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NO851876L - Nye terapeutisk virksomme 1,n-diarylpyrazol-3-aminer og fremgangsmaate til deres fremstilling. - Google Patents

Nye terapeutisk virksomme 1,n-diarylpyrazol-3-aminer og fremgangsmaate til deres fremstilling.

Info

Publication number
NO851876L
NO851876L NO851876A NO851876A NO851876L NO 851876 L NO851876 L NO 851876L NO 851876 A NO851876 A NO 851876A NO 851876 A NO851876 A NO 851876A NO 851876 L NO851876 L NO 851876L
Authority
NO
Norway
Prior art keywords
alkyl
diarylpyrazol
amines
procedures
preparation
Prior art date
Application number
NO851876A
Other languages
English (en)
Other versions
NO169283B (no
NO169283C (no
Inventor
Richard Anthony Appleton
Sidney Clifford Burford
David Norman Hardern
David Wilkinson
Original Assignee
Fisons Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848412181A external-priority patent/GB8412181D0/en
Priority claimed from GB848429128A external-priority patent/GB8429128D0/en
Application filed by Fisons Plc filed Critical Fisons Plc
Publication of NO851876L publication Critical patent/NO851876L/no
Publication of NO169283B publication Critical patent/NO169283B/no
Publication of NO169283C publication Critical patent/NO169283C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heat Treatment Of Sheet Steel (AREA)
  • Jib Cranes (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
NO85851876A 1984-05-12 1985-05-10 Analogifremgangsmaate for fremstilling av nye terapeutisk virksomme 1,n-diarylpyrazol-3-aminer NO169283C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848412181A GB8412181D0 (en) 1984-05-12 1984-05-12 Heterocyclic compounds
GB848429128A GB8429128D0 (en) 1984-11-17 1984-11-17 Heterocyclic compounds

Publications (3)

Publication Number Publication Date
NO851876L true NO851876L (no) 1985-11-13
NO169283B NO169283B (no) 1992-02-24
NO169283C NO169283C (no) 1992-06-10

Family

ID=26287734

Family Applications (1)

Application Number Title Priority Date Filing Date
NO85851876A NO169283C (no) 1984-05-12 1985-05-10 Analogifremgangsmaate for fremstilling av nye terapeutisk virksomme 1,n-diarylpyrazol-3-aminer

Country Status (15)

Country Link
US (1) US4810719A (no)
EP (1) EP0178035B1 (no)
JP (1) JPH0625134B2 (no)
AT (1) ATE49198T1 (no)
AU (1) AU586166B2 (no)
CA (1) CA1246567A (no)
DE (1) DE3575130D1 (no)
DK (1) DK204085A (no)
ES (2) ES8609267A1 (no)
FI (1) FI851836A7 (no)
GR (1) GR851132B (no)
IL (1) IL75146A (no)
NO (1) NO169283C (no)
NZ (1) NZ212025A (no)
PT (1) PT80435B (no)

Families Citing this family (46)

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IL73418A (en) * 1983-11-07 1988-02-29 Lilly Co Eli 5-cyano-1h-pyrazole-4-(thio)carboxamide derivatives,their preparation and herbicidal compositions containing them
EP0248523B1 (en) * 1986-05-07 1991-10-16 FISONS plc Pyrazoles
DK377487A (da) * 1986-07-21 1988-01-22 Otsuka Pharma Co Ltd P-aminophenolderivater
US4970210A (en) * 1987-07-17 1990-11-13 Abbott Laboratories Triazinone lipoxygenase compounds
GR900100380A (el) * 1989-05-20 1991-10-10 Fisons Plc Μέ?οδος παρασκευής αντι-φλεγμονωδών παραγώγων αμινοφενόλης.
PH27357A (en) * 1989-09-22 1993-06-21 Fujisawa Pharmaceutical Co Pyrazole derivatives and pharmaceutical compositions comprising the same
US5550147A (en) * 1992-02-05 1996-08-27 Fujisawa Pharmaceutical Co., Ltd. Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same
GB9312853D0 (en) * 1993-06-22 1993-08-04 Euro Celtique Sa Chemical compounds
US5922751A (en) * 1994-06-24 1999-07-13 Euro-Celtique, S.A. Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
US5591776A (en) * 1994-06-24 1997-01-07 Euro-Celtique, S.A. Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
CA2206287C (en) * 1994-12-13 2001-03-20 Mark Chasin Aryl thioxanthines
ATE247655T1 (de) * 1994-12-13 2003-09-15 Euro Celtique Sa Dreifachsubstituierte thioxanthine
US6025361A (en) * 1994-12-13 2000-02-15 Euro-Celtique, S.A. Trisubstituted thioxanthines
JPH11507670A (ja) * 1995-06-12 1999-07-06 ジー．ディー．サール アンド カンパニー シクロオキシゲナーゼ−２インヒビターと５−リポキシゲナーゼインヒビターの組合せによる炎症と炎症関連疾患の治療
US6166041A (en) * 1995-10-11 2000-12-26 Euro-Celtique, S.A. 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
US6075016A (en) * 1996-04-10 2000-06-13 Euro-Celtique S.A. 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
CA2348234A1 (en) * 1998-10-29 2000-05-11 Chunjian Liu Compounds derived from an amine nucleus that are inhibitors of impdh enzyme
EP1268472B1 (en) 2000-02-07 2004-10-13 Bristol-Myers Squibb Company 3-aminopyrazole inhibitors of cyclin dependent kinases
AU2001232175B2 (en) * 2000-03-03 2005-07-07 Pfizer Products Inc. Pyrazole ether derivatives as anti-inflammatory/analgesic agents
JP4759207B2 (ja) * 2000-05-15 2011-08-31 あすか製薬株式会社 １−（ベンゾチアゾール−２−イル）ピラゾール誘導体およびそれを含有するｃｏｘ−２阻害剤
GB0016787D0 (en) 2000-07-07 2000-08-30 Pfizer Ltd Compounds useful in therapy
WO2003037352A1 (en) * 2001-11-02 2003-05-08 Pfizer Products Inc. 1-phenyl-5-n-heterocyclyl-pyrazoles as cyclooxygenase inhibitors for the treatment of inflammation associated disorders
US7329288B2 (en) 2004-02-27 2008-02-12 L'oreal S.A. N-heteroaryl secondary para-phenylenediamine, a dye composition comprising such a para-phenylenediamine, a process for preparing this composition and use thereof
FR2866887A1 (fr) * 2004-02-27 2005-09-02 Oreal Para-phenylenediamine secondaire n-heteroaryle, compositon tinctoriale comprenant une telle para-phenylenediamine, procede mettant en oeuvre cette composition et utilisation
CN103739595A (zh) * 2006-10-02 2014-04-23 Irm责任有限公司 作为蛋白激酶抑制剂的化合物和组合物
EA201000561A1 (ru) * 2007-10-09 2010-10-29 Мерк Патент Гмбх Производные пиридина, пригодные в качестве активаторов глюкокиназы
RU2011117935A (ru) * 2008-10-15 2012-11-27 Нитто Денко Корпорейшн Способ получения конъюгатов полиглутаматов
US9675774B2 (en) 2009-04-02 2017-06-13 Breathe Technologies, Inc. Methods, systems and devices for non-invasive open ventilation with gas delivery nozzles in free space
BR112012013305A2 (pt) * 2009-12-16 2016-03-01 Nitto Denko Corp processos para a preparação de ácido poliglutâmico
US9161894B2 (en) 2011-03-01 2015-10-20 Npharmakon, Llc Use of N-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-3-amine and related compounds
WO2015058020A1 (en) 2013-10-17 2015-04-23 Dow Agrosciences Llc Processes for the preparation of pesticidal compounds
KR20160072154A (ko) 2013-10-17 2016-06-22 다우 아그로사이언시즈 엘엘씨 살충성 화합물의 제조 방법
CA2925952A1 (en) 2013-10-17 2015-04-23 Dow Agrosciences Llc Processes for the preparation of pesticidal compounds
MX2016004940A (es) 2013-10-17 2016-06-28 Dow Agrosciences Llc Proceso para la preparacion de compuestos plaguicidas.
US9044017B2 (en) 2013-10-17 2015-06-02 Dow Agrosciences Llc Processes for the preparation of pesticidal compounds
CA2925953C (en) 2013-10-17 2021-11-02 Dow Agrosciences Llc Processes for the preparation of pesticidal compounds
CN106061969B (zh) 2014-01-06 2019-10-29 阿尔戈么迪克斯有限公司 Trpa1调节剂
AU2015281799B2 (en) * 2014-06-26 2019-11-28 Central Adelaide Local Health Network Incorporated Enzyme interacting agents
KR20170039121A (ko) * 2014-07-31 2017-04-10 다우 아그로사이언시즈 엘엘씨 3-(3-클로로-1h-피라졸-1-일)피리딘의 제조 방법
BR112017000293A2 (pt) 2014-07-31 2017-10-31 Dow Agrosciences Llc processo para a preparação de 3-(3-cloro-1h-pirazol-1-il)piridina
JP2017525703A (ja) 2014-08-19 2017-09-07 ダウ アグロサイエンシィズ エルエルシー ３−（３−クロロ−１ｈ−ピラゾール−１−イル）ピリジンの調製方法
BR112017004613A2 (pt) 2014-09-12 2017-12-05 Dow Agrosciences Llc processo para a preparação de 3-(3-cloro-1h-pirazol-1-il)piridina
US10233155B2 (en) 2016-12-29 2019-03-19 Dow Agrosciences Llc Processes for the preparation of pesticide compounds
EP3562807B1 (en) 2016-12-29 2022-08-03 Corteva Agriscience LLC Processes for the preparation of pesticidal compounds
WO2025166015A2 (en) * 2024-02-02 2025-08-07 Photys Therapeutics, Inc. Bifunctional abl1-binding compounds and uses thereof

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US3398158A (en) * 1964-02-19 1968-08-20 Warner Lambert Pharmaceutical 1-phenyl-4-alkylamino-pyrazoles
IT1061812B (it) * 1976-06-25 1983-04-30 Montedison Spa Processo per la preparazione di i fenil 3 ammino pirazoli
JPS6039269B2 (ja) * 1977-05-24 1985-09-05 三共株式会社 アシルケテン−ｓ・ｎ−アセタ−ル化合物、およびその製法
DE2747531A1 (de) * 1977-10-22 1979-04-26 Basf Ag Substituierte 3-aminopyrazole
DE3072103D1 (en) * 1979-07-13 1988-08-04 Wellcome Found Pharmaceutical compositions containing 3-amino-pyrazoline derivatives
DD149231A1 (de) * 1980-02-20 1981-07-01 Manfred Schulz Stabilisatoren fuer hochpolymere,niedermolekulare organische verbindungen und oele
DD151366A1 (de) * 1980-06-06 1981-10-14 Regina Werndl Diazotypiematerial mit verbesserter lichtstabilitaet der bildfarbstoffe
DE3035395A1 (de) * 1980-09-19 1982-05-06 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von pyrazol
BE891489A (fr) * 1980-12-16 1982-06-15 Wellcome Found Composes heterocycliques
DK556381A (da) * 1980-12-16 1982-06-17 Wellcome Found Pyrazolinforbindelser og deres fremstilling
EP0070376A1 (en) * 1981-07-13 1983-01-26 American Cyanamid Company Heterocyclic substituted-amino-pyrazolines
MA19539A1 (fr) * 1981-07-17 1983-04-01 May & Baker Ltd N Acylaminophenylpyrazoles
EP0119450A1 (en) * 1983-02-11 1984-09-26 The Wellcome Foundation Limited Preparation of aminopyrazolines and intermediates used therein
GB8303782D0 (en) * 1983-02-11 1983-03-16 Wellcome Found Heterocyclic compounds

Also Published As

Publication number Publication date
FI851836L (fi) 1985-11-13
EP0178035A1 (en) 1986-04-16
IL75146A0 (en) 1985-09-29
NO169283B (no) 1992-02-24
AU4227585A (en) 1985-11-14
ES543046A0 (es) 1986-07-16
EP0178035B1 (en) 1990-01-03
ES8609267A1 (es) 1986-07-16
PT80435A (en) 1985-06-01
IL75146A (en) 1989-07-31
JPH0625134B2 (ja) 1994-04-06
US4810719A (en) 1989-03-07
FI851836A7 (fi) 1985-11-13
PT80435B (en) 1987-04-13
ES8705393A1 (es) 1987-05-01
NZ212025A (en) 1989-03-29
GR851132B (no) 1985-11-25
NO169283C (no) 1992-06-10
ATE49198T1 (de) 1990-01-15
FI851836A0 (fi) 1985-05-09
DK204085A (da) 1985-11-13
ES551362A0 (es) 1987-05-01
AU586166B2 (en) 1989-07-06
DK204085D0 (da) 1985-05-08
JPS60246371A (ja) 1985-12-06
CA1246567A (en) 1988-12-13
DE3575130D1 (de) 1990-02-08

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