 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| JP2006501306A (ja) * | 2002-09-30 | 2006-01-12 | サイトキネティクス・インコーポレーテッド | 化合物、組成物および方法 |
| GB0317631D0 (en) * | 2003-07-28 | 2003-08-27 | Btg Int Ltd | Synthetic method |
| WO2005041888A2 (en) * | 2003-11-03 | 2005-05-12 | Cytokinetics, Inc. | Pyrimidin-4-one compounds, compositions and methods |
| EP1680420A4 (en) * | 2003-11-07 | 2008-09-24 | Cytokinetics Inc | COMPOUNDS, COMPOSITIONS AND METHODS |
| EP1692112A4 (en) * | 2003-12-08 | 2008-09-24 | Cytokinetics Inc | COMPOUNDS, COMPOSITIONS, AND METHODS |
| AU2008268613A1 (en) * | 2007-06-22 | 2008-12-31 | Arqule, Inc. | Quinazolinone compounds and methods of use thereof |
| US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| WO2015051241A1 (en) | 2013-10-04 | 2015-04-09 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| HUE057734T2 (hu) | 2013-10-04 | 2022-06-28 | Infinity Pharmaceuticals Inc | Heterociklusos vegyületek és alkalmazásuk |
| CN113616656B (zh) | 2014-03-19 | 2023-02-17 | 无限药品股份有限公司 | 用于治疗PI3K-γ介导的障碍的杂环化合物 |
| WO2016054491A1 (en) | 2014-10-03 | 2016-04-07 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| EP3350183B1 (en) | 2015-09-14 | 2025-04-02 | Twelve Therapeutics, Inc. | Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same |
| WO2017161116A1 (en) | 2016-03-17 | 2017-09-21 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors |
| WO2017214269A1 (en) | 2016-06-08 | 2017-12-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0031237B1 (en) * | 1979-12-19 | 1984-10-17 | National Research Development Corporation | Quinazoline derivatives, processes for their preparation, compositions containing them and their use as anti-cancer agents |
| GB8513754D0 (en) * | 1985-05-31 | 1985-07-03 | Jones T R | Anti-cancer quinazoline derivatives |
| GB8607683D0 (en) * | 1986-03-27 | 1986-04-30 | Ici Plc | Anti-tumor agents |
-
1987
- 1987-03-25 GB GB878707053A patent/GB8707053D0/en active Pending
-
1988
- 1988-03-10 IL IL85696A patent/IL85696A/xx not_active IP Right Cessation
- 1988-03-14 GB GB8805982A patent/GB2202847B/en not_active Expired - Lifetime
- 1988-03-16 ZA ZA881885A patent/ZA881885B/xx unknown
- 1988-03-18 AU AU13279/88A patent/AU600105B2/en not_active Ceased
- 1988-03-21 FI FI881340A patent/FI881340A7/fi not_active IP Right Cessation
- 1988-03-22 EP EP88302486A patent/EP0284338B1/en not_active Expired - Lifetime
- 1988-03-22 ES ES88302486T patent/ES2061641T3/es not_active Expired - Lifetime
- 1988-03-22 DE DE88302486T patent/DE3886435T2/de not_active Expired - Fee Related
- 1988-03-22 AT AT88302486T patent/ATE98956T1/de not_active IP Right Cessation
- 1988-03-24 PT PT87074A patent/PT87074B/pt active IP Right Grant
- 1988-03-24 NO NO881300A patent/NO881300L/no unknown
- 1988-03-24 NZ NZ224010A patent/NZ224010A/en unknown
- 1988-03-24 CA CA000562300A patent/CA1301756C/en not_active Expired - Lifetime
- 1988-03-25 JP JP63069943A patent/JP2577036B2/ja not_active Expired - Fee Related
- 1988-03-25 DK DK168488A patent/DK167013B1/da not_active IP Right Cessation
-
1990
- 1990-04-12 US US07/508,528 patent/US4981856A/en not_active Expired - Lifetime
-
1993
- 1993-12-23 GR GR920402608T patent/GR3010208T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2061641T3 (es) | 1994-12-16 |
| NO881300D0 (no) | 1988-03-24 |
| GB2202847B (en) | 1990-06-06 |
| JP2577036B2 (ja) | 1997-01-29 |
| EP0284338A3 (en) | 1989-05-17 |
| JPS63255270A (ja) | 1988-10-21 |
| IL85696A (en) | 1993-05-13 |
| DK167013B1 (da) | 1993-08-16 |
| FI881340A7 (fi) | 1988-09-26 |
| EP0284338B1 (en) | 1993-12-22 |
| GR3010208T3 (no) | 1994-03-31 |
| GB2202847A (en) | 1988-10-05 |
| PT87074A (pt) | 1988-04-01 |
| GB8707053D0 (en) | 1987-04-29 |
| DK168488A (da) | 1988-09-26 |
| NZ224010A (en) | 1990-12-21 |
| DE3886435D1 (de) | 1994-02-03 |
| PT87074B (pt) | 1992-07-31 |
| GB8805982D0 (en) | 1988-04-13 |
| DK168488D0 (da) | 1988-03-25 |
| AU1327988A (en) | 1988-09-29 |
| US4981856A (en) | 1991-01-01 |
| EP0284338A2 (en) | 1988-09-28 |
| AU600105B2 (en) | 1990-08-02 |
| CA1301756C (en) | 1992-05-26 |
| FI881340A0 (fi) | 1988-03-21 |
| ATE98956T1 (de) | 1994-01-15 |
| DE3886435T2 (de) | 1994-04-14 |
| ZA881885B (en) | 1988-09-26 |
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